-
2
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
-
Kolch, W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ ERK pathway by protein interactions. Biochem. J., 351: 289-305, 2000.
-
(2000)
Biochem. J.
, vol.351
, pp. 289-305
-
-
Kolch, W.1
-
3
-
-
0035787526
-
Ras activation of the Raf kinase: Tyrosine kinase recruitment of the MAP kinase cascade
-
Avruch, J., Khokhlatchev, A., Kyriakis, J. M., Luo, Z., Tzivion, G., Vavvas, D., and Zhang, X. F. Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade. Recent Prog. Horm. Res., 56: 127-155, 2001.
-
(2001)
Recent Prog. Horm. Res.
, vol.56
, pp. 127-155
-
-
Avruch, J.1
Khokhlatchev, A.2
Kyriakis, J.M.3
Luo, Z.4
Tzivion, G.5
Vavvas, D.6
Zhang, X.F.7
-
4
-
-
0034762203
-
The Raf/MEK/ERK pathway: New concepts of activation
-
Peyssonnaux, C., and Eychene, A. The Raf/MEK/ERK pathway: new concepts of activation. Biol. Cell, 93: 53-62, 2001.
-
(2001)
Biol. Cell
, vol.93
, pp. 53-62
-
-
Peyssonnaux, C.1
Eychene, A.2
-
5
-
-
0034084163
-
Phosphorylation meets ubiquitination: The control of NF-κB activity
-
Karin, M., and Ben-Neriah, Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol., 18: 621-663, 2000.
-
(2000)
Annu. Rev. Immunol.
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
6
-
-
0034175930
-
The IKK complex: An integrator of all signals that activate NF-κB?
-
Israel, A. The IKK complex: an integrator of all signals that activate NF-κB? Trends Cell Biol., 10: 129-133, 2000.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 129-133
-
-
Israel, A.1
-
7
-
-
0036234459
-
Missing pieces in the NF-κB puzzle
-
Ghosh, S., and Karin, M. Missing pieces in the NF-κB puzzle. Cell, 109: 81-96, 2002.
-
(2002)
Cell
, vol.109
, pp. 81-96
-
-
Ghosh, S.1
Karin, M.2
-
8
-
-
12944305960
-
Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation
-
Baumann, B., Weber, C. K., Troppmair, J., Whiteside, S., Israel, A., Rapp, U. R., and Wirth, T. Raf induces NF-κB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc. Natl. Acad. Sci. USA, 97: 4615-4620, 2000.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 4615-4620
-
-
Baumann, B.1
Weber, C.K.2
Troppmair, J.3
Whiteside, S.4
Israel, A.5
Rapp, U.R.6
Wirth, T.7
-
9
-
-
0029130410
-
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes
-
McCarthy, S. A., Samuels, M. L., Pritchard, C. A., Abraham, J. A., and McMahon, M. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. Genes Dev., 9: 1953-1964, 1995.
-
(1995)
Genes Dev.
, vol.9
, pp. 1953-1964
-
-
McCarthy, S.A.1
Samuels, M.L.2
Pritchard, C.A.3
Abraham, J.A.4
McMahon, M.5
-
10
-
-
0030901947
-
Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1
-
Kerkhoff, E., and Rapp, U. R. Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol. Cell. Biol., 17: 2576-2586, 1997.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 2576-2586
-
-
Kerkhoff, E.1
Rapp, U.R.2
-
11
-
-
0035863394
-
Raf-induced transformation requires an interleukin 1 autocrine loop
-
Vale, T., Ngo, T. T., White, M. A., and Lipsky, P. E. Raf-induced transformation requires an interleukin 1 autocrine loop. Cancer Res., 61: 602-607, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 602-607
-
-
Vale, T.1
Ngo, T.T.2
White, M.A.3
Lipsky, P.E.4
-
12
-
-
0034675919
-
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
-
Zhang, B. H., and Guan, K. L. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J., 19: 5429-5439, 2000.
-
(2000)
EMBO J.
, vol.19
, pp. 5429-5439
-
-
Zhang, B.H.1
Guan, K.L.2
-
13
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C. J., Wooster, R., Stratton, M. R., and Futreal, P. A. Mutations of the BRAF gene in human cancer. Nature (Lond.), 417: 949-954, 2002.
-
(2002)
Nature (Lond.)
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmieri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
14
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B., and Velculescu, V. E. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature (Lond.), 418: 934, 2002.
-
(2002)
Nature (Lond.)
