-
1
-
-
0345363003
-
Ras proteins: Recent advances and new functions
-
Rebollo A, Martinez AC. Ras proteins: recent advances and new functions. Blood. 1999;94:2971-2980.
-
(1999)
Blood
, vol.94
, pp. 2971-2980
-
-
Rebollo, A.1
Martinez, A.C.2
-
2
-
-
0033014304
-
Ras leukemia: From basic mechanisms to gene-directed therapy
-
Beaupre DM, Kurzrock R. RAS and leukemia: from basic mechanisms to gene-directed therapy. J Clin Oncol. 1999;17:1071-1079.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1071-1079
-
-
Beaupre, D.M.1
Kurzrock, R.2
-
4
-
-
0030992130
-
Protein prenylation, et cetera: Signal transduction in two dimensions
-
Gelb MH. Protein prenylation, et cetera: signal transduction in two dimensions. Science. 1997;275:1750-1751
-
(1997)
Science
, vol.275
, pp. 1750-1751
-
-
Gelb, M.H.1
-
5
-
-
0026909770
-
Ras and human tumors
-
Rodenhuls S. ras and human tumors. Semin Cancer Biol. 1992;3:241-247.
-
(1992)
Semin Cancer Biol
, vol.3
, pp. 241-247
-
-
Rodenhuls, S.1
-
6
-
-
0024376173
-
Ras oncogenes in human cancer: A review
-
Bos JL. ras oncogenes in human cancer: a review. Cancer Res. 1989;49:4682-4689.
-
(1989)
Cancer Res
, vol.49
, pp. 4682-4689
-
-
Bos, J.L.1
-
7
-
-
0028147448
-
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway
-
Pull L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J. 1994;13:764-773.
-
(1994)
EMBO J
, vol.13
, pp. 764-773
-
-
Pull, L.1
Liu, J.2
Gish, G.3
Mbamalu, G.4
Bowtell, D.5
Pelicci, P.G.6
Arlinghaus, R.7
Pawson, T.8
-
8
-
-
0033565561
-
The biology of chronic myeloid leukemia
-
Faded S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. The biology of chronic myeloid leukemia. N Engl J Med. 1999;341:164-172.
-
(1999)
N Engl J Med
, vol.341
, pp. 164-172
-
-
Faded, S.1
Talpaz, M.2
Estrov, Z.3
O'Brien, S.4
Kurzrock, R.5
Kantarjian, H.M.6
-
9
-
-
0035908493
-
Blocking oncogenic Ras signaling for cancer therapy
-
Adjei AA. Blocking oncogenic Ras signaling for cancer therapy. J Natl Cancer Inst. 2001;93:1062-1074.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 1062-1074
-
-
Adjei, A.A.1
-
10
-
-
0033375466
-
Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway
-
End DW. Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway. Invest New Drugs. 1999;17:241-258.
-
(1999)
Invest New Drugs
, vol.17
, pp. 241-258
-
-
End, D.W.1
-
11
-
-
0032704708
-
Ras protein farnesyltransterase: A strategic target for anticancer therapeutic development
-
Rowinsky EK, Windle JJ, Von Hoff DD. Ras protein farnesyltransterase: A strategic target for anticancer therapeutic development. J Clin Oncol. 1999;17:3631-3652.
-
(1999)
J Clin Oncol
, vol.17
, pp. 3631-3652
-
-
Rowinsky, E.K.1
Windle, J.J.2
Von Hoff, D.D.3
-
12
-
-
0034474092
-
Farnesyltransterase inhibitors: Antineoplastic properties, mechanisms of action, and clinical prospects
-
Prendergast GC, Oliff A. Farnesyltransterase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects. Semin Cancer Biol. 2000;10:443-452.
-
(2000)
Semin Cancer Biol
, vol.10
, pp. 443-452
-
-
Prendergast, G.C.1
Oliff, A.2
-
13
-
-
0035132538
-
Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
-
End DW, Smets G, Todd AV, et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 2001;61:131-137.
-
(2001)
Cancer Res
, vol.61
, pp. 131-137
-
-
End, D.W.1
Smets, G.2
Todd, A.V.3
-
14
-
-
0034665786
-
Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes
-
Aguayo A, Kantarjian H, Manshouri T et al. Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes. Blood. 2000;96:2240-2245.
-
(2000)
Blood
, vol.96
, pp. 2240-2245
-
-
Aguayo, A.1
Kantarjian, H.2
Manshouri, T.3
-
15
-
-
0037085781
-
Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia
-
Verstovsek S, Kantarjian H, Manshouri T, et al. Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia. Blood. 2002;99:2265-2267.
-
(2002)
Blood
, vol.99
, pp. 2265-2267
-
-
Verstovsek, S.1
Kantarjian, H.2
Manshouri, T.3
-
16
-
-
0037081268
-
Farnesyl-transferase inhibitors reverse Ras-mediated inhibition of Fas gene expression
-
Zhang B, Prendergast GC, Fenton RG. Farnesyl-transferase inhibitors reverse Ras-mediated inhibition of Fas gene expression. Cancer Res. 2002;62:450-458.
