Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 13, 2003, Pages 7785-7790

  Huang, Jianzhong ^a   Frischer, Jason S ^a   Serur, Anna ^a   Kadenhe, Angela ^a   Yokoi, Akiko ^a   McCrudden, Kimberly W ^a   New, Tamara ^a   O'Toole, Kathleen ^a   Zabski, Stephanie ^b   Rudge, John S ^b   Holash, Jocelyn ^b   Yancopoulos, George D ^b   Yamashiro, Darrell J ^a   Kandel, Jessica J ^a  

^a Coll Phys/Surgs of Columbia Univ ^*  (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VEGF TRAP;

ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL INTERACTION; CONTROLLED STUDY; FEMALE; LUNG METASTASIS; METASTASIS; MINIMAL RESIDUAL DISEASE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; TUMOR REGRESSION; VASCULARIZATION; XENOGRAFT;

ACTINS; ANIMALS; ANTIGENS, CD31; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOOD PLATELETS; DISEASE PROGRESSION; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS; LUNG NEOPLASMS; LYMPHOKINES; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH; NECROSIS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PERFUSION; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA;

EID: 0037934449     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1432908100     Document Type: Article

References (21)

1. Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S. & Ferrara, N. (1993) Nature 362, 841-844.
2. Gerber, H. P., Kowalski, J., Sherman, D., Eberhard, D. A. & Ferrara, N. (2000) Cancer Res. 60, 6253-6258.
3. Prewett, M., Huber, J., Li, Y., Santiago, A., O'Connor, W., King, K., Overholser, J., Hooper, A., Pytowski, B., Witte, L., et al. (1999) Cancer Res. 59, 5209-5218.
4. Yang, J. C., Haworth, L., Steinberg, S. M., Rosenberg, S. A. & Novotny, W. (2002) Proc. Am. Soc. Clin. Oncol. 21, 5.
5. Benjamin, L. E., Hemo, I. & Keshet, E. (1998) Development (Cambridge, U.K.) 125, 1591-1598.
6. Benjamin, L. E., Golijanin, D., Itin, A., Pode, D. & Keshet, E. (1999) J. Clin. Invest. 103, 159-165.
7. Abramovitch, R., Dafni, H., Smouha, E., Benjamin, L. E. & Neeman, M. (1999) Cancer Res. 59, 5012-5016.
8. Morikawa, S., Baluk, P., Kaidoh, T., Haskell, A., Jain, R. K. & McDonald, D. M. (2002) Am. J. Pathol. 160, 985-1000.
9. Kuo, C. J., Farnebo, F., Yu, E. Y., Christofferson, R., Swearingen, R. A., Carter, R., von Recum, H. A., Yuan, J., Kamihara, J., Flynn, E., et al. (2001) Proc. Natl. Acad. Sci. USA 98, 4605-4610.
10. Kim, E. S., Serur, A., Huang, J., Manley, C. A., McCrudden, K. W., Frischer, J. S., Soffer, S. Z., Ring, L., New, T., Zabski, S., et al. (2002) Proc. Natl. Acad. Sci. USA 99, 11399-11404.
11. Holash, J., Davis, S., Papadopoulos, N., Croll, S. D., Ho, L., Russell, M., Boland, P., Leidich, R., Hylton, D., Burova, E., et al. (2002) Proc. Natl. Acad. Sci. USA 99, 11393-11398.
12. Thurston, G., Baluk, P., Hirata, A. & McDonald, D. M. (1996) Am. J. Physiol. 271, H2547-H2562.
13. Wild, R., Ramakrishnan, S., Sedgewick, J. & Griffioen, A. W. (2000) Microvasc. Res. 59, 368-376.
14. Holash, J., Maisonpierre, P. C., Compton, D., Boland, P., Alexander, C. R., Zagzag, D., Yancopoulos, G. D. & Wiegand, S. J. (1999) Science 284, 1994-1998.
15. Shweiki, D., Itin, A., Soffer, D. & Keshet, E. (1992) Nature 359, 843-845.
16. Levy, A. P., Levy, N. S., Wegner, S. & Goldberg, M. A. (1995) J. Biol. Chem. 270, 13333-13340.
17. Oh, H., Takagi, H., Suzuma, K., Otani, A., Matsumura, M. & Honda, Y. (1999) J. Biol. Chem. 274, 15732-15739.
18. Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) Science 277, 55-60.
19. Rowe, D. H., Huang, J., Kayton, M. L., Thompson, R., Troxel, A., O'Toole, K. M., Yamashiro, D., Stolar, C. J. & Kandel, J. J. (2000) J. Pediatr. Surg. 35, 30-33.
20. Folkman, J. (1972) Ann. Surg. 175, 409-416.
21. Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) Nat. Med. 7, 1194-1201.