-
1
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
2
-
-
0038664387
-
BRAF mutation in papillary thyroid carcinoma
-
Cohen Y, Xing M, Mambo E, et al. BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 2003;95:625-7.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 625-627
-
-
Cohen, Y.1
Xing, M.2
Mambo, E.3
-
3
-
-
0037379904
-
High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
-
Kimura ET, Nikiforova MN, Zhu Z, et al. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 2003;63:1454-7.
-
(2003)
Cancer Res
, vol.63
, pp. 1454-1457
-
-
Kimura, E.T.1
Nikiforova, M.N.2
Zhu, Z.3
-
4
-
-
0037112438
-
Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia
-
Yuen ST, Davies H, Chan TL, et al. Similarity of the phenotypic patterns associated with BRAF and KRAS mutations in colorectal neoplasia. Cancer Res 2002;62:6451-5.
-
(2002)
Cancer Res
, vol.62
, pp. 6451-6455
-
-
Yuen, S.T.1
Davies, H.2
Chan, T.L.3
-
5
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H, Bardelli A, Langauer C, et al. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002;418:934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Langauer, C.3
-
8
-
-
0037400975
-
A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
-
Smalley KS. A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 2003;104:527-32.
-
(2003)
Int J Cancer
, vol.104
, pp. 527-532
-
-
Smalley, K.S.1
-
9
-
-
0037442752
-
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation
-
Satyamoorthy K, Li G, Gerrero MR, et al. Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res 2003;63:756-9.
-
(2003)
Cancer Res
, vol.63
, pp. 756-759
-
-
Satyamoorthy, K.1
Li, G.2
Gerrero, M.R.3
-
10
-
-
0346963109
-
Detection of mutations in the mitogen-activated protein kinase pathway in human melanoma
-
Alsina J, Gorsk DH, Germino FJ, et al. Detection of mutations in the mitogen-activated protein kinase pathway in human melanoma. Clin Cancer Res 2003;9:6419-25.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 6419-6425
-
-
Alsina, J.1
Gorsk, D.H.2
Germino, F.J.3
-
11
-
-
3442883359
-
Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines
-
U. Schuierer MM, Bataille F, Hagan S, Kolch W, Bosserhoff A-K. Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines. Cancer Res 2004;64:5186-92.
-
(2004)
Cancer Res
, vol.64
, pp. 5186-5192
-
-
Schuierer, M.M.1
Bataille, F.2
Hagan, S.3
Kolch, W.4
Bosserhoff, A.-K.5
-
12
-
-
0032559228
-
Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
-
Hacohen N, Kramer S, Sutherland D, Hiromi Y, Krasnow MA. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. Cell 1998;92:253-63.
-
(1998)
Cell
, vol.92
, pp. 253-263
-
-
Hacohen, N.1
Kramer, S.2
Sutherland, D.3
Hiromi, Y.4
Krasnow, M.A.5
-
13
-
-
4344660712
-
The Ras/Mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, Sprouty 1 and Sprouty 2 are deregulated in breast cancer
-
Lo TL, Yusoff P, Fong CW, et al. The Ras/Mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, Sprouty 1 and Sprouty 2 are deregulated in breast cancer. Cancer Res 2004;64:6127-36.
-
(2004)
Cancer Res
, vol.64
, pp. 6127-6136
-
-
Lo, T.L.1
Yusoff, P.2
Fong, C.W.3
-
14
-
-
0038613087
-
Mammalian Sprouty 4 suppresses Ras-independent ERK activation by binding to Raf1
-
Sasaki A, Taketomi T, Kato R, et al. Mammalian Sprouty 4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol 2003;5:427-32.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 427-432
-
-
Sasaki, A.1
Taketomi, T.2
Kato, R.3
-
15
-
-
4143139997
-
SPRY2 is an inhibitor of the Ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild type BRAF but not with the V599E mutant
-
Tsavachidou D, Coleman ML, Athanasiadis G, et al. SPRY2 is an inhibitor of the Ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild type BRAF but not with the V599E mutant. Cancer Res 2004;64:5556-9.
