메뉴 건너뛰기




Volumn 119, Issue 10, 2006, Pages 2261-2271

Raf kinases: Oncogenesis and drug discovery

Author keywords

Cancer; Clinical trials; Drug delivery; Mitogenic cascade; Raf kinases; Signal transduction; Transformation

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; A RAF KINASE; AAL 881; ANSAMYCIN DERIVATIVE; B RAF KINASE; C RAF KINASE; CARBOPLATIN; CHIR 265; GELDANAMYCIN; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE INHIBITOR; L 779450; LBT 613; N [5 (3 DIMETHYLAMINOBENZAMIDO) 2 METHYLPHENYL] 4 HYDROXYBENZAMIDE; PACLITAXEL; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PLX 4032; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; RAF PROTEIN; SB 590885; SORAFENIB; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

EID: 33749635119     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22144     Document Type: Short Survey
Times cited : (98)

References (195)
  • 2
    • 0020565721 scopus 로고
    • Avian oncovirus MH2: Molecular cloning of proviral DNA and structural analysis of viral RNA and protein
    • Jansen HW, Patschinsky T, Bister K. Avian oncovirus MH2: molecular cloning of proviral DNA and structural analysis of viral RNA and protein. J Virol 1983;48:61-73.
    • (1983) J Virol , vol.48 , pp. 61-73
    • Jansen, H.W.1    Patschinsky, T.2    Bister, K.3
  • 3
    • 0021011006 scopus 로고
    • Two unrelated cell-derived sequences in the genome of avian leukemia and carcinoma inducing retrovirus MH2
    • Jansen HW, Ruckert B, Lurz R, Bister K. Two unrelated cell-derived sequences in the genome of avian leukemia and carcinoma inducing retrovirus MH2. EMBO J 1983;2:1969-75.
    • (1983) EMBO J , vol.2 , pp. 1969-1975
    • Jansen, H.W.1    Ruckert, B.2    Lurz, R.3    Bister, K.4
  • 4
    • 0021176623 scopus 로고
    • Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611
    • Jansen HW, Lurz R, Bister K, Bonner TI, Mark GE, Rapp UR. Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611. Nature 1984;307:281-4.
    • (1984) Nature , vol.307 , pp. 281-284
    • Jansen, H.W.1    Lurz, R.2    Bister, K.3    Bonner, T.I.4    Mark, G.E.5    Rapp, U.R.6
  • 5
    • 0021277977 scopus 로고
    • Nucleotide sequence of avian retroviral oncogene v-mil: Homologue of murine retroviral oncogene v-raf
    • Sutrave P, Bonner TI, Rapp UR, Jansen HW, Patschinsky T, Bister K. Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf. Nature 1984;309:85-8.
    • (1984) Nature , vol.309 , pp. 85-88
    • Sutrave, P.1    Bonner, T.I.2    Rapp, U.R.3    Jansen, H.W.4    Patschinsky, T.5    Bister, K.6
  • 7
    • 0020695648 scopus 로고
    • New mammalian transforming retrovirus: Demonstration of a polyprotein gene product
    • Rapp UR, Reynolds FH, Jr, Stephenson JR. New mammalian transforming retrovirus: demonstration of a polyprotein gene product. J Virol 1983;45:914-24.
    • (1983) J Virol , vol.45 , pp. 914-924
    • Rapp, U.R.1    Reynolds Jr., F.H.2    Stephenson, J.R.3
  • 8
    • 0021343853 scopus 로고
    • Primary structure of v-raf: Relatedness to the src family of oncogenes
    • Mark GE, Rapp UR. Primary structure of v-raf. relatedness to the src family of oncogenes. Science 1984;224:285-9.
    • (1984) Science , vol.224 , pp. 285-289
    • Mark, G.E.1    Rapp, U.R.2
  • 9
    • 0021711728 scopus 로고
    • Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins
    • Moelling K, Heimann B, Beimling P, Rapp UR, Sander T. Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature 1984;312:558-61.
    • (1984) Nature , vol.312 , pp. 558-561
    • Moelling, K.1    Heimann, B.2    Beimling, P.3    Rapp, U.R.4    Sander, T.5
  • 10
    • 0021748921 scopus 로고
    • 3′-terminal region of avian carcinoma virus MH2 shares sequence elements with avian sarcoma viruses Y73 and SR-A
    • Sutrave P, Jansen HW, Bister K, Rapp UR. 3′-Terminal region of avian carcinoma virus MH2 shares sequence elements with avian sarcoma viruses Y73 and SR-A. J Virol 1984;52:703-5.
    • (1984) J Virol , vol.52 , pp. 703-705
    • Sutrave, P.1    Jansen, H.W.2    Bister, K.3    Rapp, U.R.4
  • 14
    • 0022401274 scopus 로고
    • Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus
    • Blasi E, Mathieson BJ, Varesio L, Cleveland JL, Borchert PA, Rapp UR. Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature 1985;318:667-70.
    • (1985) Nature , vol.318 , pp. 667-670
    • Blasi, E.1    Mathieson, B.J.2    Varesio, L.3    Cleveland, J.L.4    Borchert, P.A.5    Rapp, U.R.6
  • 16
    • 0021998699 scopus 로고
    • Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes
    • Rapp UR, Cleveland JL, Brightman K, Scott A, Ihle JN. Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Nature 1985;317:434-8.
    • (1985) Nature , vol.317 , pp. 434-438
    • Rapp, U.R.1    Cleveland, J.L.2    Brightman, K.3    Scott, A.4    Ihle, J.N.5
  • 17
    • 33749611522 scopus 로고
    • The raf oncogene
    • Gallo RC, Stehelin D, Varnier OE, eds. Clifton, New Jersey: Humana Press
    • Rapp UR, Bonner TI, Cleveland JL. The raf oncogene. In: Gallo RC, Stehelin D, Varnier OE, eds. Retroviruses and human pathology. Clifton, New Jersey: Humana Press, 1986, 449-72.
