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Volumn 18, Issue 1, 2000, Pages 178-186

Phase I and pharmacologic study of the specific matrix metalloproteinase inhibitor BAY 12-9566 on a protracted oral daily dosing schedule in patients with solid malignancies

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE INHIBITOR; TANOMASTAT;

EID: 0033986165     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/jco.2000.18.1.178     Document Type: Article
Times cited : (80)

References (48)
  • 1
    • 0026896029 scopus 로고
    • The matrix-degrading metalloproteinases
    • Matrisian LM: The matrix-degrading metalloproteinases. Bioessays 14:455-463, 1992
    • (1992) Bioessays , vol.14 , pp. 455-463
    • Matrisian, L.M.1
  • 2
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers AF, Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89:1260-1270, 1997
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 4
    • 0030723230 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: Present achievements and future prospects
    • Denis LJ, Verweij J: Matrix metalloproteinase inhibitors: Present achievements and future prospects. Invest New Drugs 15:175-185, 1997
    • (1997) Invest New Drugs , vol.15 , pp. 175-185
    • Denis, L.J.1    Verweij, J.2
  • 5
    • 0027140406 scopus 로고
    • Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastases
    • Stetler-Stevenson WG, Liotta LA, Kleiner DE Jr: Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastases. FASEB J 7:1434-1441, 1993
    • (1993) FASEB J , vol.7 , pp. 1434-1441
    • Stetler-Stevenson, W.G.1    Liotta, L.A.2    Kleiner D.E., Jr.3
  • 6
    • 0024394212 scopus 로고
    • Tissue inhibitor of metalloproteinase (TIMP-2): A new member of the metalloproteinase inhibitor family
    • Stetler-Stevenson WG, Krutzsch HC, Liotta L: Tissue inhibitor of metalloproteinase (TIMP-2): A new member of the metalloproteinase inhibitor family. J Biol Chem 264:17374-17378, 1989
    • (1989) J Biol Chem , vol.264 , pp. 17374-17378
    • Stetler-Stevenson, W.G.1    Krutzsch, H.C.2    Liotta, L.3
  • 7
    • 0028244447 scopus 로고
    • Tissue inhibitor of metalloproteinases-3 (TIMP-3) as an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues
    • Leco KJ, Khokha R, Pavloff N, et al: Tissue inhibitor of metalloproteinases-3 (TIMP-3) as an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues. J Biol Chem 269:9352-9360, 1994
    • (1994) J Biol Chem , vol.269 , pp. 9352-9360
    • Leco, K.J.1    Khokha, R.2    Pavloff, N.3
  • 8
    • 0026425631 scopus 로고
    • Tumor invasion and metastasis: An imbalance of positive and negative regulation
    • Liotta LA, Stetler-Stevenson WG: Tumor invasion and metastasis: An imbalance of positive and negative regulation. Cancer Res 51:5054s-5059s, 1991 (suppl 18)
    • (1991) Cancer Res , vol.51 , Issue.SUPPL. 18
    • Liotta, L.A.1    Stetler-Stevenson, W.G.2
  • 11
    • 0028073883 scopus 로고
    • The role of metalloproteinases and their inhibitors in tumour invasion, metastasis, and angiogenesis
    • Ray JM, Stetler-Stevenson WG: The role of metalloproteinases and their inhibitors in tumour invasion, metastasis, and angiogenesis. Eur Respir J 7:2062-2072, 1994
    • (1994) Eur Respir J , vol.7 , pp. 2062-2072
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 12
    • 0029052883 scopus 로고
    • Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors
    • Khokha R, Martin DC, Fata JE: Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors. Cancer Metastasis Rev 14:97-111, 1995
    • (1995) Cancer Metastasis Rev , vol.14 , pp. 97-111
    • Khokha, R.1    Martin, D.C.2    Fata, J.E.3
  • 13
    • 84871474517 scopus 로고    scopus 로고
    • Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94)