-
(2002)
Cancer Res
, vol.62
, pp. 450-458
-
-
Zhang, B.1
Prendergast, G.C.2
Fenton, R.G.3
-
17
-
-
0028813711
-
Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-alpha therapy
-
The Leukemia Service
-
Kartarjlan HM, Smith T, O'Brien S, Beran M, Pierce S, Talpaz M, The Leukemia Service. Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-alpha therapy. Ann Intern Med. 1995;122:254-261.
-
(1995)
Ann Intern Med
, vol.122
, pp. 254-261
-
-
Kartarjlan, H.M.1
Smith, T.2
O'Brien, S.3
Beran, M.4
Pierce, S.5
Talpaz, M.6
-
18
-
-
0035383789
-
Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
-
Karp JE, Lancet JE, Kaufmann SH, et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial. Blood. 2001;97:3361-3369.
-
(2001)
Blood
, vol.97
, pp. 3361-3369
-
-
Karp, J.E.1
Lancet, J.E.2
Kaufmann, S.H.3
-
19
-
-
79960970803
-
Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome
-
Kurzrock R, Cortes JE, Ryback ME, et al. Phase II study of R115777, a farnesyltransferase inhibitor, in myelodysplastic syndrome. Blood. 2001;98:848a.
-
(2001)
Blood
, vol.98
-
-
Kurzrock, R.1
Cortes, J.E.2
Ryback, M.E.3
-
20
-
-
79960970844
-
Phase I study of a farnesyl transferase inhibitor, R115777, in patients with myelodysplastic syndrome
-
Kurzrock R, Sebti SM, Kantarjian HM, et al. Phase I study of a farnesyl transferase inhibitor, R115777, in patients with myelodysplastic syndrome. Blood. 2001;98:623a.
-
(2001)
Blood
, vol.98
-
-
Kurzrock, R.1
Sebti, S.M.2
Kantarjian, H.M.3
-
21
-
-
0035282901
-
Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia
-
Peters DG, Hoover RR, Gerlach MJ, et al. Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia. Blood. 2001;97:1404-1412.
-
(2001)
Blood
, vol.97
, pp. 1404-1412
-
-
Peters, D.G.1
Hoover, R.R.2
Gerlach, M.J.3
-
22
-
-
0035282735
-
Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the famesyl transferase inhibitor SCH66336
-
Reichert A, Helsterkamp N, Daley GQ, Groffen J. Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the famesyl transferase inhibitor SCH66336. Blood. 2001;97:1399-1403.
-
(2001)
Blood
, vol.97
, pp. 1399-1403
-
-
Reichert, A.1
Helsterkamp, N.2
Daley, G.Q.3
Groffen, J.4
-
23
-
-
0036683409
-
Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336
-
Hoover RR, Mahon F-X, Melo JV, Daley GQ. Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336. Blood. 2002;100:1068-1071.
-
(2002)
Blood
, vol.100
, pp. 1068-1071
-
-
Hoover, R.R.1
Mahon, F.-X.2
Melo, J.V.3
Daley, G.Q.4
-
24
-
-
79960970868
-
Efficacy of SCH66336, the farnesyl transferase inhibitor, in conjunction with other antileukemic agents against Glivec-resistant BCR-ABL-positive cells
-
Nakajima A, Tauchi T, Sumi M, Bishop WR, Ohyashiki K. Efficacy of SCH66336, the farnesyl transferase inhibitor, in conjunction with other antileukemic agents against Glivec-resistant BCR-ABL-positive cells. Blood. 2001;98:575a.
-
(2001)
Blood
, vol.98
-
-
Nakajima, A.1
Tauchi, T.2
Sumi, M.3
Bishop, W.R.4
Ohyashiki, K.5
-
25
-
-
79960970545
-
The farnesyltransferase inhibitor, R115777, has significant in vitro activity in myelofibrosis with myeloid metaplasia
-
Mesa RA, Tefferi A, Gray L, Schroeder G, Kaufmann SH. The farnesyltransferase inhibitor, R115777, has significant in vitro activity in myelofibrosis with myeloid metaplasia. Blood. 2001;98:469a.
-
(2001)
Blood
, vol.98
-
-
Mesa, R.A.1
Tefferi, A.2
Gray, L.3
Schroeder, G.4
Kaufmann, S.H.5
-
26
-
-
4243722601
-
Activity of farnesyl transferase inhibitor, FTI-277, in human myeloma cells correlates with inhibition of Ras processing
-
Bolick SC, Sebti SM, Hamilton TH, Landowski TH, Dalton WS. Activity of farnesyl transferase inhibitor, FTI-277, in human myeloma cells correlates with inhibition of Ras processing. Clin Cancer Res. 2001;7:3805s
-
(2001)
Clin Cancer Res
, vol.7
-
-
Bolick, S.C.1
Sebti, S.M.2
Hamilton, T.H.3
Landowski, T.H.4
Dalton, W.S.5
-
27
-
-
79960971542
-
Preclinical investigation of a farnesyl transferase inhibitor for multiple myeloma
-
Beaupre DM, Grad J, Bahlis N, Boise LH, Lichtenheld MG. Preclinical investigation of a farnesyl transferase inhibitor for multiple myeloma. Blood. 2001;98:640a.
