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Volumn 87, Issue 2, 2002, Pages 161-167

A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer

(6) Bramhall, S R a Schulz, J b Nemunaitis, J c Brown, P D d Baillet, M d Buckels, J A C a

a QUEEN ELIZABETH HOSPITAL (United Kingdom)

b US Oncology (United States)

c Developmental Therapeutics Committee and Co Chair of the Genitourinary Committee (United States)

d British Biotech Pharmaceuticals Ltd (United Kingdom)

Author keywords

Gemcitabine; Marimastat; Pancreatic cancer

Indexed keywords

GEMCITABINE; MARIMASTAT; PLACEBO;

ADULT; AGED; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MUSCULOSKELETAL DISEASE; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TREATMENT FAILURE; TREATMENT OUTCOME; TREATMENT PLANNING;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DEOXYCYTIDINE; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROXAMIC ACIDS; LIFE TABLES; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; MUSCULOSKELETAL DISEASES; NEOPLASM PROTEINS; PANCREATIC NEOPLASMS; PROTEASE INHIBITORS; QUALITY OF LIFE; SAFETY; SURVIVAL ANALYSIS;

EID: 0037100983 PISSN: 00070920 EISSN: None Source Type: Journal
DOI: 10.1038/sj.bjc.6600446 Document Type: Article

Times cited : (530)

References (36)

1
- 0031692883
- Patient-reported short-term and long-term physical and psychologic symptoms: Results of the continuous hyperfractionated accelerated (correction of acclerated) radiotherapy (CHART) randomized trial in non-small-cell lung cancer
- CHART Steering Committee
- (1998) J Clin Oncol , vol.16 , pp. 3082-3093
- Bailey, A.J.¹ Parmar, M.K.² Stephens, R.J.³

2
- 0028985078
- Incidence, treatment and survival in 13, 560 patients with pancreatic cancer: An epidemiological study in the West Midlands
- (1995) Br J Surg , vol.82 , pp. 111-115
- Bramhall, S.R.¹ Allum, W.H.² Jones, A.G.³ Allwood, A.⁴ Cummins, C.⁵ Neoptolemos, J.P.⁶

3
- 85006298819
- Marimastat as maintenance therapy for patients with advanced gastric and gastro-oesophageal cancer: A randomized trial
- (2001) Br J Cancer
- Bramhall, S.R.¹ Hallissey, M.T.² Whiting, J.³ Scholefield, J.⁴ Tierney, G.⁵ Stuart, R.C.⁶ Hawkins, R.E.⁷ McCulloch, P.⁸ Maughan, T.⁹ Brown, P.D.¹⁰ Baillet, M.¹¹ Fielding, J.W.L.¹²

4
- 0030897883
- Adjuvant chemotherapy in pancreatic cancer
- (1997) Int J Pancreatol , vol.21 , pp. 59-63
- Bramhall, S.R.¹ Neoptolemos, J.P.²

5
- 0030801093
- Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma
- (1997) J Pathol , vol.182 , pp. 347-355
- Bramhall, S.R.¹ Neoptolemos, J.P.² Stamp, G.W.³ Lemoine, N.R.⁴

6
- 0035424135
- Marimastat as first line therapy for patients with unresectable pancreatic cancer - A randomized trial
- (2001) J Clin Oncol , vol.19 , pp. 3447-3455
- Bramhall, S.R.¹ Rosemurgy, A.² Brown, P.D.³ Bowry, C.⁴ Buckels, J.A.C.⁵

7
- 0029979467
- Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease
- (1996) Br J Cancer , vol.73 , pp. 972-978
- Bramhall, S.R.¹ Stamp, G.W.² Dunn, J.³ Lemoine, N.R.⁴ Neoptolemos, J.P.⁵

8
- 0029586589
- Matrix metalloproteinase inhibition: A review of anti-tumour activity
- (1995) Ann Oncol , vol.6 , pp. 967-974
- Brown, P.D.¹ Giavazzi, R.²

9
- 8244254377
- Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
- (1997) J Clin Oncol , vol.15 , pp. 2403-2413
- Burris, H.A.¹ Moore, M.J.² Andersen, J.³ Green, M.R.⁴ Rothenberg, M.L.⁵ Modiano, M.R.⁶ Cripps, M.C.⁷ Portenoy, R.K.⁸ Storniolo, A.M.⁹ Tarassoff, P.¹⁰ Nelson, R.¹¹ Dorr, F.A.¹² Stephens, C.D.¹³ Von Hoff, D.D.¹⁴

