The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 2, 2006, Pages 378-381

  Takle, Andrew K ^a   Brown, Murray J B ^a   Davies, Susannah ^a   Dean, David K ^a   Francis, Gerraint ^a   Gaiba, Alessandra ^a   Hird, Alex W ^a   King, Frank D ^a   Lovell, Peter J ^a   Naylor, Antoinette ^a   Reith, Alastair D ^a   Steadman, Jon G ^a   Wilson, David M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

B Raf; Imidazole

Indexed keywords

B RAF KINASE; IMIDAZOLE; IMIDAZOLE DERIVATIVE; INDENE DERIVATIVE; L 779450; OXIME DERIVATIVE; SB 477790; SB 590885;

ARTICLE; CHEMICAL REACTION; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY;

CYCLIZATION; IMIDAZOLES; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS B-RAF; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 27944490693     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.072     Document Type: Article

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