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Volumn 11, Issue , 2004, Pages S193-S206

Histone deacetylase inhibitors potentiate tnf-related apoptosis-inducing ligand (Trail)-induced apoptosis in lymphoid malignancies

Author keywords

Chronic lymphocytic leukemia; Depsipeptide; Disc; Histone deacetlyase inhibitors; Tumor necrosis factorrelated apoptosis inducing ligand

Indexed keywords

CASPASE 8; DEATH RECEPTOR 5; DEPSIPEPTIDE; HISTONE DEACETYLASE INHIBITOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 12744261484     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401535     Document Type: Article
Times cited : (149)

References (68)
  • 1
    • 0034630330 scopus 로고    scopus 로고
    • Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis
    • Bratton SB, MacFarlane M, Cain K and Cohen GM (2000) Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp. Cell. Res. 256: 27-33
    • (2000) Exp. Cell. Res , vol.256 , pp. 27-33
    • Bratton, S.B.1    Macfarlane, M.2    Cain, K.3    Cohen, G.M.4
  • 2
    • 0034320568 scopus 로고    scopus 로고
    • Mechanisms of apoptosis
    • Reed JC (2000) Mechanisms of apoptosis. Am. J. Pathol. 157: 1415-1430
    • (2000) Am. J. Pathol , vol.157 , pp. 1415-1430
    • Reed, J.C.1
  • 3
    • 0029026548 scopus 로고
    • FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    • Chinnaiyan AM, O’Rourke K, Tewari M and Dixit VM (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505-512
    • (1995) Cell , vol.81 , pp. 505-512
    • Chinnaiyan, A.M.1    O’Rourke, K.2    Tewari, M.3    Dixit, V.M.4
  • 4
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    • Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH and Peter ME (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 14: 5579-5588
    • (1995) EMBO J , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbardt, S.2    Behrmann, I.3    Germer, M.4    Pawlita, M.5    Krammer, P.H.6    Peter, M.E.7
  • 8
    • 0030011398 scopus 로고    scopus 로고
    • Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
    • Boldin MP, Goncharov TM, Goltsev YV and Wallach D (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell 85: 803-815
    • (1996) Cell , vol.85 , pp. 803-815
    • Boldin, M.P.1    Goncharov, T.M.2    Goltsev, Y.V.3    Wallach, D.4
  • 10
  • 13
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A and Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 1305-1308
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 15
    • 0033556310 scopus 로고    scopus 로고
    • The role of c-FLIP in modulation of CD95-induced apoptosis
    • Scaffidi C, Schmitz I, Krammer PH and Peter ME (1999) The role of c-FLIP in modulation of CD95-induced apoptosis. J. Biol. Chem. 274: 1541-1548
    • (1999) J. Biol. Chem , vol.274 , pp. 1541-1548
    • Scaffidi, C.1    Schmitz, I.2    Krammer, P.H.3    Peter, M.E.4
  • 16
    • 0035827569 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
    • Krueger A, Schmitz I, Baumann S, Krammer PH and Kirchhoff S (2001) Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J. Biol. Chem. 276: 20633-20640
    • (2001) J. Biol. Chem , vol.276 , pp. 20633-20640
    • Krueger, A.1    Schmitz, I.2    Baumann, S.3    Krammer, P.H.4    Kirchhoff, S.5
  • 17
    • 0032523201 scopus 로고    scopus 로고
    • Tumor B cells from non-Hodgkin’s lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis
    • Plumas J, Jacob MC, Chaperot L, Molens JP, Sotto JJ and Bensa JC (1998) Tumor B cells from non-Hodgkin’s lymphoma are resistant to CD95 (Fas/Apo-1)-mediated apoptosis. Blood 91: 2875-2885
    • (1998) Blood , vol.91 , pp. 2875-2885
