Overexpression of I kappa B alpha without inhibition of NF-κB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells

Blood

Volumn 94, Issue 9, 1999, Pages 3129-3134

  Emmerich, Florian ^b   Meiser, Martina ^b   Hummel, Michael ^b   Demel, Gudrun ^b   Foss, Hans Dieter ^b   Jundt, Franziska ^b   Mathas, Stephan ^b   Krappmann, Daniel ^b   Scheidereit, Claus ^b   Stein, Harald ^a   Dörken, Bernd ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CONTROLLED STUDY; GENE CONTROL; GENE MUTATION; GENE OVEREXPRESSION; HODGKIN DISEASE; HUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; REED STERNBERG CELL;

EID: 0033230955     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.9.3129     Document Type: Article

References (30)

1. Baeuerle PA, Henkel T: Function and activation of NF-κB in the immune system. Annu Rev Immunol 12:141, 1994
2. Wulczyn FG, Krappmann D, Scheidereit C: The NF-κB and IκB gene families: Mediators of immune response and inflammation. J Mol Med 74:749, 1996
3. Baeuerle P, Baltimore D: NF-κB: Ten years after. Cell 87:13, 1996
4. Traencker EB, Wilk S, Baeuerle P: A proteasome inhibitor prevents activation of NF-κB. EMBO J 13:5433, 1994
5. Brockman JA, Scherer DC, McKinsey TA, Hall SM, Qi X, Lee WY, Ballard DW: Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation. Mol Cell Biol 15:2809, 1995
6. Brown KS, Gerstberger L, Carlson G, Franzose U, Siebenlist U: Control of IκBα proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485, 1993
7. Scherer DC, Brockman ZJ, Chen T, Maniatis T, Balard DW: Signal-induced degradation of IκBα requires site-specific ubiquitination. Proc Natl Acad Sci USA 92:11259, 1995
8. Whiteside ST, Ernst MK, LeBail O, Laurent-Winter C, Rice N, Israel A: N- and C-terminal sequences control degradation of MAD3/ IκBα in response to inducers of NF-κB activity. Mol Cell Biol 15:5339, 1995
9. Sun SC, Elwood J, Greene WC: Both amino- and carboxy-terminal sequences within IκBα regulate its inducible degradation. Mol Cell Biol 16:1058, 1996
10. Baldwin AS: The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu Rev Immunol 14:649, 1996
11. Sun SC, Ganchi PA, Ballard DW, Greene WC: NF-kappa B controls expression of inhibitor I kappa B alpha: Evidence for an inducible autoregulatory pathway. Science 259:1912, 1993
12. Arenzana-Seisdedos F, Thompson J, Rodriguez MS, Bachelerie F, Thomas D, Hay RT: Inducible nuclear expression of newly synthesized IκBα negatively regulates DNA binding and transcriptional activities of NF-κB. Mol Cell Biol 15:2689, 1995
13. Arenzana-Seisdedos F, Turpin P, Rodriguez M, Thomas D, Hay RT, Virelizier J-L, Dargemont C: Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm. J Cell Sci 110:369, 1997
14. Harris NL, Jaffe ES, Stein H, Banks PM, Chan JKC, Cleary ML, Delsol G, DeWolf-Peeters C, Falini B, Gatter KC, Grogan TM, Isaacson PG, Knowles DM, Mason DY, Muller-Hermelink H-K, Pileri SA, Piris MA, Ralfkiaer E, Warnke RA: A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group. Blood 84:1361, 1994
15. Bargou RC, Leng C, Krappmann D, Emmerich F, Mapara MY, Bommert K, Royer HD, Scheidereit C, Dörken B: High-level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood 87:4340, 1996
16. Bargou RC, Emmerich F, Krappmann D, Bommert K, Mapara MY, Arnold W, Royer HD, Grinstein E, Greiner A, Scheidereit C, Dörken B: Constitutive NF-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 100:2961, 1997
17. Beg AA, Sha WC, Bronson RT, Baltimore D: Constitutive activation, enhanced granulopoiesis and neolethal lethality in IκBα-deficient mice. Genes Dev 9:2736, 1995
18. Marafioti T, Hummel M, Anagnostopoulos I, Foss HD, Falini B, Desol G, Isaacson PG, Pileri S, Stein H: Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal center B cells. N Engl J Med 337:453, 1997
19. Haskill S, Beg AA, Tompkins SM, Morris JS, Yurochko AD, Sampson-Johannes A, Mondal K, Ralph P, Baldwin AS Jr: Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. Cell 65:1281, 1991
20. Ito CY, Adey N, Bautch VL, Baldwin AS Jr: Structure and evolution of the IκBα gene. Genomics 29:490, 1995
21. Foss HD, Hummel M, Gottstein S, Ziemann K, Falini B, Herbst H, Stein H: Frequent expression of IL-7 gene transcripts in tumor cells of classical Hodgkin's disease. Am J Pathol 146:33, 1995
22. Krappmann D, Emmerich F, Kordes U, Scharschmidt E, Dörken B, Scheidereit C: Molecular mechanisms of aberrant constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene 18:943, 1999
23. Wood KM, Roff M, Hay R: Defective IκBα in Hodgkin cell lines with constitutively active NF-κB. Oncogene 16:2131, 1998
24. Hatada EN, Naumann M, Scheidereit C: Common structural constituents confer I kappa B activity to NF kappa B/p105 and I kappa B/MAD3. EMBO J 12:2781, 1993
25. Ernst MK, Dunn LL, Rice NR: The PEST-like sequence if I kappa B alpha is responsible for inhibition of DNA binding but not for cytoplasmatic retention of c-Rel or RelA homodimers. Mol Cell Biol 15:872, 1995
26. Barroga CF, Stevenson JK, Schwarz EM, Verma IM: Constitutive phosphorylation of IκBα by casein kinase II. Proc Natl Acad Sci 92:7637, 1995
27. Liu L, Kwak YT, Bex F, Garcia-Martinez LF, Li XH, Meek K, Lane WS, Gaynor RB: DNA-dependant protein kinase phosphorylation of IκBα and IκBβ regulates NF-κB binding properties. Mol Cell Biol 18:4221, 1998
28. Jacobs MD, Harrison S: Structure of the IκBα/ NF-κB complex. Cell 95:749, 1998
29. Huxford T, Huang DB, Malek S, Gosh G: The crystal structure of the IκBα/ NF-κB complex reveals mechanisms of NF-κB inactivation. Cell 95:759, 1998
30. Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT: Mutations in the IκBα gene in Hodgkin's disease suggest a tumor suppressor role for IκBα. Oncogene 18:3063, 1999