-
(2004)
Cancer Res
, vol.64
, pp. 5556-5559
-
-
Tsavachidou, D.1
Coleman, M.L.2
Athanasiadis, G.3
-
16
-
-
0346995278
-
Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein Bad
-
Eisenmann KM, VanBrocklin MW, Staffend NA, Kitchen SM, Koo H-M. Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein Bad. Cancer Res 2003;63:8330-7.
-
(2003)
Cancer Res
, vol.63
, pp. 8330-8337
-
-
Eisenmann, K.M.1
Vanbrocklin, M.W.2
Staffend, N.A.3
Kitchen, S.M.4
Koo, H.-M.5
-
18
-
-
0037213368
-
The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions
-
Borner C. The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions. Mol Immunol 2003;39:615-47.
-
(2003)
Mol Immunol
, vol.39
, pp. 615-647
-
-
Borner, C.1
-
20
-
-
1842613595
-
Conformational control of Bax localization and apoptotic activity by Pro168
-
Schinzel A, Kaufmann T, Schuler M, et al. Conformational control of Bax localization and apoptotic activity by Pro168. J Cell Biol 2004;164:1021-32.
-
(2004)
J Cell Biol
, vol.164
, pp. 1021-1032
-
-
Schinzel, A.1
Kaufmann, T.2
Schuler, M.3
-
21
-
-
9744244990
-
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA
-
Cartron PF, Gallenne T, Bougras G, et al. The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA Mol Cell 2004;16:807-18.
-
(2004)
Mol Cell
, vol.16
, pp. 807-818
-
-
Cartron, P.F.1
Gallenne, T.2
Bougras, G.3
-
22
-
-
0028206341
-
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
-
Yin X-M, Oltvai ZN, Korsemeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994;369:321-3.
-
(1994)
Nature
, vol.369
, pp. 321-323
-
-
Yin, X.-M.1
Oltvai, Z.N.2
Korsemeyer, S.J.3
-
23
-
-
0032793067
-
B-raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
-
Erhardt P, Schremser EJ, Cooper GM. B-raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol Cell Biol 1999;19:5308-15.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5308-5315
-
-
Erhardt, P.1
Schremser, E.J.2
Cooper, G.M.3
-
24
-
-
17744378364
-
MEK kinase activity is not necessary for Raf-1 function
-
Huser M, Luckett J, Chiloeches A, et al. MEK kinase activity is not necessary for Raf-1 function. EMBO J 2001;20:1940-51.
-
(2001)
EMBO J
, vol.20
, pp. 1940-1951
-
-
Huser, M.1
Luckett, J.2
Chiloeches, A.3
-
25
-
-
0037089089
-
Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases
-
Hindley A, Kolch W. Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases. J Cell Sci 2002;115:1575-81.
-
(2002)
J Cell Sci
, vol.115
, pp. 1575-1581
-
-
Hindley, A.1
Kolch, W.2
-
26
-
-
9644295769
-
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis
-
Yamaguchi O, Watanabe T, Nishida K, et al. Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest 2004;114:937-43.
-
(2004)
J Clin Invest
, vol.114
, pp. 937-943
-
-
Yamaguchi, O.1
Watanabe, T.2
Nishida, K.3
-
27
-
-
11144267126
-
Role of the kinase MST2 in suppression of apoptosis by the protooncogene product Raf-1
-
O'Neill E, Rushworth L, Baccarini M, Kolch W. Role of the kinase MST2 in suppression of apoptosis by the protooncogene product Raf-1. Science 2004;306:2267-70.
-
(2004)
Science
, vol.306
, pp. 2267-2270
-
-
O'Neill, E.1
Rushworth, L.2
Baccarini, M.3
Kolch, W.4
-
28
-
-
0141508024
-
Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade
-
Collisson EA, De A, Suzuki H, Gambhir SS, Kolodney MS. Treatment of metastatic melanoma with an orally available inhibitor of the Ras-Raf-MAPK cascade. Cancer Res 2003;63:5669-73.