    • (1986) Retroviruses and Human Pathology , pp. 449-472
    • Rapp, U.R.1    Bonner, T.I.2    Cleveland, J.L.3
  • 19
    • 0024850431 scopus 로고
    • An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis
    • Troppmair J, Potter M, Wax JS, Rapp UR. An altered v-raf is required in addition to v-myc in J3V1 virus for acceleration of murine plasmacytomagenesis. Proc Natl Acad Sci USA 1989;86:9941-5.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 9941-9945
    • Troppmair, J.1    Potter, M.2    Wax, J.S.3    Rapp, U.R.4
  • 20
    • 85053314148 scopus 로고
    • Role of the raf signal transduction pathway in Fos/Jun regulation and determination of cell fates
    • Angel PE, Herrlich PA, eds. Boca Raton: CRC Press
    • Rapp UR, Bruder JT, Troppmair J. Role of the raf signal transduction pathway in Fos/Jun regulation and determination of cell fates. In: Angel PE, Herrlich PA, eds. The FOS and JUN families of transcription factors. Boca Raton: CRC Press, 1994, 221-47.
    • (1994) The FOS and JUN Families of Transcription Factors , pp. 221-247
    • Rapp, U.R.1    Bruder, J.T.2    Troppmair, J.3
  • 22
    • 0025339731 scopus 로고
    • Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages
    • Principato M, Cleveland JL, Rapp UR, Holmes KL, Pierce JH, Morse HC, III, Klinken SP. Transformation of murine bone marrow cells with combined v-raf-v-myc oncogenes yields clonally related mature B cells and macrophages. Mol Cell Biol 1990;10:3562-8.
    • (1990) Mol Cell Biol , vol.10 , pp. 3562-3568
    • Principato, M.1    Cleveland, J.L.2    Rapp, U.R.3    Holmes, K.L.4    Pierce, J.H.5    Morse III, H.C.6    Klinken, S.P.7
  • 23
    • 0038036832 scopus 로고    scopus 로고
    • Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch
    • Fedorov LM, Papadopoulos T, Tyrsin OY, Twardzik T, Goetz R, Rapp UR. Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. Cancer Res 2003;63: 2268-77.
    • (2003) Cancer Res , vol.63 , pp. 2268-2277
    • Fedorov, L.M.1    Papadopoulos, T.2    Tyrsin, O.Y.3    Twardzik, T.4    Goetz, R.5    Rapp, U.R.6
  • 25
    • 33749604944 scopus 로고
    • Role of oncogenes in the abrogation of growth factor requirements of hemopoietic cells
    • Paukovits WR, ed. Boca Raton: CRC Press
    • Kolch W, Cleveland JL, Rapp UR. Role of oncogenes in the abrogation of growth factor requirements of hemopoietic cells. In: Paukovits WR, ed. Growth regulation and cancerogenesis. Boca Raton: CRC Press, 1991, 279-303.
    • (1991) Growth Regulation and Cancerogenesis , pp. 279-303
    • Kolch, W.1    Cleveland, J.L.2    Rapp, U.R.3
  • 26
    • 0026596576 scopus 로고
    • Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase
    • Bruder JT, Heidecker G, Rapp UR. Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev 1992;6:545-56.
    • (1992) Genes Dev , vol.6 , pp. 545-556
    • Bruder, J.T.1    Heidecker, G.2    Rapp, U.R.3
  • 30
    • 0026641090 scopus 로고
    • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro
    • Dent P, Haser W, Haystead TA, Vincent LA, Roberts TM, Sturgill TW. Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science 1992;257:1404-7.
    • (1992) Science , vol.257 , pp. 1404-1407
    • Dent, P.1    Haser, W.2    Haystead, T.A.3    Vincent, L.A.4    Roberts, T.M.5    Sturgill, T.W.6
  • 33
    • 0023133794 scopus 로고
    • The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus
    • Beck TW, Huleihel M, Gunnell M, Bonner TI, Rapp UR. The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. Nucleic Acids Res 1987;15:595-609.
    • (1987) Nucleic Acids Res , vol.15 , pp. 595-609
    • Beck, T.W.1    Huleihel, M.2    Gunnell, M.3    Bonner, T.I.4    Rapp, U.R.5
  • 35
    • 0025604178 scopus 로고
    • Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies
    • Sithanandam G, Kolch W, Duh FM, Rapp UR. Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. Oncogene 1990;5:1775-80.
    • (1990) Oncogene , vol.5 , pp. 1775-1780
    • Sithanandam, G.1    Kolch, W.2    Duh, F.M.3    Rapp, U.R.4
  • 37
    • 0033604576 scopus 로고    scopus 로고
    • Isotype-specific functions of Raf kinases
    • Hagemann C, Rapp UR. Isotype-specific functions of Raf kinases. Exp Cell Res 1999;253:34-46.
    • (1999) Exp Cell Res , vol.253 , pp. 34-46
    • Hagemann, C.1    Rapp, U.R.2
  • 38
    • 0037400510 scopus 로고    scopus 로고
    • Mechanisms of regulating the Raf kinase family
    • Chong H, Vikis HG, Guan KL. Mechanisms of regulating the Raf kinase family. Cell Signal 2003;15:463-9.
    • (2003) Cell Signal , vol.15 , pp. 463-469
    • Chong, H.1    Vikis, H.G.2    Guan, K.L.3
  • 39
    • 0027457349 scopus 로고
    • Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors
    • Storm SM, Rapp UR. Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors. Toxicol Lett 1993;67: 201-10.
    • (1993) Toxicol Lett , vol.67 , pp. 201-210
    • Storm, S.M.1    Rapp, U.R.2
  • 41
    • 0345498292 scopus 로고    scopus 로고
    • Bcl-2 targets the protein kinase Raf-1 to mitochondria
    • Wang HG, Rapp UR, Reed JC. Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 1996;87:629-38.
    • (1996) Cell , vol.87 , pp. 629-638
    • Wang, H.G.1    Rapp, U.R.2    Reed, J.C.3
  • 42
    • 0029937303 scopus 로고    scopus 로고
    • Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1
    • Wang HG, Takayama S, Rapp UR, Reed JC. Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci USA 1996;93:7063-8.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7063-7068
    • Wang, H.G.1    Takayama, S.2    Rapp, U.R.3    Reed, J.C.4
  • 43
    • 0030835430 scopus 로고    scopus 로고
    • Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
    • Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 1997;17:5598-611.
