-
1
-
-
0015311426
-
Anti-angiogenesis: New concept for therapy of solid tumors
-
(1972)
Ann. Surg.
, vol.175
, pp. 409-416
-
-
Folkman, J.1
-
2
-
-
0033580889
-
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF
-
(1999)
Science
, vol.284
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
Boland, P.4
Alexander, C.R.5
Zagzag, D.6
Yancopoulos, G.D.7
Wiegand, S.J.8
-
8
-
-
0031907022
-
Evaluation of epidermal growth factor-related growth factors and receptors and of neoangiogenesis in completely resected stage I-IIIA non-small-cell lung cancer: Amphiregulin and microvessel count are independent prognostic indicators of survival
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 241-249
-
-
Fontanini, G.1
De Laurentiis, M.2
Vignati, S.3
Chine, S.4
Lucchi, M.5
Silvestri, V.6
Mussi, A.7
De Placido, S.8
Tortora, G.9
Bianco, A.R.10
Gullick, W.11
Angeletti, C.A.12
Bevilacqua, G.13
Ciardiello, F.14
-
13
-
-
84970070220
-
Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
-
(1995)
Cancer Res.
, vol.55
, pp. 3964-3968
-
-
Takahashi, Y.1
Kitadai, Y.2
Bucana, C.D.3
Cleary, K.R.4
Ellis, L.M.5
-
15
-
-
0032852528
-
Molecular and biological properties of vascular endothelial growth factor
-
(1999)
J. Mol. Med.
, vol.77
, pp. 527-543
-
-
Ferrara, N.1
-
17
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
18
-
-
0033135876
-
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
-
(1999)
Genes Dev.
, vol.13
, pp. 1055-1066
-
-
Gale, N.W.1
Yancopoulos, G.D.2
-
21
-
-
0030004485
-
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
-
(1996)
Nature (Lond.)
, vol.380
, pp. 439-442
-
-
Ferrara, N.1
Carver-Moore, K.2
Chen, H.3
Dowd, M.4
Lu, L.5
O’Shea, K.S.6
Powell-Braxton, L.7
Hillan, K.J.8
Moore, M.W.9
-
22
-
-
0030031898
-
Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis
-
(1996)
Cancer Res.
, vol.56
, pp. 172-181
-
-
Claffey, K.P.1
Brown, L.F.2
Del Aguila, L.F.3
Tognazzi, K.4
Yeo, K.T.5
Manseau, E.J.6
Dvorak, H.F.7
-
24
-
-
0034069028
-
Antitumor and antimetastatic activity of ribozymes targeting the messenger RNA of vascular endothelial growth factor receptors
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2094-2103
-
-
Pavco, P.A.1
Bouhana, K.S.2
Gallegos, A.M.3
Agrawal, A.4
Blanchard, K.S.5
Grimm, S.L.6
Jensen, K.L.7
Andrews, L.E.8
Wincott, F.E.9
Pitot, P.A.10
Tressler, R.J.11
Cushman, C.12
Reynolds, M.A.13
Parry, T.J.14
-
28
-
-
0032893263
-
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
-
(1999)
Cancer Res.
, vol.59
, pp. 99-106
-
-
Fong, T.A.1
Shawver, L.K.2
Sun, L.3
Tang, C.4
App, H.5
Powell, T.J.6
Kim, Y.H.7
Schreck, R.8
Wang, X.9
Risau, W.10
Ullrich, A.11
Hirth, K.P.12
McMahon, G.13
-
29
-
-
12244277954
-
Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
-
(2000)
Anticancer Drug Design
, vol.15
, pp. 29-41
-
-
Mendel, D.B.1
Laird, D.A.2
Smolich, B.3
Blake, R.A.4
Liang, C.5
Hannah, A.L.6
Shaheen, R.7
Ellis, L.M.8
Weitman, S.9
Shawver, L.K.10
Cherrington, J.M.11
-
30
-
-
0033107767
-
Inhibition of tumor growth, angiogenesis, and microcirculation by the novel FLK-1 inhibitor SU5416 as assessed by intravital multifluorescence videomicroscopy
-
(1999)
Neoplasia
, vol.1
, pp. 31-41
-
-
Vajkoczy, P.1
Menger, M.D.2
Vollmar, B.3
Schilling, L.4
Schmiedek, P.5
Hirth, P.K.6
Ullrich, A.7
Fong, T.A.T.8
-
31
-
-
0033231069
-
Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor (VEGF) receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
-
(1999)
Cancer Res.
