Clinical investigation of a cytostatic calcium influx inhibitor in patients with refractory cancers

Cancer Research

Volumn 56, Issue 3, 1996, Pages 569-573

  Kohn, Elise C ^a,c   Reed, Eddie ^a   Sarosy, Gisele ^a   Christian, Michaele ^a   Link, Charles J ^a   Cole, Kristina ^a   Figg, William D ^a   Davis, Patricia A ^a   Jacob, Joan ^a   Goldspiel, Barry ^b   Liotta, Lance A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c Laboratory of Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; CALCIUM CHANNEL BLOCKING AGENT; GELATIN;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; CALCIUM TRANSPORT; CANCER; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; FEMALE; GASTROINTESTINAL TOXICITY; HUMAN; KIDNEY CARCINOMA; LUNG NON SMALL CELL CANCER; MALE; MELANOMA; NEUROTOXICITY; NEUTROPENIA; ORAL DRUG ADMINISTRATION; OVARY CANCER; PANCREAS CARCINOMA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADMINISTRATION, ORAL; ADULT; AGED; ANTINEOPLASTIC AGENTS; CALCIUM CHANNEL BLOCKERS; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; TRIAZOLES;

EID: 9044229717     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Gibbs, J. B., and Oliff, A. Pharmaceutical research in molecular oncology. Cell, 79: 193-198, 1994.
2. Cole, K. A., and Kohn, E. C Calcium-mediated signal transduction, biology, biochemistry, and therapy. Cancer Metastasis Rev., 13: 33-41, 1994.
3. Schipper, H., Goh, C. R., and Wang, T. L Shifting the cancer paradigm: must we kill to cure? J. Clin. Oncol., 13: 801-807, 1995.
4. Powis, G. Signaling targets for anticancer drug development. Trends Pharmacol. Sci., 12: 188-194, 1991.
5. Powis. G. Drugs active against growth factor and oncogene phosphatidylinositol signaling pathways. Semin. Cancer Biol , 3: 343-350, 1992
6. 2+ regulation in platelets. J. Biol. Chem., 268: 2277-2279, 1993.
7. Chapron, Y., Cochet, C , Crouzy, S., Jullien, T , Keramidas, M., and Verdetti, J. Tyrosine protein kinase activity of the EGF receptor is required to induce activation of receptor-operated calcium channels. Biochem. Biophys. Res. Commun., 158: 527-533, 1989.
8. Berridae, M. J., and Irvine, R. F. Inositol phosphates and cell signalling. Nature (Lond.), 341, 197-205, 1989.
9. Gusovsky, F., Lueders, J E., Kohn, E. C., and Felder, C. C. Muscarinic receptor-mediated tyrosine phosphorylation of phospholipase C-γ alternative mechanism for cholinergic receptor-induced phosphoinositide breakdown J. Biol. Chem, 268, 7768-7772, 1993.
10. Rink, T. J Receptor-mediated calcium entry. FEBS Lett., 268: 381-385, 1990.
11. 2+ influx following receptor activation. Trends Pharmacol Sci , 12, 289-292, 1991.
12. Putney, J. W. Excitement about calcium signaling in inexcitable cells Science (Washington DC), 262: 676-678, 1993.
13. Kohn, E. C., and Liotta, L. A. L651582, a novel antiproliferative and antimetastasis agent. J Natl. Cancer Inst , 82: 54-60, 1990.
14. Felder, C. C., Ma, A L., Liotta, L. A., and Kohn, E. C. The antiproliferative and antimetastatic compound L651582, inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J. Pharmacol. Exp. Ther., 257: 967-971, 1991
15. Kohn, E C., Sandeen, M. A., and Liotta, L. A. In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and mositol phosphates. Cancer Res., 52: 3208-3212, 1992.
16. Kohn, E. C., Felder, C. C., Jacobs, W., Holmes, K. A., Day, A F., Freer, R., and Liotta, L. A. Stucture function analysis of signal and growth inhibition by carboxy-amido-triazole, CAI. Cancer Res , 54: 935-942, 1994.
17. Kohn, E. C., Jacobs, W , Kim, Y. S., Alessandro, R., Stetler-Stevenson, W. G., and Liotta, L. A. Calcium influx modulates expression of matrix metalloproteinase-2 (72 kDa type IV collagenase, gelatinase A) expression. J. Biol. Chem., 269: 21505-21511, 1994.
18. Kohn, E. C., Alessandro, R., Spoonster, J., Wersto, R., and Liotta, L. A. Angiogenesis role of calcium-mediated signal transduction. Proc. Natl Acad. Sci. USA, 92: 1307-1311, 1995.
19. Hupe, D. J., Boltz, R., Cohen, C. J., Felix, J., Ham, E., Miller, D., Sodernian, D., and Van Skiver, D. The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582. J. Biol. Chem., 266: 10136-10142, 1991.
20. Holmes, K. A., Chaffins, C , Osborne, B., Liotta, L. A., and Kohn, E. C. Quantitation of plasma levels of a novel anticancer drug, carboxyamido triazole (CAI) by high pressure liquid chromatography. J. Chromatogr. Biomed. Appl., 613: 317-325, 1993.
21. Figg, W. D., Cole, K. A., Reed, E., Steinberg, S. M., Piscitelli, S. C., Davis, P. A., Soltis, M J., Jacob, J., Soudoulas, S., Goldspiel, B., Sarosy, G., Liotta, L. A , and Kohn, E C. Pharmacokinetics of orally administered carboxyamido-triazole (CAI), an inhibitor of calcium-mediated signal transduction. Clin Cancer Res., 1: 797-803, 1995.
22. Ludden, L. K., Strong, J M., Kohn, E. C., and Collins, J. M. Similarity of metabolism for CAI (NSC 609974) in human liver tissue in vitro and in humans in vivo Clin. Cancer Res., 1: 399-405, 1995.
23. Astrow, A. B Commentary. Rethinking cancer. Lancet, 343: 494-495, 1994
24. Levitzki, A. Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction. FASEB J., 6: 3275-3282, 1992.