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Volumn 59, Issue 21, 1999, Pages 5536-5541

Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; SEMAXANIB; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

EID: 0033229939     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (102)

References (69)
  • 2
    • 0031832226 scopus 로고    scopus 로고
    • Neurogenic sarcomas: Experience at the University of Toronto
    • Angelov, L., Davis, A., O'Sullivan, B., Bell, R., and Guha, A. Neurogenic sarcomas: experience at the University of Toronto. Neurosurgery, 43: 56-65, 1998.
    • (1998) Neurosurgery , vol.43 , pp. 56-65
    • Angelov, L.1    Davis, A.2    O'Sullivan, B.3    Bell, R.4    Guha, A.5
  • 3
    • 0026639806 scopus 로고
    • Angiogenesis
    • Folkman, J., and Shing, Y. Angiogenesis. J. Biol. Chem., 267: 10931-10934, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10931-10934
    • Folkman, J.1    Shing, Y.2
  • 4
    • 0026319891 scopus 로고
    • Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor
    • Hori, A., Sasada, R., Matsutani, E., Naito, K., Sakura, Y., Fujita, T., and Kozai, Y. Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor. Cancer Res., 51: 6180-6184, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 6180-6184
    • Hori, A.1    Sasada, R.2    Matsutani, E.3    Naito, K.4    Sakura, Y.5    Fujita, T.6    Kozai, Y.7
  • 5
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Lond.
    • Kim, K. J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H. S., and Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature (Lond.), 362: 841-844, 1993.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 6
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
    • Lond.
    • Millauer, B., Shawver, L. K., Plate, K. H., Risau, W., and Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature (Lond.), 367: 576-579, 1994.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3    Risau, W.4    Ullrich, A.5
  • 7
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 285: 1182-1186, 1971.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 8
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 82: 4-6, 1990.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 4-6
    • Folkman, J.1
  • 9
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon, T., Hemo, I., Itin, A., Peer, J., Stone, J., and Keshet, E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med., 1: 1024-1028, 1995.
    • (1995) Nat. Med. , vol.1 , pp. 1024-1028
    • Alon, T.1    Hemo, I.2    Itin, A.3    Peer, J.4    Stone, J.5    Keshet, E.6
  • 10
    • 0024801035 scopus 로고
    • Vascular permeability factor, an endothelial cell mitogen related to PDGF
    • Washington DC
    • Keck, P. J., Hauser, S., Krivi, G., Sanzo, K., Warren, T., Feder, J., and Conolly, D. T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science (Washington DC), 246: 1309-1312, 1989.
    • (1989) Science , vol.246 , pp. 1309-1312
    • Keck, P.J.1    Hauser, S.2    Krivi, G.3    Sanzo, K.4    Warren, T.5    Feder, J.6    Conolly, D.T.7
  • 12
    • 0032559597 scopus 로고    scopus 로고
    • Vascular endothelial growth factor induces endothelial fenestrations in vitro
    • Esser, S., Wolburg, K., Breier, G., Kurzchalia, T., and Risau, W. Vascular endothelial growth factor induces endothelial fenestrations in vitro. J. Cell Biol., 140: 947-959, 1998.
    • (1998) J. Cell Biol. , vol.140 , pp. 947-959
    • Esser, S.1    Wolburg, K.2    Breier, G.3    Kurzchalia, T.4    Risau, W.5
  • 13
    • 0031045279 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts, W. G., and Palade, G. E. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res., 57: 765-772, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 14
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
    • Lond.
    • Plate, K. H., Breier, G., Weich, H. A., and Risau, W. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature (Lond.), 359: 845-848, 1992.
