In vivo therapy of malignant melanoma by means of antagonists of αv integrins

International Journal of Cancer

Volumn 87, Issue 5, 2000, Pages 716-723

  Mitjans, Francesc ^a   Meyer, Tim ^b   Fittschen, Claus ^c   Goodman, Simon ^c   Jonczyk, Alfred ^c   Marshall, John F ^b   Reyes, German ^d   Piulats, Jaume ^a  

^a S A Laboratorio de Bioinvestigacion   (Spain)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c MERCK KGAA   (Germany)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER SURVIVAL; CELL INTERACTION; CONTROLLED STUDY; DRUG EFFECT; EXTRACELLULAR MATRIX; IN VIVO STUDY; LIGAND BINDING; MALIGNANT TRANSFORMATION; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; CELL ADHESION; CELL DIVISION; DISEASE PROGRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; GROWTH INHIBITORS; HT29 CELLS; HUMANS; INTEGRINS; KINETICS; MALE; MELANOMA; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; PEPTIDES, CYCLIC; RECEPTORS, VITRONECTIN; TUMOR CELLS, CULTURED;

EID: 0033866240     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000901)87:5<716::AID-IJC14>3.0.CO;2-R     Document Type: Article

References (39)

1. ALBELDA, S.M., METTE, S.A., ELDER, D.E., STEWART, R., DAMJANOVICH, L., HERLYN, M. and BUCK, C.A., Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression. Cancer Res., 50, 6757-6764 (1990).
2. ALBINI, A., PAGLIERI, I., ORENGO, G., CARLONE, S., ALUIGI, M.G., DEMARCHI, R., MATTEUCCI, C., MANTOVANI, A., CAROZZI, F., DONINI, S. and BENELLI, R., The beta-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line. AIDS, 11, 713-721 (1997).
3. BOUKERCHE, H., BERTHIER-VERGNES, O., BAILLY, M., DORE, J.F., LEUNG, L.L. and MCGREGOR, J.L., A monoclonal antibody (LYP18) directed against the blood platelet glycoprotein IIb/IIIa complex inhibits human melanoma growth in vivo. Blood, 74, 909-912 (1989).
4. BROOKS, P.C., CLARK, R.A. and CHERESH, D.A., Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science, 264, 569-571 (1994).
5. BROOKS, P.C., MONTGOMERY, A.M., ROSENFELD, M., REISFELD, R.A., HU, T., KLIER, G. and CHERESH, D.A., Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell, 79, 1157-1164 (1994).
6. BROOKS, P.C., STROMBLAD, S., KLEMKE, R., VISSCHER, D., SARKAR, F.H. and CHERESH, D.A., Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. J. clin. Invest., 96, 1815-1822 (1995).
7. CASTEL, S., PAGAN, R., GARCÍA, R., CASAROLI-MARANO, R.P., REINA, M., MITJANS, F., PIULATS, J. and VILARÓ, S., Alpha v integrin antagonists induce the disassembly of focal contacts in melanoma cells. Europ. J. Cell Biol. (2000). (In press).
8. CHERESH, D.A. and KLIER, P.C., Disialoganglioside GD2 distributes preferentially into substrate-associated microprocesses on human melanoma cells during their attachment to fibronectin. J. Cell Biol., 102, 1887-1897 (1986).
9. CHERESH, D.A. and SPIRO, R.C., Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor. J. biol. Chem., 262, 17703-17711 (1987).
10. DECHANTSREITER, M.A., PLANKER, E., MATHAE, B., LOHOF, E., HOELZEMANN, G., JONCZYK, A., GOODMAN, S.L. and KESSLER, H., N-Methylated cyclic RGD peptides as highly active and selective avb3 integrin antagonists. J. med. Chem., 42, 3033-3040 (1999).
11. DEDHAR, S., Integrin mediated signal transduction in oncogenesis: an overview. Cancer Metastasis Rev., 14, 165-172 (1995).
12. ERHARD, H., RIETVELD F.J., VAN ALTENA, M.C., BROCKER, E.B., RUITER, D.J. and DE WAAL, R.M., Transition of horizontal to vertical growth phase melanoma is accompanied by induction of vascular endothelial growth factor expression and angiogenesis. Melanoma Res., 7 (Suppl. 2), S19-S26 (1997).
13. FELDING-HABERMANN, B., MUELLER, B.M., ROMERDAHL, C.A. and CHERESH, D.A., Involvement of integrin alpha V gene expression in human melanoma tumorigenicity. J. clin. Invest., 89, 2018-2022 (1992).
14. HAMMES, H.P., BROWNLEE, M., JONCZYK, A., SUTTER, A. and PREISSNER, K.T., Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization. Nature (Med.), 2, 529-533 (1996).
15. HSU, M.Y., SHIH, D.T., MEIER, F.E., VAN BELLE, P., HSU, J.Y., ELDER, D.E., BUCK, C.A. and HERLYN, M., Adenoviral gene transfer of beta3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma. Amer. J. Pathol. 153, 1435-1442 (1998).
16. HUMPHRIES, M.J., OLDEN, K. and YAMADA, K.M., A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science, 233, 467-470 (1986).