    • (1997) Mol Cell Biol , vol.17 , pp. 5598-5611
    • Woods, D.1    Parry, D.2    Cherwinski, H.3    Bosch, E.4    Lees, E.5    McMahon, M.6
  • 44
    • 0032522816 scopus 로고    scopus 로고
    • High-intensity Raf signals convert mitotic cell cycling into cellular growth
    • Kerkhoff E, Rapp UR. High-intensity Raf signals convert mitotic cell cycling into cellular growth. Cancer Res 1998;58:1636-40.
    • (1998) Cancer Res , vol.58 , pp. 1636-1640
    • Kerkhoff, E.1    Rapp, U.R.2
  • 45
    • 0027482547 scopus 로고
    • Raf-1 protein kinase activates the NF-K B transcription factor by dissociating the cytoplasmic NF-K B-I K B complex
    • Li S, Sedivy JM. Raf-1 protein kinase activates the NF-K B transcription factor by dissociating the cytoplasmic NF-K B-I K B complex. Proc Natl Acad Sci USA 1993;90:9247-51.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9247-9251
    • Li, S.1    Sedivy, J.M.2
  • 47
    • 20444411532 scopus 로고    scopus 로고
    • Second nature: Biological functions of the Raf-1 "kinase"
    • Baccarini M. Second nature: biological functions of the Raf-1 "kinase". FEBS Lett 2005;579:3271-7.
    • (2005) FEBS Lett , vol.579 , pp. 3271-3277
    • Baccarini, M.1
  • 48
    • 11144267126 scopus 로고    scopus 로고
    • Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1
    • O'Neill E, Rushworth L, Baccarini M, Kolch W. Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 2004;306:2267-70.
    • (2004) Science , vol.306 , pp. 2267-2270
    • O'Neill, E.1    Rushworth, L.2    Baccarini, M.3    Kolch, W.4
  • 49
    • 0034944380 scopus 로고    scopus 로고
    • Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism
    • Chen J, Fujii K, Zhang L, Roberts T, Fu H. Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci USA 2001;98:7783-8.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 7783-7788
    • Chen, J.1    Fujii, K.2    Zhang, L.3    Roberts, T.4    Fu, H.5
  • 51
    • 27644575157 scopus 로고    scopus 로고
    • Coordinating ERK/MAPK signalling through scaffolds and inhibitors
    • Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 2005;6:827-37.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 827-837
    • Kolch, W.1
  • 52
    • 30344463327 scopus 로고    scopus 로고
    • BuCy RAFs drive cells into MEK addiction
    • Rapp UR, Gotz R, Albert S. BuCy RAFs drive cells into MEK addiction. Cancer Cell 2006;9:9-12.
    • (2006) Cancer Cell , vol.9 , pp. 9-12
    • Rapp, U.R.1    Gotz, R.2    Albert, S.3
  • 53
    • 33745327045 scopus 로고    scopus 로고
    • Back to the roots: The remarkable RAF oncogene story
    • Zebisch A, Troppmair J. Back to the roots: the remarkable RAF oncogene story. Cell Mol Life Sci 2006;63:1314-30.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 1314-1330
    • Zebisch, A.1    Troppmair, J.2
  • 55
    • 33646034613 scopus 로고    scopus 로고
    • A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
    • Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell 2006;22:217-30.
    • (2006) Mol Cell , vol.22 , pp. 217-230
    • Rodriguez-Viciana, P.1    Oses-Prieto, J.2    Burlingame, A.3    Fried, M.4    McCormick, F.5
  • 56
    • 33645520353 scopus 로고    scopus 로고
    • A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila
    • Douziech M, Sahmi M, Laberge G, Therrien M. A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Genes Dev 2006;20:807-19.
    • (2006) Genes Dev , vol.20 , pp. 807-819
    • Douziech, M.1    Sahmi, M.2    Laberge, G.3    Therrien, M.4
  • 58
    • 0029807304 scopus 로고    scopus 로고
    • Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization
    • Farrar MA, Alberol I, Perlmutter RM. Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization. Nature 1996;383: 178-81.
    • (1996) Nature , vol.383 , pp. 178-181
    • Farrar, M.A.1    Alberol, I.2    Perlmutter, R.M.3
  • 59
    • 0035328521 scopus 로고    scopus 로고
    • Active Ras induces heterodimerization of cRaf and BRaf
    • Weber CK, Slupsky JR, Kalmes HA, Rapp UR. Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res 2001;61:3595-8.
    • (2001) Cancer Res , vol.61 , pp. 3595-3598
    • Weber, C.K.1    Slupsky, J.R.2    Kalmes, H.A.3    Rapp, U.R.4
  • 60
    • 33645229806 scopus 로고    scopus 로고
    • Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein
    • Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proc Natl Acad Sci USA 2006;103:4463-8.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4463-4468
    • Chadee, D.N.1    Xu, D.2    Hung, G.3    Andalibi, A.4    Lim, D.J.5    Luo, Z.6    Gutmann, D.H.7    Kyriakis, J.M.8
  • 63
    • 29144462587 scopus 로고    scopus 로고
    • Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
    • Garnett MJ, Rana S, Paterson H, Barford D, Marais R. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell 2005;20:963-9.
    • (2005) Mol Cell , vol.20 , pp. 963-969
    • Garnett, M.J.1    Rana, S.2    Paterson, H.3    Barford, D.4    Marais, R.5
  • 64
    • 4143127726 scopus 로고    scopus 로고
    • Forty years of cancer modelling in the mouse
    • Hirst GL, Balmain A. Forty years of cancer modelling in the mouse. Eur J Cancer 2004;40:1974-80.
    • (2004) Eur J Cancer , vol.40 , pp. 1974-1980
    • Hirst, G.L.1    Balmain, A.2
  • 65
    • 13644266446 scopus 로고    scopus 로고
    • New approaches for modelling cancer mechanisms in the mouse
    • Maddison K, Clarke AR. New approaches for modelling cancer mechanisms in the mouse. J Pathol 2005;205:181-93.
