Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation

Nature Structural and Molecular Biology

Volumn 11, Issue 8, 2004, Pages 747-755

  Peterson, Jeffrey R ^a,e   Bickford, Lincoln C ^b   Morgan, David ^c   Kim, Annette S ^d   Ouerfelli, Ouathek ^b   Kirschner, Marc W ^a   Rosen, Michael K ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^e FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; WISKOSTATIN; WISKOTT ALDRICH SYNDROME PROTEIN;

ALLOSTERISM; ARTICLE; BINDING SITE; COMPLEX FORMATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

ALLOSTERIC SITE; ANIMALS; BINDING SITES; CARBAZOLES; CATALYSIS; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PROPANOLAMINES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL; XENOPUS LAEVIS;

EID: 3543015540     PISSN: 15459993     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsmb796     Document Type: Article

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