BAY 43-9006: Preclinical data

Current Pharmaceutical Design

Volumn 8, Issue 25, 2002, Pages 2255-2257

  Wilhelm, Scott ^a   Chien, Du Shieng ^a  

^a BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE INHIBITOR; RAF PROTEIN; RAS PROTEIN; SORAFENIB; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLASSIFICATION; DRUG DESIGN; DRUG HALF LIFE; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; REACTION OPTIMIZATION; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZENESULFONATES; CELL DIVISION; DISEASE PROGRESSION; HUMANS; MICE; NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-RAF; PYRIDINES;

EID: 0036401105     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612023393026     Document Type: Article

References (10)

1. Smith, R.A., Barbosa, J., Blum, C.L., Bobko, M.A., Caringal, Y.V., Dally, R., Johnson, J.S., Katz, M.E., Kennure, N., Kingery-Wood, J., Lee, W., Lowinger, T.B., Lyons, J., Marsh, V., Rogers, D.H., Swartz, S., Walling, T., Wild, H. Bioorg. Med. Chem. Lett., 2001, 11, 2775-8.
2. Riedl, B., Lowinger, T.B., Bankston, D., Barbosa, J., Brittelli, D.R., Carlson, R., Dumas, J., Hibner, B., Kadono, H., Katz, M., Kennure, N., Khire, U., Lee, W., Monahan, M.-K., Natero, R., Renick, J., Rong, H., Scott, W.J., Sibley, R.N., Smith, R.A. Proc. Am. Assoc. Cancer Res., 2001, 42, 923.
3. Wilhelm, S., Housley, T., Kennure, N., Rong, H., Carlson, R., McHugh, M., Hibner, B., Riedl, B., Lyons, J., Taylor, R., Knepper, M., Roscoe, W., Bollag, G. Proc. Am. Assoc. Cancer Res., 2001, 42, 923.
4. Lyons, J.F., Hibner, B., Gianpaolo-Ostravage, C., Bankston, D., Natero, R., Chien, D.-S., Dumas, J., Riedl, B., Roscoe, W., Housley, T., Kennure, N., Rong, H., Carlson, R., Wilhelm, S., Bollag, G. BAY 43-9006, a Raf Inhibitor with a Novel Mechanism of Action. Submitted to PNAS, 2002.
5. Gianpaolo-Ostravage, C., Bankston, D., Natero, R., Monahan, M.C., Riedl, B., Hibner, B., Carter, C. Proc. Am. Assoc. Cancer Res., 2001, 42, 923.
6. Harwerth, I.M., Wels, W., Schlegel, J., Muller, M., Hynes, N.E. Br. J. Cancer, 1993, 68, 1140-5.
7. Hsieh, S.S., Malerczyk, C., Aigner, A., Czubayko, F. Int. J. Cancer, 2000, 86, 644-51.
8. McPhillips, F., Mullen, P., Monia, B.P., Ritchie, A.A., Dorr, F.A., Smyth, J.F., Langdon, S.P. Br. J. Cancer, 2001, 85, 1753-8.
9. Naumann, U., Eisenmann-Tappe, I., Rapp, U.R. Recent Results Cancer Res., 1997, 143, 237-44.
10. Sebolt-Leopold, J.S., Dudley, D.T., Herrera, R., Van Becelaere, K., Wiland, A., Gowan, R.C., Tecle, H., Barrett, S.D., Bridges, A., Przybranowski, S., Leopold, W.R., Saltiel, A.R. Nat. Med., 1999, 5, 810-16.