메뉴 건너뛰기




Volumn 3, Issue , 2004, Pages

Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE; RAF PROTEIN; RAS PROTEIN; VALINE;

EID: 2942607408     PISSN: 14773163     EISSN: None     Source Type: Journal    
DOI: 10.1186/1477-3163-3-6     Document Type: Article
Times cited : (264)

References (42)
  • 3
    • 0035160974 scopus 로고    scopus 로고
    • The melanocortin-1 receptor: Red hair and beyond
    • Schaffer JV, Bolognia JL: The melanocortin-1 receptor: red hair and beyond. Arch Dermatol 2001, 137(11):1477-1485.
    • (2001) Arch. Dermatol. , vol.137 , Issue.11 , pp. 1477-1485
    • Schaffer, J.V.1    Bolognia, J.L.2
  • 4
    • 0035081414 scopus 로고    scopus 로고
    • Update on genetic events in the pathogenesis of melanoma
    • Halachmi S, Gilchrest BA: Update on genetic events in the pathogenesis of melanoma. Curr Opin Oncol 2001, 13(2):129-136.
    • (2001) Curr. Opin. Oncol. , vol.13 , Issue.2 , pp. 129-136
    • Halachmi, S.1    Gilchrest, B.A.2
  • 5
    • 0034486175 scopus 로고    scopus 로고
    • The genetics of cutaneous melanoma
    • Pollock PM, Trent JM: The genetics of cutaneous melanoma. Clin Lab Med 2000, 20(4):667-690.
    • (2000) Clin. Lab. Med. , vol.20 , Issue.4 , pp. 667-690
    • Pollock, P.M.1    Trent, J.M.2
  • 9
    • 0033604576 scopus 로고    scopus 로고
    • Isotype-specific functions of Raf kinases
    • Hagemann C, Rapp UR: Isotype-specific functions of Raf kinases. Exp Cell Res 1999, 253(1):34-46.
    • (1999) Exp. Cell Res. , vol.253 , Issue.1 , pp. 34-46
    • Hagemann, C.1    Rapp, U.R.2
  • 10
    • 0034659736 scopus 로고    scopus 로고
    • Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
    • Busca R, Abbe P, Mantoux F, Aberdam E, Peyssonnaux C, Eychene A, Ortonne JP, Ballotti R: Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. Embo J 2000, 19(12):2900-2910.
    • (2000) Embo J. , vol.19 , Issue.12 , pp. 2900-2910
    • Busca, R.1    Abbe, P.2    Mantoux, F.3    Aberdam, E.4    Peyssonnaux, C.5    Eychene, A.6    Ortonne, J.P.7    Ballotti, R.8
  • 12
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA: High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 2003, 63(7):1454-1457.
    • (2003) Cancer Res. , vol.63 , Issue.7 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 17
    • 0027457349 scopus 로고
    • Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors
    • Storm SM, Rapp UR: Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors. Toxicol Lett 1993, 67(1-3):201-210.
    • (1993) Toxicol. Lett. , vol.67 , Issue.1-3 , pp. 201-210
    • Storm, S.M.1    Rapp, U.R.2
  • 19
    • 0037222652 scopus 로고    scopus 로고
    • Absence of exon 15 BRAF germline mutations in familial melanoma
    • Lang J, Boxer M, MacKie R: Absence of exon 15 BRAF germline mutations in familial melanoma. Hum Mutat 2003, 21(3):327-330.
    • (2003) Hum. Mutat. , vol.21 , Issue.3 , pp. 327-330
    • Lang, J.1    Boxer, M.2    MacKie, R.3
  • 21
    • 0042743826 scopus 로고    scopus 로고
    • BRAF Oncogenic Mutations Correlate with Progression rather than Initiation of Human Melanoma
    • Dong J, Phelps RG, Qiao R, Yao S, Benard O, Ronai Z, Aaronson SA: BRAF Oncogenic Mutations Correlate with Progression rather than Initiation of Human Melanoma. Cancer Res 2003, 63(14):3883-3885.
    • (2003) Cancer Res. , vol.63 , Issue.14 , pp. 3883-3885
    • Dong, J.1    Phelps, R.G.2    Qiao, R.3    Yao, S.4    Benard, O.5    Ronai, Z.6    Aaronson, S.A.7
  • 22
    • 0034675919 scopus 로고    scopus 로고
    • Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
    • Zhang BH, Guan KL: Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. Embo J 2000, 19(20):5429-5439.
    • (2000) Embo J. , vol.19 , Issue.20 , pp. 5429-5439
    • Zhang, B.H.1    Guan, K.L.2
  • 23
    • 0038697566 scopus 로고    scopus 로고
    • Raf proteins and cancer: B-Raf is identified as a mutational target
    • Mercer KE, Pritchard CA: Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim Biophys Acta 2003, 1653(1):25-40.
    • (2003) Biochim. Biophys. Acta , vol.1653 , Issue.1 , pp. 25-40
    • Mercer, K.E.1    Pritchard, C.A.2
  • 24
    • 0038036832 scopus 로고    scopus 로고
    • Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch
    • Fedorov LM, Papadopoulos T, Tyrsin OY, Twardzik T, Gotz R, Rapp UR: Loss of p53 in craf-induced transgenic lung adenoma leads to tumor acceleration and phenotypic switch. Cancer Res 2003, 63(9):2268-2277.
    • (2003) Cancer Res. , vol.63 , Issue.9 , pp. 2268-2277
    • Fedorov, L.M.1    Papadopoulos, T.2    Tyrsin, O.Y.3    Twardzik, T.4    Gotz, R.5    Rapp, U.R.6
  • 25
    • 0033931447 scopus 로고    scopus 로고
    • The p53 tumor suppressor gene: From molecular biology to clinical investigation
    • discussion 137-129
    • Soussi T: The p53 tumor suppressor gene: from molecular biology to clinical investigation. Ann N Y Acad Sci 2000, 910:121-137; discussion 137-129.
    • (2000) Ann. N. Y. Acad. Sci. , vol.910 , pp. 121-137
    • Soussi, T.1
  • 26
    • 0032190629 scopus 로고    scopus 로고
    • Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
    • Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW: Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev 1998, 12(19):3008-3019.
    • (1998) Genes Dev. , vol.12 , Issue.19 , pp. 3008-3019
    • Lin, A.W.1    Barradas, M.2    Stone, J.C.3    van Aelst, L.4    Serrano, M.5    Lowe, S.W.6
  • 27
    • 0032522816 scopus 로고    scopus 로고
    • High-intensity Raf signals convert mitotic cell cycling into cellular growth
    • Kerkhoff E, Rapp UR: High-intensity Raf signals convert mitotic cell cycling into cellular growth. Cancer Res 1998, 58(8):1636-1640.
    • (1998) Cancer Res. , vol.58 , Issue.8 , pp. 1636-1640
    • Kerkhoff, E.1    Rapp, U.R.2
  • 28
    • 0038275924 scopus 로고    scopus 로고
    • Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis
    • Fu Z, Smith PC, Zhang L, Rubin MA, Dunn RL, Yao Z, Keller ET: Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis. J Natl Cancer Inst 2003, 95(12):878-889.
    • (2003) J. Natl. Cancer Inst. , vol.95 , Issue.12 , pp. 878-889
    • Fu, Z.1    Smith, P.C.2    Zhang, L.3    Rubin, M.A.4    Dunn, R.L.5    Yao, Z.6    Keller, E.T.7
  • 29
    • 0037379794 scopus 로고    scopus 로고
    • ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK)
    • Aguirre-Ghiso JA, Estrada Y, Liu D, Ossowski L: ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). Cancer Res 2003, 63(7):1684-1695.
    • (2003) Cancer Res. , vol.63 , Issue.7 , pp. 1684-1695
    • Aguirre-Ghiso, J.A.1    Estrada, Y.2    Liu, D.3    Ossowski, L.4
  • 30
    • 0035172910 scopus 로고    scopus 로고
    • Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
    • Aguirre-Ghiso JA, Liu D, Mignatti A, Kovalski K, Ossowski L: Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 2001, 12(4):863-879.
    • (2001) Mol. Biol. Cell , vol.12 , Issue.4 , pp. 863-879
    • Aguirre-Ghiso, J.A.1    Liu, D.2    Mignatti, A.3    Kovalski, K.4    Ossowski, L.5
  • 31
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of Hras and Smad2 levels
    • Oft M, Akhurst RJ, Balmain A: Metastasis is driven by sequential elevation of Hras and Smad2 levels. Nat Cell Biol 2002, 4(7):487-494.
    • (2002) Nat. Cell Biol. , vol.4 , Issue.7 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 32
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A: TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001, 29(2):117-129.
    • (2001) Nat. Genet. , vol.29 , Issue.2 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 34
    • 0033774196 scopus 로고    scopus 로고
    • Classical chemotherapy for metastatic melanoma
    • Becker JC, Kampgen E, Brocker E: Classical chemotherapy for metastatic melanoma. Clin Exp Dermatol 2000, 25(6):503-508.
    • (2000) Clin. Exp. Dermatol. , vol.25 , Issue.6 , pp. 503-508
    • Becker, J.C.1    Kampgen, E.2    Brocker, E.3
  • 35
    • 0037400975 scopus 로고    scopus 로고
    • A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?
    • Smalley KS: A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer 2003, 104(5):527-532.
    • (2003) Int. J. Cancer , vol.104 , Issue.5 , pp. 527-532
    • Smalley, K.S.1
  • 36
    • 0038456399 scopus 로고    scopus 로고
    • PTEN signaling pathways in melanoma
    • Wu H, Goel V, Haluska FG: PTEN signaling pathways in melanoma. Oncogene 2003, 22(20):3113-3122.
    • (2003) Oncogene , vol.22 , Issue.20 , pp. 3113-3122
    • Wu, H.1    Goel, V.2    Haluska, F.G.3
  • 37
    • 0034085811 scopus 로고    scopus 로고
    • Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
    • Tsao H, Zhang X, Fowlkes K, Haluska FG: Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res 2000, 60(7):1800-1804.
    • (2000) Cancer Res. , vol.60 , Issue.7 , pp. 1800-1804
    • Tsao, H.1    Zhang, X.2    Fowlkes, K.3    Haluska, F.G.4
  • 39
    • 0034642548 scopus 로고    scopus 로고
    • Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes
    • Weber CK, Slupsky JR, Herrmann C, Schuler M, Rapp UR, Block C: Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes. Oncogene 2000, 19(2):169-176.
    • (2000) Oncogene , vol.19 , Issue.2 , pp. 169-176
    • Weber, C.K.1    Slupsky, J.R.2    Herrmann, C.3    Schuler, M.4    Rapp, U.R.5    Block, C.6
  • 42
    • 0025604178 scopus 로고
    • Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies
    • Sithanandam G, Kolch W, Duh FM, Rapp UR: Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. Oncogene 1990, 5(12):1775-1780.
    • (1990) Oncogene , vol.5 , Issue.12 , pp. 1775-1780
    • Sithanandam, G.1    Kolch, W.2    Duh, F.M.3    Rapp, U.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.