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Epidermal growth factor receptor dependence in human tumors: More than just expression?
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Oncologist
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Arteaga, C.L.1
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Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib (‘Iressa’, ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2
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Bailey LR, Kris M, Wolf M, Kay A, Averbuch S, Askaa J, Janas M, Schmidt K, Fukuoka M (2003) Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib (‘Iressa’, ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL 1 and 2. Proc Am Assoc Cancer Res 44: 1362 (abs LB-170)
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84984770138
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Disease-related symptoms in advanced nonsmall- cell lung cancer as measured by the Lung Cancer Subscale of the FACT-L questionnaire: Clinically meaningful improvement with gefitinib (‘Iressa’, ZD1839
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Poster presented at ASCO, Chicago, IL, USA, May 31– June 3
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Cella D, Natale RB, Lynch TJ, Lee C, Carbone D, Douillard J-Y, Kay A, Wolf M, Heyes A, Ward J (2003) Disease-related symptoms in advanced nonsmall- cell lung cancer as measured by the Lung Cancer Subscale of the FACT-L questionnaire: clinically meaningful improvement with gefitinib (‘Iressa’, ZD1839). Poster presented at ASCO, Chicago, IL, USA, May 31– June 3, Poster no. 2531
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0000642964
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Improvement in disease-related symptoms and quality of life in patients with advanced non-small-cell lung cancer (NSCLC) treated with ZD1839 (‘Iressa’) (IDEAL 1)
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Douillard J-Y, Giaccone G, Horai T, Noda K, Vansteenkiste JF, Takata I, Gatzeimeir U, Fukuoka K, Macleod A, Feyereislova A, Averbuch S, Nogi Y, Heyes A, Baselga J (2002) Improvement in disease-related symptoms and quality of life in patients with advanced non-small-cell lung cancer (NSCLC) treated with ZD1839 (‘Iressa’) (IDEAL 1). Proc Am Soc Clin Oncol 21: 298a (abs 1195)
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0033015810
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Study of prognostic predictors for non-small cell lung cancer
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0012381722
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Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
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Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard J-Y, Nishiwaki Y, Vansteenkiste J, Kudoh S, Rischin D, Eek R, Horai T, Noda K, Takata I, Smit E, Averbuch S, Macleod A, Feyereislova A, Dong R-P, Baselga J (2003) Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 21: 2237– 2246
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Fukuoka, M.1
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Nishiwaki, Y.7
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Feyereislova, A.18
Dong, R.-P.19
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7
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0345204078
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Results of a multivariate analysis of prognostic factors of overall survival of patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib (ZD1839) in combination with platinum-based chemotherapy (CT) in two large phase III trials (INTACT 1 and 2)
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Giaccone G, Johnson D, Scagliotti GV, Manegold C, Rosell R, Rennie P, Wolf M, Averbuch S, Grous J, Fandi A (2003) Results of a multivariate analysis of prognostic factors of overall survival of patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib (ZD1839) in combination with platinum-based chemotherapy (CT) in two large phase III trials (INTACT 1 and 2). Proc Am Soc Clin Oncol 22: 627 (abs 2522)
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Fandi, A.10
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8
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0346651119
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The Israeli experience with gefitinib (‘Iressa’, ZD1839) as single agent treatment of advanced non-small-cell lung cancer
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Gips M, Heching Y, Levitt M, Kuten A, Shmueli E, Segal A, Peretz T (2003) The Israeli experience with gefitinib (‘Iressa’, ZD1839) as single agent treatment of advanced non-small-cell lung cancer. Lung Cancer 41(Suppl 2): S247 (abs P-613)
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9
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84984770143
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Canada, August
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Haringhuizen A, Vaessen HFR, Baas P, van Zandwijk N (2003) Gefinitib (‘Iressa’, ZD1839) as a last option for patients with recurrent non-smallcell lung cancer (NSCLC). Poster presented at the 10th WCLC, Vancouver, Canada, August 10–14
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Gefinitib (‘Iressa’, ZD1839) as a Last Option for Patients with Recurrent Non-Smallcell Lung Cancer (NSCLC). Poster Presented at the 10Th WCLC, Vancouver
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Haringhuizen, A.1
Vaessen, H.2
Baas, P.3
Van Zandwijk, N.4
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10
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0345204078
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Subset analyses of INTACT results for gefitinib (‘Iressa’, ZD1839) when combined with platinum-based chemotherapy for advanced non-small-cell lung cancer
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Herbst R, Giaccone G, Schiller J, Miller V, Natale R, Rennie P, Ochs J, Fandi A, Grous J, Johnson D (2003) Subset analyses of INTACT results for gefitinib (‘Iressa’, ZD1839) when combined with platinum-based chemotherapy for advanced non-small-cell lung cancer. Proc Am Soc Clin Oncol 22: 627 (abs 2523)
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Ochs, J.7
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0346031809
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Interobserver reproducibility of visually interpreted EGFR immunohistochemical staining in non-small-cell lung cancer
