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Volumn 59, Issue 1, 1999, Pages 183-188

Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN VASCULOTROPIN; HYBRID PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

EID: 0032943892     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (115)

References (29)
  • 1
    • 84975525035 scopus 로고
    • Seminars in Medicine of Beth Israel Hospital. Clinical applications of research in angiogenesis
    • Folkman, J. Seminars in Medicine of Beth Israel Hospital. Clinical applications of research in angiogenesis. N. Engl. J. Med., 333: 1757-1763, 1995.
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1757-1763
    • Folkman, J.1
  • 2
    • 0030044984 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, a potent and selective angiogenic agent
    • Thomas, K. A. Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem., 271: 603-606, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 603-606
    • Thomas, K.A.1
  • 3
    • 0030448814 scopus 로고    scopus 로고
    • Blood vessel formation: What is the molecular basis?
    • Folkman, J., and D'Amore, P. A. Blood vessel formation: what is the molecular basis? Cell, 87: 1153-1155, 1996.
    • (1996) Cell , vol.87 , pp. 1153-1155
    • Folkman, J.1    D'Amore, P.A.2
  • 4
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • Fidler, I. J., and Ellis, L. M. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell, 79: 185-188, 1994.
    • (1994) Cell , vol.79 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 5
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim, K., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature (Lond.), 362: 841-844, 1993.
    • (1993) Nature (Lond.) , vol.362 , pp. 841-844
    • Kim, K.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 6
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor: Multiple protein forms are encoded through alternative exon splicing
    • Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., and Abraham, J. A. The human gene for vascular endothelial growth factor: multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem., 266: 11947-11954, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 11947-11954
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3    Silva, M.4    Gospodarowicz, D.5    Fiddes, J.C.6    Abraham, J.A.7
  • 7
    • 0027064888 scopus 로고
    • Dual regulation of vascular endothelial growth factor bioavailabilty by genetic and proteolytic mechanisms
    • Houck, K. A., Leung, D. W., Rowland A. M., Winer, J., and Ferrara, N. Dual regulation of vascular endothelial growth factor bioavailabilty by genetic and proteolytic mechanisms. J. Biol. Chem., 267: 26031-26037, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 26031-26037
    • Houck, K.A.1    Leung, D.W.2    Rowland, A.M.3    Winer, J.4    Ferrara, N.5
  • 8
    • 0029937679 scopus 로고    scopus 로고
    • The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency
    • Keyt, B. A., Berleau, L. T., Nguyen, H. V., Chen, H., Heinsohn, H., Vandeln, R., and Ferrara, N. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem., 271: 7788-7795, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7788-7795
    • Keyt, B.A.1    Berleau, L.T.2    Nguyen, H.V.3    Chen, H.4    Heinsohn, H.5    Vandeln, R.6    Ferrara, N.7
  • 11
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • Washington DC
    • de Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (Washington DC), 255: 989-991, 1992.
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 12
    • 0029920944 scopus 로고    scopus 로고
    • Identification of vascular endothelial growth factor determinants for binding KDR and Flt-1 receptors
    • Keyt, B. A., Nguyen, H. V., Berleau, L. T., Duarte, C. M., Park, J., Chen, H., and Ferrara, N. Identification of vascular endothelial growth factor determinants for binding KDR and Flt-1 receptors. J. Biol. Chem., 271: 5638-5646, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5638-5646
    • Keyt, B.A.1    Nguyen, H.V.2    Berleau, L.T.3    Duarte, C.M.4    Park, J.5    Chen, H.6    Ferrara, N.7
  • 13
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • Millauer, B., Shawver, L. K., Plate, K. H., Risau, W., and Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature (Lond.), 367: 576-579, 1994.
    • (1994) Nature (Lond.) , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 16
    • 0015217329 scopus 로고
    • Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule
    • Drazin, R., Kandel, J., and Collier, R. J. Structure and activity of diphtheria toxin. II. Attack by trypsin at a specific site within the intact toxin molecule. J. Biol. Chem., 246: 1504-1510, 1971.
    • (1971) J. Biol. Chem., 246 , pp. 1504-1510
    • Drazin, R.1    Kandel, J.2    Collier, R.J.3
  • 17
    • 0015217337 scopus 로고
