Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors

Journal of Biological Chemistry

Volumn 280, Issue 29, 2005, Pages 26729-26734

  Bali, Purva ^a   Pranpat, Michael ^a   Bradner, James ^b   Balasis, Maria ^a   Fiskus, Warren ^a   Guo, Fei ^a   Rocha, Kathy ^a   Kumaraswamy, Sandhya ^a   Boyapalle, Sandhya ^a   Atadja, Peter ^c   Seto, Edward ^a   Bhalla, Kapil ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLATION; BIOCHEMISTRY; BIODEGRADATION; CELLS; DISEASES; RNA;

CHAPERONE FUNCTIONS; HEAT SHOCK PROTEIN (HSP); HYDROXAMIC ACID (HAA); POLYUBIQUITYLATION;

ENZYMES;

4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; ADENOSINE TRIPHOSPHATE; ALPHA TUBULIN; BCR ABL PROTEIN; CHAPERONE; FLT3 LIGAND; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; LBH 589; PROTEASOME INHIBITOR; PROTEIN C RAF; PROTEIN KINASE B; RAF PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACETYLATION; AGGRESOME; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG MECHANISM; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LEUKEMIA CELL; MICROTUBULE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; UBIQUITINATION;

ACETYLATION; ANTINEOPLASTIC AGENTS; ENZYME INHIBITORS; HISTONE DEACETYLASES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYDROXAMIC ACIDS; K562 CELLS; LEUKEMIA; MOLECULAR CHAPERONES; NEOPLASM PROTEINS; PROTEIN BINDING; UBIQUITIN;

EID: 22844432021     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C500186200     Document Type: Article

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