    • (1992) Nature , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 15
    • 0029935566 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, its receptor and other angiogenic factors in breast cancer
    • Yoshiji, H., Gomez, D. E., Shibuya, M., and Thorgeirsson, U. P. Expression of vascular endothelial growth factor, its receptor and other angiogenic factors in breast cancer. Cancer Res., 56: 2013-2016, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 2013-2016
    • Yoshiji, H.1    Gomez, D.E.2    Shibuya, M.3    Thorgeirsson, U.P.4
  • 16
    • 0028920358 scopus 로고
    • Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors
    • Samoto, K., Ikezaki, K., Ono, M., Shono, T., Kimitoshi, K., Kuwano, M., and Fukui, M. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Res., 55: 1189-1193, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 1189-1193
    • Samoto, K.1    Ikezaki, K.2    Ono, M.3    Shono, T.4    Kimitoshi, K.5    Kuwano, M.6    Fukui, M.7
  • 17
    • 0028822834 scopus 로고
    • Mutant ras oncogenes up-regulate VEGF/VPF expression: Implications of induction and inhibition of tumor angiogenesis
    • Rak, J., Mitsuhashi, Y., Bayko, L., Filmus, J., Shirasawa, S., Sasazuki, T., and Kerbel, R. S. Mutant ras oncogenes up-regulate VEGF/VPF expression: implications of induction and inhibition of tumor angiogenesis. Cancer Res., 55: 4575-4580, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirasawa, S.5    Sasazuki, T.6    Kerbel, R.S.7
  • 18
    • 0027482251 scopus 로고
    • Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract
    • Brown, L. F., Berse, B., Jackman, R. W., Tognazzi, K., Manseau, E. J., Senger, D. R., and Dvorak, H. F. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res., 53: 4727-4735, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 4727-4735
    • Brown, L.F.1    Berse, B.2    Jackman, R.W.3    Tognazzi, K.4    Manseau, E.J.5    Senger, D.R.6    Dvorak, H.F.7
  • 19
    • 0030031898 scopus 로고    scopus 로고
    • Expression of vascular permeability/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis
    • Claffey, K. P., Brown, L. F., del Aguila, L. F., Tognazzi, K., Yeo, K-T., Manseau, E. J., and Dvorak, H. F. Expression of vascular permeability/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis. Cancer Res., 56: 172-181, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 172-181
    • Claffey, K.P.1    Brown, L.F.2    Del Aguila, L.F.3    Tognazzi, K.4    Yeo, K.-T.5    Manseau, E.J.6    Dvorak, H.F.7
  • 20
    • 0028834638 scopus 로고
    • Both v-Ha-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
    • Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B., and Marme, D. Both v-Ha-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem., 270: 25915-25919, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25915-25919
    • Grugel, S.1    Finkenzeller, G.2    Weindel, K.3    Barleon, B.4    Marme, D.5
  • 21
    • 0033051030 scopus 로고    scopus 로고
    • Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by ras
    • Feldkamp, M. M., Lau, N., Rak, J., Kerbel, R. S., and Guha, A. Normoxic and hypoxic regulation of vascular endothelial growth factor (VEGF) by astrocytoma cells is mediated by ras. Int. J. Cancer, 81: 118-124, 1999.
    • (1999) Int. J. Cancer , vol.81 , pp. 118-124
    • Feldkamp, M.M.1    Lau, N.2    Rak, J.3    Kerbel, R.S.4    Guha, A.5
  • 23
    • 0030046481 scopus 로고    scopus 로고
    • Interleukin-6 induces the expression of vascular endothelial growth factor
    • Cohen, T., Nahari, D., Cerem-Weiss, L., Neufeld, G., and Levi, B. Interleukin-6 induces the expression of vascular endothelial growth factor. J. Biol. Chem., 271: 736-741, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 736-741
    • Cohen, T.1    Nahari, D.2    Cerem-Weiss, L.3    Neufeld, G.4    Levi, B.5
  • 24
    • 0031457364 scopus 로고    scopus 로고
    • Angiogenesis by fibroblast growth factor 4 is mediated through an autocrine up-regulation of vascular endothelial growth factor expression
    • Deroanne, C. F., Hajitou, A., Calberg-Bacq, C. M., Nusgens, B. V., and Lapiere, C. M. Angiogenesis by fibroblast growth factor 4 is mediated through an autocrine up-regulation of vascular endothelial growth factor expression. Cancer Res., 57: 5590-5597, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 5590-5597
    • Deroanne, C.F.1    Hajitou, A.2    Calberg-Bacq, C.M.3    Nusgens, B.V.4    Lapiere, C.M.5
  • 25
    • 0030753430 scopus 로고    scopus 로고
    • Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression
    • Finkenzeller, G., Sparacio, A., Technau, A., Marme, D., and Seimeister, G. Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression. Oncogene, 15: 669-676, 1997.