17. KIESSLING, F., KARTENBECK, J. and HALLER, C., Cell-cell contacts in the human cell line ECV304 exhibit both endothelial and epithelial characteristics. Cell Tissue Res., 297, 131-140 (1999).
18. KRAFT, S., DIEFENBACH, B., MEHTA, R., JONCZYK, A., LUCKENBACH, G.A. and GOODMAN, S.L., Definition of an unexpected ligand recognition motif for alphav beta6 integrin. J. biol. Chem., 274, 1979-1985 (1999).
19. LIU, K.Y., TIMMONS, S., LIN, Y.Z. and HAWIGER, J., Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs. Proc. nat. Acad. Sci. (Wash.), 93, 11819-11824 (1996).
20. MACKIE, R.M., Incidence, risk factors and prevention of melanoma. Europ. J. Cancer, 34 (Suppl. 3), S3-S6 (1998).
21. MARSHALL, J.F., RUTHERFORD, D.C., HAPPERFIELD, L., HANBY, A., MCCARTNEY, A.C., NEWTON-BISHOP, J. and HART, I.R., Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas. Brit. J. Cancer, 77, 522-529 (1998).
22. MARSHALL, J.F., RUTHERFORD, D.C., MCCARTNEY, A.C., MITJANS, F., GOODMAN, S.L. and HART, I.R., Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin. J. Cell Sci., 108, 1227-1238 (1995).
23. MEYER, T. and HART, I.R., Mechanisms of tumor metastasis. Europ. J. Cancer, 34, 214-221 (1998).
24. MEYER, T., MARSHALL, J.F. and HART, I.R., Expression of alphav integrins and vitronectin receptor identity in breast cancer cells. Brit. J. Cancer, 77, 530-536 (1998).
25. MITJANS, F., SANDER, D., ADAN, J., SUTTER, A., MARTINEZ, J.M., JAGGLE, C.S., MOYANO, J.M., KREYSCH, H.G., PIULATS, J. and GOODMAN, S.L., An anti-alpha v-integrin antibody that blocks integrin function inhibits the development of a human melanoma in nude mice. J. Cell Sci., 108, 2825-2838 (1995).
26. MONTGOMERY A.M., REISFELD R.A. and CHERESH D.A. Integrin αvβ3 rescues melanoma cells from apoptosis in 3D dermal collagen. Proc. Natl. Acad. Sci. USA, 91, 8856-60 (1994).
27. NEITZEL, L.T., NEITZEL, C.D., MAGEE, K.L. and MALAFA, M.P., Angiogenesis correlates with metastasis in melanoma. Ann. surg. Oncol., 6, 70-74 (1999).
28. PETITCLERC, E., STROMBLAD, S., VON SCHALSCHA, T.L., MITJANS, F., PIULATS, J., MONTGOMERY, A.M., CHERESH, D.A. and BROOKS, P.C., Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival. Cancer Res., 59, 2724-2730 (1999).
29. PIULATS, J. and MITJANS, F., Angiogenesis switch pathways. In: Bronchud, Robinson, and Peters (eds.), The molecular manual of cancer, pp. 269-691. Humana Press, New York (2000).
30. REYES, G., VILLANUEVA, A., GARCIA, C., SANCHO, F.J., PIULATS, J., LLUIS, F. and CAPELLA, G., Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice. Cancer Res., 56, 5713-5719 (1996).
31. SEFTOR, R.E., Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression. Amer. J. Pathol., 153, 1347-1351 (1998).
32. SEFTOR, R.E., SEFTOR, E.A., GEHLSEN, K.R., STETLER-STEVENSON, W.G., BROWN, P.D., RUOSLAHTI, E. and HENDRIX, M.J., Role of the alpha v beta 3 integrin in human melanoma cell invasion. Proc. nat. Acad. Sci. (Wash.), 89, 1557-1561 (1992).
33. SEFTOR, R.E., SEFTOR, E.A., STETLER-STEVENSON, W.G. and HENDRIX, M.J., The 72 kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta 1 integrins during human melanoma cell invasion. Cancer Res., 53, 3411-3415 (1993).
34. STEELE, J.G., DALTON, B.A., JOHNSON, G. and UNDERWOOD, P.A., Polystyrene chemistry affects vitronectin activity: an explanation for cell attachment to tissue culture polystyrene but not to unmodified polystyrene. J. biomed. Mater. Res., 27, 927-940 (1993).
35. VAN BELLE, P.A., ELENITSAS, R., SATYAMOORTHY, K., WOLFE, J.T., GUERRY IV, D., SCHUCHTER, L., VAN BELLE, T.J., ALBELDA, S., TAHIN, P., HERLYN, M. and ELDER, D.E., Progression-related expression of beta3 integrin in melanomas and nevi. Hum. Pathol., 30, 562-567 (1999).
36. WAYNER, E.A., ORLANDO, R.A. and CHERESH, D.A., Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface J. Cell Biol., 113, 919-929 (1991).
37. WONG, N.C., MUELLER, B.M., BARBAS, C.F., RUMINSKI, P., QUARANTA, V., LIN, E.C. and SMITH, J.W., Alphav integrins mediate adhesion and migration of breast carcinoma cell lines. Clin. exp. Metastasis, 16, 50-61 (1998).
38. ZHENG, D.Q., WOODARD, A.S., FORNARO, M., TALLINI, G. and LANGUINO, L.R., Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway. Cancer Res., 59, 1655-1664 (1999).
39. ZHU, W.Y., JONES, C.S., AMIN, S., MATSUKUMA, K., HAQUE, M., VULIGONDA, V., CHANDRARATNA, R.A. and DE LUCA, L.M., Retinoic acid increases tyrosine phosphorylation of focal adhesion kinase and paxillin in MCF-7 human breast cancer cells. Cancer Res., 59, 85-90 (1999).