Tailoring in Vitro Selection for a Picomolar Affinity Human Antibody Directed against Vascular Endothelial Growth Factor Receptor 2 for Enhanced Neutralizing Activity

Journal of Biological Chemistry

Volumn 278, Issue 44, 2003, Pages 43496-43507

  Lu, Dan ^a   Shen, Juqun ^a   Vil, Marie D ^a   Zhang, Haifan ^a   Jimenez, Xenia ^a   Bohlen, Peter ^a   Witte, Larry ^a   Zhut, Zhenping ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHEMICAL BONDS; CLONING; DISSOCIATION; IMMUNOLOGY; TUMORS;

ENDOTHELIAL GROWTH FACTORS;

ANTIBODIES;

IMCLONE; IMMUNOGLOBULIN F(AB) FRAGMENT; KDR ANTIBODY; KINASE INSERTING DOMAIN CONTAINING RECEPTOR; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN RECEPTOR 2;

ANTIGEN BINDING; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; METASTASIS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SOLID TUMOR; TUMOR GROWTH; TUMOR VASCULARIZATION;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; ANTIBODIES; CELL LINE, TUMOR; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 0242353266     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307742200     Document Type: Article

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