10
- 0345148774
- Randomized phase III study of gemcitabine-cisplatin versus etoposide- cisplatin in the treatment of locally advanced or metastatic non-small- cell lung cancer
- (1999) J Clin Oncol , vol.17 , pp. 12-18
- Cardenal, F.¹ Lopez-Cabrerizo, M.P.² Anton, A.³ Alberola, V.⁴ Massuti, B.⁵ Carrato, A.⁶ Barneto, I.⁷ Lomas, M.⁸ Garcia, M.⁹ Lianes, P.¹⁰ Montalar, J.¹¹ Vadell, C.¹² Gonzalez-Larriba, J.L.¹³ Nguyen, B.¹⁴ Artal, A.¹⁵ Rosell, R.¹⁶

11
- 0030049697
- Phase II study of gemcitabine in patients with advanced pancreatic cancer
- (1995) Br J Cancer , vol.73 , pp. 101-105
- Carmichael, J.¹ Fink, U.² Russell, R.C.G.³ Spittle, M.F.⁴ Harris, A.⁵ Spiessl, G.⁶

12
- 0033029525
- A combination of gemcitabine and 5-fluorouracil in advanced pancreatic cancer, a report from the Italian Group for the Study of Digestive Tract Cancer (GISCAD)
- Process Citation
- (1999) Br J Cancer , vol.80 , pp. 1595-1598
- Cascinu, S.¹ Silva, R.R.² Barni, S.³ Labianca, R.⁴ Frontini, L.⁵ Piazza, E.⁶ Pancera, G.⁷ Giordani, P.⁸ Giuliodori, L.⁹ Pessi, M.A.¹⁰ Fusco, V.¹¹ Luporini, G.¹² Cellerino, R.¹³ Catalano, G.¹⁴

13
- 0028292341
- Phase II trial of gemcitabine in patients with adenocarcinoma of the pancreas
- (1994) Invest New Drugs , vol.12 , pp. 29-34
- Casper, E.S.¹ Green, M.R.² Kelsen, D.P.³ Heelan, R.T.⁴ Brown, T.D.⁵ Flombaum, C.D.⁶

14
- 0028129059
- Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor
- (1994) Int J Cancer , vol.58 , pp. 460-464
- Chivri, R.S.¹ Garofalo, A.² Crimmin, M.J.³ Bawden, L.J.⁴ Brown, P.D.⁵ Giavazzi, R.G.⁶

15
- 0003293665
- Gemcitabine alone or with cisplatin in advanced pancreatic cancer: Preliminary results of a randomized study of the Southern Italy Oncology Group
- (1998) Proc ASCO , vol.17 , pp. 289a
- Colucci, G.¹ Giuliani, F.² Riccardi, F.³ Lopez, M.⁴ Gebbia, V.⁵ Pedicini, A.⁶ Biglietto, M.⁷ Carteni, G.⁸ Maiello, E.⁹ Gebbia, N.¹⁰

16
- 0027223141
- Regulation of matrix metalloproteinases: Their role in tumor invasion and metastasis
- (1993) Int J Oncol , vol.2 , pp. 861-872
- Cottam, D.W.¹ Rees, R.C.²

17
- 0027251836
- A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
- (1993) Cancer Res , vol.53 , pp. 2087-2091
- Davies, B.¹ Brown, P.D.² East, N.³ Crimmin, M.J.⁴ Balkwili, E.R.⁵

18
- 0023493614
- Pancreatic cancer: Nihilism is obsoletel
- (1987) Pancreas , vol.2 , pp. 230-232
- Douglass, H.O.¹

19
- 0035556141
- A phase II study of marimastat in advanced pancreatic cancer
- (2001) Br J Cancer , vol.85 , pp. 1865-1870
- Evans, J.D.¹ Stark, A.² Johnson, C.D.³ Daniel, F.⁴ Carmichael, J.⁵ Buckels, J.⁶ Imrie, C.W.⁷ Brown, P.⁸ Neoptolemos, J.P.⁹

20
- 0028339877
- Trends in pancreatic cancer mortality in Europe, 1955-1989
- (1994) Int J Cancer , vol.57 , pp. 786-792
- Fernandez, E.¹ La-Vecchia, C.² Porta, M.³ Negri, E.⁴ Lucchini, F.⁵ Levi, F.⁶

21
- 0029080314
- Expression and in-situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer
- (1995) Int J Cancer , vol.62 , pp. 407-413
- Gress, T.M.¹ Muller-Pillasch, F.² Lerch, M.M.³ Friess, H.⁴ Buchler, M.⁵ Adler, G.⁶

22
- 0023626809
- Cancer of the pancreas 50 years of surgery
- (1987) Cancer , vol.60 , pp. 2284-2303
- Gudjonsson, B.¹

23
- 0033012340
- Phase I-II study of gemcitabine and fluorouracil as a continuous infusion in patients with pancreatic cancer
- (1999) J Clin Oncol , vol.17 , pp. 585-592
- Hidalgo, M.¹ Castellano, D.² Paz-Ares, L.³ Gravalos, C.⁴ Diaz-Puente, M.⁵ Hitt, R.⁶ Alonso, S.⁷ Cortes-Funes, H.⁸

