The antiangiogenic agent neovastat (Æ-941) induces endothelial cell apoptosis

Molecular Cancer Therapeutics

Volumn 1, Issue 10, 2002, Pages 795-802

  Boivin, Dominique ^a   Gendron, Sébastien ^a   Beaulieu, Édith ^a   Gingras, Denis ^a   Béliveau, Richard ^a  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASP3 PROTEIN, HUMAN; CASP3 PROTEIN, MOUSE; CASP8 PROTEIN, HUMAN; CASP8 PROTEIN, MOUSE; CASP9 PROTEIN, HUMAN; CASP9 PROTEIN, MOUSE; CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME C; DNA; DNA FRAGMENT; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEPTIDE CHLOROMETHYL KETONE; PROTEIN BCL 2; SHARK CARTILAGE EXTRACT AE 941; TISSUE EXTRACT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; AORTA; APOPTOSIS; ARTICLE; CATTLE; CELL CULTURE; CELL DEATH; CELL LINE; CELL STRAIN 3T3; CELL STRAIN COS1; CELL SURVIVAL; CHROMATIN; CYTOLOGY; CYTOSOL; DOSE RESPONSE; DRUG EFFECT; HUMAN; IMMUNOBLOTTING; METABOLISM; MITOCHONDRION; MOUSE; NICK END LABELING; PATHOLOGY; TIME; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

3T3 CELLS; AMINO ACID CHLOROMETHYL KETONES; ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CATTLE; CELL DEATH; CELL LINE; CELL SURVIVAL; CELLS, CULTURED; CHROMATIN; COS CELLS; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROME C GROUP; CYTOSOL; DNA; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HUMANS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; MICE; MITOCHONDRIA; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TIME FACTORS; TISSUE EXTRACTS; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036692153     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med., 1: 27-31, 1995.
2. Hanahan, D., and Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 86: 353-364, 1996. (Pubitemid 26272076)
3. Brem, S. Angiogenesis and cancer control: from concept to therapeutic trial. Cancer Control, 6: 436-458, 1999. (Pubitemid 29508291)
4. Boehm, T., Folkman, J., Browder, T., and O'Reilly. M. S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (Lond.), 390: 404-407, 1997.
5. Pluda, J. M. Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies. Semin. Oncol., 24: 203-218, 1997. (Pubitemid 27181127)
6. Rak, J., and Kerbel, R. S. Treating cancer by inhibiting angiogenesis: new hopes and potential pitfalls. Cancer Metastasis Rev., 15: 231-236, 1996. (Pubitemid 26236121)
7. Taraboletti, G., and Margosio, B. Antiangiogenic and antivascular therapy for cancer. Curr. Opin. Pharmacol., 1: 378-384, 2001. (Pubitemid 33585987)
8. Cao, Y. Endogenous angiogenesis inhibitors and their therapeutic implications. Int. J. Biochem. Cell Biol., 33: 357-369, 2001. (Pubitemid 32324004)
9. Kerr, J. F., Wyllie, A. H., and Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer, 26: 239-257, 1972.
10. Wyllie, A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond.), 284: 555-556, 1980. (Pubitemid 10070336)
11. Strasser, A., O'Connor, L., and Dixit, V. M. Apoptosis signaling. Annu. Rev. Biochem., 69: 217-245, 2000.
12. Nicholson, D. W. Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ., 6: 1028-1042, 1999.
13. Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., Mann, M., Krammer, P. H., Peter, M. E., and Dixit, V. M. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell, 85: 817-827, 1996. (Pubitemid 26193033)
14. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1-and TNF receptor-induced cell death. Cell, 85: 803-815, 1996.
15. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., and Wang, X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489, 1997. (Pubitemid 27508237)
16. Slee, E. A., Harte, M. T., Kluck, R. M., Wolf, B. B., Casiano, C. A., Newmeyer, D. D., Wang, H. G., Reed, J. C., Nicholson, D. W., Alnemri, E. S., Green, D. R., and Martin, S. J. Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J. Cell Biol., 144: 281-292, 1999. (Pubitemid 29066031)
17. Li, H., Zhu, H., Xu, C. J., and Yuan, J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 94: 491-501, 1998. (Pubitemid 28391865)
18. Nor, J. E., Mitra, R. S., Sutorik, M. M., Mooney, D. J., Castle, V. P., and Polverini, P. J. Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway. J. Vasc. Res., 37: 209-218, 2000. (Pubitemid 30350890)
19. Jimenez, B., Volpert, O. V., Crawford, S. E., Febbraio, M., Silverstein, R. L., and Bouck, N. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat. Med., 6: 41-48, 2000. (Pubitemid 30048524)
20. Guo, N., Krutzsch, H. C., Inman, J. K., and Roberts, D. D. Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells. Cancer Res., 57: 1735-1742, 1997. (Pubitemid 27199668)
21. Claesson-Welsh, L., Welsh, M., Ito, N., Anand-Apte, B., Soker, S., Zetter, B., O'Reilly, M., and Folkman, J. Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD. Proc. Natl. Acad. Sci. USA, 95: 5579-5583, 1998. (Pubitemid 28224137)
22. Lucas, R., Holmgren, L., Garcia, I., Jimenez, B., Mandriota, S. J., Borlat, F., Sim, B. K., Wu, Z., Grau, G. E., Shing, Y., Soff, G. A., Bouck, N., and Pepper, M. S. Multiple forms of angiostatin induce apoptosis in endothelial cells. Blood, 92: 4730-4741, 1998. (Pubitemid 29005875)
23. Dhanabal, M., Ramchandran, R., Waterman, M. J., Lu, H., Knebelmann, B., Segal, M., and Sukhatme, V. P. Endostatin induces endothelial cell apoptosis. J. Biol. Chem., 274: 11721-11726, 1999.
24. Kamphaus, G. D., Colorado, P. C., Panka, D. J., Hopfer, H., Ramchandran, R., Torre, A., Maeshima, Y., Mier, J. W., Sukhatme, V. P., and Kalluri, R. Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth. J. Biol. Chem., 275: 1209-1215, 2000. (Pubitemid 30051173)
25. Larsson, H., Sjoblom, T., Dixelius, J., Ostman, A., Ylinenjarvi, K., Bjork, I., and Claesson-Welsh, L. Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells. Cancer Res., 60: 6723-6729, 2000.
26. Lu, H., Dhanabal, M., Volk, R., Waterman, M. J., Ramchandran, R., Knebelmann, B., Segal, M., and Sukhatme, V. P. Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells. Biochem. Biophys. Res. Commun., 258: 668-673, 1999. (Pubitemid 29290327)
27. Brem, H., and Folkman, J. Inhibition of tumor angiogenesis mediated by cartilage. J. Exp. Med., 141: 427-439, 1975.
28. Moses, M. A., Sudhalter, J., and Langer, R. Identification of an inhibitor of neovascularization from cartilage. Science (Wash. DC), 248: 1408-1410, 1990.
29. Murray, J. B., Allison, K., Sudhalter, J., and Langer, R. Purification and partial amino acid sequence of a bovine cartilage-derived collagenase inhibitor. J. Biol. Chem., 261: 4154-4159, 1986. (Pubitemid 17198852)
30. Moses, M. A., Wiederschain, D., Wu, I., Fernandez, C. A., Ghazizadeh, V., Lane, W. S., Flynn, E., Sytkowski, A., Tao, T., and Langer, R. Troponin I is present in human cartilage and inhibits angiogenesis. Proc. Natl. Acad. Sci. USA, 96: 2645-2650, 1999. (Pubitemid 29148771)
31. Liang, J. H., and Wong, K. P. The characterization of angiogenesis inhibitor from shark cartilage. Adv. Exp. Med. Biol., 476: 209-223, 2000. (Pubitemid 32176138)
32. Miller, R. R., and McDevitt, C. A. Thrombospondin is present in articular cartilage and is synthesized by articular chondrocytes. Biochem. Biophys. Res. Commun., 153: 708-714, 1988.
33. Liu, N., Lapcevich, R. K., Underhill, C. B., Han, Z., Gao, F., Swartz, G., Plum, S. M., Zhang, L., and Gree, S. J. Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth. Cancer Res., 61: 1022-1028, 2001. (Pubitemid 32174420)
34. Gingras, D., Batist, G., and Béliveau, R. Æ-941 (Neovastat®): a novel multifunctional antiangiogenic compound. Expert Rev. Anticancer Ther., 1: 341-347, 2001. (Pubitemid 34685464)
35. Falardeau, P., Champagne, P., Poyet, P., Hariton, C., and Dupont,É. Æ-941 (Neovastat), a naturally occurring multifunctional antiangiogenic product in Phase III clinical trials. Semin. Oncol., 28: 620-625, 2001. (Pubitemid 33134422)
36. Gingras, D., Renaud, A., Mousseau, N., and Béliveau, R. Shark cartilage extracts as antiangiogenic agents: smart drinks or bitter pills? Cancer Metastasis Rev., 19: 83-86, 2000. (Pubitemid 32004696)
37. Dupont, É., Falardeau, P., Mousa, S. A., Dimitriadou, V., Pépin, M-C., Wang, T., and Alaoui-Jamali, M. A. Antiangiogenic and antimetastatic properties of neovastat (Æ-941), an orally active extract derived from cartilage tissue. Clin Exp Metastasis, 19: 145-153, 2002. (Pubitemid 34264084)
38. Dupont, É., Alaoui-Jamali, M., Wang, T., Doillon, C., Ross, N., Thibodeau, A., Alpert, L., Savard, P., and Falardeau, P. Angiostatic and antitumoral activity of Neovastat (Æ-941), a molecular fraction derived from shark cartilage. Proc. Am. Assoc. Cancer Res., 38: 227, 1997.