    • Watson SA, Morris TM, Robinson G, et al: Inhibition of organ invasion by the matrix metalloproteinase inhibitor batimastat (BB-94). Cancer Res 56:2815-2822, 1996
    • (1996) Cancer Res , vol.56 , pp. 2815-2822
    • Watson, S.A.1    Morris, T.M.2    Robinson, G.3
  • 14
    • 0028346025 scopus 로고
    • Direct evidence linking expression of matrix metalloproteinase 9 (92 kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells
    • Bernhard EJ, Gruber SB, Muschel RJ: Direct evidence linking expression of matrix metalloproteinase 9 (92 kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA 91:4293-4297, 1994
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4293-4297
    • Bernhard, E.J.1    Gruber, S.B.2    Muschel, R.J.3
  • 15
    • 84871473057 scopus 로고
    • Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase I mRNA expression in human colorectal cancer and liver metastases
    • Zeng ZS, Guillem JG: Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase I mRNA expression in human colorectal cancer and liver metastases. Br J Cancer 67:1126-1131, 1993
    • (1993) Br J Cancer , vol.67 , pp. 1126-1131
    • Zeng, Z.S.1    Guillem, J.G.2
  • 16
    • 0009708546 scopus 로고    scopus 로고
    • Prediction of colorectal cancer relapse and survival via tissue RNA levels of matrix metalloproteinase-9
    • Zeng ZS, Huang Y, Cohen AM, et al: Prediction of colorectal cancer relapse and survival via tissue RNA levels of matrix metalloproteinase-9. J Clin Oncol 14:3133-3140, 1996
    • (1996) J Clin Oncol , vol.14 , pp. 3133-3140
    • Zeng, Z.S.1    Huang, Y.2    Cohen, A.M.3
  • 17
    • 0029034457 scopus 로고
    • Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)
    • Friedman R, Toth M, Pena D, et al: Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res 55:2528-2555, 1995
    • (1995) Cancer Res , vol.55 , pp. 2528-2555
    • Friedman, R.1    Toth, M.2    Pena, D.3
  • 18
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta LA, Steeg PS, Stetler-Stevenson WG: Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 64:327-336, 1991
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 19
    • 0028948844 scopus 로고
    • Gelatinase A activity directly modulates melanoma cell adhesion and spreading
    • Ray JM, Stetler-Stevenson WG: Gelatinase A activity directly modulates melanoma cell adhesion and spreading. EMBO J 14:908-917, 1995
    • (1995) EMBO J , vol.14 , pp. 908-917
    • Ray, J.M.1    Stetler-Stevenson, W.G.2
  • 20
    • 0031776982 scopus 로고    scopus 로고
    • Phase I trial of marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer
    • Wojtowicz-Praga S, Torri J, Johnson M, et al: Phase I trial of marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancer. J Clin Oncol 16:2150-2156, 1998
    • (1998) J Clin Oncol , vol.16 , pp. 2150-2156
    • Wojtowicz-Praga, S.1    Torri, J.2    Johnson, M.3
  • 21
    • 0027014484 scopus 로고
    • Characterization of metalloproteinases and tissue inhibitors of metalloproteinases in human plasma
    • Moutsiakis D, Mancuso P, Krutzsch H, et al: Characterization of metalloproteinases and tissue inhibitors of metalloproteinases in human plasma. Connective Tissue Res 28:213-230, 1992
    • (1992) Connective Tissue Res , vol.28 , pp. 213-230
    • Moutsiakis, D.1    Mancuso, P.2    Krutzsch, H.3
  • 23
    • 0030839472 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition as a novel anticancer strategy: A review with special focus on batimastat and marimastat
    • Rasmussen HS, McCann PP: Matrix metalloproteinase inhibition as a novel anticancer strategy: A review with special focus on batimastat and marimastat. Pharm Ther 75:69-75, 1997
    • (1997) Pharm Ther , vol.75 , pp. 69-75
