TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors

Leukemia

Volumn 16, Issue 1, 2002, Pages 67-73

  Plasilova, M ^a   Zivny, J ^b   Jelinek, J ^a   Neuwirtova, R ^c   Cermak, J ^a   Necas, E ^b   Andera, L ^d   Stopka, T ^a,b  

^a INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

^d INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

Apoptosis; Hematopoiesis; Leukemia; TRAIL

Indexed keywords

ALPHA INTERFERON; CD34 ANTIGEN; HISTIDINE; LEUCINE ZIPPER PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ACUTE GRANULOCYTIC LEUKEMIA; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW; BONE MARROW CELL; CANCER CELL CULTURE; CANCER INHIBITION; CANCER TRANSPLANTATION; CHRONIC GRANULOCYTIC LEUKEMIA; CLONE; COLONY FORMING UNIT GM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ESCHERICHIA COLI; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA REMISSION; LYMPHOMA; MAJOR CLINICAL STUDY; MOUSE; MYELODYSPLASTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN VARIANT; SCID MOUSE; STEM CELL; UMBILICAL CORD BLOOD;

EID: 85009895235     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402338     Document Type: Article

References (28)

1. Safety and antitumor activity of recombinant soluble Apo2 ligand
2. TRAIL leads to apoptosis in acute promyelocytic leukaemia
3. Direct stimulation of apoptotic signaling by soluble Apo21/tumor necrosis factor-related apoptosis-inducing ligand leads to selective killing of glioma cells
4. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
5. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
6. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
7. FADD is required for DR4- and DR5-mediated apoptosis: Lack of trail-induced apoptosis in FADD-deficient mouse embryonic fibroblasts
8. A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins
9. FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
10. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
11. Inhibition of death receptor signals by cellular FLIP
12. p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha
13. Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL
14. Antileukemic drugs increase death receptor 5 levels and enhance apo-2L-induced apoptosis of human acute leukemia cells
15. Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells
16. TNF-related apoptosis-inducing ligand (TRAIL) as a negative regulator of normal human erythropoiesis
17. TRAIL is a potent inducer of apoptosis in myeloma cells derived from multiple myeloma patients and is not cytotoxic to hematopoietic stem cells
18. Enhanced proliferation and increased IFN-gamma production in T cells by signal transduced through TNF-related apoptosis-inducing ligand
19. CFU-GFU growth and survival in 258 patients with myelodysplastic syndrome
20. Identification of lymphomyeloid primitive progenitor cells in fresh human cord blood and in the marrow of nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice transplanted with human CD34(+) cord blood cells
21. Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis
22. Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive tumor necrosis factor-related apoptosis-inducing ligand
23. In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activity
24. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
25. Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL)
26. Don't blaze the trailblazer TRAIL too early
27. Human hematopoietic progenitors express erythropoietin
28. Erythroid progenitors differentiate and mature in response to endogenous erythropoietin