    • Plumas, J.1    Jacob, M.C.2    Chaperot, L.3    Molens, J.P.4    Sotto, J.J.5    Bensa, J.C.6
  • 18
    • 0030687949 scopus 로고    scopus 로고
    • Malignant and reactive cells from human lymphomas frequently express Fas ligand but display a different sensitivity to Fas-mediated apoptosis
    • Xerri L, Devilard E, Hassoun J, Haddad P and Birg F (1997) Malignant and reactive cells from human lymphomas frequently express Fas ligand but display a different sensitivity to Fas-mediated apoptosis. Leukemia 11: 1868-1877
    • (1997) Leukemia , vol.11 , pp. 1868-1877
    • Xerri, L.1    Devilard, E.2    Hassoun, J.3    Haddad, P.4    Birg, F.5
  • 19
    • 0031866665 scopus 로고    scopus 로고
    • Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin’s lymphomas and is moderately increased by CD40 ligation
    • Xerri L, Bouabdallah R, Devilard E, Hassoun J, Stoppa AM and Birg F (1998) Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin’s lymphomas and is moderately increased by CD40 ligation. Br. J. Cancer 78: 225-232
    • (1998) Br. J. Cancer , vol.78 , pp. 225-232
    • Xerri, L.1    Bouabdallah, R.2    Devilard, E.3    Hassoun, J.4    Stoppa, A.M.5    Birg, F.6
  • 21
    • 0030971074 scopus 로고    scopus 로고
    • Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies
    • Wang D, Freeman GJ, Levine H, Ritz J and Robertson MJ (1997) Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies. Br. J. Haematol. 97: 409-417
    • (1997) Br. J. Haematol , vol.97 , pp. 409-417
    • Wang, D.1    Freeman, G.J.2    Levine, H.3    Ritz, J.4    Robertson, M.J.5
  • 22
    • 0037376788 scopus 로고    scopus 로고
    • Cell surface death receptor signaling in normal and cancer cells. Semin
    • Ozoren N and El-Deiry WS (2003) Cell surface death receptor signaling in normal and cancer cells. Semin. Cancer Biol. 13: 135-147
    • (2003) Cancer Biol , vol.13 , pp. 135-147
    • Ozoren, N.1    El-Deiry, W.S.2
  • 23
    • 0036792685 scopus 로고    scopus 로고
    • TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy
    • Wajant H, Pfizenmaier K and Scheurich P (2002) TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy. Apoptosis 7: 449-459
    • (2002) Apoptosis , vol.7 , pp. 449-459
    • Wajant, H.1    Pfizenmaier, K.2    Scheurich, P.3
  • 24
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer. Nat
    • Johnstone RW (2002) Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov. 1: 287-299
    • (2002) Rev. Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 26
    • 0036014986 scopus 로고    scopus 로고
    • Histone deacetylases as therapeutic targets in hematologic malignancies
    • Melnick A and Licht JD (2002) Histone deacetylases as therapeutic targets in hematologic malignancies. Curr. Opin. Hematol. 9: 322-332
    • (2002) Curr. Opin. Hematol , vol.9 , pp. 322-332
    • Melnick, A.1    Licht, J.D.2
  • 27
    • 0038494686 scopus 로고    scopus 로고
    • Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein
    • Aron JL, Parthun MR, Marcucci G, Kitada S, Mone AP, Davis ME, Shen T, Murphy T, Wickham J, Kanakry C, Lucas DM, Reed JC, Grever MR and Byrd JC (2003) Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Blood 102: 652-658
    • (2003) Blood , vol.102 , pp. 652-658
    • Aron, J.L.1    Parthun, M.R.2    Marcucci, G.3    Kitada, S.4    Mone, A.P.5    Davis, M.E.6    Shen, T.7    Murphy, T.8    Wickham, J.9    Kanakry, C.10    Lucas, D.M.11    Reed, J.C.12    Grever, M.R.13    Byrd, J.C.14
  • 28
    • 0038485588 scopus 로고    scopus 로고
    • Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA)
    • Henderson C, Mizzau M, Paroni G, Maestro R, Schneider C and Brancolini C (2003) Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA). J. Biol. Chem. 278: 12579-12589
