-
1
-
-
0000784537
-
Identification of potent, selective kinase inhibitors of Raf
-
285016; Abs 3793
-
285016 Identification of potent, selective kinase inhibitors of Raf. Heimbrook DC, Huber HE, Stirdivant SM, Claremon D, Liverton N, Patrick DR, Selnick H, Ahern J, Conroy R, Drakas R, Falconi N et al Proc Annu Meet Am Assoc Cancer Res 1998 39 Abs 3793
-
(1998)
Proc Annu Meet Am Assoc Cancer Res
, vol.39
-
-
Heimbrook, D.C.1
Huber, H.E.2
Stirdivant, S.M.3
Claremon, D.4
Liverton, N.5
Patrick, D.R.6
Selnick, H.7
Ahern, J.8
Conroy, R.9
Drakas, R.10
Falconi, N.11
-
2
-
-
0013384697
-
Drug discovery efforts toward the identification of c-Raf1 kinase inhibitors as anti-cancer agents
-
322585; Abs 828
-
322585 Drug discovery efforts toward the identification of c-Raf1 kinase inhibitors as anti-cancer agents. Lackey K, Chapman D, Crosby RM, Davenport E, Dickerson S, Gilmer TM, Griffin RJ, Hunter RN, Jung DK, Keith BR, Mahoney WB et al Proc Annu Meet Am Assoc Cancer Res 1999 40 Abs 828
-
(1999)
Proc Annu Meet Am Assoc Cancer Res
, vol.40
-
-
Lackey, K.1
Chapman, D.2
Crosby, R.M.3
Davenport, E.4
Dickerson, S.5
Gilmer, T.M.6
Griffin, R.J.7
Hunter, R.N.8
Jung, D.K.9
Keith, B.R.10
Mahoney, W.B.11
-
3
-
-
0005920328
-
American Association for Cancer Research - 90th Annual Meeting (Part XII), Philadelphia, PA, USA
-
322280
-
322280 American Association for Cancer Research - 90th Annual Meeting (Part XII), Philadelphia, PA, USA. Kelland LR IDDB Meeting Report 1999 April 10-14
-
IDDB Meeting Report 1999 April 10-14
-
-
Kelland, L.R.1
-
5
-
-
0041496770
-
Discovery of a novel class of potent Raf kinase inhibitors: Structure activity relationships
-
390882; November 7-11 Abs 335
-
390882 Discovery of a novel class of potent Raf kinase inhibitors: Structure activity relationships. Lowinger T, Riedl B, Wood J, Dumas J, Smith RA, Khire U, Bankston D, Monahan MK, Scott WJ, Lee W, Johnson JS et al NCI EORTC Symp New Drugs Cancer Ther 2000 11 November 7-11 Abs 335
-
(2000)
NCI EORTC Symp New Drugs Cancer Ther
, vol.11
-
-
Lowinger, T.1
Riedl, B.2
Wood, J.3
Dumas, J.4
Smith, R.A.5
Khire, U.6
Bankston, D.7
Monahan, M.K.8
Scott, W.J.9
Lee, W.10
Johnson, J.S.11
-
6
-
-
0013340162
-
Potent Raf kinase inhibitors from the diphenylurea class: Structure activity relationships
-
402451; March 24-28 Abs 4956
-
402451 Potent Raf kinase inhibitors from the diphenylurea class: Structure activity relationships. Riedl B, Lowinger TB, Bankston D, Barbosa J, Brittelli D R, Carlson R, Dumas J, Hibner B, Kadano H, Katz M, Kennure N et al Proc Annu Meet Am Assoc Cancer Res 2001 42 March 24-28 Abs 4956
-
(2001)
Proc Annu Meet Am Assoc Cancer Res
, vol.42
-
-
Riedl, B.1
Lowinger, T.B.2
Bankston, D.3
Barbosa, J.4
Brittelli, D.R.5
Carlson, R.6
Dumas, J.7
Hibner, B.8
Kadano, H.9
Katz, M.10
Kennure, N.11
-
7
-
-
0041997734
-
American Association for Cancer Research 92nd Annual Meeting (Part VII), New Orleans, LA, USA
-
403615
-
403615 American Association for Cancer Research 92nd Annual Meeting (Part VII), New Orleans, LA, USA. Jones E IDDB Meeting Report 2001 March 24-28