-
(2001)
Blood
, vol.98
-
-
Beaupre, D.M.1
Grad, J.2
Bahlis, N.3
Boise, L.H.4
Lichtenheld, M.G.5
-
28
-
-
0013329920
-
Farnesyl transferase inhibitor FTI-R115777 is well tolerated, induces stabilization of disease and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma
-
Abstract no. 4960
-
Alsina M, Overton R, Belle N, et al. Farnesyl transferase inhibitor FTI-R115777 is well tolerated, induces stabilization of disease and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma. Proceedings of AACR. 2002;43:1000 (Abstract no. 4960).
-
(2002)
Proceedings of AACR
, vol.43
, pp. 1000
-
-
Alsina, M.1
Overton, R.2
Belle, N.3
-
29
-
-
0034284027
-
Targeting the Ras signaling pathway: A rational, mechanism-based treatment for hematologic malignancies?
-
Reuter CW, Morgan MA, Bergmann L. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood. 2000;96:1655-1669.
-
(2000)
Blood
, vol.96
, pp. 1655-1669
-
-
Reuter, C.W.1
Morgan, M.A.2
Bergmann, L.3
-
30
-
-
0033016719
-
Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB
-
Du W, Lebowitz PF, Prendergast GC. Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB. Mol Cell Biol. 1999;19:1831-1840.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1831-1840
-
-
Du, W.1
Lebowitz, P.F.2
Prendergast, G.C.3
-
31
-
-
0034730625
-
Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules
-
Ashar HR, James L, Gray K, et al. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. J Biol Chem. 2000;275:30451-30457.
-
(2000)
J Biol Chem
, vol.275
, pp. 30451-30457
-
-
Ashar, H.R.1
James, L.2
Gray, K.3
-
32
-
-
0035893740
-
Evaluation of farnesyl: Protein transferase and geranylgeranyl: Protein transferase inhibitor combinations in preclinical models
-
Lobell RB, Omer CA, Abrams MT, et al. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Res. 2001;61:8758-8768.
-
(2001)
Cancer Res
, vol.61
, pp. 8758-8768
-
-
Lobell, R.B.1
Omer, C.A.2
Abrams, M.T.3
-
33
-
-
0034070276
-
Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue
-
Tahir SK, Gu WZ, Zhang HC, et al. Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue. Eur J Cancer. 2000;36:1161-1170.
-
(2000)
Eur J Cancer
, vol.36
, pp. 1161-1170
-
-
Tahir, S.K.1
Gu, W.Z.2
Zhang, H.C.3
-
34
-
-
0033198180
-
Effect of novel CAAX peptidomimetic farnesyl-transferase inhibitor on angiogenesis in vitro and in vivo
-
Gu WZ, Tahir SK, Wang YC, Zhang HC, Cherian SP, O'Connor S, Leal JA, Rosenberg SH, Ng SC. Effect of novel CAAX peptidomimetic farnesyl-transferase inhibitor on angiogenesis in vitro and in vivo. Eur J Cancer. 1999;35:1394-1401.
-
(1999)
Eur J Cancer
, vol.35
, pp. 1394-1401
-
-
Gu, W.Z.1
Tahir, S.K.2
Wang, Y.C.3
Zhang, H.C.4
Cherian, S.P.5
O'Connor, S.6
Leal, J.A.7
Rosenberg, S.H.8
Ng, S.C.9
-
35
-
-
0033539952
-
Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects
-
Feldkamp MM, Lau N, Guha A. Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects. Oncogene. 1999;18:7514-7526.
-
(1999)
Oncogene
, vol.18
, pp. 7514-7526
-
-
Feldkamp, M.M.1
Lau, N.2
Guha, A.3
-
36
-
-
0032928810
-
The up-regulation of vascular endothelial growth factor in mutated Ha-ras HaCaT cell lines is reduced by a farnesyl transferase inhibitor
-
Charvat S, Duchesne M, Parvaz P, Chignol MC, Schmitt D, Serres M. The up-regulation of vascular endothelial growth factor in mutated Ha-ras HaCaT cell lines is reduced by a farnesyl transferase inhibitor. Anticancer Res. 1999;19:557-561.
-
(1999)
Anticancer Res
, vol.19
, pp. 557-561
-
-
Charvat, S.1
Duchesne, M.2
Parvaz, P.3
Chignol, M.C.4
Schmitt, D.5
Serres, M.6
-
37
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
-
Rak J, Mitsuhashi Y, Bayko L, et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res. 1995;55:4575-4580.
-
(1995)
Cancer Res
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
-
38
-
-
0033051030
-
Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras
-
Feldkamp MM, Lau N, Rak J, Kerbel RS, Guha A. Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by Ras. Int J Cancer. 1999;81:118-124.
-
(1999)
Int J Cancer
, vol.81
, pp. 118-124
-
-
Feldkamp, M.M.1
Lau, N.2
Rak, J.3
Kerbel, R.S.4
Guha, A.5
|