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
15
-
-
0037112438
-
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia
-
Yuen, S. T., Davies, H., Chan, T. L., Ho, J. W., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Tsui, W. W., Chan, A. S., Futreal, P. A., Stratton, M. R., Wooster, R., and Leung, S. Y. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res., 62: 6451-6455, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 6451-6455
-
-
Yuen, S.T.1
Davies, H.2
Chan, T.L.3
Ho, J.W.4
Bignell, G.R.5
Cox, C.6
Stephens, P.7
Edkins, S.8
Tsui, W.W.9
Chan, A.S.10
Futreal, P.A.11
Stratton, M.R.12
Wooster, R.13
Leung, S.Y.14
-
16
-
-
0037228055
-
High frequency of BRAF mutations in nevi
-
Pollock, P. M., Harper, U. L., Hansen, K. S., Yudt, L. M., Stark, M., Robbins, C. M., Moses, T. Y., Hostetter, G., Wagner, U., Kakareka, J., Salem, G., Pohida, T., Heenan, P., Duray, P., Kallioniemi, O., Hayward, N. K., Trent, J. M., and Meltzer, P. S. High frequency of BRAF mutations in nevi. Nat. Genet., 33: 19-20, 2003.
-
(2003)
Nat. Genet.
, vol.33
, pp. 19-20
-
-
Pollock, P.M.1
Harper, U.L.2
Hansen, K.S.3
Yudt, L.M.4
Stark, M.5
Robbins, C.M.6
Moses, T.Y.7
Hostetter, G.8
Wagner, U.9
Kakareka, J.10
Salem, G.11
Pohida, T.12
Heenan, P.13
Duray, P.14
Kallioniemi, O.15
Hayward, N.K.16
Trent, J.M.17
Meltzer, P.S.18
-
17
-
-
0036894746
-
BRAF RAS mutations in human lung cancer and melanoma
-
Brosc, M. S., Volpe, P., Feldman, M., Kumar, M., Rishi, I., Gerrero, R., Einhorn, E., Herlyn, M., Minna, J., Nicholson, A., Roth, J. A., Albelda, S. M., Davies, H., Cox, C., Brignell, G., Stephens, P., Futreal, P. A., Wooster, R., Stratton, M. R., and Weber, B. L. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res., 62: 6997-7000, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 6997-7000
-
-
Brosc, M.S.1
Volpe, P.2
Feldman, M.3
Kumar, M.4
Rishi, I.5
Gerrero, R.6
Einhorn, E.7
Herlyn, M.8
Minna, J.9
Nicholson, A.10
Roth, J.A.11
Albelda, S.M.12
Davies, H.13
Cox, C.14
Brignell, G.15
Stephens, P.16
Futreal, P.A.17
Wooster, R.18
Stratton, M.R.19
Weber, B.L.20
more..
-
18
-
-
0036895599
-
Missense mutations of the BRAF gene in human lung adenocarcinoma
-
Naoki, K., Chen, T. H., Richards, W. G., Sugarbaker, D. J., and Meyerson, M. Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res., 62: 7001-7003, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 7001-7003
-
-
Naoki, K.1
Chen, T.H.2
Richards, W.G.3
Sugarbaker, D.J.4
Meyerson, M.5
-
19
-
-
0038664387
-
BRAF mutation in papillary thyroid carcinoma
-
Cohen, Y., Xing, M., Mambo, E., Guo, Z., Wu, G., Trink, B., Beller, U., Westra, W. H., Ladenson, P. W., and Sidransky, D. BRAF mutation in papillary thyroid carcinoma. J. Natl. Cancer Inst., 95: 625-627, 2003.
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 625-627
-
-
Cohen, Y.1
Xing, M.2
Mambo, E.3
Guo, Z.4
Wu, G.5
Trink, B.6
Beller, U.7
Westra, W.H.8
Ladenson, P.W.9
Sidransky, D.10
-
20
-
-
0037379904
-
High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
-
Kimura, E. T., Nikiforova, M. N., Zhu, Z., Knauf, J. A., Nikiforov, Y. E., and Fagin, J. A. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res., 63: 1454-1457, 2003.
-
(2003)
Cancer Res.
, vol.63
, pp. 1454-1457
-
-
Kimura, E.T.1
Nikiforova, M.N.2
Zhu, Z.3
Knauf, J.A.4
Nikiforov, Y.E.5
Fagin, J.A.6
-
21
-
-
0037624602
-
Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
-
Tannapfel, A., Sommerer, F., Benicke, M., Katalinic, A., Uhlmann, D., Witzigmann, H., Hauss, J., and Wittekind, C. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut, 52: 706-712, 2003.
-
(2003)
Gut
, vol.52
, pp. 706-712
-
-
Tannapfel, A.1
Sommerer, F.2
Benicke, M.3
Katalinic, A.4
Uhlmann, D.5
Witzigmann, H.6
Hauss, J.7
Wittekind, C.8
-
22
-
-
0037454224
-
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
-
Singer, G., Oldt, R. 3rd, Cohen, Y., Wang, B. G., Sidransky, D., Kurman, R. J., and Shih le, M. Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J. Natl. Cancer Inst., 95: 484-486, 2003.
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 484-486
-
-
Singer, G.1
Oldt III, R.2
Cohen, Y.3
Wang, B.G.4
Sidransky, D.5
Kurman, R.J.6
Shih Le, M.7
-
23
-
-
0034235373
-
H. pylori activates NF-κB through a signaling pathway involving IκB kinases. NF-κB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
-
Maeda, S., Yoshida, H., Ogura, K., Mitsuno, Y., Hirata, Y., Yamaji, Y., Akanuma, M., Shiratori, Y., and Omata, M. H. pylori activates NF-κB through a signaling pathway involving IκB kinases. NF-κB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells. Gastroenterology, 119: 97-108, 2000.