-
IDDB Meeting Report 2001 March 24-28
-
-
Jones, E.1
-
8
-
-
0042999261
-
Phase I and pharmacokinetic study of the rat kinase inhibitor BAY 43-9006 in patients with locally advanced or metastatic cancer
-
404504; Abs 2921
-
404504 Phase I and pharmacokinetic study of the rat kinase inhibitor BAY 43-9006 in patients with locally advanced or metastatic cancer. Strumberg D, Schuehly U, Moeller JG, Hedley D, Hilger R, Stellberg W, Richly H, Heinig R, Kuhlmann J, Scheulen ME, Seeber S Proc Annu Meet Am Assoc Cancer Res 2001 42 Abs 2921
-
(2001)
Proc Annu Meet Am Assoc Cancer Res
, vol.42
-
-
Strumberg, D.1
Schuehly, U.2
Moeller, J.G.3
Hedley, D.4
Hilger, R.5
Stellberg, W.6
Richly, H.7
Heinig, R.8
Kuhlmann, J.9
Scheulen, M.E.10
Seeber, S.11
-
9
-
-
0041997732
-
American Association for Cancer Research 92nd Annual Meeting (Part XI), Novel Molecular Targets and Drugs New Orleans, LA, USA
-
404875
-
404875 American Association for Cancer Research 92nd Annual Meeting (Part XI), Novel Molecular Targets and Drugs New Orleans, LA, USA. Clarke R IDDB Meeting Report 2001 March 24-28
-
IDDB Meeting Report 2001 March 24-28
-
-
Clarke, R.1
-
10
-
-
0041496779
-
Drug development pipeline: BAY-43-9006, Raf inhibitors, ONYX/Bayer
-
408527; May 08
-
408527 Drug development pipeline: BAY-43-9006, Raf inhibitors, ONYX/Bayer. Bayer Corp Company Communication 2001 May 08
-
(2001)
Bayer Corp Company Communication
-
-
-
11
-
-
0000165437
-
Phase I clinical, pharmacokinetic and pharmacodynamic study of the Raf kinase inhibitor BAY 43-9006 in patients with locally advanced or metastatic cancer
-
409891; Abs 330
-
409891 Phase I clinical, pharmacokinetic and pharmacodynamic study of the Raf kinase inhibitor BAY 43-9006 in patients with locally advanced or metastatic cancer. Strumberg D, Schuehly U, Moeller J G, Hedley D, Hilger R, Stellberg W, Richly H, Heinig R, Ahr G, Wensing G, Kuhlmann J et al Proc Am Soc Clin Oncol 2001 20 Pt 1 Abs 330
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, Issue.PART 1
-
-
Strumberg, D.1
Schuehly, U.2
Moeller, J.G.3
Hedley, D.4
Hilger, R.5
Stellberg, W.6
Richly, H.7
Heinig, R.8
Ahr, G.9
Wensing, G.10
Kuhlmann, J.11
-
12
-
-
0035935203
-
Discovery of heteroocyclic ureas as a new class of raf kinase inhibitors: Identification of a second generation lead by a combinatorial chemistry approach
-
425815; note
-
425815 Discovery of heteroocyclic ureas as a new class of raf kinase inhibitors: Identification of a second generation lead by a combinatorial chemistry approach. Smith RA, Barbosa J, Blum C, Bobko MA, Caringl YV, Dally R, Johnson J, Katz ME, Kennure N, Kingrey Wood J, Lee W et al Bioorg Med Chem Lett 2001 11 20 2775-2778 An original publication describing the synthesis of heterocyclic ureas as novel Raf kinase inhibitors.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, Issue.20
, pp. 2775-2778
-
-
Smith, R.A.1
Barbosa, J.2
Blum, C.3
Bobko, M.A.4
Caringl, Y.V.5
Dally, R.6
Johnson, J.7
Katz, M.E.8
Kennure, N.9
Kingrey Wood, J.10
Lee, W.11
-
13
-
-
