Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 26, 1996, Pages 15481-15484

  Monia, Brett P ^a   Sasmor, Henri ^a   Johnston, Joseph F ^a   Freier, Susan M ^a   Lesnik, Elena A ^a   Muller, Marcel ^b   Geiger, Thomas ^b   Altmann, Karl Heinz ^b   Moser, Heinz ^b   Fabbro, Doriano ^b  

^a ISIS PHARMACEUTICALS   (United States)

^b CIBA GEIGY LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; CGP 69846A; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; PRIORITY JOURNAL; TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL DIVISION; CELL LINE; CELL SURVIVAL; FEMALE; HUMANS; KINETICS; LUNG NEOPLASMS; MICE; MICE, NUDE; NUCLEIC ACID DENATURATION; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; STRUCTURE-ACTIVITY RELATIONSHIP; THIONUCLEOTIDES; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 12644268252     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.26.15481     Document Type: Article

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