The molecular genetic architecture of human personality: Beyond self-report questionnaires

Molecular Psychiatry

Volumn 11, Issue 5, 2006, Pages 427-445

  Ebstein, R P ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HERZOG HOSPITAL   (Israel)

Author keywords

Dopamine d4 receptor (DRD4); Molecular genetics; Personality; Review; Serotonin transporter (SLC6A4); Temperament

Indexed keywords

DOPAMINE 4 RECEPTOR; SEROTONIN TRANSPORTER;

ANXIETY; AVOIDANCE BEHAVIOR; BEHAVIOR; DRD4 GENE; EXTRAVERSION; GAME; GENE; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MOLECULAR GENETICS; MULTIFACTORIAL INHERITANCE; NEUROIMAGING; NEUROPHYSIOLOGY; NEUROPSYCHOLOGY; NEUROSIS; NONHUMAN; NOVELTY SEEKING BEHAVIOR; PERSONALITY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; QUESTIONNAIRE; REVIEW; SELF REPORT; SLC6A4 GENE; TEMPERAMENT;

ANIMALS; HAPLOTYPES; HUMANS; PERSONALITY; PERSONALITY TESTS; RECEPTORS, DOPAMINE D4; SELF ASSESSMENT (PSYCHOLOGY); SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TEMPERAMENT;

EID: 33646383104     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/sj.mp.4001814     Document Type: Review

References (229)

