메뉴 건너뛰기




Volumn 60, Issue 4, 2000, Pages 970-975

ZD4190: An orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 [2 (1H 1,2,3 TRIAZOL 1 YL)ETHOXY] 4 QUINAZOLINAMINE; PROTEIN TYROSINE KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 0034652716     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (220)

References (73)
  • 1
    • 0031789314 scopus 로고    scopus 로고
    • Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer
    • Ishigami, S-I., Arii, S., Furutani, M., Niwano, M., Harada, T., Mizumoto, M., Mori, A., Onodera, H., and Imamura, M. Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br. J. Cancer, 78: 1379-1384, 1998.
    • (1998) Br. J. Cancer , vol.78 , pp. 1379-1384
    • Ishigami, S.-I.1    Arii, S.2    Furutani, M.3    Niwano, M.4    Harada, T.5    Mizumoto, M.6    Mori, A.7    Onodera, H.8    Imamura, M.9
  • 2
    • 0030829035 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothehal growth factor in metastatic melanoma
    • Salven, P., Heikkila, P., and Joensuu, H. Enhanced expression of vascular endothehal growth factor in metastatic melanoma. Br. J. Cancer, 76: 930-934, 1997.
    • (1997) Br. J. Cancer , vol.76 , pp. 930-934
    • Salven, P.1    Heikkila, P.2    Joensuu, H.3
  • 3
    • 0031779403 scopus 로고    scopus 로고
    • Tumour angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma
    • Shibusa, T., Shijubo, N. And Abe, S. Tumour angiogenesis and vascular endothelial growth factor expression in stage I lung adenocarcinoma. Clin. Cancer Res., 4: 1483-1487, 1998.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 1483-1487
    • Shibusa, T.1    Shijubo, N.A.2    Abe, S.3
  • 4
    • 0031955262 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor correlates with tumour progression in gallbladder cancer clinical studies
    • Okita, S., Kondoh, S., Shiraishi, K., Kaino, S., Hatano, S., and Okita, K. Expression of vascular endothelial growth factor correlates with tumour progression in gallbladder cancer clinical studies. Int. J. Oncol., 12: 1013-1018, 1998.
    • (1998) Int. J. Oncol. , vol.12 , pp. 1013-1018
    • Okita, S.1    Kondoh, S.2    Shiraishi, K.3    Kaino, S.4    Hatano, S.5    Okita, K.6
  • 5
    • 0031941942 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma
    • Abdulrauf, S. I., Edvardsen, K., Ho, K. L., Yang, X. Y., Rock, J. P., and Rosenblum, M. L. Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with low-grade astrocytoma. J. Neurosurg., 88: 513-520, 1998.
    • (1998) J. Neurosurg. , vol.88 , pp. 513-520
    • Abdulrauf, S.I.1    Edvardsen, K.2    Ho, K.L.3    Yang, X.Y.4    Rock, J.P.5    Rosenblum, M.L.6
  • 7
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Washington DC
    • Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D. T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science (Washington DC), 246: 1309-1312, 1989.
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.D.2    Krivi, G.3    Sanzo, K.4    Warren, T.5    Feder, J.6    Connolly, D.T.7
  • 8
    • 0027053487 scopus 로고
    • Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
    • Pepper, M. S., Ferrara, N., Orci, L., and Montesano, R. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochern. Biophys. Res. Commun., 189: 824-831, 1992.
    • (1992) Biochern. Biophys. Res. Commun. , vol.189 , pp. 824-831
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 9
    • 0026321129 scopus 로고
    • Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells
    • Pepper, M. S., Ferrara, N, Orci, L., and Montesano, R. Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem. Biophys. Res. Commun., 181: 902-906, 1991.
    • (1991) Biochem. Biophys. Res. Commun. , vol.181 , pp. 902-906
    • Pepper, M.S.1    Ferrara, N.2    Orci, L.3    Montesano, R.4
  • 10
    • 0026446859 scopus 로고
    • Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells
    • Unemori, E. N., Ferrari, N., Bauer, E. A., and Amento, E. P. Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J. Cell. Physiol., 153: 557-562, 1992.
