Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site

Biochemistry

Volumn 37, Issue 51, 1998, Pages 17754-17764

  Fairbrother, Wayne J ^a   Christinger, Hans W ^a   Cochran, Andrea G ^a   Fuh, Germaine ^a   Keenan, Christopher J ^a   Quan, Clifford ^a   Shriver, Stephanie K ^a   Tom, Jeffrey Y K ^a   Wells, James A ^a,b   Cunningham, Brian C ^a,b  

^a GENENTECH INC   (United States)

^b Sunesis Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE DERIVATIVE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RECEPTOR BINDING; VASCULAR ENDOTHELIUM;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CELL DIVISION; CELLS, CULTURED; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; GROWTH INHIBITORS; HUMANS; LYMPHOKINES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE LIBRARY; PEPTIDES; RANDOM ALLOCATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032559040     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981931e     Document Type: Article

References (53)

1. Dvorak, H. F., Brown, L. F., Detmar, M., and Dvorak, A. M. (1995) Am. J. Pathol. 146, 1029-1039.
2. Ferrara, N. (1995) Breast Cancer Res. Treat. 36, 127-137.
3. Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., and Ferrara, N. (1989) Science 246, 1306-1309.
4. Keck, P. J., Hauser, S. D., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Connolly, D. T. (1989) Science 246, 1309-1312.
5. Houck, K. A., Ferrara, N., Winer, J., Cachianes, G., Li, B., and Leung, D. W. (1991) Mol. Endocrinol. 5, 1806-1814.
6. Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D., Fiddes, J. C., and Abraham, J. A. (1991) J. Biol. Chem. 266, 11947-11954.
7. Poltorak, Z., Cohen, T., Sivan, R., Kandelis, Y., Spira, G., Vlodavsky, I., Keshet, E., and Neufeld, G. (1997) J. Biol. Chem. 272, 7151-7158.
8. Keyt, B. A., Berleau, L. T., Nguyen, H. V., Chen, H., Heinsohn, H., Vandlen, R., and Ferrara, N. (1996) J. Biol. Chem. 271, 7788-7795.
9. Fairbrother, W. J., Champe, M. A., Christinger, H. W., Keyt, B. A., and Starovasnik, M. A. (1998) Structure 6, 637-648.
10. Terman, B. C., Dougher-Vermazen, M., Carrion, M. E., Dimitrov, D., Armellino, D. C., Gospodarowicz, D., and Böhlen, P. (1992) Biochem. Biophys. Res. Commun. 187, 1579-1586.
11. Millauer, B., Wizigmann-Voos, S., Schnurch, H., Martinez, R., Moller, N. P. H., Risau, W., and Ullrich, A. (1993) Cell 72, 835-846.
12. de Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. (1992) Science 255, 989-991.
13. Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., and Schuh, A. C. (1995) Nature 376, 62-6.
14. Shalaby, F., Ho, J., Stanford, W. L., Fischer, K.-D., Schuh, A. C., Schwartz, L., Bernstein, A., and Rossant, J. (1997) Cell 89, 981-90.
15. Fong, G.-H., Rossant, J., Gertsenstein, M., and Breitman, M. L. (1995) Nature 376, 66-70.
16. Fong, G.-H., Klingensmith, J., Wood, C. R., Rossant, J., and Breitman, M. L. (1996) Dev. Dyn. 207, 1-10.
17. Keyt, B. A., Nguyen, H. V., Berleau, L. T., Duarte, C. M., Park, J., Chen, H., and Ferrara, N. (1996) J. Biol. Chem. 271, 5638-5646.
18. Muller, Y. A., Li, B., Christinger, H. W., Wells, J. A., Cunningham, B. A., and de Vos, A. M. (1997) Proc. Nat. Acad. Sci. 94, 7192-7197.
19. Wiesmann, C., Fuh, G., Christinger, H. W., Eigenbrot, C., Wells, J. A., and de Vos, A. M. (1997) Cell 91, 695-704.
20. Fuh, G., Li, B., Crowley, C., Cunningham, B. C., and Wells, J. A. (1998) J. Biol. Chem. 273, 11197-11204.
21. Folkman, J. (1995) Nat. Med. 1, 27-31.
22. Kim, K. J., Li, B., Houck, K., Winer, J., and Ferrara, N. (1992) Growth Factors 7, 53-64.
23. Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. (1993) Nature 362, 841-844.
24. Jellinek, D., Green, L. S., Bell, C., and Janjic, N. (1994) Biochemistry 33, 10450-10456.