-
(2000)
Gastroenterology
, vol.119
, pp. 97-108
-
-
Maeda, S.1
Yoshida, H.2
Ogura, K.3
Mitsuno, Y.4
Hirata, Y.5
Yamaji, Y.6
Akanuma, M.7
Shiratori, Y.8
Omata, M.9
-
24
-
-
0035976734
-
Systematic analysis of the TGF-β-Smad signaling pathway in gastrointestinal cancer cells
-
Ijichi, H., Ikenoue, T., Kato, N., Mitsuno, Y., Togo, G., Kato, J., Kanai, F., Shiratori, Y., and Omata, M. Systematic analysis of the TGF-β-Smad signaling pathway in gastrointestinal cancer cells. Biochem. Biophys. Res. Commun., 289: 350-357, 2001.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.289
, pp. 350-357
-
-
Ijichi, H.1
Ikenoue, T.2
Kato, N.3
Mitsuno, Y.4
Togo, G.5
Kato, J.6
Kanai, F.7
Shiratori, Y.8
Omata, M.9
-
25
-
-
17744380191
-
TAZ a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins
-
Kanai, F., Marignani, P. A., Sarbassova, D., Yagi, R., Hall, R. A., Donowitz, M., Hisaminato, A., Fujiwara, T., Ito, Y., Cantley, L. C., and Yaffe, M. B. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J., 19: 6778-6791, 2000.
-
(2000)
EMBO J.
, vol.19
, pp. 6778-6791
-
-
Kanai, F.1
Marignani, P.A.2
Sarbassova, D.3
Yagi, R.4
Hall, R.A.5
Donowitz, M.6
Hisaminato, A.7
Fujiwara, T.8
Ito, Y.9
Cantley, L.C.10
Yaffe, M.B.11
-
26
-
-
0033561041
-
Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation
-
Mason, C. S., Springer, C. J., Cooper, R. G., Superti-Furga, G., Marshall, C. J., and Marais, R. Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation. EMBO J., 18: 2137-2148, 1999.
-
(1999)
EMBO J.
, vol.18
, pp. 2137-2148
-
-
Mason, C.S.1
Springer, C.J.2
Cooper, R.G.3
Superti-Furga, G.4
Marshall, C.J.5
Marais, R.6
-
27
-
-
0032474838
-
A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity
-
Tzivion, G., Luo, Z., and Avruch, J. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature (Lond.), 394: 88-92, 1998.
-
(1998)
Nature (Lond.)
, vol.394
, pp. 88-92
-
-
Tzivion, G.1
Luo, Z.2
Avruch, J.3
-
28
-
-
0033055908
-
p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function
-
Grammatikakis, N., Lin, J. H., Grammatikakis, A., Tsichlis, P. N., and Cochran, B. H. p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. Mol. Cell. Biol., 19: 1661-1672, 1999.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1661-1672
-
-
Grammatikakis, N.1
Lin, J.H.2
Grammatikakis, A.3
Tsichlis, P.N.4
Cochran, B.H.5
-
29
-
-
0037080956
-
Regulation of Raf-1 activation and signalling by dephosphorylation
-
Dhillon, A. S., Meikle, S., Yazici, Z., Eulitz, M., and Kolch, W. Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J., 21: 64-71, 2002.
-
(2002)
EMBO J.
, vol.21
, pp. 64-71
-
-
Dhillon, A.S.1
Meikle, S.2
Yazici, Z.3
Eulitz, M.4
Kolch, W.5
-
30
-
-
0034528937
-
Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation
-
Pearson, G., Bumeister, R., Henry, D. O., Cobb, M. H., and White, M. A. Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation. J. Biol. Chem., 275: 37303-37306, 2000.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 37303-37306
-
-
Pearson, G.1
Bumeister, R.2
Henry, D.O.3
Cobb, M.H.4
White, M.A.5
-
31
-
-
0030296744
-
G protein-coupled receptors: Heterologous regulation of homologous desensitization and its implications
-
Chuang, T. T., Iacovelli, L., Sallese, M., and De Blasi, A. G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends Pharmacol. Sci., 17: 416-421, 1996.
-
(1996)
Trends Pharmacol. Sci.
, vol.17
, pp. 416-421
-
-
Chuang, T.T.1
Iacovelli, L.2
Sallese, M.3
De Blasi, A.4
-
32
-
-
0031692337
-
G protein-coupled receptors
-
Pitcher, J. A., Freedman, N. J., and Lefkowitz, R. J. G protein-coupled receptors. Annu. Rev. Biochem., 67: 653-692, 1998.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 653-692
-
-
Pitcher, J.A.1
Freedman, N.J.2
Lefkowitz, R.J.3
|