Active ras induces heterodimerization of cRaf and BRaf

Cancer Research

Volumn 61, Issue 9, 2001, Pages 3595-3598

  Weber, C K ^a   Slupsky, J R ^a   Andreas Kalmes, H ^a   Rapp, U R ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; GROWTH FACTOR; PROTEIN CRAF; RAF PROTEIN; RAS PROTEIN; SERINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; EMBRYO; GENE EXPRESSION REGULATION; GROWTH REGULATION; HUMAN; HUMAN CELL; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

14-3-3 PROTEINS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE; DIMERIZATION; HUMANS; PEPTIDE FRAGMENTS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-RAF; RAS PROTEINS; TYROSINE 3-MONOOXYGENASE;

EID: 0035328521     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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4. Endothelial apoptosis in BRaf-deficient mice
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7. Overlapping and specific functions of BRaf and cRaf1 proto-oncogenes during mouse embryogenesis
8. Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells
9. Activation of Raf as a result of recruitment to the plasma membrane
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11. Oligomerization activates c-Raf-1 through a Ras-dependent mechanism
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13. Purification of a Ras-dependent mitogen-activated protein kinase kinase kinase from bovine brain cytosol and its identification as a complex of B-Raf and 14-3-3 proteins
14. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity
15. 14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo
16. Autoregulation of the Raf-1 serine/threonine kinase
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19. The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases
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21. Isotype-specific functions of raf kinases
22. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
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27. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
28. Two co-existing mechanisms for nuclear import of MAP kinase: Passive diffusion of a monomer and active transport of a dimer