-
1
-
-
0025204548
-
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
-
Hockenbery D, Nunez G, Milliman C, et al: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336, 1990
-
(1990)
Nature
, vol.348
, pp. 334-336
-
-
Hockenbery, D.1
Nunez, G.2
Milliman, C.3
-
2
-
-
0026781986
-
Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
-
Miyashita T, Reed JC: Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 52:5407-5411, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 5407-5411
-
-
Miyashita, T.1
Reed, J.C.2
-
3
-
-
0025274436
-
Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population
-
McDonnell TJ, Nunez G, Platt FM, et al: Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population. Mol Cell Biol 10: 1901-1907, 1990
-
(1990)
Mol Cell Biol
, vol.10
, pp. 1901-1907
-
-
McDonnell, T.J.1
Nunez, G.2
Platt, F.M.3
-
4
-
-
0026053958
-
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18)
-
McDonnell TJ, Korsmeyer SJ: Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature 349:254-256, 1991
-
(1991)
Nature
, vol.349
, pp. 254-256
-
-
McDonnell, T.J.1
Korsmeyer, S.J.2
-
5
-
-
0030029443
-
Prognostic significance of bcl-2 protein expression in aggressive non-hodgkin's lymphoma: Groupe d'Etude des Lymphomes de l'Adulte (GELA)
-
Hermine O, Haioun C, Lepage E, et al: Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma: Groupe d'Etude des Lymphomes de l'Adulte (GELA). Blood 87:265-272, 1996
-
(1996)
Blood
, vol.87
, pp. 265-272
-
-
Hermine, O.1
Haioun, C.2
Lepage, E.3
-
6
-
-
10144246572
-
Prognostic significance of BCL-2 expression and Bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: A British National Lymphoma Investigation study
-
Hill ME, MacLennan KA, Cunningham DC, et al: Prognostic significance of BCL-2 expression and Bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: A British National Lymphoma Investigation study. Blood 88:1046-1051, 1996
-
(1996)
Blood
, vol.88
, pp. 1046-1051
-
-
Hill, M.E.1
MacLennan, K.A.2
Cunningham, D.C.3
-
7
-
-
0030985194
-
Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma
-
Gascoyne RD, Adomat SA, Krajewski S, et al: Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood 90:244-251, 1997
-
(1997)
Blood
, vol.90
, pp. 244-251
-
-
Gascoyne, R.D.1
Adomat, S.A.2
Krajewski, S.3
-
8
-
-
0027217846
-
Investigations of antisense oligonucleotides targeted against bcl-2 RNAs
-
Kitada S, Miyashita T, Tanaka S, et al: Investigations of antisense oligonucleotides targeted against bcl-2 RNAs. Antisense Res Dev 3:157-169, 1993
-
(1993)
Antisense Res Dev
, vol.3
, pp. 157-169
-
-
Kitada, S.1
Miyashita, T.2
Tanaka, S.3
-
9
-
-
0028060247
-
Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression
-
Kitada S, Takayatna S, de Riel K, et al: Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression. Antisense Res Dev 4:71-79, 1994
-
(1994)
Antisense Res Dev
, vol.4
, pp. 71-79
-
-
Kitada, S.1
Takayatna, S.2
De Riel, K.3
-
10
-
-
0028066802
-
Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model
-
Cotter FE, Johnson P, Hall P, et al: Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model. Oncogene 9:3049-3055, 1994
-
(1994)
Oncogene
, vol.9
, pp. 3049-3055
-
-
Cotter, F.E.1
Johnson, P.2
Hall, P.3
-
11
-
-
0030888664
-
Bcl-2 antisense therapy in patients with non Hodgkin's lymphoma
-
Webb A, Cunningham D, Cotter F, et al: Bcl-2 antisense therapy in patients with non Hodgkin's lymphoma. Lancet 349:1137-1141, 1997
-
(1997)
Lancet
, vol.349
, pp. 1137-1141
-
-
Webb, A.1
Cunningham, D.2
Cotter, F.3
-
12
-
-
0031007491
-
Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice
