Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins

Journal of the National Cancer Institute

Volumn 93, Issue 6, 2001, Pages 463-471

  Gautschi, Oliver ^a   Tschopp, Stefan ^a   Olie, Robert A ^a   Leech, Siân H ^a   Simões Wüst, A Paula ^a   Ziegler, Annemarie ^a   Baumann, Bettina ^b   Odermatt, Bernhard ^a   Hall, Jonathan ^c   Stahel, Rolf A ^a   Zangemeister Wittke, Uwe ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE 4625; MESSENGER RNA; PROPIDIUM IODIDE; PROTEIN BCL 2; PROTEIN BCL X; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CARCINOGENESIS; CELL LYSATE; CELL NUCLEUS; CELL VIABILITY; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG CARCINOMA; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; TUMOR GROWTH; TUMOR XENOGRAFT; WESTERN BLOTTING;

EID: 0035925537     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/93.6.463     Document Type: Article

References (43)

1. Bcl-2 family: Regulators of cell death
2. Mitochondria and apoptosis
3. The Bcl-2 protein family: Arbiters of cell survival
4. Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death
5. Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells
6. Diminished cell proliferation associated with the death-protective activity of Bcl-2
7. Bcl-2-mediated inhibition of apoptosis prevents immunogenicity and restores tumorigenicity of spontaneously regressive tumors
8. Bcl-2 protein expression correlates with nodal status in non small cell lung cancer
9. Apoptosis and Bcl-2 expression in relation to age, tumor characteristics and prognosis in breast cancer. South-East Sweden Breast Cancer Group
10. Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases
11. Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas
12. Immunohistochemical analysis of bcl-2, bax, bcl-x, and mcl-1 expression in prostate cancers
13. BCL-2 and p53 expression in clinically localized prostate cancer predicts response to external beam radiotherapy
14. Bcl-2 expression in malignant melanoma and its prognostic significance
15. Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL
16. Bcl-2 overexpression results in reciprocal downregulation of Bcl-X(L) and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis
17. Antisense therapeutics
18. Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression
19. Antisense oligonucleotides suppress B-cell lymphoma growth in a SCID-hu mouse model
20. bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
21. Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines
22. Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines
23. Induction of apoptosis in lung-cancer cells following bcl-xL anti-sense treatment
24. Bcl-xl antisense treatment induces apoptosis in breast carcinoma cells
25. A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells
26. Antisense oligonucleotides
27. Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)
28. Expression of apoptosis-regulatory genes in lung tumour cell lines: Relationship to p53 expression and relevance to acquired drug resistance
29. Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: Multifactorial relationships with topoisomerase I, protein kinase C, MDM-2 and caspase pathways
30. 5-Fluorouracil induces apoptosis in human colon cancer cell lines with modulation of Bcl-2 family proteins
31. Fas-mediated apoptosis in human prostatic carcinoma cell lines
32. Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and in melanoma cell lines
33. Uptake of oligodeoxyribonucleotides by lymphoid cells is heterogeneous and inducible
34. Anti-tumor activity of C-raf antisense-correction
35. BCL-2 antisense therapy in patients with non-Hodgkin lymphoma
36. Chemosensitisation of malignant melanoma by BCL2 antisense therapy
37. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
38. Immunohistochemical analysis of the Bcl-2 oncoprotein in human neuroblastomas. Comparisons with tumor cell differentiation and N-Myc protein
39. bcl-2 protein in non-small-cell lung carcinoma
40. Prognostic value of bcl-2 expression in invasive breast cancer
41. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance
42. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
43. Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors