Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin

Cancer Research

Volumn 65, Issue 22, 2005, Pages 10536-10544

  Guo, Fei ^a   Rocha, Kathy ^a   Bali, Purva ^a   Pranpat, Michael ^a   Fiskus, Warren ^a   Boyapalle, Sandhya ^a   Kumaraswamy, Sandhya ^a   Balasis, Maria ^a   Greedy, Benjamin ^a   Armitage, E Simon M ^a   Lawrence, Nicholas ^a   Bhalla, Kapil ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; ANTILEUKEMIC AGENT; BCR ABL PROTEIN; BENZYLIDENE DERIVATIVE; CYTARABINE; ETOPOSIDE; HEAT SHOCK PROTEIN 70; KNK 437; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN BAX; PROTEIN C RAF; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIZATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEAT TOLERANCE; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZHYDRYL COMPOUNDS; BENZOQUINONES; COMBINED MODALITY THERAPY; CYTARABINE; DRUG SYNERGISM; ETOPOSIDE; HL-60 CELLS; HSP70 HEAT-SHOCK PROTEINS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; K562 CELLS; LACTAMS, MACROCYCLIC; LEUKEMIA, MYELOCYTIC, ACUTE; MITOCHONDRIA; PROTEIN CONFORMATION; PYRROLIDINONES; RIFABUTIN; RNA, SMALL INTERFERING;

EID: 28544433004     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1799     Document Type: Article

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