-
Raynaud FI, Orr RM, Goddard PM, et al: Pharmacokinetics of G3139, a phosphorothioate oligodeoxynucleotide antisense to bcl-2, after intravenous administration or continuous subcutaneous infusion to mice. J Pharmacol Exp Ther 281:420-428, 1997
-
(1997)
J Pharmacol Exp Ther
, vol.281
, pp. 420-428
-
-
Raynaud, F.I.1
Orr, R.M.2
Goddard, P.M.3
-
13
-
-
0000102814
-
A phase I-II study with dacarbazine and BCL-2 antisense oligonucleotide G3139 (GENTA) as a chemosensitizer in patients with advanced malignant melanoma
-
abstr 2049
-
Jansen B, Wacheck V, Heere-Ress E, et al: A phase I-II study with dacarbazine and BCL-2 antisense oligonucleotide G3139 (GENTA) as a chemosensitizer in patients with advanced malignant melanoma. Proc Am Soc Clin Oncol 18:531a, 1999 (abstr 2049)
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
-
-
Jansen, B.1
Wacheck, V.2
Heere-Ress, E.3
-
14
-
-
0000642129
-
A phase I/IIa trial of bcl-2 antisense (G3139) treatment by 14-day continuous infusion (CI) for patients with androgen-independent prostate cancer or other advanced solid tumor malignancies
-
abstr 1243
-
Morris MJ, Tong W, Osman I, et al: A phase I/IIa trial of bcl-2 antisense (G3139) treatment by 14-day continuous infusion (CI) for patients with androgen-independent prostate cancer or other advanced solid tumor malignancies. Proc Am Soc Clin Oncol 18:323a, 1999 (abstr 1243)
-
(1999)
Proc Am Soc Clin Oncol
, vol.18
-
-
Morris, M.J.1
Tong, W.2
Osman, I.3
-
15
-
-
0003253726
-
Phase I evaluation of CGP 6412SA, an antisense inhibitor of protein kinase C-alpha (PKCα), in patients with refractory cancer
-
abstr 870
-
Nemunaitis J, Eckhardt G, Dorr A, et al: Phase I evaluation of CGP 6412SA, an antisense inhibitor of protein kinase C-alpha (PKCα), in patients with refractory cancer. Proc Am Soc Clin Oncol 16:246a, 1997 (abstr 870)
-
(1997)
Proc Am Soc Clin Oncol
, vol.16
-
-
Nemunaitis, J.1
Eckhardt, G.2
Dorr, A.3
-
16
-
-
0031907428
-
Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
-
Jansen B, Schlagbauer-Wadl H, Brown BD, et al: Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat Med 4:232-234, 1998
-
(1998)
Nat Med
, vol.4
, pp. 232-234
-
-
Jansen, B.1
Schlagbauer-Wadl, H.2
Brown, B.D.3
-
17
-
-
0003303170
-
Phase I/pharmacokinetic/pharmacodynamic trial of Raf-1 antisense ODN (ISIS 5132, CGP 69846A)
-
abstr 810
-
O'Dwyer PJ, Stevenson JP, Gallagher M, et al: Phase I/pharmacokinetic/pharmacodynamic trial of Raf-1 antisense ODN (ISIS 5132, CGP 69846A). Proc Am Soc Clin Oncol 17:210a, 1998 (abstr 810)
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
O'Dwyer, P.J.1
Stevenson, J.P.2
Gallagher, M.3
-
18
-
-
0031782392
-
A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
-
Yacyshyn BR, Bowen Y-MB, Jewell L, et al: A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology 114:1133-1142, 1998
-
(1998)
Gastroenterology
, vol.114
, pp. 1133-1142
-
-
Yacyshyn, B.R.1
Bowen, Y.-M.B.2
Jewell, L.3
-
19
-
-
0030900680
-
Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma
-
Wooldridge JE, Ballas Z, Krieg AM, et al: Immunostimulatory oligodeoxynucleotides containing CpG motifs enhance the efficacy of monoclonal antibody therapy of lymphoma. Blood 89:2994-2998, 1997
-
(1997)
Blood
, vol.89
, pp. 2994-2998
-
-
Wooldridge, J.E.1
Ballas, Z.2
Krieg, A.M.3
-
20
-
-
0030239828
-
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
-
Ballas ZK, Rasmussen WL., Krieg AM: Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 157:1840-1845, 1996
-
(1996)
J Immunol
, vol.157
, pp. 1840-1845
-
-
Ballas, Z.K.1
