Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: Effects on Hsp90 and client proteins in melanoma models

Cancer Chemotherapy and Pharmacology

Volumn 56, Issue 2, 2005, Pages 126-137

  Smith, Victoria ^a   Sausville, Edward A ^b,c   Camalier, Richard F ^b   Fiebig, Heinz Herbert ^a   Burger, Angelika M ^a,d  

^a UNIVERSITY OF FREIBURG   (Germany)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTER   (United States)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

17AAG; 17DMAG; Hsp90 modulation; Melanoma

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; 17 DIMETHYLAMINOETHYLAMINO 17 DEMETHOXYGELDANAMYCIN; 4 HYDROXYCYCLOPHOSPHAMIDE; 4 HYDROXYIFOSFAMIDE; B RAF KINASE; BLEOMYCIN; CISPLATIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; DACARBAZINE; DOXORUBICIN; ELMUSTINE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; ETOPOSIDE; FLUOROURACIL; GELDANAMYCIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; IFOSFAMIDE; MITOXANTRONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NSC 707545; PROTEIN KINASE B; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE; VINDESINE;

ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CLONOGENIC ASSAY; COLON TUMOR; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SENSITIVITY; DRUG TARGETING; GROWTH INHIBITION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; IC 50; LUNG METASTASIS; LYMPH NODE METASTASIS; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA; TUMOR XENOGRAFT;

ANIMALS; BASE SEQUENCE; BENZOQUINONES; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MELANOMA; MICE; MICE, NUDE; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; QUINONES; RIFABUTIN; SKIN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 21244466289     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0947-2     Document Type: Article

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