39. Castronovo, V., Dimitriadou, V., Savard, P., Rivière, M., and Dupont, E. Cartilage as a source of natural inhibitors of angiogenesis. In: B. Teicher (ed.), Antiangiogenic Agents in Cancer Therapy, pp. 175-183. Totowa, NJ: Humana Press Inc, 1999.
40. Berger, F., Jourde, P., and Benabid, A.-L. Æ-941 (Neovastat) shows a beneficial effect in experimental glioma and is associated with high angiostatin level in treated tumors. Proc. Am. Assoc. Cancer Res., 42: 724, 2001.
41. Gingras, D., Renaud, A., Mousseau, N., Beaulieu, É., Kachra, Z., and Béliveau, R. Matrix proteinase inhibition by Æ-941, a multifunctional antiangiogenic compound. Anticancer Res., 21: 145-155, 2001.
42. Dupont, É., Savard, P. E., Jourdain, C., Juneau, C., Thibodeau, A., Ross, N., Marenus, K., Maes, D. H., Pelletier, G., and Sauder, D. N. Antiangiogenic properties of a novel shark cartilage extract: potential role in the treatment of psoriasis. J. Cutan. Med. Surg., 2: 146-152, 1998. (Pubitemid 28266271)
43. Béliveau, R., Gingras, D., Kruger, E. A., Lamy, S., Sirois, P., Simard, B., Sirois, M. G., Tranqui, L., Baffert, F., Beaulieu, É., Dimitriadou, V., Pépin, M-C., Courjal, F., Ricard, I., Poyet, P., Falardeau, P., Figg, W. D., and Dupont, É. The antiangiogenic agent Neovastat (Æ-941) inhibits VEGF-mediated biological effects. Clin. Cancer Res., 8: 1242-1250, 2002. (Pubitemid 35177381)
44. Berger, F., Jourdes, P., and Benabid, A-L. Æ-941 (Neovastat) shows a beneficial effect in experimental glioma and is associated with high angiostatin level in treated tumors. Proc. Am. Assoc. Cancer Res., 42: 724, 2001.
45. Dupont, É., Brazeau, P., and Juneau, C. Extracts of shark cartilage having an antiangiogenic activity and an effect on tumor progression: process of making thereof. United States Patent, 5,618,925. Washington, D.C.: Government Printing Office, 1997.
46. Ades, E. W., Candal, F. J., Swerlick, R. A., George, V. G., Summers, S., Bosse, D. C., and Lawley, T. J. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J. Investig. Dermatol., 99: 683-690, 1992. (Pubitemid 23002027)
47. Hirt, B. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol., 26: 365-369, 1967.
48. Tang, D. G., Li, L., Zhu, Z., and Joshi, B. Apoptosis in the absence of cytochrome c accumulation in the cytosol. Biochem. Biophys. Res. Commun., 242: 380-384, 1998. (Pubitemid 28412436)
49. Schulze-Osthoff, K., Ferrari, D., Los, M., Wesselborg, S., and Peter, M. E. Apoptosis signaling by death receptors. Eur. J. Biochem., 254: 439-459, 1998. (Pubitemid 28308094)
50. Deveraux, Q. L., Takahashi, R., Salvesen, G. S., and Reed, J. C. X-linked IAP is a direct inhibitor of cell-death proteases. Nature (Lond.), 388: 300-304, 1997. (Pubitemid 27317977)
51. Takahashi, R., Deveraux, Q., Tamm, I., Welsh, K., Assa-Munt, N., Salvesen, G. S., and Reed, J. C. A single BIR domain of XIAP sufficient for inhibiting caspases. J. Biol. Chem., 273: 7787-7790, 1998. (Pubitemid 28168819)
52. Luo, X., Budihardjo, I., Zou, H., Slaughter, C., and Wang, X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 94: 481-490, 1998. (Pubitemid 28391864)
53. Engels, I. H., Stepczynska, A., Stroh, C., Lauber, K., Berg, C., Schwenzer, R., Wajant, H., Janicke, R. U., Porter, A. G., Belka, C., Gregor, M., Schulze-Osthoff, K., and Wesselborg, S. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene, 19: 4563-4573, 2000.