-
(2003)
Cancer Res
, vol.63
, pp. 5669-5673
-
-
Collisson, E.A.1
De, A.2
Suzuki, H.3
Gambhir, S.S.4
Kolodney, M.S.5
-
29
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang LY, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.Y.3
-
31
-
-
0032575752
-
Mitochondria and apoptosis
-
Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-12.
-
(1998)
Science
, vol.281
, pp. 1309-1312
-
-
Green, D.R.1
Reed, J.C.2
-
33
-
-
0023079956
-
Isolation and analysis of nuclear RNA
-
Academic Press
-
Nevins JR. Isolation and analysis of nuclear RNA. Methods Enzymol, Academic Press 1987;152:234-6.
-
(1987)
Methods Enzymol
, vol.152
, pp. 234-236
-
-
Nevins, J.R.1
-
34
-
-
85080491178
-
Endostatin regulates endothelial cell adhesion and cytoskeletal organization
-
Dixelius J, Cross M, Matsumoto T, et al. Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Res 2000;62:6723-9.
-
(2000)
Cancer Res
, vol.62
, pp. 6723-6729
-
-
Dixelius, J.1
Cross, M.2
Matsumoto, T.3
-
35
-
-
0033535347
-
Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis
-
Griffiths GJ, Dubrez L, Morgan CP, et al. Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis. J Cell Biol 1999;144:903-14.
-
(1999)
J Cell Biol
, vol.144
, pp. 903-914
-
-
Griffiths, G.J.1
Dubrez, L.2
Morgan, C.P.3
-
36
-
-
0035977072
-
14-3-3 Proteins mediate an essential anti-apoptotic signal
-
Masters SC, Fu H. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem 2001;276:45193-200.
-
(2001)
J Biol Chem
, vol.276
, pp. 45193-45200
-
-
Masters, S.C.1
Fu, H.2
-
37
-
-
0034617449
-
Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
-
Daugas E, Nochy D, Ravagnan L, et al. Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis. FEBS Lett 2000;476:118-23.
-
(2000)
FEBS Lett
, vol.476
, pp. 118-123
-
-
Daugas, E.1
Nochy, D.2
Ravagnan, L.3
-
38
-
-
0037131519
-
Dueling activities of AIF in cell death versus survival: DNA binding and redox activity
-
Lipton SA, Bossy-Wetzel E. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell 2002;111:147-50.
-
(2002)
Cell
, vol.111
, pp. 147-150
-
-
Lipton, S.A.1
Bossy-Wetzel, E.2
-
39
-
-
2442621492
-
Role of AIF in caspase-dependent and caspase-independent cell death
-
Cregan SP, Dawson VL, Slack RS. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 2004;23:2785-96.
-
(2004)
Oncogene
, vol.23
, pp. 2785-2796
-
-
Cregan, S.P.1
Dawson, V.L.2
Slack, R.S.3
-
40
-
-
0037179691
-
The harlequin mouse mutation downregulates apoptosis-inducing factor
-
Klein JA, Longo-Guess CM, Rossmann MP, et al. The harlequin mouse mutation downregulates apoptosis-inducing factor. Nature 2002;419:367-74.
-
(2002)
Nature
, vol.419
, pp. 367-374
-
-
Klein, J.A.1
Longo-Guess, C.M.2
Rossmann, M.P.3
-
41
-
-
0033521741
-
Molecular characterization of mitochondrial apoptosis-inducing factor
-
Susin SA, Lorenzo HK, Zamzami N, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-6.
-
(1999)
Nature
, vol.397
, pp. 441-446
-
-
Susin, S.A.1
Lorenzo, H.K.2
Zamzami, N.3
-
42
-
-
12244268624
-
Apoptosis-inducing factor (AIF): Key to the conserved caspase-independent pathways of cell death?
-
Cande C, Cecconi F, Dessen P, Kroemer G. Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death? J Cell Sci 2002;115:4727-34.
-
(2002)
J Cell Sci
, vol.115
, pp. 4727-4734
-
-
Cande, C.1
Cecconi, F.2
Dessen, P.3
Kroemer, G.4
|