    • Rasmussen, H.S.1    McCann, P.P.2
  • 24
    • 0001419988 scopus 로고    scopus 로고
    • BAY 12-9566, a novel, biphenyl matrix metalloproteinase inhibitor, demonstrates anti-invasive and anti-angiogenic properties
    • abstr 2063
    • Hibner B, Card A, Flynn C, et al: BAY 12-9566, a novel, biphenyl matrix metalloproteinase inhibitor, demonstrates anti-invasive and anti-angiogenic properties. Proc Am Assoc Cancer Res 39:302, 1998 (abstr 2063)
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 302
    • Hibner, B.1    Card, A.2    Flynn, C.3
  • 25
    • 0001845325 scopus 로고    scopus 로고
    • Activity of the matrix metalloproteinase inhibitor BAY 12-9566 against murine subcutaneous and metastatic in vivo models
    • Hibner B, Bull C, Flynn C, et al: Activity of the matrix metalloproteinase inhibitor BAY 12-9566 against murine subcutaneous and metastatic in vivo models. Ann Oncol 9:75, 1998 (suppl 2)
    • (1998) Ann Oncol , vol.9 , Issue.SUPPL. 2 , pp. 75
    • Hibner, B.1    Bull, C.2    Flynn, C.3
  • 26
    • 0001419989 scopus 로고    scopus 로고
    • Activity of the biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in murine in vivo models
    • abstr 2062
    • Bull C, Flynn C, Eberwein D, et al: Activity of the biphenyl matrix metalloproteinase inhibitor BAY 12-9566 in murine in vivo models. Proc Am Assoc Cancer Res 39:302, 1998 (abstr 2062)
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 302
    • Bull, C.1    Flynn, C.2    Eberwein, D.3
  • 27
    • 4243853430 scopus 로고    scopus 로고
    • Anti-angiogenic activity of BAY 12-9566, an inhibitor of matrix metalloproteinase
    • Gatto C, Rieppi M, Borsotti P, et al: Anti-angiogenic activity of BAY 12-9566, an inhibitor of matrix metalloproteinase. Ann Oncol 9:74, 1998 (suppl 2)
    • (1998) Ann Oncol , vol.9 , Issue.SUPPL. 2 , pp. 74
    • Gatto, C.1    Rieppi, M.2    Borsotti, P.3
  • 28
    • 0000823543 scopus 로고    scopus 로고
    • Anti-metastatic activity of BAY 12-9566 in a human colon carcinoma HCT116 orthotopic model
    • abstr 2057
    • Flynn C, Bull C, Eberwein D, et al: Anti-metastatic activity of BAY 12-9566 in a human colon carcinoma HCT116 orthotopic model. Proc Am Assoc Cancer Res 39:301, 1998 (abstr 2057)
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 301
    • Flynn, C.1    Bull, C.2    Eberwein, D.3
  • 29
    • 0002287775 scopus 로고    scopus 로고
    • Anti-invasive and antimetastatic activity of the novel MMP inhibitor BAY 12-9566 in subcutaneous and orthotopic models using the human colon carcinoma, HCT 116
    • Flynn C, Bull C, Matherne C, et al: Anti-invasive and antimetastatic activity of the novel MMP inhibitor BAY 12-9566 in subcutaneous and orthotopic models using the human colon carcinoma, HCT 116. Ann Oncol 9:75, 1998 (suppl 2)
    • (1998) Ann Oncol , vol.9 , Issue.SUPPL. 2 , pp. 75
    • Flynn, C.1    Bull, C.2    Matherne, C.3
  • 30
    • 0000520907 scopus 로고    scopus 로고
    • Preclinical drug safety profile for the anti-metastatic matrix metalloproteinase inhibitory agent BAY 12-9566
    • Clemens GR, Detzer K, Bomhard E, et al: Preclinical drug safety profile for the anti-metastatic matrix metalloproteinase inhibitory agent BAY 12-9566. Ann Oncol 9:74, 1998 (suppl 2)
    • (1998) Ann Oncol , vol.9 , Issue.SUPPL. 2 , pp. 74
    • Clemens, G.R.1    Detzer, K.2    Bomhard, E.3
  • 31
    • 0001719456 scopus 로고    scopus 로고
    • Comparative pharmacokinetics of BAY 12-9566, a metalloproteinase inhibitor, in healthy volunteers and cancer patients
    • abstr 3547
    • Shah A, Sundaresan P, Humphrey R, et al: Comparative pharmacokinetics of BAY 12-9566, a metalloproteinase inhibitor, in healthy volunteers and cancer patients. Proc Am Assoc Cancer Res 39:521, 1998 (abstr 3547)