    • (1992) J. Cell. Physiol. , vol.153 , pp. 557-562
    • Unemori, E.N.1    Ferrari, N.2    Bauer, E.A.3    Amento, E.P.4
  • 11
    • 0031870786 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvaseular endothelial cells in vitro
    • Lamoreaux, W. J., Fitzgerald, M. E., Reiner, A., Hasty, K. A., and Charles, S. T. Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvaseular endothelial cells in vitro. Microvasc. Res., 55: 29-42, 1998.
    • (1998) Microvasc. Res. , vol.55 , pp. 29-42
    • Lamoreaux, W.J.1    Fitzgerald, M.E.2    Reiner, A.3    Hasty, K.A.4    Charles, S.T.5
  • 12
    • 0029999603 scopus 로고    scopus 로고
    • Stimulation of endothelial cell migration by vascular endothelial growth factor through cooperative mechanisms involving the αvβ3 integrin, osteopontin, and thrombin
    • Senger, D. R., Ledbetter, S. R., Claffey, K. P., Papadopoulos-Sergio, A., Perruzzi, C. A., and Detmar, M. Stimulation of endothelial cell migration by vascular endothelial growth factor through cooperative mechanisms involving the αvβ3 integrin, osteopontin, and thrombin. Am. J. Pathol., 149: 293-305, 1996.
    • (1996) Am. J. Pathol. , vol.149 , pp. 293-305
    • Senger, D.R.1    Ledbetter, S.R.2    Claffey, K.P.3    Papadopoulos-Sergio, A.4    Perruzzi, C.A.5    Detmar, M.6
  • 13
    • 0031459892 scopus 로고    scopus 로고
    • Angiogenesis promoted by vascular endothelial growth factor: Regulation through α1β1 and α2α2 integrins
    • Senger, D. R., Claffey, K. P., Benes, J. E., Perruzzi, C. A., Sergiou, A. P., and Detmar, M. Angiogenesis promoted by vascular endothelial growth factor: regulation through α1β1 and α2α2 integrins. Proc. Natl. Acad. Sci. USA, 94: 13612-13617, 1997.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13612-13617
    • Senger, D.R.1    Claffey, K.P.2    Benes, J.E.3    Perruzzi, C.A.4    Sergiou, A.P.5    Detmar, M.6
  • 14
    • 0029047695 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor an important mediator of angiogenesis in malignancy and inflammation
    • Dvorak, H. F., Detmar, M., Claffey, K. P., Nagy, J. A., van de Water, L., and Senger, D. R. Vascular permeability factor/vascular endothelial growth factor an important mediator of angiogenesis in malignancy and inflammation. Int. Arch. Allergy Appl. Immunol., 107: 233-235, 1995.
    • (1995) Int. Arch. Allergy Appl. Immunol. , vol.107 , pp. 233-235
    • Dvorak, H.F.1    Detmar, M.2    Claffey, K.P.3    Nagy, J.A.4    Van De Water, L.A.5    Senger, D.R.6
  • 15
    • 0031045279 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts, W. G., and Palade, G. E. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res., 57: 765-772, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 16
    • 0026673043 scopus 로고
    • Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C
    • Finkenzeller, G., Marmé, D., Weich, H. A., and Hug, H. Platelet-derived growth factor-induced transcription of the vascular endothelial growth factor gene is mediated by protein kinase C. Cancer Res., 52: 4821-4823, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 4821-4823
    • Finkenzeller, G.1    Marmé, D.2    Weich, H.A.3    Hug, H.4
  • 17
    • 0028221238 scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells
    • Pertovaara, L., Kaipainen, A., Mustonen, T., Orpana, A., Ferrara, N., Saksela, O., and Alitalo, K. Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J. Biol. Chem., 269: 6271-6274, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3    Orpana, A.4    Ferrara, N.5    Saksela, O.6    Alitalo, K.7
  • 18
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin 6 induces the expression of vascular endothelial growth factor
    • Cohen, T., Nahari, D., Cerem, L. W., Neufeld, G., and Levi, B. Z. Interleukin 6 induces the expression of vascular endothelial growth factor. J. Biol. Chem., 271: 736-741, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem, L.W.3    Neufeld, G.4    Levi, B.Z.5
  • 19
    • 0028870050 scopus 로고
    • Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids-implications for tumour angiogenesis
    • Shweiki, D., Neeman, M., Itin, A., and Keshet, E. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids-implications for tumour angiogenesis. Proc. Natl. Acad. Sci. USA, 92: 768-772, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 768-772
    • Shweiki, D.1    Neeman, M.2    Itin, A.3    Keshet, E.4
  • 20
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumour angiogenesis
    • Rak, J., Mitsuhashi, L., Bayo, L., Filmus, J., Shirasawa, S., Sasazuki, T., and Kerbel, R. S. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumour angiogenesis. Cancer Res., 55: 4575-4580, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, L.2    Bayo, L.3    Filmus, J.4    Shirasawa, S.5    Sasazuki, T.6    Kerbel, R.S.7
  • 21
    • 0028834638 scopus 로고
    • Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B., and Marme, D. Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem., 270: 25915-25919, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marme, D.5
  • 22
    • 0029068339 scopus 로고
    • Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
    • Lond.
