Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

Oncogene

Volumn 21, Issue 43, 2002, Pages 6587-6597

  Pene, Frédéric ^a   Claessens, Yann Erick ^a   Muller, Odile ^a   Viguié, Franck ^c   Mayeux, Patrick ^a   Dreyfus, François ^a,b   Lacombe, Catherine ^a,b   Bouscary, Didier ^a,b  

^a INSTITUT COCHIN   (France)

^b AP HP ^*  (France)

^c HÔTEL DIEU   (France)

Author keywords

Multiple myeloma; p27Kip1; P70 S6 kinase; Phosphatidylinositol 3 kinase; Skp2

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 3; CASPASE INHIBITOR; CYCLIN D1; GROWTH FACTOR; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN; PROTEIN KINASE B; RAPAMYCIN; S PHASE KINASE ASSOCIATED PROTEIN 2; S6 KINASE; SOMATOMEDIN C; UNCLASSIFIED DRUG; WORTMANNIN;

ADULT; AGED; APOPTOSIS; ARTICLE; BONE MARROW; CARCINOGENESIS; CASE REPORT; CELL CYCLE; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MALE; MULTIPLE MYELOMA; PLASMA CELL; PLASMA CELL LEUKEMIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD95; APOPTOSIS; CASPASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE; CYCLIN D1; FAS LIGAND PROTEIN; HUMANS; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPLE MYELOMA; MUSCLE PROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RIBOSOMAL PROTEIN S6 KINASES; S-PHASE KINASE-ASSOCIATED PROTEINS; TUMOR SUPPRESSOR PROTEINS;

MAMMALIA;

EID: 0037179847     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1205923     Document Type: Article

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