    • (2005) J Pathol , vol.205 , pp. 181-193
    • Maddison, K.1    Clarke, A.R.2
  • 66
    • 4544259832 scopus 로고    scopus 로고
    • Mouse models of human cancer as tools in drug development
    • Holland EC. Mouse models of human cancer as tools in drug development. Cancer Cell 2004;6:197-8.
    • (2004) Cancer Cell , vol.6 , pp. 197-198
    • Holland, E.C.1
  • 67
    • 0037933855 scopus 로고
    • Tumorigenic activity of artificially activated oncogenes
    • Klein G, ed. New York: Marcel Dekker
    • Morse HC, III, Rapp UR. Tumorigenic activity of artificially activated oncogenes. In: Klein G, ed. Cellular oncogene activation. New York: Marcel Dekker, 1988;41:335-64.
    • (1988) Cellular Oncogene Activation , vol.41 , pp. 335-364
    • Morse III, H.C.1    Rapp, U.R.2
  • 68
    • 14644436355 scopus 로고    scopus 로고
    • B-raf and Ha-ras mutations in chemically induced mouse liver tumors
    • Jaworski M, Buchmann A, Bauer P, Riess O, Schwarz M. B-raf and Ha-ras mutations in chemically induced mouse liver tumors. Oncogene 2005;24:1290-5.
    • (2005) Oncogene , vol.24 , pp. 1290-1295
    • Jaworski, M.1    Buchmann, A.2    Bauer, P.3    Riess, O.4    Schwarz, M.5
  • 69
    • 22444444402 scopus 로고    scopus 로고
    • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
    • Collier LS, Carlson CM, Ravimohan S, Dupuy AJ, Largaespada DA. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 2005;436:272-6.
    • (2005) Nature , vol.436 , pp. 272-276
    • Collier, L.S.1    Carlson, C.M.2    Ravimohan, S.3    Dupuy, A.J.4    Largaespada, D.A.5
  • 70
    • 0034036430 scopus 로고    scopus 로고
    • Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein
    • Kerkhoff E, Fedorov LM, Siefken R, Walter AO, Papadopoulos T, Rapp UR. Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth Differ 2000;11:185-90.
    • (2000) Cell Growth Differ , vol.11 , pp. 185-190
    • Kerkhoff, E.1    Fedorov, L.M.2    Siefken, R.3    Walter, A.O.4    Papadopoulos, T.5    Rapp, U.R.6
  • 74
    • 3042838587 scopus 로고    scopus 로고
    • Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure
    • Kramer BW, Goetz R, Rapp UR. Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure. BMC Cancer 2004;4:24.
    • (2004) BMC Cancer , vol.4 , pp. 24
    • Kramer, B.W.1    Goetz, R.2    Rapp, U.R.3
  • 76
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 77
    • 20144372793 scopus 로고    scopus 로고
    • Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    • Knauf JA, Ma X, Smith EP, Zhang L, Mitsutake N, Liao XH, Refetoff S, Nikiforov YE, Fagin JA. Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res 2005;65:4238-45.
    • (2005) Cancer Res , vol.65 , pp. 4238-4245
    • Knauf, J.A.1    Ma, X.2    Smith, E.P.3    Zhang, L.4    Mitsutake, N.5    Liao, X.H.6    Refetoff, S.7    Nikiforov, Y.E.8    Fagin, J.A.9
  • 78
    • 29244487538 scopus 로고    scopus 로고
    • Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts
    • Mercer K, Giblett S, Green S, Lloyd D, Dias SD, Plumb M, Marais R, Pritchard C. Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res 2005;65:11493-500.
    • (2005) Cancer Res , vol.65 , pp. 11493-11500
    • Mercer, K.1    Giblett, S.2    Green, S.3    Lloyd, D.4    Dias, S.D.5    Plumb, M.6    Marais, R.7    Pritchard, C.8
  • 81
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: The first 30 years
    • Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nat Rev Cancer 2003;3:459-65.
    • (2003) Nat Rev Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 82
    • 0035977185 scopus 로고    scopus 로고
    • Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer
    • McPhillips F, Mullen P, Monia BP, Ritchie AA, Dorr FA, Smyth JF, Langdon SP. Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer. Br J Cancer 2001;85:1753-8.
    • (2001) Br J Cancer , vol.85 , pp. 1753-1758
    • McPhillips, F.1    Mullen, P.2    Monia, B.P.3    Ritchie, A.A.4    Dorr, F.A.5    Smyth, J.F.6    Langdon, S.P.7
  • 85
    • 27544453376 scopus 로고    scopus 로고
    • Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF
    • Emuss V, Garnett M, Mason C, Marais R. Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF. Cancer Res 2005;65:9719-26.
    • (2005) Cancer Res , vol.65 , pp. 9719-9726
    • Emuss, V.1    Garnett, M.2    Mason, C.3    Marais, R.4
  • 86
    • 5444227865 scopus 로고    scopus 로고
    • Guilty as charged: B-RAF is a human oncogene
    • Garnett MJ, Marais R. Guilty as charged: B-RAF is a human oncogene. Cancer Cell 2004;6:313-19.
    • (2004) Cancer Cell , vol.6 , pp. 313-319
    • Garnett, M.J.1    Marais, R.2
  • 88
    • 0037442752 scopus 로고    scopus 로고
    • Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation
    • Satyamoorthy K, Li G, Gerrero MR, Brose MS, Volpe P, Weber BL, Van Belle P, Elder DE, Herlyn M. Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res 2003;63:756-9.
    • (2003) Cancer Res , vol.63 , pp. 756-759
    • Satyamoorthy, K.1    Li, G.2    Gerrero, M.R.3    Brose, M.S.4    Volpe, P.5    Weber, B.L.6    Van Belle, P.7    Elder, D.E.8    Herlyn, M.9
  • 91
    • 33749609834 scopus 로고    scopus 로고
    • COSMIC. Available at: www.sanger.ac.uk/genetics/CGP/cosmic/.
  • 92
    • 4544302751 scopus 로고    scopus 로고
    • Switching on kinases: Oncogenic activation of BRAF and the PDGFR family
    • Dibb NJ, Dilworth SM, Mol CD. Switching on kinases: oncogenic activation of BRAF and the PDGFR family. Nat Rev Cancer 2004;4: 718-27.