24
- 0019208060
- Chemotherapy in pancreatic cancer: Results of a controlled prospective randomised, multicentre trial
- (1980) Br Med J , vol.281 , pp. 1589-1591
- Mallinson, C.N.¹ Rake, M.D.² Cocking, J.B.³ Fox, C.A.⁴ Cwynarski, M.T.⁵ Diffey, B.L.⁶ Jackson, G.A.⁷ Hanley, J.⁸ Wass, V.J.⁹

25
- 14444284598
- Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biologically active and tolerable dose for longer-term studies
- (1998) Clin Cancer Res , vol.4 , pp. 1101-1109
- Nemunaitis, J.¹ Poole, C.² Primrose, J.³ Rosemurgy, A.⁴ Malfetano, J.⁵ Brown, P.⁶ Berrington, A.⁷ Cornish, A.⁸ Lynch, K.⁹ Rasmussen, H.¹⁰ Kerr, D.¹¹ Cox, D.¹² Millar, A.¹³

26
- 0028291349
- Chemotherapy prolongs survival in inoperable pancreatic carcinoma
- (1994) Br J Surg , vol.81 , pp. 882-885
- Palmer, K.R.¹ Kerr, M.² Knowles, G.³ Cull, A.⁴ Carter, D.C.⁵ Leonard, R.C.⁶

27
- 84970055947
- National Cancer Institute, Vol. Pub. No.94-2789. Bethesda, MD: NIH
- (1994) SEER Cancer Statistics Review: Tables and Graphs
- Ries, L.A.G.¹ Miller, B.A.² Hankey, B.F.³

28
- 8944261362
- A phase II trial of gemcitabine in patients with 5-FU-refractory pancreas cancer
- (1996) Ann Oncol , vol.7 , pp. 347-353
- Rothenberg, M.L.¹ Moore, M.J.² Cripps, M.C.³ Andersen, J.S.⁴ Portenoy, R.K.⁵ Burris H.A. III⁶ Green, M.R.⁷ Tarassoff, P.G.⁸ Brown, T.D.⁹ Casper, E.S.¹⁰ Storniolo, A.M.¹¹ Von Hoff, D.D.¹²

29
- 0028291737
- A matrix metalloproteinase expressed on the surface of invasive tumour cells
- (1994) Nature , vol.370 , pp. 61-65
- Sato, H.¹ Takino, T.² Okada, Y.³ Cao, J.⁴ Shinagawa, A.⁵ Yamamoto, E.⁶ Seiki, M.⁷

30
- 0033559213
- An investigational new drug treatment program for patients with gemcitabine: Results for over 3000 patients with pancreatic carcinoma
- (1999) Cancer , vol.85 , pp. 1261-1268
- Storniolo, A.M.¹ Enas, N.H.² Brown, C.A.³ Voi, M.⁴ Rothenberg, M.L.⁵ Schilsky, R.⁶

31
- 0030990737
- Combination chemotherapy studies with gemcitabine
- (1997) Semin Oncol , vol.24 , pp. S7-S17
- Van Moorsel, C.J.¹ Veerman, G.² Bergman, A.M.³ Guechev, A.⁴ Vermorken, J.B.⁵ Postmus, P.E.⁶ Peters, G.J.⁷

32
- 0032834472
- Inhibition of tumour growth by marimastat in a human xenograft model of gastric cancer: Relationship with levels of circulating CEA
- (1999) Br J Cancer , vol.81 , pp. 19-23
- Watson, S.A.¹ Morris, T.M.² Collins, H.M.³ Bawden, L.J.⁴ Hawkins, K.⁵ Bone, E.A.⁶

33
- 0029165411
- Inhibition of organ invasion by the matrix metalloproteinase inhibitor Batimastat (BB-94) in two human colon carcinoma metastasis models
- (1995) Cancer Res , vol.55 , pp. 3629-3633
- Watson, S.A.¹ Morris, T.M.² Robinson, G.³ Crimmin, M.J.⁴ Brown, P.D.⁵ Hardcastle, J.D.⁶

34
- 0028835677
- Cancer statistics, 1995
- (1995) CA Cancer J Clin , vol.45 , pp. 8-30
- Wingo, P.A.¹ Tong, T.² Bolden, S.³

35
- 0031148314
- Matrix metalloproteinase inhibition attenuates human pancreatic cancer growth in vitro and decreases mortality and tumorigenesis in vivo
- (1997) J Surg Res , vol.69 , pp. 367-371
- Zervos, E.E.¹ Norman, J.G.² Gower, W.R.³ Franz, M.G.⁴ Rosemurgy, A.S.⁵

36
- 0032837731
- Matrix metalloproteinase (MMP) inhibition selectively decreases type II MMP activity in a murine model of pancreatic cancer
- (1999) J Surg Res , vol.81 , pp. 65-68
- Zervos, E.E.¹ Shafii, A.E.² Rosemurgy, A.S.³

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