    • (1997) Oncogene , vol.15 , pp. 669-676
    • Finkenzeller, G.1    Sparacio, A.2    Technau, A.3    Marme, D.4    Seimeister, G.5
  • 26
    • 0029953517 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by tumor necrosis factor α in human glioma cells: Possible roles of SP-1
    • Ryuto, M., Ono, M., Izumi, H., Yoshida, S., Weich, H. A., Kohno, K., and Kuwano, M. Induction of vascular endothelial growth factor by tumor necrosis factor α in human glioma cells: possible roles of SP-1. J. Biol. Chem., 271: 28220-28228, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 28220-28228
    • Ryuto, M.1    Ono, M.2    Izumi, H.3    Yoshida, S.4    Weich, H.A.5    Kohno, K.6    Kuwano, M.7
  • 27
    • 0028221238 scopus 로고
    • Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells
    • Pertovaara, L., Kaipainen, A., Mustonen, T., Orpana, A., Ferrara, N., Saksela, O., and Alitalo, K. Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells. J. Biol. Chem., 269: 6271-6274, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6271-6274
    • Pertovaara, L.1    Kaipainen, A.2    Mustonen, T.3    Orpana, A.4    Ferrara, N.5    Saksela, O.6    Alitalo, K.7
  • 28
    • 0029045246 scopus 로고
    • Regulation of vascular endothelial growth factor expression in cultured keratinocytes: Implications for normal and impaired wound healing
    • Frank, S., Hubner, G., Breier, G., Longaker, M. T., Greenhalgh, D. G., and Werner, S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes: implications for normal and impaired wound healing. J. Biol. Chem., 270: 12607-12613, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12607-12613
    • Frank, S.1    Hubner, G.2    Breier, G.3    Longaker, M.T.4    Greenhalgh, D.G.5    Werner, S.6
  • 29
    • 0030006574 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I
    • Goad, D. L., Rubin, J., Wang, H., Tashjian, A. H., and Patterson, C. Enhanced expression of vascular endothelial growth factor in human SaOS-2 osteoblast-like cells and murine osteoblasts induced by insulin-like growth factor I. Endocrinology, 137: 2262-2268, 1996.
    • (1996) Endocrinology , vol.137 , pp. 2262-2268
    • Goad, D.L.1    Rubin, J.2    Wang, H.3    Tashjian, A.H.4    Patterson, C.5
  • 30
    • 0027958348 scopus 로고
    • Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression
    • Kieser, A., Welch, H. A., Brandner, G., Marme, D., and Kolch, W. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene, 9: 963-969, 1994.
    • (1994) Oncogene , vol.9 , pp. 963-969
    • Kieser, A.1    Welch, H.A.2    Brandner, G.3    Marme, D.4    Kolch, W.5
  • 31
    • 0027225863 scopus 로고
    • Synthesis and secretion of vascular permiability factor/vascular endothelial growth factor by human retinal pigment epithelial cells
    • Adamis, A. P., Shima, D. T., Yeo, K-T., Yeo, T-K., Brown, L. F., Berse, B., D'Amore, P. A., and Folkman, J. Synthesis and secretion of vascular permiability factor/vascular endothelial growth factor by human retinal pigment epithelial cells. Biochem. Biophys. Res. Commun., 193: 631-638, 1993.
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 631-638
    • Adamis, A.P.1    Shima, D.T.2    Yeo, K.-T.3    Yeo, T.-K.4    Brown, L.F.5    Berse, B.6    D'Amore, P.A.7    Folkman, J.8
  • 32
    • 0028897916 scopus 로고
    • Hypoxia induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor
    • Finkenzeller, G., Technau, A., and Marmé, D. Hypoxia induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor. Biochem. Biophys. Res. Commun., 208: 432-439, 1995.
