The role of Mcl-1 downregulation in the proapoptotic activity of the multikinase inhibitor BAY 43-9006

Oncogene

Volumn 24, Issue 46, 2005, Pages 6861-6869

  Yu, Chunrong ^a   Bruzek, Laura M ^a   Xue, Wei Meng ^a   Gores, Gregory J ^a   Carter, Christopher A ^b   Kaufmann, Scott H ^a   Adjei, Alex A ^a  

^a MAYO CLINIC   (United States)

^b BAYER CORPORATION   (United States)

Author keywords

Adaphostin; Apoptosis; BAY 43 9006 (sorafenib); Mcl 1; MEK; Raf

Indexed keywords

CASPASE; CASPASE INHIBITOR; CYTOCHROME C; MESSENGER RNA; N TERT BUTYLOXYCARBONYLASPARTIC ACID FLUOROMETHYL KETONE; PHOSPHOTRANSFERASE INHIBITOR; PROTEASOME; PROTEIN BCL 2; PROTEIN MCL 1; RNA; SORAFENIB; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN FUNCTION; TIME;

ADAMANTANE; APOPTOSIS; BASE SEQUENCE; BENZENESULFONATES; CASPASES; CELL LINE, TUMOR; DNA PRIMERS; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; HYDROQUINONES; MAP KINASE SIGNALING SYSTEM; NEOPLASM PROTEINS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 27144502652     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208841     Document Type: Article

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