    • Mukhopadhyay, D., Tsiokas, L., Zhou, X-M., Foster, D., Brugge, J. S., and Sukhatme, V. P. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature (Lond.), 375: 577-580, 1995.
    • (1995) Nature , vol.375 , pp. 577-580
    • Mukhopadhyay, D.1    Tsiokas, L.2    Zhou, X.-M.3    Foster, D.4    Brugge, J.S.5    Sukhatme, V.P.6
  • 24
    • 0028865988 scopus 로고
    • Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression
    • Mukhopadhyay, D., Tsiokas, L., and Sukhatme, V. P. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res., 55: 6161-6165, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 6161-6165
    • Mukhopadhyay, D.1    Tsiokas, L.2    Sukhatme, V.P.3
  • 25
    • 0030806074 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms
    • Damert, A., Machein, M., Breier, G., Fujita, M. Q., Hanahan, D., Risau, W., and Plate, K. H. Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms. Cancer Res., 57: 3860-3864, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 3860-3864
    • Damert, A.1    Machein, M.2    Breier, G.3    Fujita, M.Q.4    Hanahan, D.5    Risau, W.6    Plate, K.H.7
  • 26
    • 0032941747 scopus 로고    scopus 로고
    • Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements
    • Dibbens, J. A., Miller, D. L., Damert, A., Risau, W., Vadas, M. A., and Goodall, G. J. Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements. Mol. Biol. Cell, 10: 907-919, 1999.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 907-919
    • Dibbens, J.A.1    Miller, D.L.2    Damert, A.3    Risau, W.4    Vadas, M.A.5    Goodall, G.J.6
  • 27
    • 0027298573 scopus 로고
    • Characterisation of vascular-permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes
    • Shen, H., Clauss, M., Ryan, J., Schmidt, A. M., Tijburg, P., Borden, L., Connolly, D., Stem, D., and Kao, J. Characterisation of vascular-permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood, 81: 2767-2773, 1993.
    • (1993) Blood , vol.81 , pp. 2767-2773
    • Shen, H.1    Clauss, M.2    Ryan, J.3    Schmidt, A.M.4    Tijburg, P.5    Borden, L.6    Connolly, D.7    Stem, D.8    Kao, J.9
  • 29
    • 0032547763 scopus 로고    scopus 로고
    • Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: Role of Flt-I
    • Wang, H., and Keiser, J. A. Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of Flt-I. Circ. Res., 83: 832-840, 1998.
    • (1998) Circ. Res. , vol.83 , pp. 832-840
    • Wang, H.1    Keiser, J.A.2
  • 30
    • 0028090642 scopus 로고
    • Vascular endothelial growth factor and glioma angiogenesis: Coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms
    • Plate, K H., Breier, G., Weich, H. A., Mennel, H. D., and Risau, W. Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int. J. Cancer, 59: 520-529, 1994.
    • (1994) Int. J. Cancer , vol.59 , pp. 520-529
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Mennel, H.D.4    Risau, W.5
  • 31
    • 0032080310 scopus 로고    scopus 로고
    • Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor
    • Fuh, G., Li, B., Crowley, C., Cunningham, B., and Wells, J. A. Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor. J. Biol. Chem., 273: 11197-11204, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11197-11204
    • Fuh, G.1    Li, B.2    Crowley, C.3    Cunningham, B.4    Wells, J.A.5
  • 33
    • 0033118228 scopus 로고    scopus 로고
    • VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
    • Takahashi, T., Ueno, H., and Shibuya, M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene, 18: 2221-2230, 1999.
