CDDO induces apoptosis via the intrinsic pathway in lymphoid cells

Leukemia

Volumn 18, Issue 5, 2004, Pages 948-952

  Inoue, S ^a   Snowden, R T ^a   Dyer, M J S ^a   Cohen, G M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Apoptosis; CDDO; Chronic lymphocytic leukemia (CLL); Intrinsic pathway

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CASPASE INHIBITOR; CYTOCHROME C; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PROTEIN BCL XL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; 2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CASP9 PROTEIN, HUMAN; CASPASE; CASPASE 9; DRUG DERIVATIVE; LEUPEPTIN; OLEANOLIC ACID;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL TYPE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHOID CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; DRUG EFFECT; PATHOLOGY; PHYSIOLOGY;

APOPTOSIS; CASPASE 9; CASPASES; HUMANS; JURKAT CELLS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LEUPEPTINS; OLEANOLIC ACID;

EID: 2342465492     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2403328     Document Type: Article

References (26)

1. Bratton SB, MacFarlane M, Cain K, Cohen GM. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res 2000; 256: 27-33.
2. van Loo G, Saelens X, van Gurp M, MacFarlane M, Martin SJ, Vandenabeele P. The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell Death Differ 2002; 9: 1031-1042.
3. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997; 91: 479-489.
4. Cain K, Brown DG, Langlais C, Cohen GM. Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex. J Biol Chem 1999; 274: 22686-22692.
5. Bratton SB, Walker G, Srinivasula SM, Sun XM, Butterworth M, Alnemri ES et al. Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J 2001; 20: 998-1009.
6. Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281: 1305-1308.
7. Kersten S, Desvergne B, Wahli W. Roles of PPARs in health and disease. Nature 2000; 405: 421-424.
8. Murphy GJ, Holder JC. PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer. Trends Pharmacol Sci 2000; 21: 469-474.
9. Willson TM, Lambert MH, Kliewer SA. Peroxisome proliferator-activated receptor gamma and metabolic disease. Annu Rev Biochem 2001; 70: 341-367.
10. Suh N, Wang Y, Honda T, Gribble GW, Dmitrovsky E, Hickey WF et al. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, anti-proliferative, and anti-inflammatory activity. Cancer Res 1999; 59: 336-341.
11. Ito Y, Pandey P, Place A, Sporn MB, Gribble GW, Honda T et al. The novel triterpenoid 2-cyano-3, 12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism. Cell Growth Differ 2000; 11: 261-267.
12. Ito Y, Pandey P, Sporn MB, Datta R, Kharbanda S, Kufe D. The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism. Mol Pharmacol 2001; 59: 1094-1099.
13. Pedersen IM, Kitada S, Schimmer A, Kim Y, Zapata JM, Charboneau L et al. The triterpenoid CDDO induces apoptosis in refractory CLL B cells. Blood 2002; 100: 2965-2972.
14. Kim KB, Lotan R, Yue P, Sporn MB, Suh N, Gribble GW et al. Identification of a novel synthetic triterpenoid, methyl-2-cyano-3, 12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells. Mol Cancer Ther 2002; 1: 177-184.
15. Almond JB, Snowden RT, Hunter A, Dinsdale D, Cain K, Cohen GM. Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex. Leukemia 2001; 15: 1388-1397.
16. MacFarlane M, Harper N, Snowden RT, Dyer MJ, Barnett GA, Pringle JH et al. Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia. Oncogene 2002; 21: 6809-6818.
17. Harper N, Hughes M. MacFarlane M, Cohen GM. Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J Biol Chem 2003; 278: 25534-25541.
18. Sun XM, Bratton SB, Butterworth M, MacFarlane M, Cohen CM. Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem 2002; 277: 11345-11351.
19. Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR, Cohen GM. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 1999; 274: 5053-5060.
20. Dewson G, Snowden RT, Almond JB, Dyer MJ, Cohen GM. Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells. Oncogene 2003; 22: 2643-2654.
21. Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH et al. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 1997; 16: 2794-2804.
22. Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD et al. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 1999; 144: 281-292.
23. Bratton SB, Lewis J, Butterworth M, Duckett CS, Cohen GM. XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. Cell Death Differ 2002; 9: 881-892.
24. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell 1998; 1: 949-957.
25. Suh N, Wang Y, Williams CR, Risingsong R, Gilmer T, Willson TM et al. A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW7845, inhibits rat mammary carcinogenesis. Cancer Res 1999; 59: 5671-5673.
26. Fehlberg S, Trautwein S, Goke A, Goke R. Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners. Biochem J 2002; 362: 573-578.