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 521
    • Shah, A.1    Sundaresan, P.2    Humphrey, R.3
  • 32
    • 0006176886 scopus 로고    scopus 로고
    • Pharmacokinetics of BAY 12-9566 in animals: Species comparison
    • abstr 2589
    • Brubaker WF, Perrino P, Wu W, et al: Pharmacokinetics of BAY 12-9566 in animals: Species comparison. Proc Am Assoc Can Res 40:391, 1999 (abstr 2589)
    • (1999) Proc Am Assoc Can Res , vol.40 , pp. 391
    • Brubaker, W.F.1    Perrino, P.2    Wu, W.3
  • 33
    • 0032989196 scopus 로고    scopus 로고
    • Quantitative HPLC analysis of 4-[4-4-(chloropheyl)phenyl]-4-oxo-2S-(phenylthiomethyl) butanoic acid (BAY 12-9566), a metalloproteinase inhibitor and its metabolites in human plasma
    • Agarwal VK, Rose DL, Krol GJ: Quantitative HPLC analysis of 4-[4-4-(chloropheyl)phenyl]-4-oxo-2S-(phenylthiomethyl) butanoic acid (BAY 12-9566), a metalloproteinase inhibitor and its metabolites in human plasma. J Liq Chromo Rel Technol 22:1893-1906, 1999
    • (1999) J Liq Chromo Rel Technol , vol.22 , pp. 1893-1906
    • Agarwal, V.K.1    Rose, D.L.2    Krol, G.J.3
  • 34
    • 14444284598 scopus 로고    scopus 로고
    • Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biologically active and tolerable dose for longer-term studies
    • Neumanaitis J, Poole C, Primrose J, et al: Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biologically active and tolerable dose for longer-term studies. Clin Can Res 45:1101-1119, 1998
    • (1998) Clin Can Res , vol.45 , pp. 1101-1119
    • Neumanaitis, J.1    Poole, C.2    Primrose, J.3
  • 35
    • 0031882946 scopus 로고    scopus 로고
    • Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers
    • Millar AW, Brown PD, Moore J, et al: Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers. Br J Clin Pharmacol 45:21-26, 1998
    • (1998) Br J Clin Pharmacol , vol.45 , pp. 21-26
    • Millar, A.W.1    Brown, P.D.2    Moore, J.3
  • 36
    • 0000100116 scopus 로고    scopus 로고
    • Phase I study of BAY 12-9566: A matrix metalloproteinase inhibitor
    • abstr 837
    • Erlichman C, Adjei A, Alberts, S, et al: Phase I study of BAY 12-9566: A matrix metalloproteinase inhibitor. Proc Am Soc Clin Oncol 17:217a, 1998 (abstr 837)
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Erlichman, C.1    Adjei, A.2    Alberts, S.3
  • 37
    • 0002930613 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the matrix metalloproteinase inhibitor BAY 12-9566
    • abstr 822
    • Grochow LB, O'Reilly S, Humphrey R, et al: Phase I and pharmacokinetic study of the matrix metalloproteinase inhibitor BAY 12-9566. Proc Am Soc Clin Oncol 17:213a, 1998 (abstr 822)
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Grochow, L.B.1    O'Reilly, S.2    Humphrey, R.3
  • 38
    • 0000100115 scopus 로고    scopus 로고
    • Phase I study of the matrix metalloproteinase inhibitor (MMPI) BAY 12-9566 in patients with advanced cancer
    • abstr 840
    • Goel R, Hirte H, Goel R, et al: Phase I study of the matrix metalloproteinase inhibitor (MMPI) BAY 12-9566 in patients with advanced cancer. Proc Am Soc Clin Oncol 17:217a, 1998 (abstr 840)
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Goel, R.1    Hirte, H.2    Goel, R.3
  • 39
    • 0027451998 scopus 로고
    • Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production
    • Azzam HS, Arand G, Lippman ME, et al: Association of MMP-2 activation potential with metastatic progression in human breast cancer cell lines independent of MMP-2 production. J Natl Cancer Inst 85:1758-1764, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1758-1764
    • Azzam, H.S.1    Arand, G.2    Lippman, M.E.3
  • 40
    • 0028658361 scopus 로고
    • Plasma assay of matrix metalloproteinases (MMPs) and MMP-inhibitor complexes in cancer: Potential use in predicting metastasis and monitoring treatment
    • Zucker S, Lysik RM, Zarrabi HM, et al: Plasma assay of matrix metalloproteinases (MMPs) and MMP-inhibitor complexes in cancer: Potential use in predicting metastasis and monitoring treatment. Ann NY Acad Sci 732:248-262, 1994
    • (1994) Ann NY Acad Sci , vol.732 , pp. 248-262
    • Zucker, S.1    Lysik, R.M.2    Zarrabi, H.M.3
  • 41
    • 0025924794 scopus 로고
    • Increased expression of the Mr 72,000 type IV collagenase in human colonie adenocarcinoma
    • Levy TD, Cioce V, Sobel ME, et al: Increased expression of the Mr 72,000 type IV collagenase in human colonie adenocarcinoma. Cancer Res 51:439-444, 1994
    • (1994) Cancer Res , vol.51 , pp. 439-444
    • Levy, T.D.1    Cioce, V.2    Sobel, M.E.3
  • 42
    • 0027388922 scopus 로고
    • r 92,000 type IV collagenase is increased in plasma of patients with colon and breast cancer
    • r 92,000 type IV collagenase is increased in plasma of patients with colon and breast cancer. Cancer Res 53:140-146, 1993
    • (1993) Cancer Res , vol.53 , pp. 140-146
    • Zucker, S.1    Lysik, R.M.2    Zarrabi, M.H.3
  • 43
    • 0027469921 scopus 로고
    • Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small cell lung carcinoma
    • Brown PD, Bloxidge RE, Stuart NSA, et al: Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small cell lung carcinoma. J Natl Cancer Inst 85:574-578, 1993
    • (1993) J Natl Cancer Inst , vol.85 , pp. 574-578
    • Brown, P.D.1    Bloxidge, R.E.2    Stuart, N.S.A.3
  • 44
    • 0032926187 scopus 로고    scopus 로고
    • Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients
    • Iizasa T, Fujisawa T, Suzuki M, et al: Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients. Clin Cancer Res 5:149-153, 1999
    • (1999) Clin Cancer Res , vol.5 , pp. 149-153
    • Iizasa, T.1    Fujisawa, T.2    Suzuki, M.3
  • 45
    • 0032054579 scopus 로고    scopus 로고
    • Increased incidence of matrix metalloproteinases in urine and cancer patients
    • Moses M, Wiederschain D, Loughlin KR, et al: Increased incidence of matrix metalloproteinases in urine and cancer patients. Cancer Res 58:1395-1399, 1998
    • (1998) Cancer Res , vol.58 , pp. 1395-1399
    • Moses, M.1    Wiederschain, D.2    Loughlin, K.R.3
  • 46
    • 0029847630 scopus 로고    scopus 로고
    • Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer
    • Wojtowicz-Praga S, Low J, Marshall J, et al: Phase I trial of a novel matrix metalloproteinase inhibitor batimastat (BB-94) in patients with advanced cancer. Invest New Drug 14:193-202, 1996
    • (1996) Invest New Drug , vol.14 , pp. 193-202
    • Wojtowicz-Praga, S.1    Low, J.2    Marshall, J.3
  • 47
    • 0027014484 scopus 로고
    • Characterization of metalloproteinases and tissue inhibitors of metalloproteinases in human plasma
    • Moutsiakis D, Mancuso P, Krutzsch H, et al: Characterization of metalloproteinases and tissue inhibitors of metalloproteinases in human plasma. Connective Tissue Res 28:213-230, 1992
    • (1992) Connective Tissue Res , vol.28 , pp. 213-230
    • Moutsiakis, D.1    Mancuso, P.2    Krutzsch, H.3
  • 48
    • 0026921109 scopus 로고
    • Type IV collagenase/ gelatinase (MMP-2) is not increased in plasma of patients with cancer
    • Zucker S, Lysik RM, Zarrabi MH, et al: Type IV collagenase/ gelatinase (MMP-2) is not increased in plasma of patients with cancer. Cancer Epidemiol Biomarkers Prev 1:475-479, 1992
    • (1992) Cancer Epidemiol Biomarkers Prev , vol.1 , pp. 475-479
    • Zucker, S.1    Lysik, R.M.2    Zarrabi, M.H.3


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