0042498547
-
BAY 43-9006 phase I data presented at 2001 AACR-NCI-EORTC meeting
-
427755; November 01
-
427755 BAY 43-9006 phase I data presented at 2001 AACR-NCI-EORTC meeting. Onyx Pharmaceuticals Inc, Bayer Corp Press Release 2001 November 01
-
(2001)
Onyx Pharmaceuticals Inc, Bayer Corp Press Release
-
-
-
14
-
-
0041496777
-
A phase I pharmacokinetic and pharmacodynamic study of the Raf kinase inhibitor BAY 43-9006 given orally to patients with solid tumors
-
430134; October 29-November 02 Abs 285
-
430134 A phase I pharmacokinetic and pharmacodynamic study of the Raf kinase inhibitor BAY 43-9006 given orally to patients with solid tumors. Strumberg D, Bauer RJ, Moeller JG, Hilger R, Diaz-Carballo D, Richly H, Kredtke S, Beling C, Faghih M, Heinig R, Hedley D et al AACR NCI EORTC Mol Targets Cancer Ther 2001 October 29-November 02 Abs 285
-
(2001)
AACR NCI EORTC Mol Targets Cancer Ther
-
-
Strumberg, D.1
Bauer, R.J.2
Moeller, J.G.3
Hilger, R.4
Diaz-Carballo, D.5
Richly, H.6
Kredtke, S.7
Beling, C.8
Faghih, M.9
Heinig, R.10
Hedley, D.11
-
15
-
-
0013436822
-
Application of a novel flow cytometry method for pharmacodynamic monitoring of the Raf kinase inhibitor BAY 43-9006 during phase I clinical trial
-
430159; October 29-November 02 Abs 293
-
430159 Application of a novel flow cytometry method for pharmacodynamic monitoring of the Raf kinase inhibitor BAY 43-9006 during phase I clinical trial. Hedley DW, Chow S, Moore MJ, Bollag G, Lyons J, Wilhelm S AACR NCI EORTC MOL Targets Cancer Ther 2001 October 29-November 02 Abs 293
-
(2001)
AACR NCI EORTC MOL Targets Cancer Ther
-
-
Hedley, D.W.1
Chow, S.2
Moore, M.J.3
Bollag, G.4
Lyons, J.5
Wilhelm, S.6
-
16
-
-
0042999260
-
Phase I study to determine the safety and pharmacokinetics of BAY 43-9006 in patients with advanced refractory solid tumors
-
436956; October 29-November 02 Abs 567
-
436956 Phase I study to determine the safety and pharmacokinetics of BAY 43-9006 in patients with advanced refractory solid tumors. Hirte H, Moore MJ, Oza AM, Siu LL, Harris H, Maclean M, Petreniuc O, Fiander W, Lathia C AACR NCI EORTC Mol Targets Cancer Ther 2001 October 29-November 02 Abs 567
-
(2001)
AACR NCI EORTC Mol Targets Cancer Ther
-
-
Hirte, H.1
Moore, M.J.2
Oza, A.M.3
Siu, L.L.4
Harris, H.5
Maclean, M.6
Petreniuc, O.7
Fiander, W.8
Lathia, C.9
-
17
-
-
0003275189
-
A clinical, pharmacokinetic and pharmacodynamic phase I study of the Raf kinase inhibitor BAY 43-9006 in patients with advanced solid cancers
-
436952; October 29-November 02 Abs 569
-
436952 A clinical, pharmacokinetic and pharmacodynamic phase I study of the Raf kinase inhibitor BAY 43-9006 in patients with advanced solid cancers. Awada A, Hendlisz A, Gil T, Bleiberg H, Bartholomeus S, De Valeriola D, Dewitte M, Coppieters S, Moeller J, De Becker D, Meert A et al AACR NCI EORTC Mol Targets Cancer Ther 2001 October 29-November 02 Abs 569
-
(2001)
AACR NCI EORTC Mol Targets Cancer Ther
-
-
Awada, A.1
Hendlisz, A.2
Gil, T.3
Bleiberg, H.4
Bartholomeus, S.5
De Valeriola, D.6
Dewitte, M.7
Coppieters, S.8
