메뉴 건너뛰기




Volumn 15, Issue 2, 1997, Pages 781-789

Phase I clinical and pharmacokinetic study of oral carboxyamidotriazole, a signal transduction inhibitor

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE;

EID: 0031015772     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1997.15.2.781     Document Type: Article
Times cited : (46)

References (17)
  • 1
    • 0025012854 scopus 로고
    • L651582: A novel antiproliferative and antimetastasis agent
    • Kohn EC, Liotta LA: L651582: A novel antiproliferative and antimetastasis agent. J Natl Cancer Inst 82:54-60, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 54-60
    • Kohn, E.C.1    Liotta, L.A.2
  • 2
    • 0026740712 scopus 로고
    • In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium arachidonate, and inositol phosphates
    • Kohn EC, Sandeen MA, Liotta LA: In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium arachidonate, and inositol phosphates. Cancer Res 52:3208-3212, 1992
    • (1992) Cancer Res , vol.52 , pp. 3208-3212
    • Kohn, E.C.1    Sandeen, M.A.2    Liotta, L.A.3
  • 3
    • 0025043173 scopus 로고
    • Anti-proliferative activity of L-651582 correlates with calcium-mediated regulation of nucleotide metabolism at phosphoribosyl pyrophosphate synthetase
    • Hupe DJ, Behrens ND, Baltz R: Anti-proliferative activity of L-651582 correlates with calcium-mediated regulation of nucleotide metabolism at phosphoribosyl pyrophosphate synthetase. J Cell Physiol 144:457-466, 1990
    • (1990) J Cell Physiol , vol.144 , pp. 457-466
    • Hupe, D.J.1    Behrens, N.D.2    Baltz, R.3
  • 4
    • 0025912644 scopus 로고
    • The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582
    • Hupe DJ, Boltz R, Cohen CJ, et al.: The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582. J Biol Chem 266:10136-10142, 1991
    • (1991) J Biol Chem , vol.266 , pp. 10136-10142
    • Hupe, D.J.1    Boltz, R.2    Cohen, C.J.3
  • 5
    • 0025772585 scopus 로고
    • The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release
    • Felder CC, Ma AL, Liotta LA, et al.: The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J Pharm Exp Ther 257:967-971, 1991
    • (1991) J Pharm Exp Ther , vol.257 , pp. 967-971
    • Felder, C.C.1    Ma, A.L.2    Liotta, L.A.3
  • 6
    • 0028205812 scopus 로고
    • Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI
    • Kohn EC, Felder CC, Jacobs W, et al.: Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI. Cancer Res 54:935-942, 1994
    • (1994) Cancer Res , vol.54 , pp. 935-942
    • Kohn, E.C.1    Felder, C.C.2    Jacobs, W.3
  • 7
    • 0028913347 scopus 로고
    • Angiogenesis: Role of calcium-mediated signal transduction
    • Kohn EC, Alessandro R, Spoonster J, et al.: Angiogenesis: Role of calcium-mediated signal transduction. Proc Natl Acad Sci USA 92:1307-1311, 1995
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1307-1311
    • Kohn, E.C.1    Alessandro, R.2    Spoonster, J.3
  • 8
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82:4-6, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 9
    • 0028040432 scopus 로고
    • Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A)
    • Kohn EC, Jacobs W, Kim YS, et al.: Calcium influx modulates expression of matrix metalloproteinase-2 (72-kDa type IV collagenase, gelatinase A). J Biol Chem 269:21505-21511, 1994
    • (1994) J Biol Chem , vol.269 , pp. 21505-21511
    • Kohn, E.C.1    Jacobs, W.2    Kim, Y.S.3
  • 12
    • 0028945544 scopus 로고
    • Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo
    • Ludden LK, Strong JM, Kohn EC, et al.: Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo. Clin Cancer Res 1:399-405, 1995
    • (1995) Clin Cancer Res , vol.1 , pp. 399-405
    • Ludden, L.K.1    Strong, J.M.2    Kohn, E.C.3
  • 13
    • 9044229717 scopus 로고    scopus 로고
    • Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers
    • Kohn E, Reed E, Sarosy G, et al.: Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers. Cancer Res 56:569-573, 1996
    • (1996) Cancer Res , vol.56 , pp. 569-573
    • Kohn, E.1    Reed, E.2    Sarosy, G.3
  • 14
    • 0028144689 scopus 로고
    • Pain and its treatment in outpatients with metastatic cancer
    • Cleeland CS, Gonin R, Hatfield AK, et al.: Pain and its treatment in outpatients with metastatic cancer. N Engl J Med 330:592-596, 1994
    • (1994) N Engl J Med , vol.330 , pp. 592-596
    • Cleeland, C.S.1    Gonin, R.2    Hatfield, A.K.3
  • 15
    • 0028395482 scopus 로고
    • Pain assessment: Global use of the brief pain inventory
    • Cleeland CS, Ryan KM: Pain assessment: global use of the brief pain inventory. Ann Acad Med Singapore. 23:129-138, 1994
    • (1994) Ann Acad Med Singapore , vol.23 , pp. 129-138
    • Cleeland, C.S.1    Ryan, K.M.2
  • 16
    • 0029011940 scopus 로고
    • When is pain mild, moderate or severe? Grading pain severity by its interference with function
    • Serlin RC, Mendoza TR, Nakamura Y, et al.: When is pain mild, moderate or severe? Grading pain severity by its interference with function. Pain 61:277-284, 1995
    • (1995) Pain , vol.61 , pp. 277-284
    • Serlin, R.C.1    Mendoza, T.R.2    Nakamura, Y.3
  • 17
    • 0029116458 scopus 로고
    • Pharmacokinetics of orally administered carboxyamido-triazole, an inhibitor of calcium-mediated signal transduction
    • Figg WD, Cole KA, Reed E, et al.: Pharmacokinetics of orally administered carboxyamido-triazole, an inhibitor of calcium-mediated signal transduction. Clin Cancer Res 1:797-803, 1995
    • (1995) Clin Cancer Res , vol.1 , pp. 797-803
    • Figg, W.D.1    Cole, K.A.2    Reed, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.