Rasmussen, W.L.2
Krieg, A.M.3
-
21
-
-
0032531036
-
Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
-
Jakob T, Walker PS, Krieg AM, et al: Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J Immunol 161:3042-3049, 1998
-
(1998)
J Immunol
, vol.161
, pp. 3042-3049
-
-
Jakob, T.1
Walker, P.S.2
Krieg, A.M.3
-
22
-
-
0003263248
-
Antisense oligonucleotide therapy targeted to protein kinase C-alpha (ISIS 3521/CGP 64128A) by 21 day infusion: Results of the phase I trial and activity in ovarian carcinomas
-
abstr 1654
-
Sikic BI, Yuen AR, Advani R, et al: Antisense oligonucleotide therapy targeted to protein kinase C-alpha (ISIS 3521/CGP 64128A) by 21 day infusion: Results of the phase I trial and activity in ovarian carcinomas. Proc Am Soc Clin Oncol 17:429a, 1998 (abstr 1654)
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Sikic, B.I.1
Yuen, A.R.2
Advani, R.3
-
23
-
-
0003241331
-
Phase I trial of c-raf antisense oligonucleotide ISIS 5132 (CGP 69846A) by 21-day continuous intravenous infusion (CIV) in patients with advanced cancer
-
abstr 811
-
Holmlund J, Nemunaitis J, Schiller J, et al: Phase I trial of c-raf antisense oligonucleotide ISIS 5132 (CGP 69846A) by 21-day continuous intravenous infusion (CIV) in patients with advanced cancer. Proc Am Soc Clin Oncol 17:210a, 1998 (abstr 811)
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Holmlund, J.1
Nemunaitis, J.2
Schiller, J.3
-
24
-
-
0030987678
-
Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302)
-
Glover JM, Leeds JM, Mant TG, et al: Phase I safety and pharmacokinetic profile of an intercellular adhesion molecule-1 antisense oligodeoxynucleotide (ISIS 2302). J Pharmacol Exp Ther 282: 1173-1180, 1997
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 1173-1180
-
-
Glover, J.M.1
Leeds, J.M.2
Mant, T.G.3
-
25
-
-
9244223546
-
Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies
-
Bishop MR, Iversen PL, Bayever E, et al: Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies. J Clin Oncol 14:1320-1326, 1996
-
(1996)
J Clin Oncol
, vol.14
, pp. 1320-1326
-
-
Bishop, M.R.1
Iversen, P.L.2
Bayever, E.3
-
26
-
-
0031006756
-
Effects of synthetic oligonucleotides on human complement and coagulation
-
Shaw DR, Rustagi PK, Kandimalla ER, et al: Effects of synthetic oligonucleotides on human complement and coagulation. Biochem Pharmacol 53:1123-1132, 1997
-
(1997)
Biochem Pharmacol
, vol.53
, pp. 1123-1132
-
-
Shaw, D.R.1
Rustagi, P.K.2
Kandimalla, E.R.3
-
27
-
-
0025835716
-
Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death
-
Hockenbery DM, Zutter M, Hickey W, et al: Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci U S A 88:6961-6965, 1991
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 6961-6965
-
-
Hockenbery, D.M.1
Zutter, M.2
Hickey, W.3
-
28
-
-
0027427492
-
Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
-
Veis DJ, Sorenson CM, Shutter JR, et al: Bcl-2 deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229-240, 1993
-
(1993)
Cell
, vol.75
, pp. 229-240
-
-
Veis, D.J.1
Sorenson, C.M.2
Shutter, J.R.3
-
29
-
-
0028833859
-
Bcl-2 deficiency in mice leads to pleiotropic abnormalities: Accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine
-
Kamada S, Shimono A, Shinto Y, et al: Bcl-2 deficiency in mice leads to pleiotropic abnormalities: Accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine. Cancer Res 55:354-359, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 354-359
-
-
Kamada, S.1
Shimono, A.2
Shinto, Y.3
-
30
-
-
0029156492
-
Primitive human haematopoietic precursors express bcl-x but not bcl-2