    • (1999) Oncogene , vol.18 , pp. 2221-2230
    • Takahashi, T.1    Ueno, H.2    Shibuya, M.3
  • 34
    • 0030734010 scopus 로고    scopus 로고
    • p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
    • Rousseau. S., Houle, F., Landry, J., and Huoi, J. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene, 15: 2169-2177, 1997.
    • (1997) Oncogene , vol.15 , pp. 2169-2177
    • Rousseau, S.1    Houle, F.2    Landry, J.3    Huoi, J.4
  • 35
    • 0030908042 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
    • Abedi, H., and Zachary, I. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J. Biol. Chem., 272: 15442-15451, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15442-15451
    • Abedi, H.1    Zachary, I.2
  • 36
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Lond.
    • Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature (Lond.), 362: 841-844, 1993.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 37
    • 0031870765 scopus 로고    scopus 로고
    • Anti-tumour and anti-melastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted ortholopically into nude mice
    • Kanai. T., Konno, H., Tanaka, T., Baba, M., Matsumoto, K., Nakamura, S., Yukita, A., Asano, M., Suzuki, H., and Baba, S. Anti-tumour and anti-melastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted ortholopically into nude mice. Int. J. Cancer, 77: 933-936, 1998.
    • (1998) Int. J. Cancer , vol.77 , pp. 933-936
    • Kanai, T.1    Konno, H.2    Tanaka, T.3    Baba, M.4    Matsumoto, K.5    Nakamura, S.6    Yukita, A.7    Asano, M.8    Suzuki, H.9    Baba, S.10
  • 38
    • 0032145315 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single chain antibodies from a phage display library
    • Zhu, Z., Rockwell, P., Lu, D., Kotanides, H., Pytowski, B., Hicklin, D. J., Bohlen, P., and Witte, L. Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single chain antibodies from a phage display library. Cancer Res., 58: 3209-3214, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 3209-3214
    • Zhu, Z.1    Rockwell, P.2    Lu, D.3    Kotanides, H.4    Pytowski, B.5    Hicklin, D.J.6    Bohlen, P.7    Witte, L.8
  • 39
    • 0032515980 scopus 로고    scopus 로고
    • An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells
    • Siemeister, G., Schimer, M., Reusch, P., Barleon, B., Marme, D., and Martiny-Baron, G. An antagonistic vascular endothelial growth factor (VEGF) variant inhibits VEGF-stimulated receptor autophosphorylation and proliferation of human endothelial cells. Proc. Natl. Acad. Sci. USA, 95: 4625-4629, 1998.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4625-4629
    • Siemeister, G.1    Schimer, M.2    Reusch, P.3    Barleon, B.4    Marme, D.5    Martiny-Baron, G.6
  • 40
    • 0031965353 scopus 로고    scopus 로고
    • Inhibition of tumour growth by targeting tumour endothelium using a soluble vascular endothelial growth factor receptor
    • Lin, P., Sankar, S., Shan, S., Dewhirst, M. W., Polverini, P. J., Quinn, T. Q., and Peters, K. G. Inhibition of tumour growth by targeting tumour endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ., 9: 49-58, 1998.
    • (1998) Cell Growth Differ. , vol.9 , pp. 49-58
    • Lin, P.1    Sankar, S.2    Shan, S.3    Dewhirst, M.W.4    Polverini, P.J.5    Quinn, T.Q.6    Peters, K.G.7
  • 41
  • 42
    • 0029863730 scopus 로고    scopus 로고
    • Dominant-negative inhibition of Flk-1 suppresses the growth of many tumour types in vivo
    • Millauer, B., Longhi, M. P., Plate, K. H., Shawver, L. K., Risau, W., Ullrich, A., and Strawn, L. M. Dominant-negative inhibition of Flk-1 suppresses the growth of many tumour types in vivo. Cancer Res., 56: 1615-1620, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 1615-1620
    • Millauer, B.1    Longhi, M.P.2    Plate, K.H.3    Shawver, L.K.4    Risau, W.5    Ullrich, A.6    Strawn, L.M.7
  • 43
    • 0042966942 scopus 로고    scopus 로고
    • A novel approach to glioma gene therapy: Down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes
    • Ke, L. D., Fueyo, J., Chen, X., Steck, P. A., Shi, Y-X., Im, A-A., and Yung, W. K. A. A novel approach to glioma gene therapy: down-regulation of the vascular endothelial growth factor in glioma cells using ribozymes. Int. J. Oncol., 12: 1391-1396, 1998.
    • (1998) Int. J. Oncol. , vol.12 , pp. 1391-1396
    • Ke, L.D.1    Fueyo, J.2    Chen, X.3    Steck, P.A.4    Shi, Y.-X.5    Im, A.-A.6    Yung, W.K.A.7
  • 45
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber, H-P., Vu, T. H., Ryan, A. M., Kowalski, J., Werb, Z., and Ferrara, N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med., 5: 623-628, 1999.
    • (1999) Nat. Med. , vol.5 , pp. 623-628
    • Gerber, H.-P.1    Vu, T.H.2    Ryan, A.M.3    Kowalski, J.4    Werb, Z.5    Ferrara, N.6
  • 46
    • 85027609620 scopus 로고
    • The structural aspects of vascular invasion of the tibial epiphyscal plate of growing rats
    • Schenk, R. K., Weiner, J., and Shapiro, D. The structural aspects of vascular invasion of the tibial epiphyscal plate of growing rats. Acta Anat., 68: 1-17, 1968.
    • (1968) Acta Anat. , vol.68 , pp. 1-17
    • Schenk, R.K.1    Weiner, J.2    Shapiro, D.3
  • 47
    • 0032790417 scopus 로고    scopus 로고
    • Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plale cartilage
    • Homer, A., Bishop, N. J., Bord, S., Beeton, C., Kelsall, A. W., Coleman, N., and Compston, J. E. Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plale cartilage. J. Anat., 194: 519-524, 1999.
    • (1999) J. Anat. , vol.194 , pp. 519-524
    • Homer, A.1    Bishop, N.J.2    Bord, S.3    Beeton, C.4    Kelsall, A.W.5    Coleman, N.6    Compston, J.E.7
  • 49
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumours by anti-vascular endothelial growth factor neutralizing antibodies. Novel concepts of angiostatic therapy from intravital videomicroscopy
    • Borgström, P., Hillan, K. J., Sriramarao, P., and Ferrara, N. Complete inhibition of angiogenesis and growth of microtumours by anti-vascular endothelial growth factor neutralizing antibodies. Novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res., 56: 4032-4039, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4032-4039
    • Borgström, P.1    Hillan, K.J.2    Sriramarao, P.3    Ferrara, N.4
  • 50
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular cndothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumour vascularisation, and growth of multiple tumour types
    • Fong, T. A., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, J., Kim, Y. H., Schreck, R., Wang, X., Risau, W., Ullrich, A., Hirth, P., and McMahon, G. SU5416 is a potent and selective inhibitor of the vascular cndothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumour vascularisation, and growth of multiple tumour types. Cancer Res., 59: 99-106, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, P.12    McMahon, G.13
  • 51
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt-1: Two receptors for vascular endothelial growth factor
    • Waltenberger, J., Claesson-Welsh, L., Siegbahn, A., Shibuya, M., and Heldin, C-H. Different signal transduction properties of KDR and Flt-1: two receptors for vascular endothelial growth factor. J. Biol. Chem., 269: 26988-26995, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26988-26995
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.-H.5
  • 52
    • 0026092346 scopus 로고
    • Specific binding of vascular permeability factor to endothelial cells
    • Olander, J. V., Connolly, D. T., and DeLarco, J. E. Specific binding of vascular permeability factor to endothelial cells. Biochem. Biophys. Res. Commun., 175: 68-76, 1991.
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 68-76
    • Olander, J.V.1    Connolly, D.T.2    DeLarco, J.E.3
  • 53
    • 0031577563 scopus 로고    scopus 로고
    • The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCγ
    • Sawano, A., Takahashi, T., Yamaguchi, S., and Shibuya, M. The phosphorylated 1169-tyrosine containing region of flt-1 kinase (VEGFR-1) is a major binding site for PLCγ. Biochem. Biophys. Res. Commun., 238: 487-491, 1997.
    • (1997) Biochem. Biophys. Res. Commun. , vol.238 , pp. 487-491
    • Sawano, A.1    Takahashi, T.2    Yamaguchi, S.3    Shibuya, M.4
  • 55
    • 0344637004 scopus 로고    scopus 로고
    • Systemic activation of the vascular endothelial growth factor receptor KDR/flk-1 selectively triggers endothelial cells with an angiogenic phenotype
    • Ortéga, N., Jonca, F., Vincent, S., Favard, C., Ruchoux, M-M., and Plouët, J. Systemic activation of the vascular endothelial growth factor receptor KDR/flk-1 selectively triggers endothelial cells with an angiogenic phenotype. Am. J. Pathol., 151: 1215-1224, 1997
    • (1997) Am. J. Pathol. , vol.151 , pp. 1215-1224
    • Ortéga, N.1    Jonca, F.2    Vincent, S.3    Favard, C.4    Ruchoux, M.-M.5    Plouët, J.6
  • 56
    • 0032553299 scopus 로고    scopus 로고
    • A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
    • Ogawa, S., Oku, A., Sawano, A., Yamaguchi, S., Yazaki, Y., and Shibuya, M. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J. Biol. Chem., 273: 31273-31282, 1998.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31273-31282
    • Ogawa, S.1    Oku, A.2    Sawano, A.3    Yamaguchi, S.4    Yazaki, Y.5    Shibuya, M.6
  • 57
    • 0028134936 scopus 로고
    • Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity in vitro and in vivo and high affinity binding to Flt-1 but not to Flk-1/KDR
    • Park, J. E., Chen, H. H., Winer, J., Houck, A. A., and Ferrara, N. J. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity in vitro and in vivo and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem., 269: 25646-25654, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 25646-25654
    • Park, J.E.1    Chen, H.H.2    Winer, J.3    Houck, A.A.4    Ferrara, N.J.5
  • 58
    • 0033556287 scopus 로고    scopus 로고
    • A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1 ) receptor tyrosine kinase
    • Meyer, M., Clauss, M., Lepple-Wienhues, A., Waltenberger, J., Augustin, H. G., Ziche, M., Lanz, C., Büttner, M., Rziha, H-J., and Dehio, C. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1 ) receptor tyrosine kinase. EMBO J., 18: 363-374, 1999.
    • (1999) EMBO J. , vol.18 , pp. 363-374
    • Meyer, M.1    Clauss, M.2    Lepple-Wienhues, A.3    Waltenberger, J.4    Augustin, H.G.5    Ziche, M.6    Lanz, C.7    Büttner, M.8    Rziha, H.-J.9    Dehio, C.10
  • 59
    • 0027432324 scopus 로고
    • Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumour angiogenesis
    • Plate, K. H., Breier, G., Millauer, B., Ullrich, A., and Risau, W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumour angiogenesis. Cancer Res., 53: 5822-5827, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 5822-5827
    • Plate, K.H.1    Breier, G.2    Millauer, B.3    Ullrich, A.4    Risau, W.5
  • 60
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi, Y., Kitadal, Y., Bucana, C. D., Cleary, K. R., and Ellis, L. M. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res., 55: 3964-3968, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadal, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 61
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka, S., Minowa, O., Kuno, J., Noda, T., and Shibuya, M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA, 95: 9349-9354, 1998.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 62
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Lond.
    • Fong, G-H., Rossant, J., Gertsenstein, M., and Breitman, M. L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature (Lond.), 376: 66-70, 1995.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.-H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 63
    • 0032556950 scopus 로고    scopus 로고
    • Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1
    • Landgren, E., Schiller, P., Cao, Y., and Claesson-Welsh, L. Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1. Oncogene, 16: 359-367, 1998.
    • (1998) Oncogene , vol.16 , pp. 359-367
    • Landgren, E.1    Schiller, P.2    Cao, Y.3    Claesson-Welsh, L.4
  • 64
    • 0029867554 scopus 로고    scopus 로고
    • Migration of human monocytes in response to human vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
    • Barleon, B., Sozzani, S., Zhou, D., Weich, H. A., Mantovani, A., and Marmé, D. Migration of human monocytes in response to human vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood, 87: 3336-3343, 1996.