    • (1995) Biochem. Biophys. Res. Commun. , vol.208 , pp. 432-439
    • Finkenzeller, G.1    Technau, A.2    Marmé, D.3
  • 33
    • 0028095127 scopus 로고
    • Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
    • Goldberg, M. A., and Schneider, T. J. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J. Biol. Chem., 269: 4355-4359, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 4355-4359
    • Goldberg, M.A.1    Schneider, T.J.2
  • 34
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy, A. P., Levy, N. S., and Goldberg, M. A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem., 271: 2746-2753, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 35
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Lond.
    • Shweiki, D., Itin, A., Soffer, D., and Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (Lond.), 359: 843-845, 1992.
    • (1992) Nature , vol.359 , pp. 843-845
    • Shweiki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 36
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • Washington DC
    • De Vries, C., Escobedo, J. A., Ueno, H., Houck, K., Ferrara, N., and Williams, L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science (Washington DC), 255: 989-991, 1992.
    • (1992) Science , vol.255 , pp. 989-991
    • De Vries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 39
    • 0025770646 scopus 로고
    • A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell enriched populations
    • Matthews, W., Jordan, C. T., Weigand, G. W., Pardoll, D., and Lemischka, I. R. A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell enriched populations. Cell, 65: 1143-1152, 1991.
    • (1991) Cell , vol.65 , pp. 1143-1152
    • Matthews, W.1    Jordan, C.T.2    Weigand, G.W.3    Pardoll, D.4    Lemischka, I.R.5
  • 40
    • 0025259592 scopus 로고
    • Nucleotide sequence and expression of a novel human receptor type tyrosine kinase gene (flt) closely related to the fms family
    • Shibuya, M., Yamaguchi, S., Yamane, A., Ikeda, T., Tojo, A., Matsushime, H., and Sato, M. Nucleotide sequence and expression of a novel human receptor type tyrosine kinase gene (flt) closely related to the fms family. Oncogene, 5: 519-524, 1990.
    • (1990) Oncogene , vol.5 , pp. 519-524
    • Shibuya, M.1    Yamaguchi, S.2    Yamane, A.3    Ikeda, T.4    Tojo, A.5    Matsushime, H.6    Sato, M.7
  • 41
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
    • Waltenberger, J., Claesson-Welsh, L., Siegnahn, A., Shibuya, S., and Heldin, C-H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem., 269: 26988-26995, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26988-26995
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegnahn, A.3    Shibuya, S.4    Heldin, C.-H.5
  • 42
    • 0032212959 scopus 로고    scopus 로고
    • Vascular endothelial growth factor
    • Zachary, I. Vascular endothelial growth factor. Int. J. Biochem. Cell Biol., 30: 1169-1174, 1998.
    • (1998) Int. J. Biochem. Cell Biol. , vol.30 , pp. 1169-1174
    • Zachary, I.1
  • 43
    • 0027466849 scopus 로고
    • High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis
    • Millauer, B., Wizigmann Voos, S., Schnurch, H., Martinez, R., Moller, N. P., Risau, W., and Ulrich, A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell, 72: 835-846, 1993.
    • (1993) Cell , vol.72 , pp. 835-846
    • Millauer, B.1    Wizigmann Voos, S.2    Schnurch, H.3    Martinez, R.4    Moller, N.P.5    Risau, W.6    Ulrich, A.7
  • 44
    • 0029106167 scopus 로고
    • In vitro neutralization of vascular endothelial growth factor activation of Flk-1 by a monoclonal antibody
    • Rockwell, P., Neufeld, G., Glassman, A., Caron, D., and Goldstein, N. In vitro neutralization of vascular endothelial growth factor activation of Flk-1 by a monoclonal antibody. Mol. Cell. Differ., 3: 91-109, 1995.