    • (2004) Nat Rev Cancer , vol.4 , pp. 718-727
    • Dibb, N.J.1    Dilworth, S.M.2    Mol, C.D.3
  • 95
    • 25844500824 scopus 로고    scopus 로고
    • BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization
    • Ciampi R, Zhu Z, Nikiforov YE. BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization. Endocr Pathol 2005;16:99-105.
    • (2005) Endocr Pathol , vol.16 , pp. 99-105
    • Ciampi, R.1    Zhu, Z.2    Nikiforov, Y.E.3
  • 99
    • 2942607408 scopus 로고    scopus 로고
    • Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis
    • Houben R, Becker JC, Kappel A, Terheyden P, Brocker EB, Goetz R, Rapp UR. Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J Carcinog 2004;3:6.
    • (2004) J Carcinog , vol.3 , pp. 6
    • Houben, R.1    Becker, J.C.2    Kappel, A.3    Terheyden, P.4    Brocker, E.B.5    Goetz, R.6    Rapp, U.R.7
  • 100
    • 0042743826 scopus 로고    scopus 로고
    • BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma
    • Dong J, Phelps RG, Qiao R, Yao S, Benard O, Ronai Z, Aaronson SA. BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res 2003;63:3883-5.
    • (2003) Cancer Res , vol.63 , pp. 3883-3885
    • Dong, J.1    Phelps, R.G.2    Qiao, R.3    Yao, S.4    Benard, O.5    Ronai, Z.6    Aaronson, S.A.7
  • 103
    • 7944238044 scopus 로고    scopus 로고
    • Somatic alterations in the human cancer genome
    • Weir B, Zhao X, Meyerson M. Somatic alterations in the human cancer genome. Cancer Cell 2004;6:433-8.
    • (2004) Cancer Cell , vol.6 , pp. 433-438
    • Weir, B.1    Zhao, X.2    Meyerson, M.3
  • 106
    • 25444468866 scopus 로고    scopus 로고
    • BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancer
    • Ciampi R, Knauf JA, Rabes HM, Fagin JA, Nikiforov YE. BRAF kinase activation via chromosomal rearrangement in radiation-induced and sporadic thyroid cancer. Cell Cycle 2005;4:547-8.
    • (2005) Cell Cycle , vol.4 , pp. 547-548
    • Ciampi, R.1    Knauf, J.A.2    Rabes, H.M.3    Fagin, J.A.4    Nikiforov, Y.E.5
  • 107
    • 21244457181 scopus 로고    scopus 로고
    • BRAF mutation in thyroid cancer
    • Xing M. BRAF mutation in thyroid cancer. Endocr Relat Cancer 2005;12:245-62.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 245-262
    • Xing, M.1
  • 108
    • 13244256870 scopus 로고    scopus 로고
    • Origins and molecular pathology of ovarian cancer
    • Bell DA. Origins and molecular pathology of ovarian cancer. Mod Pathol 2005;18(Suppl 2):S19-S32.
    • (2005) Mod Pathol , vol.18 , Issue.SUPPL. 2
    • Bell, D.A.1
  • 109
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn GP, Old LJ, Schreiber RD. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004;21:137-48.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 114
    • 14344264657 scopus 로고    scopus 로고
    • Raf kinase inhibitors in oncology
    • Strumberg D, Seeber S. Raf kinase inhibitors in oncology. Onkologie 2005;28:101-7.
    • (2005) Onkologie , vol.28 , pp. 101-107
    • Strumberg, D.1    Seeber, S.2
  • 115
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • Sridhar SS, Hedley D, Siu LL. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 2005;4:677-85.
    • (2005) Mol Cancer Ther , vol.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 116
    • 21644440921 scopus 로고    scopus 로고
    • Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery
    • Thompson N, Lyons J. Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr Opin Pharmacol 2005;5:350-6.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 350-356
    • Thompson, N.1    Lyons, J.2
  • 117
    • 4944242884 scopus 로고    scopus 로고
    • A vision for the national cancer program in the United States
    • von Eschenbach AC. A vision for the national cancer program in the United States. Nat Rev Cancer 2004;4:820-8.
    • (2004) Nat Rev Cancer , vol.4 , pp. 820-828
    • Von Eschenbach, A.C.1
  • 118
    • 4944239434 scopus 로고    scopus 로고
    • Recent developments in the discovery of protein kinase inhibitors from the urea class
    • Dumas J, Smith RA, Lowinger TB. Recent developments in the discovery of protein kinase inhibitors from the urea class. Curr Opin Drug Discov Devel 2004;7:600-16.
    • (2004) Curr Opin Drug Discov Devel , vol.7 , pp. 600-616
    • Dumas, J.1    Smith, R.A.2    Lowinger, T.B.3
  • 119
    • 0036401042 scopus 로고    scopus 로고
    • Design and discovery of small molecules targeting raf-1 kinase
    • Lowinger TB, Riedl B, Dumas J, Smith RA. Design and discovery of small molecules targeting raf-1 kinase. Curr Pharm Des 2002;8:2269-78.
    • (2002) Curr Pharm des , vol.8 , pp. 2269-2278
    • Lowinger, T.B.1    Riedl, B.2    Dumas, J.3    Smith, R.A.4
  • 122
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • Wilhelm S, Chien DS. BAY 43-9006: preclinical data. Curr Pharm Des 2002;8:2255-7.
    • (2002) Curr Pharm des , vol.8 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.S.2
  • 123
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64: 7099-109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6    Chen, C.7    Zhang, X.8    Vincent, P.9    McHugh, M.10    Cao, Y.11    Shujath, J.12
  • 127
    • 27144502652 scopus 로고    scopus 로고
    • The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006
    • Yu C, Bruzek LM, Meng XW, Gores GJ, Carter CA, Kaufmann SH, Adjei AA. The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006. Oncogene 2005;24: 6861-9.