    • (1996) Blood , vol.87 , pp. 3336-3343
    • Barleon, B.1    Sozzani, S.2    Zhou, D.3    Weich, H.A.4    Mantovani, A.5    Marmé, D.6
  • 65
    • 0029929716 scopus 로고    scopus 로고
    • The vascular endothelial growth factor receptor Flt-1 mediates biological activities
    • Clauss, M., Weich, H., Breier, G., Knies, U., Rockl, W., Waltenberger, J., and Risau, W. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. J. Biol. Chem., 30: 17629-17634, 1996.
    • (1996) J. Biol. Chem. , vol.30 , pp. 17629-17634
    • Clauss, M.1    Weich, H.2    Breier, G.3    Knies, U.4    Rockl, W.5    Waltenberger, J.6    Risau, W.7
  • 66
    • 0031892785 scopus 로고    scopus 로고
    • Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-KκB activation in hemopoietic progenitor cells
    • Oyama, T., Ran, S., Ishida, T., Nadaf, S., Kerr, W., Carbone, D. P., and Gabrilovich, D. I. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-KκB activation in hemopoietic progenitor cells. J. Immunol., 160: 1224-1232, 1998.
    • (1998) J. Immunol. , vol.160 , pp. 1224-1232
    • Oyama, T.1    Ran, S.2    Ishida, T.3    Nadaf, S.4    Kerr, W.5    Carbone, D.P.6    Gabrilovich, D.I.7
  • 67
    • 0031757269 scopus 로고    scopus 로고
    • The vascular endothelial growth factor family: Proteins which guide the development of the vasculature
    • Achen, M. G., and Stacker, S. A. The vascular endothelial growth factor family: proteins which guide the development of the vasculature. Int. J. Exp. Pathol., 79: 255-265, 1998.
    • (1998) Int. J. Exp. Pathol. , vol.79 , pp. 255-265
    • Achen, M.G.1    Stacker, S.A.2
  • 68
    • 0028803509 scopus 로고
    • Vascular endothelial factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon, T., Hemo, I., Itin, A., Pe'ee, J., Stone, J., and Keshet, E. Vascular endothelial factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med., 1: 1024-1028, 1995.
    • (1995) Nat. Med. , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Pe'ee, J.4    Stone, J.5    Keshet, E.6
  • 69
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumours follows vascular endothelial growth factor withdrawal
    • Benjamin, L. E., Golijanin, D., Itin, A., Pode, D., and Keshet, E. Selective ablation of immature blood vessels in established human tumours follows vascular endothelial growth factor withdrawal. J. Clin. Investig., 103: 159-165, 1999.
    • (1999) J. Clin. Investig. , vol.103 , pp. 159-165
    • Benjamin, L.E.1    Golijanin, D.2    Itin, A.3    Pode, D.4    Keshet, E.5
  • 70
    • 0032963472 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression
    • Nör, J. E., Christensen, J., Mooney, D. J., and Polverini, P. J. Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am. J. Pathol., 154: 375-384, 1999.
    • (1999) Am. J. Pathol. , vol.154 , pp. 375-384
    • Nör, J.E.1    Christensen, J.2    Mooney, D.J.3    Polverini, P.J.4
  • 72
    • 0028199835 scopus 로고
    • Vascular endothelial growth factor: A cytokine modulating endothelial function in rheumatoid arthritis
    • Koch, A. E., Harlow, L. A., Haines, G. K., Amento, E. P., Unemori, E. N., Wong, W. L., Pope, R. M., and Ferrara, N. Vascular endothelial growth factor: a cytokine modulating endothelial function in rheumatoid arthritis. J. Immunol., 152: 149-152, 1994.
    • (1994) J. Immunol. , vol.152 , pp. 149-152
    • Koch, A.E.1    Harlow, L.A.2    Haines, G.K.3    Amento, E.P.4    Unemori, E.N.5    Wong, W.L.6    Pope, R.M.7    Ferrara, N.8
  • 73
    • 0028123090 scopus 로고
    • Increased endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis, A. P., Increased endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am. J. Ophthalmol., 118: 445-450, 1994.
    • (1994) Am. J. Ophthalmol. , vol.118 , pp. 445-450
    • Adamis, A.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.