Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

New England Journal of Medicine

Volumn 347, Issue 7, 2002, Pages 481-487

  Apperley, Jane F ^a,i   Gardembas, Martine ^b   Melo, Junia V ^a   Russell Jones, Robin ^c   Bain, Barbara J ^a   Baxter, E Joanna ^d   Chase, Andrew ^d   Chessells, Judith M ^e   Colombat, Marie ^f   Dearden, Claire E ^g   Dimitrijevic, Sasa ^h   Mahon, François X ^f   Marin, David ^a   Nikolova, Zariana ^h   Olavarria, Eduardo ^a   Silberman, Sandra ^h   Schultheis, Beate ^a   Cross, Nicholas C P ^d   Goldman, John M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ANGERS UNIVERSITY HOSPITAL   (France)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d SALISBURY DISTRICT HOSPITAL   (United Kingdom)

^e GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^f BORDEAUX UNIVERSITY HOSPITAL   (France)

^g ST GEORGE S HOSPITAL   (United Kingdom)

^h NOVARTIS PHARMA AG   (Switzerland)

ⁱ HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; HYBRID PROTEIN; IMATINIB; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR; TRANSCRIPTION FACTOR ETV6; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CASE REPORT; CHROMOSOME 5Q; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 5; DRUG RESPONSE; EOSINOPHILIA; FOLLOW UP; FUSION GENE; GENE REARRANGEMENT; HUMAN; LEUKOCYTOSIS; MALE; MYELOPROLIFERATIVE DISORDER; PRIORITY JOURNAL;

ADULT; AGED; CHILD; CHROMOSOMES, HUMAN, PAIR 5; DNA-BINDING PROTEINS; EOSINOPHILIA; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKOCYTOSIS; MALE; MIDDLE AGED; MYELOPROLIFERATIVE DISORDERS; ONCOGENE PROTEINS, FUSION; PIPERAZINES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-ETS; PYRIMIDINES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; REPRESSOR PROTEINS;

EID: 0037103624     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa020150     Document Type: Article

References (26)

1. Abnormalities of chromosome 12p13 and malignant proliferation of eosinophils: A nonrandom association
2. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
3. Myeloproliferative disorders with translocations of chromosome 5q31-35: Role of the platelet-derived growth factor receptor beta
4. Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2)
5. Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5;10)(q33;q21)
6. Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemia
7. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
8. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
9. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
10. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor
11. Platelet-derived growth factor receptor signals
12. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
13. PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor
14. PDGF-D, a new protease-activated growth factor
15. A single amino acid substitution in a WW-like domain of diverse members of the PDGF receptor subfamily of tyrosine kinases causes constitutive receptor activation
16. Class III receptor tyrosine kinases: Role in leukaemogenesis
17. Signal transduction via platelet-derived growth factor receptors
18. The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice
19. Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581
20. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors
21. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
22. Molecular evidence for efficacy of STI-571 in chronic myelomonocytic leukemia (CMML) with a platelet-derived growth factorβ-receptor (PDGFβR) fusion oncogene
23. TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor
24. A case of myelodysplasia with eosinophilia having a translocation t(5;12)(q31;q13) restricted to myeloid cells but not involving eosinophils
25. Familial eosinophilia maps to the cytokine gene cluster on human chromosomal region 5q31-q33
26. Treatment of hypereosinophilic syndrome with imatinib mesylate