-
Park JR, Bernstein ID, Hockenbery DM: Primitive human haematopoietic precursors express bcl-x but not bcl-2. Blood 86:868-876, 1995
-
(1995)
Blood
, vol.86
, pp. 868-876
-
-
Park, J.R.1
Bernstein, I.D.2
Hockenbery, D.M.3
-
31
-
-
0028922885
-
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
-
Motoyama N, Wang F, Roth KA, et al: Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science 267:1506-1510, 1995
-
(1995)
Science
, vol.267
, pp. 1506-1510
-
-
Motoyama, N.1
Wang, F.2
Roth, K.A.3
-
32
-
-
0030776403
-
Pharmacokinetics, metabolism and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (GCP69846A) after intravenous and subcutaneous administration
-
Phillips JA, Craig SJ, Bayley D, et al: Pharmacokinetics, metabolism and elimination of a 20-mer phosphorothioate oligodeoxynucleotide (GCP69846A) after intravenous and subcutaneous administration. Biochem Pharmacol 54:657-668, 1997
-
(1997)
Biochem Pharmacol
, vol.54
, pp. 657-668
-
-
Phillips, J.A.1
Craig, S.J.2
Bayley, D.3
-
33
-
-
0029127845
-
Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (Gem-91) in HIV infected subjects
-
Zhang RW, Yan JM, Shahinian H, et al: Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (Gem-91) in HIV infected subjects. Clin Pharmacol Ther 58:44-53, 1995
-
(1995)
Clin Pharmacol Ther
, vol.58
, pp. 44-53
-
-
Zhang, R.W.1
Yan, J.M.2
Shahinian, H.3
-
34
-
-
0030797704
-
Antisense oligonucleotides for the treatment of cancer: I. Pharmacokinetic properties of phosphorothioate oligonucleotides
-
Geary RS, Leeds JM, Henry SP, et al: Antisense oligonucleotides for the treatment of cancer: I. Pharmacokinetic properties of phosphorothioate oligonucleotides. Anticancer Drug Design 12:383-393, 1997
-
(1997)
Anticancer Drug Design
, vol.12
, pp. 383-393
-
-
Geary, R.S.1
Leeds, J.M.2
Henry, S.P.3
-
35
-
-
84871470383
-
Antisense oligonucleotides to bcl-2 with low dose cyclophosphamide cures SCID/Rag-2 mice with a human B cell lymphoma
-
abstr
-
Wong F, Bally M, Klasa R: Antisense oligonucleotides to bcl-2 with low dose cyclophosphamide cures SCID/Rag-2 mice with a human B cell lymphoma. Proc Am Assoc Cancer Res 40:20, 1999 (abstr)
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 20
-
-
Wong, F.1
Bally, M.2
Klasa, R.3
-
36
-
-
0000818328
-
Tumour regression of human breast carcinomas by combination therapy of anti-Bcl-2 antisense oligonucleotide and chemotherapeutic drugs
-
abstr
-
Yang D, Ling Y, Almazan M, et al: Tumour regression of human breast carcinomas by combination therapy of anti-Bcl-2 antisense oligonucleotide and chemotherapeutic drugs. Proc Am Assoc Cancer Res 40:729, 1999 (abstr)
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 729
-
-
Yang, D.1
Ling, Y.2
Almazan, M.3
-
37
-
-
0031664988
-
Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines
-
Zangemeister-Wittke U, Schenker T, Luedke GH, et al: Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines. Br J Cancer 78:1035-1042, 1998
-
(1998)
Br J Cancer
, vol.78
, pp. 1035-1042
-
-
Zangemeister-Wittke, U.1
Schenker, T.2
Luedke, G.H.3
-
38
-
-
0009770472
-
Downregulation of Bcl-2 expression by antisense oligonucleotide treatment enhances mitoxantrone cytotoxicity in the androgen-dependent Shionogi tumour model
-
abstr
-
Tolcher A, Miyake H, Cleave M: Downregulation of Bcl-2 expression by antisense oligonucleotide treatment enhances mitoxantrone cytotoxicity in the androgen-dependent Shionogi tumour model. Proc Am Assoc Cancer Res 40:484, 1999 (abstr)
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 484
-
-
Tolcher, A.1
Miyake, H.2
Cleave, M.3
|