Design and discovery of small molecules targeting Raf-1 kinase

Current Pharmaceutical Design

Volumn 8, Issue 25, 2002, Pages 2269-2278

  Lowinger, Timothy B ^a   Riedl, Bernd ^a   Dumas, Jacques ^a   Smith, Roger A ^a  

^a BAYER AG   (Germany)

Author keywords

BAY 43 9006; Cancer; Diphenyl ureas; Raf 1 kinase; Ras

Indexed keywords

ALKYL GROUP; ANTINEOPLASTIC AGENT; L 779450; N [5 (3 DIMETHYLAMINOBENZAMIDO) 2 METHYLPHENYL] 4 HYDROXYBENZAMIDE; OXINDOLE; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; RAF PROTEIN; RAS PROTEIN; SORAFENIB; THIADIAZOLE DERIVATIVE; THIOPHENE DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE; XM 336372;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CELL PROLIFERATION; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG DESIGN; DRUG RESEARCH; ENZYME ACTIVITY; HUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIVISION; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; PROTO-ONCOGENE PROTEINS C-RAF; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036401042     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612023393125     Document Type: Article

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