    • (2003) J. Biol. Chem , vol.278 , pp. 12579-12589
    • Henderson, C.1    Mizzau, M.2    Paroni, G.3    Maestro, R.4    Schneider, C.5    Brancolini, C.6
  • 29
    • 18544367699 scopus 로고    scopus 로고
    • Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells
    • Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW and Han JW (2002) Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. J. Biol. Chem. 277: 2073-2080
    • (2002) J. Biol. Chem , vol.277 , pp. 2073-2080
    • Kwon, S.H.1    Ahn, S.H.2    Kim, Y.K.3    Bae, G.U.4    Yoon, J.W.5    Hong, S.6    Lee, H.Y.7    Lee, Y.W.8    Lee, H.W.9    Han, J.W.10
  • 30
    • 0035845541 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
    • Ruefli AA, Ausserlechner MJ, Bernhard D, Sutton VR, Tainton KM, Kofler R, Smyth MJ and Johnstone RW (2001) The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc. Natl. Acad. Sci. USA 98: 10833-10838
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10833-10838
    • Ruefli, A.A.1    Ausserlechner, M.J.2    Bernhard, D.3    Sutton, V.R.4    Tainton, K.M.5    Kofler, R.6    Smyth, M.J.7    Johnstone, R.W.8
  • 31
    • 0034775318 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity enhances Fas receptormediated apoptosis in leukemic lymphoblasts
    • Bernhard D, Skvortsov S, Tinhofer I, Hubl H, Greil R, Csordas A and Kofler R (2001) Inhibition of histone deacetylase activity enhances Fas receptormediated apoptosis in leukemic lymphoblasts. Cell Death Differ. 8: 1014-1021
    • (2001) Cell Death Differ , vol.8 , pp. 1014-1021
    • Bernhard, D.1    Skvortsov, S.2    Tinhofer, I.3    Hubl, H.4    Greil, R.5    Csordas, A.6    Kofler, R.7
  • 32
    • 0033199896 scopus 로고    scopus 로고
    • Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma
    • Glick RD, Swendeman SL, Coffey DC, Rifkind RA, Marks PA, Richon VM and La Quaglia MP (1999) Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Res. 59: 4392-4399
    • (1999) Cancer Res , vol.59 , pp. 4392-4399
    • Glick, R.D.1    Swendeman, S.L.2    Coffey, D.C.3    Rifkind, R.A.4    Marks, P.A.5    Richon, V.M.6    La Quaglia, M.P.7
  • 34
    • 0346725822 scopus 로고    scopus 로고
    • Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: Role of Bcl-xL downregulation. Biochem. Biophys. Res
    • Neuzil J, Swettenham E and Gellert N (2004) Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL downregulation. Biochem. Biophys. Res. Commun. 314: 186-191
    • (2004) Commun , vol.314 , pp. 186-191
    • Neuzil, J.1    Swettenham, E.2    Gellert, N.3
  • 36
    • 0036584375 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis
    • Inoue H, Shiraki K, Ohmori S, Sakai T, Deguchi M, Yamanaka T, Okano H and Nakano T (2002) Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis. Int. J. Mol. Med. 9: 521-525
    • (2002) Int. J. Mol. Med , vol.9 , pp. 521-525
    • Inoue, H.1    Shiraki, K.2    Ohmori, S.3    Sakai, T.4    Deguchi, M.5    Yamanaka, T.6    Okano, H.7    Nakano, T.8
  • 38
    • 0033566643 scopus 로고    scopus 로고
    • Depsipeptide (FR901228): A novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells
    • Byrd JC, Shinn C, Ravi R, Willis CR, Waselenko JK, Flinn IW, Dawson NA and Grever MR (1999) Depsipeptide (FR901228): a novel therapeutic agent with selective, in vitro activity against human B-cell chronic lymphocytic leukemia cells. Blood 94: 1401-1408
    • (1999) Blood , vol.94 , pp. 1401-1408
    • Byrd, J.C.1    Shinn, C.2    Ravi, R.3    Willis, C.R.4    Waselenko, J.K.5    Flinn, I.W.6    Dawson, N.A.7    Grever, M.R.8
  • 41
    • 0034658384 scopus 로고    scopus 로고