    • (1995) Mol. Cell. Differ. , vol.3 , pp. 91-109
    • Rockwell, P.1    Neufeld, G.2    Glassman, A.3    Caron, D.4    Goldstein, N.5
  • 46
    • 0030029271 scopus 로고    scopus 로고
    • Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence
    • Saleh, M., Stacker, S. A., and Wilks, A. F. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res., 56: 393-401, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 393-401
    • Saleh, M.1    Stacker, S.A.2    Wilks, A.F.3
  • 49
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65: 55-63, 1983.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 50
    • 0029150035 scopus 로고
    • Application of an image analysis system to the quantitation of tumor perfusion and vascularity in human glioma xenografts
    • Rijken, P. F. J. W., Bernsen, H. J. J. A., and van der Kogel, A. J. Application of an image analysis system to the quantitation of tumor perfusion and vascularity in human glioma xenografts. Microvasc. Res., 50: 141-153, 1995.
    • (1995) Microvasc. Res. , vol.50 , pp. 141-153
    • Rijken, P.F.J.W.1    Bernsen, H.J.J.A.2    Van Der Kogel, A.J.3
  • 51
    • 0028115003 scopus 로고
    • Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer
    • Toi, M., Hoshina, S., Takayanagi, T., and Tominaga, T. Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn. J. Cancer Res., 85: 1045-1049, 1994.
    • (1994) Jpn. J. Cancer Res. , vol.85 , pp. 1045-1049
    • Toi, M.1    Hoshina, S.2    Takayanagi, T.3    Tominaga, T.4
  • 52
    • 0029878789 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer
    • Anan, K., Morisaki, T., Katano, M., Ikubo, A., Kitsuki, H., Uchiyama, A., Kuroki, S., Takana, M., and Torisu, M. Vascular endothelial growth factor and platelet-derived growth factor are potential angiogenic and metastatic factors in human breast cancer. Surgery, 119: 333-339, 1996.
    • (1996) Surgery , vol.119 , pp. 333-339
    • Anan, K.1    Morisaki, T.2    Katano, M.3    Ikubo, A.4    Kitsuki, H.5    Uchiyama, A.6    Kuroki, S.7    Takana, M.8    Torisu, M.9
  • 53
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis and proliferation of human colon cancer
    • Takahashi, Y., Kitadai, Y., Bucana, C. D., Cleary, K. R., and Ellis, L. M. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis and proliferation of human colon cancer. Cancer Res., 55: 3964-3968, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3    Cleary, K.R.4    Ellis, L.M.5
  • 54
    • 0027933191 scopus 로고
    • Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placental growth factor in renal cell carcinoma associated with angiogenesis
    • Takahashi, Y., Sasaki, H., Kim, S. J., Tobisu, K., Kakizoe, T., Tsukamoto, T., Kumamoto, Y., Sugimura, T., and Terada, M. Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placental growth factor in renal cell carcinoma associated with angiogenesis. Cancer Res., 54: 4233-4237, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 4233-4237
    • Takahashi, Y.1    Sasaki, H.2    Kim, S.J.3    Tobisu, K.4    Kakizoe, T.5    Tsukamoto, T.6    Kumamoto, Y.7    Sugimura, T.8    Terada, M.9
  • 58
    • 0029160585 scopus 로고
    • Benign neurofibromas in type 1 neurofibromatosis (NFI) show somatic deletions of the NFI gene
    • Colman, S. D., Williams, C. A., and Wallace, M. R. Benign neurofibromas in type 1 neurofibromatosis (NFI) show somatic deletions of the NFI gene. Nat. Genet., 11: 90-92, 1995.
    • (1995) Nat. Genet. , vol.11 , pp. 90-92
    • Colman, S.D.1    Williams, C.A.2    Wallace, M.R.3
  • 59
  • 60
    • 0026521070 scopus 로고
    • Aberrant regulation of ras proteins in malignant tumor cells from type 1 neurofibromatosis patients
    • Lond.
    • Basu, T. N., Gutmann, D. H., Fletcher, J. A., Glover, T. W., Collins, F. S., and Downward, J. Aberrant regulation of ras proteins in malignant tumor cells from type 1 neurofibromatosis patients. Nature (Lond.), 356: 713-715, 1992.
