In vitro and in vivo studies of a VEGF121/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 12, 2002, Pages 7866-7871

  Veenendaal, Liesbeth M ^a,d   Jin, Hangqing ^a   Ran, Sophia ^b   Cheung, Lawrence ^a   Navone, Nora ^a   Marks, John W ^a   Waltenberger, Johannes ^c   Thorpe, Philip ^b   Rosenblum, Michael G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF ULM   (Germany)

^d Box 427 ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; GELONIN; HYBRID PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATTLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MELANOMA; METASTASIS; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN IMMOBILIZATION; PROTEIN PHOSPHORYLATION; RETICULOCYTE LYSATE; SOLID TUMOR; THROMBOSIS; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME; XENOGRAFT;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA, THORACIC; BASE SEQUENCE; CATTLE; CELL SURVIVAL; CEREBROVASCULAR CIRCULATION; DNA PRIMERS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; LYMPHOKINES; MICE; PLANT PROTEINS; POLYMERASE CHAIN REACTION; RABBITS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RETICULOCYTES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; BOS TAURUS; MUS MUSCULUS;

EID: 0037062464     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.122157899     Document Type: Article

References (56)