    • (2005) Oncogene , vol.24 , pp. 6861-6869
    • Yu, C.1    Bruzek, L.M.2    Meng, X.W.3    Gores, G.J.4    Carter, C.A.5    Kaufmann, S.H.6    Adjei, A.A.7
  • 128
    • 32944479041 scopus 로고    scopus 로고
    • The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells
    • Panka DJ, Wang W, Atkins MB, Mier JW. The Raf inhibitor BAY 43-9006 (Sorafenib) induces caspase-independent apoptosis in melanoma cells. Cancer Res 2006;66:1611-19.
    • (2006) Cancer Res , vol.66 , pp. 1611-1619
    • Panka, D.J.1    Wang, W.2    Atkins, M.B.3    Mier, J.W.4
  • 129
    • 35748951943 scopus 로고    scopus 로고
    • Clinical trials referral resource. Current clinical trials of BAY 43-9006, Part 1
    • Wright JJ, Zerivitz K, Gravell A. Clinical trials referral resource. Current clinical trials of BAY 43-9006, Part 1. Oncology (Huntingt) 2005;19:499-502.
    • (2005) Oncology (Huntingt) , vol.19 , pp. 499-502
    • Wright, J.J.1    Zerivitz, K.2    Gravell, A.3
  • 130
    • 28444483873 scopus 로고    scopus 로고
    • Clinical trials referral resource. Current clinical trials of BAY 43-9006, Part 2
    • Wright JJ, Zerivitz K, Gravell A. Clinical trials referral resource. Current clinical trials of BAY 43-9006, Part 2. Oncology (Williston Park) 2005;19:722-8.
    • (2005) Oncology (Williston Park) , vol.19 , pp. 722-728
    • Wright, J.J.1    Zerivitz, K.2    Gravell, A.3
  • 132
    • 0025979335 scopus 로고
    • Raf-1 protein kinase is required for growth of induced NIH/3T3 cells
    • Kolch W, Heidecker G, Lloyd P, Rapp UR. Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature 1991;349:426-8.
    • (1991) Nature , vol.349 , pp. 426-428
    • Kolch, W.1    Heidecker, G.2    Lloyd, P.3    Rapp, U.R.4
  • 133
    • 12644268252 scopus 로고    scopus 로고
    • Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
    • Monia BP, Sasmor H, Johnston JF, Freier SM, Lesnik EA, Muller M, Geiger T, Altmann KH, Moser H. Fabbro D. Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo. Proc Natl Acad Sci USA 1996;93:15481-4.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15481-15484
    • Monia, B.P.1    Sasmor, H.2    Johnston, J.F.3    Freier, S.M.4    Lesnik, E.A.5    Muller, M.6    Geiger, T.7    Altmann, K.H.8    Moser, H.9    Fabbro, D.10
  • 134
    • 0029977448 scopus 로고    scopus 로고
    • Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase
    • Monia BP, Johnston JF, Geiger T, Muller M, Fabbro D. Antitumor activity of a phosphorothioate antisense oligodeoxynucleotide targeted against C-raf kinase. Nat Med 1996;2:668-75.
    • (1996) Nat Med , vol.2 , pp. 668-675
    • Monia, B.P.1    Johnston, J.F.2    Geiger, T.3    Muller, M.4    Fabbro, D.5
  • 136
    • 0034026007 scopus 로고    scopus 로고
    • A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer
    • Cunningham CC, Holmlund JT, Schiller JH, Geary RS, Kwoh TJ, Dorr A, Nemunaitis J. A phase I trial of c-Raf kinase antisense oligonucleotide ISIS 5132 administered as a continuous intravenous infusion in patients with advanced cancer. Clin Cancer Res 2000;6:1626-31.
    • (2000) Clin Cancer Res , vol.6 , pp. 1626-1631
    • Cunningham, C.C.1    Holmlund, J.T.2    Schiller, J.H.3    Geary, R.S.4    Kwoh, T.J.5    Dorr, A.6    Nemunaitis, J.7
  • 138
    • 0034783583 scopus 로고    scopus 로고
    • Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) early clinical studies group report
    • Coudert B, Anthoney A, Fiedler W, Droz JP, Dieras V, Borner M, Smyth JF, Morant R, de Vries MJ, Roelvink M, Fumoleau P. Phase II trial with ISIS 5132 in patients with small-cell (SCLC) and non-small cell (NSCLC) lung cancer. A European Organization for Research and Treatment of Cancer (EORTC) early clinical studies group report. Eur J Cancer 2001;37:2194-8.
    • (2001) Eur J Cancer , vol.37 , pp. 2194-2198
    • Coudert, B.1    Anthoney, A.2    Fiedler, W.3    Droz, J.P.4    Dieras, V.5    Borner, M.6    Smyth, J.F.7    Morant, R.8    De Vries, M.J.9    Roelvink, M.10    Fumoleau, P.11
  • 139
    • 0035992350 scopus 로고    scopus 로고
    • Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: A National Cancer Institute of Canada clinical trials group study
    • Cripps MC, Figueredo AT, Oza AM, Taylor MJ, Fields AL, Holmlund JT, McIntosh LW, Geary RS, Eisenhauer EA. Phase II randomized study of ISIS 3521 and ISIS 5132 in patients with locally advanced or metastatic colorectal cancer: a National Cancer Institute of Canada clinical trials group study. Clin Cancer Res 2002;8:2188-92.
    • (2002) Clin Cancer Res , vol.8 , pp. 2188-2192
    • Cripps, M.C.1    Figueredo, A.T.2    Oza, A.M.3    Taylor, M.J.4    Fields, A.L.5    Holmlund, J.T.6    McIntosh, L.W.7    Geary, R.S.8    Eisenhauer, E.A.9
  • 140
    • 0036023413 scopus 로고    scopus 로고
    • A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer
    • Tolcher AW, Reyno L, Venner PM, Ernst SD, Moore M, Geary RS, Chi K, Hall S, Walsh W, Dorr A, Eisenhauer E. A randomized phase II and pharmacokinetic study of the antisense oligonucleotides ISIS 3521 and ISIS 5132 in patients with hormone-refractory prostate cancer. Clin Cancer Res 2002;8:2530-5.