    • JNK (C-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: Differential requirements for caspase activation
    • MacFarlane M, Cohen GM and Dickens M (2000) JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation. Biochem. J. 348 (Part 1): 93-101
    • (2000) Biochem. J , vol.348 , pp. 93-101
    • Macfarlane, M.1    Cohen, G.M.2    Dickens, M.3
  • 42
    • 0029905073 scopus 로고    scopus 로고
    • Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
    • Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Litwack G and Alnemri ES (1996) Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. USA 93: 14486-14491
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14486-14491
    • Srinivasula, S.M.1    Ahmad, M.2    Fernandes-Alnemri, T.3    Litwack, G.4    Alnemri, E.S.5
  • 43
    • 0033210894 scopus 로고    scopus 로고
    • Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: The trail to non-toxic cancer therapeutics (review)
    • Bonavida B, Ng CP, Jazirehi A, Schiller G and Mizutani Y (1999) Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: the trail to non-toxic cancer therapeutics (review). Int. J. Oncol. 15: 793-802
    • (1999) Int. J. Oncol , vol.15 , pp. 793-802
    • Bonavida, B.1    Ng, C.P.2    Jazirehi, A.3    Schiller, G.4    Mizutani, Y.5
  • 45
    • 0035192884 scopus 로고    scopus 로고
    • FLICE-inhibitory proteins: Regulators of death receptor-mediated apoptosis
    • Krueger A, Baumann S, Krammer PH and Kirchhoff S (2001) FLICE-inhibitory proteins: regulators of death receptor-mediated apoptosis. Mol. Cell. Biol. 21: 8247-8254
    • (2001) Mol. Cell. Biol , vol.21 , pp. 8247-8254
    • Krueger, A.1    Baumann, S.2    Krammer, P.H.3    Kirchhoff, S.4
  • 46
    • 0035860696 scopus 로고    scopus 로고
    • Modulation of tumor necrosis factor apoptosis-inducing ligand-induced NF-kappa B activation by inhibition of apical caspases
    • Harper N, Farrow SN, Kaptein A, Cohen GM and MacFarlane M (2001) Modulation of tumor necrosis factor apoptosis-inducing ligand-induced NF-kappa B activation by inhibition of apical caspases. J. Biol. Chem. 276: 34743-34752
    • (2001) J. Biol. Chem , vol.276 , pp. 34743-34752
    • Harper, N.1    Farrow, S.N.2    Kaptein, A.3    Cohen, G.M.4    Macfarlane, M.5
  • 48
    • 0036141029 scopus 로고    scopus 로고
    • TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO
    • Deng Y, Lin Y and Wu X (2002) TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. Genes Dev. 16: 33-45
    • (2002) Genes Dev , vol.16 , pp. 33-45
    • Deng, Y.1    Lin, Y.2    Wu, X.3
  • 50
    • 0031890032 scopus 로고    scopus 로고
    • Molecular biology of chronic lymphocytic leukemia
    • Reed JC (1998) Molecular biology of chronic lymphocytic leukemia. Semin. Oncol. 25: 11-18
    • (1998) Semin. Oncol , vol.25 , pp. 11-18
    • Reed, J.C.1
  • 51
    • 0029145624 scopus 로고
    • Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia
    • Panayiotidis P, Ganeshaguru K, Foroni L and Hoffbrand AV (1995) Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. Leukemia 9: 1227-1232
    • (1995) Leukemia , vol.9 , pp. 1227-1232
    • Panayiotidis, P.1    Ganeshaguru, K.2    Foroni, L.3    Hoffbrand, A.V.4
  • 52
    • 11144358387 scopus 로고    scopus 로고
    • Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligandinduced death inducing signaling complex activity and apoptosis of human acute leukemia cells
    • Guo F, Sigua C, Tao J, Bali P, George P, Li Y, Wittmann S, Moscinski L, Atadja P and Bhalla K (2004) Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligandinduced death inducing signaling complex activity and apoptosis of human acute leukemia cells. Cancer Res. 64: 2580-2589