, vol.59
, pp. 5412-5416
-
-
Shaheen, R.M.1
Davis, D.W.2
Liu, W.3
Zebrowski, B.K.4
Wilson, M.R.5
Bucana, C.D.6
McConkey, D.J.7
McMahon, G.8
Ellis, L.M.9
-
32
-
-
0006239483
-
The pharmacokinetic and pharmacodynamic properties of SU5416, a novel VEGF receptor inhibitor
-
(1999)
Proc. Am. Assoc. Cancer Res.
, vol.40
, pp. 388
-
-
Antonian, L.1
Yang, C.2
Sukebuntherng, J.3
Fong, T.A.T.4
Shenoy, N.5
Schreck, R.6
Wagner, G.7
Shawver, L.8
-
36
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
39
-
-
0032500505
-
Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26722-26728
-
-
Pedram, A.1
Razandi, M.2
Levin, E.R.3
-
40
-
-
0033883776
-
SU6668 is a potent anti-angiogenic and anti-tumor agent which induces regression of established tumors
-
(2000)
Cancer Res.
, vol.60
, pp. 4152-4160
-
-
Laird, A.D.1
Vajkoczy, P.2
Shawver, L.K.3
Thurnher, A.4
Liang, C.5
Mohammadi, M.6
Schlessinger, J.7
Ullrich, A.8
Hubbard, S.R.9
Blake, R.A.10
Fong, T.A.T.11
Strawn, L.M.12
Sun, L.13
Tang, C.14
Hawtin, R.15
Tang, F.16
Shenoy, N.17
Hirth, K.P.18
McMahon, G.19
Cherrington, J.M.20
more..
-
41
-
-
0033602091
-
Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization
-
(1999)
Oncogene
, vol.18
, pp. 1619-1627
-
-
Dougher, M.1
Terman, B.I.2
-
42
-
-
0033587022
-
Tyrosine kinase inhibitors, 15.4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor
-
(1999)
J. Med Chem.
, vol.42
, pp. 1803-1815
-
-
Smaill, J.B.1
Palmer, B.D.2
Rewcastle, G.W.3
Denny, W.A.4
McNamara, D.J.5
Dobrusin, E.M.6
Bridges, A.J.7
Zhou, H.8
Showalter, H.D.9
Winters, R.T.10
Leopold, W.R.11
Fry, D.W.12
Nelson, J.M.13
Slintak, V.14
Elliot, W.L.15
Roberts, B.J.16
Vincent, P.W.17
Patmore, S.J.18
-
43
-
-
0029587403
-
Inhibition of basic fibroblast growth factor-mediated tyrosine phosphorylation and protein synthesis by PD 145709, a member of the 2-thioindole class of tyrosine kinase inhibitors
-
(1995)
Anticancer Drug Design
, vol.10
, pp. 607-622
-
-
Fry, D.W.1
Nelson, J.M.2
-
45
-
-
0032830412
-
The rationale and strategy used to develop a series of highly potent, irreversible, inhibitors of the epidermal growth factor receptor family of tyrosine kinases
-
(1999)
Curr. Med. Chem.
, vol.6
, pp. 825-843
-
-
Bridges, A.J.1
-
46
-
-
0030893008
-
Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor sub-family of protein tyrosine kinases
-
(1997)
J. Med. Chem.
, vol.40
, pp. 1130-1135
-
-
Singh, J.1
Dobrusin, E.M.2
Fry, D.W.3
Haske, T.4
Whitty, A.5
McNamara, D.J.6
-
47
-
-
0033561601
-
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl) amino]-6-quinazolinyl]-2-butynamide (CL-387,785)
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 917-925
-
-
Discafani, C.M.1
Carroll, M.L.2
Floyd, M.B.3
Hollander, I.J.4
Husain, Z.5
Johnson, B.D.6
Kitchen, D.7
May, M.K.8
Malo, M.S.9
Minnick, A.A.10
Nilakantan, R.11
Shen, R.12
Wang, Y.F.13
Wissner, A.14
Greenberger, L.M.15
-
48
-
-
0033117811
-
Inhibition of p56(lck) tyrosine kinase by isothiazolones
-
(1999)
Arch. Biochem. Biophys.
, vol.364
, pp. 19-29
-
-
Trevillyan, J.M.1
Chiou, X.G.2
Ballaron, S.J.3
Tang, Q.M.4
Buko, A.5
Sheets, M.P.6
Smith, M.L.7
Putman, C.B.8
Wiedeman, P.9
Tu, N.10
Madar, D.11
Smith, H.T.12
Gubbins, E.J.13
Warrior, U.P.14
Chert, Y.W.15
Mollison, K.W.16
Faltynek, C.R.17
Djuric, S.W.18
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