Moeller, J.9
De Becker, D.10
Meert, A.11
-
18
-
-
0000409315
-
Final results of a phase I pharmacokinetic and pharmacodynamic study of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors
-
451786; Abs 121
-
451786 Final results of a phase I pharmacokinetic and pharmacodynamic study of the Raf kinase inhibitor BAY 43-9006 in patients with solid tumors. Strumberg D, Bauer RJ, Moeller JG, Hilger RA, Richly H, Kredtke S, Beling C, Faghih M, Heinig R, Hedley D, Scheulen ME, Seebers S Proc Am Soc Clin Oncol 2002 21 1 Abs 121
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 1
-
-
Strumberg, D.1
Bauer, R.J.2
Moeller, J.G.3
Hilger, R.A.4
Richly, H.5
Kredtke, S.6
Beling, C.7
Faghih, M.8
Heinig, R.9
Hedley, D.10
Scheulen, M.E.11
Seebers, S.12
-
19
-
-
0041496776
-
New BAY 43-9006 phase I data presented at 2002 ASCO meeting
-
451999; May 21
-
451999 New BAY 43-9006 phase I data presented at 2002 ASCO meeting. Onyx Pharmaceuticals Inc Press Release 2002 May 21
-
(2002)
Onyx Pharmaceuticals Inc Press Release
-
-
-
20
-
-
0042999259
-
Phase 1 study of the Raf-1 kinase inhibitor Bay 43-9006 in patients with advanced refractory solid tumors
-
452880; Abs 1816
-
452880 Phase 1 study of the Raf-1 kinase inhibitor Bay 43-9006 in patients with advanced refractory solid tumors. Moore M, Maclean M, Petenciuc O, Fiander W, Lathia C Proc Am Soc Clin Oncol 2002 21 1 Abs 1816
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 1
-
-
Moore, M.1
Maclean, M.2
Petenciuc, O.3
Fiander, W.4
Lathia, C.5
-
21
-
-
0003284698
-
Chemotherapy with the Raf kinase inhibitor BAY 43-9006 in combination with irinotecan, vinorelbine, or gemcitabine is well tolerated and efficacious in preclinical xenografts models
-
453077; Abs 1900
-
453077 Chemotherapy with the Raf kinase inhibitor BAY 43-9006 in combination with irinotecan, vinorelbine, or gemcitabine is well tolerated and efficacious in preclinical xenografts models. Vincent P, Zhang X, Chen C, Lantz L, Rembiessa C, Polony B, Carter CA Proc Am Soc Clin Oncol 2002 21 2 Abs 1900
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 2
-
-
Vincent, P.1
Zhang, X.2
Chen, C.3
Lantz, L.4
Rembiessa, C.5
Polony, B.6
Carter, C.A.7
-
22
-
-
0042498543
-
Inhibition of ERK phosphorylation and clinical outcome in patients treated with the Raf kinase inhibitor BAY 43-9006
-
453133; Abs 1916
-
453133 Inhibition of ERK phosphorylation and clinical outcome in patients treated with the Raf kinase inhibitor BAY 43-9006. Moeller JG, Bauer RJ, Stellberg W, Seeber S, Scheulen ME, Strumberg D Prof Am Soc Clin Oncol 2002 21 1 Abs 1916
-
(2002)
Prof Am Soc Clin Oncol
, vol.21
, pp. 1
-
-
Moeller, J.G.1
Bauer, R.J.2
Stellberg, W.3
Seeber, S.4
Scheulen, M.E.5
Strumberg, D.6
-
23
-
-
0034784725
-
Discovery of a novel Raf kinase inhibitor
-
456813; note
-
456813 Discovery of a novel Raf kinase inhibitor. Lyons JF, Wilhelm S, Hibner B, Bollag G Endocr-Relat Cancer 2001 8 219-225 A peer-reviewed, introductory review that discusses the need for Raf inhibitors as well as early studies with BAY-43-9006.