    • (2002) Clin Cancer Res , vol.8 , pp. 2530-2535
    • Tolcher, A.W.1    Reyno, L.2    Venner, P.M.3    Ernst, S.D.4    Moore, M.5    Geary, R.S.6    Chi, K.7    Hall, S.8    Walsh, W.9    Dorr, A.10    Eisenhauer, E.11
  • 143
    • 0036848796 scopus 로고    scopus 로고
    • Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome
    • Gokhale PC, Zhang C, Newsome JT, Pei J, Ahmad I, Rahman A, Dritschilo A, Kasid UN. Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome. Clin Cancer Res 2002;8:3611-21.
    • (2002) Clin Cancer Res , vol.8 , pp. 3611-3621
    • Gokhale, P.C.1    Zhang, C.2    Newsome, J.T.3    Pei, J.4    Ahmad, I.5    Rahman, A.6    Dritschilo, A.7    Kasid, U.N.8
  • 147
    • 4444240325 scopus 로고    scopus 로고
    • Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference
    • Sumimoto H, Miyagishi M, Miyoshi H, Yamagata S, Shimizu A, Taira K, Kawakami Y. Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 2004;23:6031-9.
    • (2004) Oncogene , vol.23 , pp. 6031-6039
    • Sumimoto, H.1    Miyagishi, M.2    Miyoshi, H.3    Yamagata, S.4    Shimizu, A.5    Taira, K.6    Kawakami, Y.7
  • 150
    • 22644439250 scopus 로고    scopus 로고
    • Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer
    • Pal A, Ahmad A, Khan S, Sakabe I, Zhang C, Kasid UN, Ahmad I. Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. Int J Oncol 2005;26:1087-91.
    • (2005) Int J Oncol , vol.26 , pp. 1087-1091
    • Pal, A.1    Ahmad, A.2    Khan, S.3    Sakabe, I.4    Zhang, C.5    Kasid, U.N.6    Ahmad, I.7
  • 151
    • 22944469778 scopus 로고    scopus 로고
    • Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo
    • Leng Q, Mixson AJ. Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo. Cancer Gene Ther 2005;12:682-90.
    • (2005) Cancer Gene Ther , vol.12 , pp. 682-690
    • Leng, Q.1    Mixson, A.J.2
  • 152
    • 15544385359 scopus 로고    scopus 로고
    • Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents
    • Miyata Y. Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. Curr Pharm Des 2005;11:1131-8.
    • (2005) Curr Pharm des , vol.11 , pp. 1131-1138
    • Miyata, Y.1
  • 153
    • 1542298267 scopus 로고    scopus 로고
    • Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone
    • Workman P. Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone. Cancer Lett 2004;206:149-57.
    • (2004) Cancer Lett , vol.206 , pp. 149-157
    • Workman, P.1
  • 156
    • 18744396967 scopus 로고    scopus 로고
    • Multiple-target drugs: Inhibitors of heat shock protein 90 and of histone deacetylase
    • Budillon A, Bruzzese F, Di Gennaro E, Caraglia M. Multiple-target drugs: inhibitors of heat shock protein 90 and of histone deacetylase. Curr Drug Targets 2005;6:337-51.
    • (2005) Curr Drug Targets , vol.6 , pp. 337-351
    • Budillon, A.1    Bruzzese, F.2    Di Gennaro, E.3    Caraglia, M.4
  • 157
    • 28244444919 scopus 로고    scopus 로고
    • Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin
    • da Rocha Dias S, Friedlos F, Light Y, Springer C, Workman P, Marais R. Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin. Cancer Res 2005;65:10686-91.
    • (2005) Cancer Res , vol.65 , pp. 10686-10691
    • Rocha Dias, S.1    Friedlos, F.2    Light, Y.3    Springer, C.4    Workman, P.5    Marais, R.6
  • 159
    • 21244466289 scopus 로고    scopus 로고
    • Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: Effects on Hsp90 and client proteins in melanoma models
    • Smith V, Sausville EA, Camalier RF, Fiebig HH, Burger AM. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models. Cancer Chemother Pharmacol 2005;56:126-37.
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 126-137
    • Smith, V.1    Sausville, E.A.2    Camalier, R.F.3    Fiebig, H.H.4    Burger, A.M.5
  • 160
    • 21244462689 scopus 로고    scopus 로고
    • In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17- demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative
    • Hollingshead M, Alley M, Burger AM, Borgel S, Pacula-Cox C, Fiebig HH, Sausville EA. In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino- 17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative. Cancer Chemother Pharmacol 2005;56:115-25.
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 115-125
    • Hollingshead, M.1    Alley, M.2    Burger, A.M.3    Borgel, S.4    Pacula-Cox, C.5    Fiebig, H.H.6    Sausville, E.A.7
  • 161
    • 0035363805 scopus 로고    scopus 로고
    • Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease
    • Sittler A, Lurz R, Lueder G, Priller J, Lehrach H, Hayer-Hartl MK, Hartl FU, Wanker EE. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum Mol Genet 2001;10:1307-15.
    • (2001) Hum Mol Genet , vol.10 , pp. 1307-1315
    • Sittler, A.1    Lurz, R.2    Lueder, G.3    Priller, J.4    Lehrach, H.5    Hayer-Hartl, M.K.6    Hartl, F.U.7    Wanker, E.E.8
  • 162
    • 25844519550 scopus 로고    scopus 로고
    • HSP90 and the chaperoning of cancer
    • Whitesell L, Lindquist SL. HSP90 and the chaperoning of cancer. Nat Rev Cancer 2005;5:761-72.
    • (2005) Nat Rev Cancer , vol.5 , pp. 761-772
    • Whitesell, L.1    Lindquist, S.L.2
  • 164
    • 26044433779 scopus 로고    scopus 로고
    • Message in a bottle: Role of the 70-kDa heat shock protein family in anti-tumor immunity
    • Calderwood SK, Theriault JR, Gong J. Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol 2005;35:2518-27.
    • (2005) Eur J Immunol , vol.35 , pp. 2518-2527
    • Calderwood, S.K.1    Theriault, J.R.2    Gong, J.3
  • 166
    • 25144440127 scopus 로고    scopus 로고
    • Rational development of histone deacetylase inhibitors as anti-cancer agents: A review
    • Acharya MR, Sparreboom A, Venitz J, Figg WD. Rational development of histone deacetylase inhibitors as anti-cancer agents: a review. Mol Pharmacol 2005;68:917-32.