25. Plate, K. H., Breier, G., and Risau, W. (1994) Brain-Pathol. 4, 207-218.
26. Muller, Y. A., Chen, Y., Christinger, H. W., Li, B., Cunningham, B. C., Lowman, H. B., and de Vos, A. M. (1998) Structure 6, 1153-1167.
27. Wrighton, N., Farrell, F., Chang, R., Kashyap, A., Barbone, F., Mulcahy, L., Johnson, D., Barrett, R., Jolliffe, L., and Dower, W. (1996) Science 273, 458-463.
28. Christinger, H. W., Muller, Y. A., Berleau, L. T., Keyt, B. A., Cunningham, B. C., Ferrara, N., and de Vos, A. M. (1996) Proteins: Struct., Funct., Genet. 26, 353-357.
29. Fairbrother, W. J., Champe, M. A., Christinger, H. W., Keyt, B. A., and Starovasnik, M. A. (1997) Protein Sci. 6, 2250-2260.
30. Lowman, H. B., Chen, Y. M., Skelton, N. J., Mortensen, D. L., Tomlinson, E. E., Sadick, M. D., Robinson, I. C. A. F., and Clark, R. G. (1998) Biochemistry 37, 8870-8878.
31. Bass, S. H., Greene, R., and Wells, J. A. (1990) Proteins: Struct., Funct., Genet. 8, 309-314.
32. Lowman, H. B. (1998) Methods Mol. Biol. 87, 249-264.
33. Cavanagh, J., Fairbrother, W. J., Palmer, A. G., III, and Skelton, N. J. (1995) Protein NMR spectroscopy: principles and practice, Academic Press, San Diego.
34. van Zijl, P. C. M., O'Neil-Johnson, M., Mori, S., and Hurd, R. E. (1995) J. Magn. Reson., Ser. A, 113, 265-270.
35. Hwang, T.-L., and Shaka, A. J. (1995) J. Magn. Reson., Ser. A, 112, 275-279.
36. Cavanagh, J., and Rance, M. (1992) J. Magn. Reson. 96, 670-678.
37. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons, Inc., New York.
38. Grzesiek, S., and Bax, A. (1993) J. Am. Chem. Soc. 115, 12593-12594.
39. Edelhoch, H. (1967) Biochemistry 6, 1948-1954.
40. Gill, S. C., and von Hippel, P. H. (1989) Anal. Biochem. 182, 319-326.
41. Livnah, O., Stura, E. A., Johnson, D. L., Middleton, S. A., Mulcahy, L. S., Wrightson, N. C., Dower, W. J., Jolliffe, L. K., and Wilson, I. A. (1996) Science 273, 464-471.
42. Cunningham, B. C., Lowe, D. G., Li, B., Bennett, B. D., and Wells, J. A. (1994) EMBO J. 13, 2508-2515.
43. Lowman, H. B., and Wells, J. A. (1993) J. Mol. Biol. 234, 564-578.
44. Wiesmann, C., Christinger, H. W., Cochran, A. G., Cunningham, B. C., Fairbrother, W. J., Keenan, C. J., Meng, G., and de Vos, A. M. (1998) Biochemistry 38, 17765-17772.
45. Spitzfaden, C., Weber, H.-P., Braun, W., Kallen, J., Wider, G., Widmer, H., Walkinshaw, M. D., and Wüthrich, K. (1992) FEBS Lett. 300, 291-300.
46. Chen, Y., Reizer, J., Saier, M. H., Jr., Fairbrother, W. J., and Wright, P. E. (1993) Biochemistry 32, 32-37.
47. Kay, B. K., Adey, N. B., He, Y.-S., Manfredi, J. P., Mataragnon, A. H., and Fowlkes, D. M. (1993) Gene 128, 59-65.
48. McDowell, R. S., Gadek, T. R., Barker, P. L., Burdick, D. J., Chan, K. S., Quan, C. L., Skelton, N., Struble, M., Thorsett, E. D., Tischler, M., Tom, J. Y. K., Webb, T. R., and Burnier, J. P. (1994) J. Am. Chem. Soc. 116, 5069-5076.
49. McDowell, R. S., Blackburn, B. K., Gadek, T. R., McGee, L. R., Rawson, T., Reynolds, M. E., Robarge, K. D., Somers, T. C., Thorsett, E. D., Tischler, M., Webb, R. R., II, and Venuti, M. C. (1994) J. Am. Chem. Soc. 116, 5077-5083.
50. McDowell, R. S., Elias, K. A., Stanley, M. S., Burdick, D. J., Burnier, J. P., Chan, K. S., Fairbrother, W. J., Hammonds, R. G., Ingle, G. S., Jacobsen, N. E., Mortensen, D. L., Rawson, T. E., Won, W. B., Clark, R. G., and Somers, T. C. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 11165-11169.
51. Muller, Y. A., Christinger, H. W., Keyt, B. A., and de Vos, A. M. (1997) Structure 5, 1325-1338.
52. Presta, L. G., Chen, H., O'Connor, S. J., Chisholm, V., Meng, Y. G., Krummen, L., Winkler, M., and Ferrara, N. (1997) Cancer Res. 57, 4593-4599.
53. Koradi, R., Billeter, M., and Wüthrich, K. (1996) J. Mol. Graphics 14, 51-55.