-
(2001)
Endocr-Relat Cancer
, vol.8
, pp. 219-225
-
-
Lyons, J.F.1
Wilhelm, S.2
Hibner, B.3
Bollag, G.4
-
24
-
-
0041997728
-
Onyx and Bayer initiate phase II studies of Raf kinase inhibitor
-
463092; September 04
-
463092 Onyx and Bayer initiate phase II studies of Raf kinase inhibitor. Onyx Pharmaceuticals Inc Press Release 2002 September 04
-
(2002)
Onyx Pharmaceuticals Inc Press Release
-
-
-
25
-
-
0041997727
-
Ω-Carboxypyridyl substituted ureas as Raf kinase inhibitors
-
463753; Abs 4211
-
463753 Ω-Carboxypyridyl substituted ureas as Raf kinase inhibitors. Khire U, Dumas J, Riedl B, Smith R, Lowinger T, Wood J, Brittelli D Proc Annu Meet Am Assoc Cancer Res 2002 43 Abs 4211
-
(2002)
Proc Annu Meet Am Assoc Cancer Res
, vol.43
-
-
Khire, U.1
Dumas, J.2
Riedl, B.3
Smith, R.4
Lowinger, T.5
Wood, J.6
Brittelli, D.7
-
26
-
-
0013388869
-
Inhibition of ERK phosphorylation in patients treated with the Raf kinase inhibitor BAY 43-9006
-
463765; Abs 2973
-
463765 Inhibition of ERK phosphorylation in patients treated with the Raf kinase inhibitor BAY 43-9006. Hilger RA, Kredtke S, Hedley D, Moeller JG, Bauer RJ, Stellberg W, Seeber S, Scheulen ME, Strumberg D Proc Annu Meet Am Assoc Cancer Res 2002 43 Abs 2973
-
(2002)
Proc Annu Meet Am Assoc Cancer Res
, vol.43
-
-
Hilger, R.A.1
Kredtke, S.2
Hedley, D.3
Moeller, J.G.4
Bauer, R.J.5
Stellberg, W.6
Seeber, S.7
Scheulen, M.E.8
Strumberg, D.9
-
27
-
-
0013388039
-
A novel diphenylurea Raf-1 kinase inhibitor (RKI) blocks the Raf/Mek/Erk pathway in tumor cells
-
463772
-
463772 A novel diphenylurea Raf-1 kinase inhibitor (RKI) blocks the Raf/Mek/Erk pathway in tumor cells. Wilhelm SM, Housley T, Kennure N, Rong H, Carlson R, Hibner B, Riedl B, Lyons J, Taylor R, Bollag G, Roscoe W Proc Annu Meet Am Assoc Cancer Res 2001 42 4957
-
(2001)
Proc Annu Meet Am Assoc Cancer Res
, vol.42
, pp. 4957
-
-
Wilhelm, S.M.1
Housley, T.2
Kennure, N.3
Rong, H.4
Carlson, R.5
Hibner, B.6
Riedl, B.7
Lyons, J.8
Taylor, R.9
Bollag, G.10
Roscoe, W.11
-
28
-
-
0013339315
-
Anti-tumor efficacy of the orally active Raf kinase inhibitor BAY 43-9006 in human tumor xenograft models
-
463774; Abs 4954
-
463774 Anti-tumor efficacy of the orally active Raf kinase inhibitor BAY 43-9006 in human tumor xenograft models. Carter CA, Gianpaolo Ostravage C, Hibner B, Bankston D, Natero R, Monahan MK, Riedl B Proc Annu Meet Am Assoc Cancer Res 2001 42 Abs 4954
-
(2001)
Proc Annu Meet Am Assoc Cancer Res
, vol.42
-
-
Carter, C.A.1
Gianpaolo Ostravage, C.2
Hibner, B.3
Bankston, D.4
Natero, R.5
Monahan, M.K.6
Riedl, B.7
-
29
-
-
0036238817
-
The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukaemia
-
466338
-
466338 The Raf/MEK/ERK signal transduction cascade as a target for chemotherapeutic intervention in leukaemia. Lee JT, McCubrey JA Leukemia 2002 16 4 486-507
-
(2002)
Leukemia
, vol.16
, Issue.4
, pp. 486-507
-
-
Lee, J.T.1
McCubrey, J.A.2
-
30
-
-
0042498545
-
Targeting the Raf kinase cascade in cancer therapy: Novel molecular, targets and therapeutic strategies
-
466340; in press
-
466340 Targeting the Raf kinase cascade in cancer therapy: Novel molecular, targets and therapeutic strategies. Lee JT, McCubrey JA Exp Opin Ther Targets 2003 in press
-
(2003)
Exp Opin Ther Targets
-
-
Lee, J.T.1
McCubrey, J.A.2
-
31
-
-
0037776897
-
New drugs in the R&D pipeline
-
466916; October 14
-
466916 New drugs in the R&D pipeline. Pharma Jpn 2002 1815 October 14 9
-
(2002)
Pharma Jpn
, vol.1815
, pp. 9
-
-
-
32
-
-
0041496774
-
Onyx provides update of development programs; Meets key manufacturing milestone
-
470312; November 14
-
470312 Onyx provides update of development programs; Meets key manufacturing milestone. Onyx Pharmaceuticals Inc Press Release 2002 November 14
-
(2002)
Onyx Pharmaceuticals Inc Press Release
-
-
-
33
-
-
0041496775
-
Final results of a clinical and pharmacokinetic (PK) phase I study of the Raf kinase inhibitor BAY 43-9006 in refractory solid cancers: A promising antitumor agent
-
470750; November 19-22 Abs 162
-
470750 Final results of a clinical and pharmacokinetic (PK) phase I study of the Raf kinase inhibitor BAY 43-9006 in refractory solid cancers: A promising antitumor agent. Awada A, Hendlisz A, Gil T, Munoz R, Bartholomeus S, De Valeriola D, Van Der Auwera J, Coppieters S, Moeller JG, Piccart M. AACR NCI EORTC Mol Targets Cancer Ther 2002 November 19-22 Abs 162
-
(2002)
AACR NCI EORTC Mol Targets Cancer Ther
-
-
Awada, A.1
Hendlisz, A.2
Gil, T.3
Munoz, R.4
Bartholomeus, S.5
De Valeriola, D.6
Van Der Auwera, J.7
Coppieters, S.8
Moeller, J.G.9
Piccart, M.10
-
34
-
-
0036402628
-
BAY 43-9006: Early clinical data in patients with advanced solid malignancies
-
471717; note
-
471717 BAY 43-9006: Early clinical data in patients with advanced solid malignancies. Hotte SJ, Hirte HW Curr Pharm Design 2002 8 25 2249-2253 This article encompasses much of the available phase I trial data in relative detail.