    • (1992) Nature , vol.356 , pp. 713-715
    • Basu, T.N.1    Gutmann, D.H.2    Fletcher, J.A.3    Glover, T.W.4    Collins, F.S.5    Downward, J.6
  • 61
    • 0029935608 scopus 로고    scopus 로고
    • Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1 : A pathological and molecular explanation
    • Feldkamp, M. M., Lau, N., Provius, J., and Guha, A. Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1 : a pathological and molecular explanation. J. Neurosurg., 84: 867-873, 1996.
    • (1996) J. Neurosurg. , vol.84 , pp. 867-873
    • Feldkamp, M.M.1    Lau, N.2    Provius, J.3    Guha, A.4
  • 62
    • 0027468594 scopus 로고
    • Somatic deletions of the neurofibromatosis type 1 gene in a neurofibrosarcoma patient supports the tumor suppressor hypothesis
    • Legius, E., Marchuk, D. A., Collins, F. S., and Glover, T. W. Somatic deletions of the neurofibromatosis type 1 gene in a neurofibrosarcoma patient supports the tumor suppressor hypothesis. Nat. Genet., 3: 122-126, 1993.
    • (1993) Nat. Genet. , vol.3 , pp. 122-126
    • Legius, E.1    Marchuk, D.A.2    Collins, F.S.3    Glover, T.W.4
  • 63
    • 0023157363 scopus 로고
    • Angiogcnic factors
    • Washington DC
    • Folkman, J., and Klagsbrun, M. Angiogcnic factors. Science (Washington DC), 235: 442-447, 1987.
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 64
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • Lond.
    • Folkman, J., Watson, K., Ingber, D., and Hanahan, D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature (Lond.), 339: 58-61, 1989.
    • (1989) Nature , vol.339 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 65
    • 0026083903 scopus 로고
    • Tumor angiogenesis and metastasis: Correlation in invasive breast carcinoma
    • Weidner, N., Semple, J. P., Welch, W. R., and Folkman, J. Tumor angiogenesis and metastasis: correlation in invasive breast carcinoma. N. Engl. J. Med., 324: 1-8, 1991.
    • (1991) N. Engl. J. Med. , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.P.2    Welch, W.R.3    Folkman, J.4
  • 66
    • 0025913891 scopus 로고
    • Neovascularization is associated with a switch to the export of bFGF in the multistep developmenl of fibrosarcoma
    • Kandel, J., Bossy-Welzel, E., Radvanyi, F., Klagsbrun, M., Folkman, J., and Hanahan, D. Neovascularization is associated with a switch to the export of bFGF in the multistep developmenl of fibrosarcoma. Cell, 66; 1095-1104, 1991.
    • (1991) Cell , vol.66 , pp. 1095-1104
    • Kandel, J.1    Bossy-Welzel, E.2    Radvanyi, F.3    Klagsbrun, M.4    Folkman, J.5    Hanahan, D.6
  • 67
    • 0026704498 scopus 로고
    • Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis
    • Hamada, J., Cavanaugh, P. G., Lotan, O., and Nicolson, G. L. Separable growth and migration factors for large-cell lymphoma cells secreted by microvascular endothelial cells derived from target organs for metastasis. Br. J. Cancer, 66: 349-354, 1992.
    • (1992) Br. J. Cancer , vol.66 , pp. 349-354
    • Hamada, J.1    Cavanaugh, P.G.2    Lotan, O.3    Nicolson, G.L.4
  • 68
    • 0022610896 scopus 로고
    • Interactions between newly formed endothelial channels and carcinoma cells in plasma clot culture
    • Nicosia, R. F., Tchao, R., and Leighton, J. Interactions between newly formed endothelial channels and carcinoma cells in plasma clot culture. Clin. Exp. Metastasis, 4: 91-104, 1986.
    • (1986) Clin. Exp. Metastasis , vol.4 , pp. 91-104
    • Nicosia, R.F.1    Tchao, R.2    Leighton, J.3
  • 69
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong, T. A. T., Shawver, L. K., Sun, L., Tang, C., App, H., Powell, T. J., Kim, Y. H., Schreck, R., Wang, X., Risau, W., Ullrich, A., Hirth, K. P., and McMahon, G. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res., 59: 99-106, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.T.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, K.P.12    McMahon, G.13


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