    • (2004) Cancer Res , vol.64 , pp. 2580-2589
    • Guo, F.1    Sigua, C.2    Tao, J.3    Bali, P.4    George, P.5    Li, Y.6    Wittmann, S.7    Moscinski, L.8    Atadja, P.9    Bhalla, K.10
  • 53
    • 2942584501 scopus 로고    scopus 로고
    • Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells
    • Rosato RR, Almenara JA, Dai Y and Grant S (2003) Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells. Mol. Cancer Ther. 2: 1273-1284
    • (2003) Mol. Cancer Ther , vol.2 , pp. 1273-1284
    • Rosato, R.R.1    Almenara, J.A.2    Dai, Y.3    Grant, S.4
  • 56
    • 0035336166 scopus 로고    scopus 로고
    • Phosphatidylinositol 30-kinase blocks CD95 aggregation and caspase- 8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD
    • Varadhachary AS, Edidin M, Hanlon AM, Peter ME, Krammer PH and Salgame P (2001) Phosphatidylinositol 30-kinase blocks CD95 aggregation and caspase- 8 cleavage at the death-inducing signaling complex by modulating lateral diffusion of CD J. Immunol. 166: 6564-6569
    • (2001) J. Immunol , vol.166 , pp. 6564-6569
    • Varadhachary, A.S.1    Edidin, M.2    Hanlon, A.M.3    Peter, M.E.4    Krammer, P.H.5    Salgame, P.6
  • 59
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM and Strasser A (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286: 1735-1738
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3    Tarlinton, D.M.4    Kay, T.W.5    Kontgen, F.6    Adams, J.M.7    Strasser, A.8
  • 60
    • 0038482050 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasomedependent degradation of the BH3-only protein
    • Ley R, Balmanno K, Hadfield K, Weston C and Cook SJ (2003) Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasomedependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 278: 18811-18816
    • (2003) Bim. J. Biol. Chem , vol.278 , pp. 18811-18816
    • Ley, R.1    Balmanno, K.2    Hadfield, K.3    Weston, C.4    Cook, S.J.5
  • 61
    • 0037085935 scopus 로고    scopus 로고
    • Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: Synergism with sulindac-mediated inhibition of Bcl-x(L)
    • Ravi R and Bedi A (2002) Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L). Cancer Res. 62: 1583-1587
    • (2002) Cancer Res , vol.62 , pp. 1583-1587
    • Ravi, R.1    Bedi, A.2
  • 62
    • 0037192790 scopus 로고    scopus 로고
    • Bcl- 2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-ofapoptosis protein
    • Sun XM, Bratton SB, Butterworth M, MacFarlane M and Cohen GM (2002) Bcl- 2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-ofapoptosis protein. J. Biol. Chem. 277: 11345-11351
    • (2002) J. Biol. Chem , vol.277 , pp. 11345-11351
    • Sun, X.M.1    Bratton, S.B.2    Butterworth, M.3    Macfarlane, M.4    Cohen, G.M.5
  • 63
    • 0037815277 scopus 로고    scopus 로고
    • Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis
    • Harper N, Hughes M, MacFarlane M and Cohen GM (2003) Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis. J. Biol. Chem. 278: 25534-25541
    • (2003) J. Biol. Chem , vol.278 , pp. 25534-25541
    • Harper, N.1    Hughes, M.2    Macfarlane, M.3    Cohen, G.M.4
  • 68
    • 0033582526 scopus 로고    scopus 로고
    • Distinct caspase cascades are initiated in receptor-mediated and chemicalinduced apoptosis
    • Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR and Cohen GM (1999) Distinct caspase cascades are initiated in receptor-mediated and chemicalinduced apoptosis. J. Biol. Chem. 274: 5053-5060
    • (1999) J. Biol. Chem , vol.274 , pp. 5053-5060
    • Sun, X.M.1    Macfarlane, M.2    Zhuang, J.3    Wolf, B.B.4    Green, D.R.5    Cohen, G.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.