-
(2002)
Curr Pharm Design
, vol.8
, Issue.25
, pp. 2249-2253
-
-
Hotte, S.J.1
Hirte, H.W.2
-
35
-
-
0036401105
-
BAY 43-9006: Preclinical data
-
471718; note
-
471718 BAY 43-9006: Preclinical data. Wilheim S, Chien DS Curr Pharm Design 2002 8 25 2255-2257 Succinct review, co-written by developers of the drug, covering data from a number of important abstracts.
-
(2002)
Curr Pharm Design
, vol.8
, Issue.25
, pp. 2255-2257
-
-
Wilheim, S.1
Chien, D.S.2
-
36
-
-
0036401042
-
Design and discovery of small molecules targeting Raf-1 kinase
-
471721; note
-
471721 Design and discovery of small molecules targeting Raf-1 kinase. Lowinger TB, Riedl B, Dumas J, Smith RA Curr Pharm Design 2002 8 25 2269-2278 Comprehensive review covering the complete synthesis and SAR of BAY-43-9006.
-
(2002)
Curr Pharm Design
, vol.8
, Issue.25
, pp. 2269-2278
-
-
Lowinger, T.B.1
Riedl, B.2
Dumas, J.3
Smith, R.A.4
-
37
-
-
25344467950
-
BAY-43-9006, a Raf inhibitor with a novel mechanism of action
-
471765; in press
-
471765 BAY-43-9006, a Raf inhibitor with a novel mechanism of action. Lyons JF, Hibner B, Gianpaolo-Ostravage C, Bankston D, Natero R, Chien DS, Dumas J, Riedl B, Roscoe W, Housley T, Kennure N et al Proc Natl Acad Sci USA 2003 in press
-
(2003)
Proc Natl Acad Sci USA
-
-
Lyons, J.F.1
Hibner, B.2
Gianpaolo-Ostravage, C.3
Bankston, D.4
Natero, R.5
Chien, D.S.6
Dumas, J.7
Riedl, B.8
Roscoe, W.9
Housley, T.10
Kennure, N.11
-
38
-
-
0013389669
-
Imatinib-resistant cell lines are sensitive to the Raf inhibitor BAY 43-9006
-
473339; Abs 1427
-
473339 Imatinib-resistant cell lines are sensitive to the Raf inhibitor BAY 43-9006. Choi Y-JC, Wang Q, White S, Gorre M, Sawyers CL, Bollag G. Blood 2002 100 11 Abs 1427
-
(2002)
Blood
, vol.100
, pp. 11
-
-
Choi, Y.-J.C.1
Wang, Q.2
White, S.3
Gorre, M.4
Sawyers, C.L.5
Bollag, G.6
-
39
-
-
0041997724
-
Perspectives: Pipeline pulse: 1,000+ drugs in development provide bright future for industry
-
475714; October
-
475714 Perspectives: Pipeline pulse: 1,000+ drugs in development provide bright future for industry. Scala SM, Sanderson IC, Moran JR, Cacciatore KC, Perreault JB SG Cowen Securities Corporation 2002 October
-
(2002)
SG Cowen Securities Corporation
-
-
Scala, S.M.1
Sanderson, I.C.2
Moran, J.R.3
Cacciatore, K.C.4
Perreault, J.B.5
-
40
-
-
0041997726
-
New targets and innovative strategies in cancer treatment. A short course for clinicians, Monte Carlo, Monaco
-
479169
-
479169 New targets and innovative strategies in cancer treatment. A short course for clinicians, Monte Carlo, Monaco. Eskens F IDDB Meeting Report 2003 February 07-08
-
IDDB Meeting Report 2003 February 07-08
-
-
Eskens, F.1
-
41
-
-
4444318599
-
Final results of a phase I study to determine the safety, maximum tolerated dose, pharmacokinetics and pharmacodynamics of BAY 43-9006 in repeated cycles of 1 week on / 1 week off in patients with advanced, refractory solid tumors
-
492982; Abs 976
-