    • Structure and activity of diphtheria toxin. I. Thiol dependent dissociation of a fraction of toxin into enzymatically active and inactive fragments
    • Collier, R. J., and Kandel, J. Structure and activity of diphtheria toxin. I. Thiol dependent dissociation of a fraction of toxin into enzymatically active and inactive fragments. J. Biol. Chem., 246: 1496-1503, 1971.
    • (1971) J. Biol. Chem. , vol.246 , pp. 1496-1503
    • Collier, R.J.1    Kandel, J.2
  • 18
    • 0026609066 scopus 로고
    • Diphtheria toxin and Pseudomonas aeruginosa exotoxin A: Active-site, structure and enzymic mechanism
    • Wilson, B. A., and Collier, R. J. Diphtheria toxin and Pseudomonas aeruginosa exotoxin A: active-site, structure and enzymic mechanism. Curr. Top. Microbiol. Immunol., 175: 27-41, 1992.
    • (1992) Curr. Top. Microbiol. Immunol. , vol.175 , pp. 27-41
    • Wilson, B.A.1    Collier, R.J.2
  • 19
    • 0026328791 scopus 로고
    • Diphtheria toxin receptor binding domain substitution with IL-6: Genetic construction and interleukin-6 receptor specific action of a diphtheria toxin-related interleukin-6 fusion protein
    • Jean, L. L., and Murphy, J. R. Diphtheria toxin receptor binding domain substitution with IL-6: genetic construction and interleukin-6 receptor specific action of a diphtheria toxin-related interleukin-6 fusion protein. Protein Eng., 4: 989-994, 1991.
    • (1991) Protein Eng. , vol.4 , pp. 989-994
    • Jean, L.L.1    Murphy, J.R.2
  • 21
    • 0031017221 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is an autocrine growth factor for AIDS-KS
    • Masood, R., Cai, J., Zheng, T., Smith, D. L., Naidu, Y., and Gill, P. Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is an autocrine growth factor for AIDS-KS. Proc. Natl. Acad. Sci. USA, 94: 979-984, 1997.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 979-984
    • Masood, R.1    Cai, J.2    Zheng, T.3    Smith, D.L.4    Naidu, Y.5    Gill, P.6
  • 22
    • 0025977037 scopus 로고
    • Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase
    • Guan, K., and Dixon, J. E. Eukaryotic proteins expressed in Escherichia coli: an improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase. Anal. Biochem., 192: 262-267, 1991.
    • (1991) Anal. Biochem. , vol.192 , pp. 262-267
    • Guan, K.1    Dixon, J.E.2
  • 23
    • 0028072074 scopus 로고
    • Fusion of anthrax toxin and lethal factor with Shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells Infect
    • Arora, N., and Leppla, S. H. Fusion of anthrax toxin and lethal factor with Shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells Infect. Immun., 62: 4955-4961, 1994.
    • (1994) Immun. , vol.62 , pp. 4955-4961
    • Arora, N.1    Leppla, S.H.2
  • 24
    • 0025353947 scopus 로고
    • Minimizing proteolysis in Escherichia coli genetic solutions
    • Gottesman, S. Minimizing proteolysis in Escherichia coli genetic solutions. Methods Enzymol., 185: 119-129, 1990.
    • (1990) Methods Enzymol. , vol.185 , pp. 119-129
    • Gottesman, S.1
  • 25
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Washington DC
    • Leung, D. W., Cachianes, G., Kuang, W. J., Goddel, D. V., and Ferrara, N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science (Washington DC), 246: 1306-1309, 1989.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goddel, D.V.4    Ferrara, N.5
  • 26
    • 0029915612 scopus 로고    scopus 로고
    • Vascular endothelial growth factor toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo
    • Ramakrishnan, S., Olson, T. A., Bautch, U. L., and Mohanraj, D. Vascular endothelial growth factor toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo. Cancer Res., 56: 1324-1330, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 1324-1330
    • Ramakrishnan, S.1    Olson, T.A.2    Bautch, U.L.3    Mohanraj, D.4
  • 27
    • 0031564123 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: Inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate
    • Olson, A., Mohanraj, D., Roy, S., and Ramakrishnan, S. Targeting the tumor vasculature: inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate. Int. J. Cancer, 73: 865-870, 1997.
    • (1997) Int. J. Cancer , vol.73 , pp. 865-870
    • Olson, A.1    Mohanraj, D.2    Roy, S.3    Ramakrishnan, S.4
  • 28
    • 0029383661 scopus 로고
    • Targeting Pseudomonas exotoxin to hematologic malignancies
    • Krietman, R. J., and Pastan, I. Targeting Pseudomonas exotoxin to hematologic malignancies. Semin. Cancer Biol., 6: 297-306, 1995.
    • (1995) Semin. Cancer Biol. , vol.6 , pp. 297-306
    • Krietman, R.J.1    Pastan, I.2
  • 29
    • 0027441541 scopus 로고
    • Immunotoxin therapy for cancer
    • Pai, L. H., and Pastan, I. Immunotoxin therapy for cancer. J. Am. Med. Assn., 269: 78-81, 1993.
    • (1993) J. Am. Med. Assn. , vol.269 , pp. 78-81
    • Pai, L.H.1    Pastan, I.2


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