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Janas M, Franklin WA, Schmidt K, Bailey LR (2003) Interobserver reproducibility of visually interpreted EGFR immunohistochemical staining in non-small-cell lung cancer. Poster presented at the AACR, Washington, DC, USA, July 11–14, Poster no. LB-213
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Janas, M.1
Franklin, W.A.2
Schmidt, K.3
Bailey, L.R.4
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12
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84984754389
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Clinical benefits in patients with advanced nonsmall- cell lung cancer treated with gefitinib (“Iressa”, ZD1839) in the compassionate use program
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Janne PA, Gurubhagavatula S, Lucca J, Ostler P, Skarin AT, Fidias P, Lynch TJ, Johnson BE (2003) Clinical benefits in patients with advanced nonsmall- cell lung cancer treated with gefitinib (“Iressa”, ZD1839) in the compassionate use program. Lung Cancer 41(Suppl 2): S71 (abs O-243)
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Fidias, P.6
Lynch, T.J.7
Johnson, B.E.8
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0142055937
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Efficacy and safety of gefitinib (Iressa, ZD1839), an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with advanced non-small cell lung cancer
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Kris MG, Natale RB, Herbst RS, Lynch Jr TJ, Prager D, Belini CP, Schiller JH, Kelly K, Spiridonidis H, Sandler A, Cella D, Wolf MK, Averbuch SD, Ochs JJ, Kay AC (2003) Efficacy and safety of gefitinib (Iressa, ZD1839), an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with advanced non-small cell lung cancer. A randomized trial. JAMA 22: 2149–2158
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Kris, M.G.1
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Cella, D.11
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14
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84984751908
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Gefitinib (‘Iressa’, ZD1839) in advanced non-small-cell lung cancer patients after progression on chemotherapy
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López Martin A, Constenla M, Martín Algarra S, Salinas P, Massuti B, Gascón P, Castellano D, López-Picazo JM, Rosell R, Cortés-Funes H (2003) Gefitinib (‘Iressa’, ZD1839) in advanced non-small-cell lung cancer patients after progression on chemotherapy. Poster presented at ASCO, Chicago, IL, USA, May 31– June 3, Poster no. 2695
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López Martin, A.1
Constenla, M.2
Martín Algarra, S.3
Salinas, P.4
Massuti, B.5
Gascón, P.6
Castellano, D.7
López-Picazo, J.M.8
Rosell, R.9
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15
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0347910287
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Quantitative gene expression in nonsmall cell lung cancer from paraffin-embedded tissue specimens: Predicting response to gefitinib, an EGFR kinase inhibitor
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Natale RB, Shak S, Aronson N, Averbuch S, Fox W, Luthringer D, Clark K, Baker J, Cronin M, Agus DB (2003) Quantitative gene expression in nonsmall cell lung cancer from paraffin-embedded tissue specimens: predicting response to gefitinib, an EGFR kinase inhibitor. Proc Am Soc Clin Oncol 22: 190 (abs 763)
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Natale, R.B.1
Shak, S.2
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Averbuch, S.4
Fox, W.5
Luthringer, D.6
Clark, K.7
Baker, J.8
Cronin, M.9
Agus, D.B.10
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16
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0000642965
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Improvement in symptoms and quality of life for advanced non-small-cell lung cancer patients receiving ZD1839 (‘Iressa’) in IDEAL 2
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Natale RB, Skarin AT, Maddox AM, Hammond LA, Thomas R, Gandara DR, Gerstein H, Panella TJ, Cole J, Jahanzeb M, Kash J, Hamm J, Langer CJ, Saleh M, Stella PJ, Heyes A, Helms L, Ochs J, Averbuch S, Wolf M, Kay A (2002) Improvement in symptoms and quality of life for advanced non-small-cell lung cancer patients receiving ZD1839 (‘Iressa’) in IDEAL 2. Proc Am Soc Clin Oncol 21: 292a (abs 1167)
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Natale, R.B.1
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Gerstein, H.7
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Kash, J.11
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Canada, August
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Park J, Park B-B, Lee S-H, Park S-H, Lee K-E, Park JO, Kim K, Im Y-H, Kang WK, Park K (2003) Gefitinib (‘Iressa’, ZD1839) monotherapy as a salvage regimen for previously treated advanced non-small-cell lung cancer. Poster presented at the 10th WCLC, Vancouver, Canada, August 10–14
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Gefitinib (‘Iressa’, ZD1839) Monotherapy as a Salvage Regimen for Previously Treated Advanced Non-Small-Cell Lung Cancer. Poster Presented at the 10Th WCLC
, pp. 10-14
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Park, J.1
Park, B.-B.2
Lee, S.-H.3
Park, S.-H.4
Lee, K.-E.5
Park, J.O.6
Kim, K.7
Im, Y.-H.8
Kang, W.K.9
Park, K.10
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84984754398
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Canada, August
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Soto Parra H, Cavina R, Zucali PA, Campagnoli E, Latteri F, Morenghi E, Roncalli M, Santoro A (2003) Analysis of responses to gefitinib (‘Iressa’, ZD1839) according to epidermal growth factor receptor expressed as staining intensity or percentage of immunoreactive cells. Poster presented at the 10th WCLC, Vancouver, Canada, August 10–14
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Analysis of Responses to Gefitinib (‘Iressa’, ZD1839) according to Epidermal Growth Factor Receptor Expressed as Staining Intensity Or Percentage of Immunoreactive Cells. Poster Presented at the 10Th WCLC
, pp. 10-14
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Soto Parra, H.1
Cavina, R.2
Zucali, P.A.3
Campagnoli, E.4
Latteri, F.5
Morenghi, E.6
Roncalli, M.7
Santoro, A.8
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