492982 Final results of a phase I study to determine the safety, maximum tolerated dose, pharmacokinetics and pharmacodynamics of BAY 43-9006 in repeated cycles of 1 week on / 1 week off in patients with advanced, refractory solid tumors. Wong KK, Eder JP, Clark J, Lenz HJ, Smith J, Lee RJ, Lathia C, Humphrey R Proc Am Soc Clin Oncol 2003 22 Abs 976
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Wong, K.K.1
Eder, J.P.2
Clark, J.3
Lenz, H.J.4
Smith, J.5
Lee, R.J.6
Lathia, C.7
Humphrey, R.8
-
42
-
-
0041496773
-
Final report of the phase I clinical program of the novel Raf kinase inhibitor BAY 43-9006 in patients with refractory solid tumors
-
491537; Abs 813
-
491537 Final report of the phase I clinical program of the novel Raf kinase inhibitor BAY 43-9006 in patients with refractory solid tumors. Strumberg D, Awada A, Piccart M, Hirte H, Moore M, Clark J, Lenz HJ, Lathia C, Coppieters S, Humphrey R Proc Am Soc Clin Oncol 2003 22 Abs 813
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Strumberg, D.1
Awada, A.2
Piccart, M.3
Hirte, H.4
Moore, M.5
Clark, J.6
Lenz, H.J.7
Lathia, C.8
Coppieters, S.9
Humphrey, R.10
-
43
-
-
0041997722
-
Novel Raf kinase inhibitor BAY 43-9006 shows early signs of tolerability and activity in phase Ib combination trials reported at ASCO
-
491853; June 02
-
491853 Novel Raf kinase inhibitor BAY 43-9006 shows early signs of tolerability and activity in phase Ib combination trials reported at ASCO. Bayer Pharmaceuticals Corp, Onyx Pharmaceuticals Inc Press Release 2003 June 02
-
(2003)
Bayer Pharmaceuticals Corp, Onyx Pharmaceuticals Inc Press Release
-
-
-
44
-
-
0041997725
-
Phase I trial of BAY 43-9006 in combination with carboplatin (C) and paclitaxel (P)
-
492037; Abs 2854
-
492037 Phase I trial of BAY 43-9006 in combination with carboplatin (C) and paclitaxel (P). Flaherty KT, Lee RJ, Humphries R, O'Dwyer PJ, Schiller J Proc Am Soc Clin Oncol 2003 22 Abs 2854
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Flaherty, K.T.1
Lee, R.J.2
Humphries, R.3
O'Dwyer, P.J.4
Schiller, J.5
-
45
-
-
0042999256
-
American Society of Clinical Oncology - 39th Annual Meeting (Part IX), Chicago, IL, USA
-
493380
-
493380 American Society of Clinical Oncology - 39th Annual Meeting (Part IX), Chicago, IL, USA. Susman E IDDB Meeting Report 2003 May 31-June 03
-
IDDB Meeting Report 2003 May 31-June 03
-
-
Susman, E.1
-
46
-
-
0042498542
-
Phase I study of oral Raf-1 kinase inhibitor BAY 43-9006 with gemcitabine in patients with advanced solid tumors
-
491883; Abs 828
-
491883 Phase I study of oral Raf-1 kinase inhibitor BAY 43-9006 with gemcitabine in patients with advanced solid tumors. Siu L, Awada A, Takimoto CH, Moore MJ, Piccart M, Fiander W, Lathia C, Petrenciuc O Proc Am Soc Clin Oncol 2003 22 Abs 828
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
-
-
Siu, L.1
Awada, A.2
Takimoto, C.H.3
Moore, M.J.4
Piccart, M.5
Fiander, W.6
Lathia, C.7
Petrenciuc, O.8
|