    • (2005) Mol Pharmacol , vol.68 , pp. 917-932
    • Acharya, M.R.1    Sparreboom, A.2    Venitz, J.3    Figg, W.D.4
  • 167
    • 4544323749 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Understanding a new wave of anticancer agents
    • Villar-Garea A, Esteller M. Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int J Cancer 2004:112: 171-8.
    • (2004) Int J Cancer , vol.112 , pp. 171-178
    • Villar-Garea, A.1    Esteller, M.2
  • 169
    • 1642490813 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
    • Fuino L, Bali P, Wittmann S, Donapaty S, Guo F, Yamaguchi H, Wang HG, Atadja P, Bhalla K. Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine,
    • (2003) Mol Cancer Ther , vol.2 , pp. 971-984
    • Fuino, L.1    Bali, P.2    Wittmann, S.3    Donapaty, S.4    Guo, F.5    Yamaguchi, H.6    Wang, H.G.7    Atadja, P.8    Bhalla, K.9
  • 170
    • 0038066488 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells
    • Yu C, Rahmani M, Almenara J, Subler M, Krystal G, Conrad D, Varticovski L, Dent P, Grant S. Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells. Cancer Res 2003;63:2118-26.
    • (2003) Cancer Res , vol.63 , pp. 2118-2126
    • Yu, C.1    Rahmani, M.2    Almenara, J.3    Subler, M.4    Krystal, G.5    Conrad, D.6    Varticovski, L.7    Dent, P.8    Grant, S.9
  • 171
    • 22844432021 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis of antileukemia activity of histone deacetylase inhibitors
    • Bali P, Pranpat M, Bradner J, Balasis M, Fiskus W, Guo F, Rocha K, Kumaraswamy S, Boyapalle S, Atadja P, Seto E, Bhalla K. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis of antileukemia activity of histone deacetylase inhibitors. J Biol Chem 2005;280:26729-34.
    • (2005) J Biol Chem , vol.280 , pp. 26729-26734
    • Bali, P.1    Pranpat, M.2    Bradner, J.3    Balasis, M.4    Fiskus, W.5    Guo, F.6    Rocha, K.7    Kumaraswamy, S.8    Boyapalle, S.9    Atadja, P.10    Seto, E.11    Bhalla, K.12
  • 172
    • 3042844293 scopus 로고    scopus 로고
    • Cancer immunotherapy: A treatment for the masses
    • Blattman JN, Greenberg PD. Cancer immunotherapy: a treatment for the masses. Science 2004;305:200-5.
    • (2004) Science , vol.305 , pp. 200-205
    • Blattman, J.N.1    Greenberg, P.D.2
  • 174
    • 28244433436 scopus 로고    scopus 로고
    • B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade
    • Robubi A, Mueller T, Fueller J, Hekman M, Rapp UR, Dandekar T. B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade. Biol Chem 2005;386:1165-71.
    • (2005) Biol Chem , vol.386 , pp. 1165-1171
    • Robubi, A.1    Mueller, T.2    Fueller, J.3    Hekman, M.4    Rapp, U.R.5    Dandekar, T.6
  • 176
    • 33644684217 scopus 로고    scopus 로고
    • Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
    • Strumberg D. Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc) 2005;41:773-84.
    • (2005) Drugs Today (Barc) , vol.41 , pp. 773-784
    • Strumberg, D.1
  • 178
  • 184
    • 33645698808 scopus 로고    scopus 로고
    • Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo
    • Ouyang B, Knauf JA, Smith EP, Zhang L, Ramsey T, Yusuff N, Batt D, Fagin JA. Inhibitors of Raf kinase activity block growth of thyroid cancer cells with RET/PTC or BRAF mutations in vitro and in vivo. Clin Cancer Res 2006;12:1785-93.
    • (2006) Clin Cancer Res , vol.12 , pp. 1785-1793
    • Ouyang, B.1    Knauf, J.A.2    Smith, E.P.3    Zhang, L.4    Ramsey, T.5    Yusuff, N.6    Batt, D.7    Fagin, J.A.8
  • 190
    • 23244448029 scopus 로고    scopus 로고
    • Disruption of protein-protein interactions: Towards new targets for chemotherapy
    • Loregian A, Palu G. Disruption of protein-protein interactions: towards new targets for chemotherapy. J Cell Physiol 2005;204:750-62.
    • (2005) J Cell Physiol , vol.204 , pp. 750-762
    • Loregian, A.1    Palu, G.2
  • 191
    • 33749619278 scopus 로고    scopus 로고
    • miRBase
    • miRBase. http://microrna.sanger.ac.uk/targets/v2/.
  • 192
    • 27144556185 scopus 로고    scopus 로고
    • Molecular classification of papillary thyroid carcinoma: Distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
    • Giordano TJ, Kuick R, Thomas DG, Misek DE, Vinco M, Sanders D, Zhu Z, Ciampi R, Roh M, Shedden K, Gauger P, Doherty G, et al. Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis. Oncogene 2005;24:6646-56.
    • (2005) Oncogene , vol.24 , pp. 6646-6656
    • Giordano, T.J.1    Kuick, R.2    Thomas, D.G.3    Misek, D.E.4    Vinco, M.5    Sanders, D.6    Zhu, Z.7    Ciampi, R.8    Roh, M.9    Shedden, K.10    Gauger, P.11    Doherty, G.12
  • 193
    • 33644863904 scopus 로고    scopus 로고
    • Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations
    • Kim IJ, Kang HC, Jang SG, Kim K, Ahn SA, Yoon HJ, Yoon SN, Park JG. Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations. Carcinogenesis 2006;27:392-404.
    • (2006) Carcinogenesis , vol.27 , pp. 392-404
    • Kim, I.J.1    Kang, H.C.2    Jang, S.G.3    Kim, K.4    Ahn, S.A.5    Yoon, H.J.6    Yoon, S.N.7    Park, J.G.8
  • 194


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.