1. Cloninger CR. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 1987; 44: 573-588.
2. Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry 1993; 50: 975-990.
3. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet 1996; 12: 78-80.
4. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet 1996; 12: 81-84.
5. Van Tol HH, Wu CM, Guan HC, Ohara K, Bunzow JR, Civelli O et al. Multiple dopamine D4 receptor variants in the human population [see comments]. Nature 1992; 358: 149-152.
6. Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 1991; 350: 610-614.
7. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527-1531.
8. Costa Jr PT, McCrae RR. Stability and change in personality assessment: the revised NEO Personality Inventory in the year 2000. J Pers Assess 1997; 68: 86-94.
9. Mayeux R. Mapping the new frontier: complex genetic disorders. J Clin Invest 2005; 115: 1404-1407.
10. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region [see comments]. Science 1996; 274: 1527-1531.
11. De Fruyt F, Van De Wiele L, Van Heeringen C. Cloninger's psychobiological model of temperament and character and the five-factor model of personality. Pers Indiv Diff 2000; 29: 441-452.
12. Stallings MC, Hewitt JK, Cloninger CR, Heath AC, Eaves LJ. Genetic and environmental structure of the Tridimensional Personality Questionnaire: three or four temperament dimensions? J Pers Soc Psychol 1996; 70: 127-140.
13. Eysenck HJ, Eysenck SBG. Manual for the Eysenck Personality Questionnaire-Revised. Educational and Industrial Testing Service: San Diego, CA, 1992.
14. Gray JA. The psychophysiological basis of introversion-extraversion. Behav Res Ther 1970; 8: 249-266.
15. Zohar AH, Lev-Ari L, Benjamin J, Ebstein R, Lichtenberg P, Osher Y. The psychometric properties of the Hebrew version of Cloninger's Tridimensional Personality Questionnaire. Pers Indiv Differ 2001; 30: 1297-1309.
16. Cloninger CR, Przybeck TR, Svrakic DM. The Tridimensional Personality Questionnaire: U.S. normative data. Psychol Rep 1991; 69(3 Part 1): 1047-1057.
17. Noblett KL, Coccaro EF. Molecular genetics of personality. Curr Psychiatry Rep 2005; 7: 73-80.
18. Torgersen S. Behavioral genetics of personality. Curr Psychiatry Rep 2005; 7: 51-56.
19. Savitz JB, Ramesar RS. Genetic variants implicated in personality: a review of the more promising candidates. Am J Med Genet B Neuropsychiatr Genet 2004; 131: 20-32.
20. Jang KL, Vernon PA, Livesley WJ. Behavioural-genetic perspectives on personality function. Can J Psychiatry 2001; 46: 234-244.
21. Ebstein RP, Kotler M. Personality, substance abuse, and genes. In: Benjamin J, Ebstein RP, Belmaker RH (eds). Molecular Genetics and the Human Personality, 1st edn. American Psychiatric Publishing, Inc.: Washington, DC, 2002, pp 151-163.
22. Benjamin J, Ebstein RP, Belmaker RH. Genes for human personality traits: endophenotypes of psychiatric disorders. In: Benjamin J, Ebstein RP, Belmaker RH (eds) Molecular Genetics and the Human Personality, 1st edn. American Psychiatric Publications, Inc.: Washington DC, 2002 pp 333-344.
23. Ebstein RP, Zohar AH, Benjamin J, Belmaker RH. An update of molecular genetic studies of human personality traits. Appl Bioinform 2002; 1: 57-68.
24. Benjamin J, Ebstein RP, Belmaker RH. Molecular Genetics and the Human Personality, 1st edn. American Psychiatric Publications, Inc.: Washington, DC, 2002.
25. Benjamin J, Ebstein RP, Belmaker RH. Molecular Genetics and the Human Personality, 1st edn. American Psychiatric Publishing, Inc.: Washington, DC, 2002.
26. Munafo MR, Clark TG, Moore LR, Payne E, Walton R, Flint J. Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Mol Psychiatry 2003; 8: 471-484.
27. Willis-Owen SA, Turri MG, Munafo MR, Surtees PG, Wainwright NW, Brixey RD et al. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol Psychiatry 2005; 58: 451-456.
28. Munafo MR, Clark T, Flint J. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol Psychiatry 2005; 10: 415-419.
29. Kluger AN, Siegfried Z, Ebstein RP. A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Mol Psychiatry 2002; 7: 712-717.
30. Schinka JA, Letsch EA, Crawford FC. DRD4 and novelty seeking: results of meta-analyses. Am J Med Genet 2002; 114: 643-648.
31. Schinka JA, Busch RM, Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 2004; 9: 197-202.
32. Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet 2004; 127B: 85-89.
33. Willis-Owen SA, Fullerton J, Surtees PG, Wainwright NW, Miller S, Flint J. The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. Biol Psychiatry 2005; 58: 738-742.
34. Munafo MR, Clark T, Flint J. Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Schinka. Mol Psychiatry 2005; 10: 895-897.
35. Munafo MR, Clark TG, Flint J. Assessing publication bias in genetic association studies: evidence from a recent meta-analysis. Psychiatry Res 2004; 129: 39-44.
36. Pritchard JK, Stephens M, Rosenberg NA, Donnelly P. Association mapping in structured populations. Am J Hum Genet 2000; 67: 170-181.
37. Pritchard JK, Rosenberg NA. Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 1999; 65: 220-228.
38. Pritchard JK, Stephens M, Donnelly P. Inference of population structure using multilocus genotype data. Genetics 2000; 155: 945-959.
39. Devlin B, Roeder K, Bacanu SA. Unbiased methods for population-based association studies. Genet Epidemiol 2001; 21: 273-284.
40. Hamer D, Sirota L. Beware the chopsticks gene. Mol Psychiatry 2000; 5: 11-13.
41. Becker K, Laucht M, El-Faddagh M, Schmidt MH. The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sample. J Neural Transm 2005; 112: 847-858.
42. Reuter M, Hennig J. Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion. NeuroReport 2005; 16: 1135-1138.
43. Strobel A, Gutknecht L, Rothe C, Reif A, Mossner R, Zeng Y et al. Allelic variation in 5-HT(1A) receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm 2003; 110: 1445-1453.
44. Kato C, Kakiuchi C, Umekage T, Tochigi M, Kato N, Kato T et al. XBP1 gene polymorphism (-116C/G) and personality. Am J Med Genet B Neuropsychiatr Genet 2005; 136: 103-105.
45. Suzuki E, Kitao Y, Ono Y, Iijima Y, Inada T. Cytochrome P450 2D6 polymorphism and character traits. Psychiatr Genet 2003; 13: 111-113.
46. Okuyama Y, Ishiguro H, Nankai M, Shibuya H, Watanabe A, Arinami T. Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. Mol Psychiatry 2000; 5: 64-69.
47. Tsai SJ, Hong CJ, Cheng CY. Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese. Psychiatr Genet 2002; 12: 165-168.
48. Tsai SJ, Hong CJ, Yu YW, Chen TJ. Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females. Neuropsychobiology 2004; 50: 153-156.
49. Fraumene C, Petretto E, Angius A, Pirastu M. Striking differentiation of sub-populations within a genetically homogeneous isolate (Ogliastra) in Sardinia as revealed by mtDNA analysis. Hum Genet 2003; 114: 1-10.
50. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621-2624.
51. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL et al. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994; 95: 157-162.
52. Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK. Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet 1999; 88: 61-66.
53. Fiskerstrand CE, Lovejoy EA, Quinn JP. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett 1999; 458: 171-174.
54. MacKenzie A, Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 1999; 96: 15251-15255.
55. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 2004; 55: 1090-1094.
56. Kremer I, Bachner-Melman R, Reshef A, Broude L, Nemanov L, Gritsenko I et al. Association of the serotonin transporter gene with smoking behavior. Am J Psychiatry 2005; 162: 924-930.
57. Bachner-Melman R, Dina C, Zohar AH, Constantini N, Lerer E, Hoch S et al. AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. PLoS Genet 2005; 1: e42.
58. De Luca V, Zai G, Tharmalingam S, de Bartolomeis A, Wong G, Kennedy JL. Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia. Eur Neuropsychopharmacol 2005.
59. Goldman D, Hu X, Zhu G, Lipsky R, Murphy D. The serotonin transporter: new alleles, function and phenotype. In: 3rd Annual Pharmacogenetics in Psychiatry Meeting 1994, pp 16-17.
60. Bradley CC, Blakely RD. Alternative splicing of the human serotonin transporter gene. J Neurochem 1997; 69: 1356-1367.
61. Battersby S, Ogilvie AD, Blackwood DH, Shen S, Muqit MM, Muir WJ et al. Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3′ untranslated region of the human serotonin transporter gene. J Neurochem 1999; 72: 1384-1388.
62. Cohen H, Buskila D, Neumann L, Ebstein RP. Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum 2002; 46: 845-847.
63. Offenbaecher M, Bondy B, de Jonge S, Glatzeder K, Kruger M, Schoeps P et al. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999; 42: 2482-2488.
64. Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch KP et al. Genetic perspectives on the serotonin transporter. Brain Res Bull 2001; 56: 487-494.
65. Ansorge MS, Zhou M, Lira A, Hen R, Gingrich JA. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004; 306: 879-881.
66. Hariri AR, Weinberger DR. Imaging genomics. Br Med Bull 2003; 65: 259-270.
67. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400-403.
68. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF et al. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 2005; 62: 146-152.
69. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS et al. 5-HTTLPR polymorphism impacts human cingulated-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828-834.
70. Cohen J. Statistical power analysis for the behavioral sciences, 2nd edn. L. Erlbaum Associates: Hillsdale, NJ, 1988.
71. Stallings MC, Corley RP, Dennehey B, Hewitt JK, Krauter KS, Lessem JM et al. A genome-wide search for quantitative trait loci that influence antisocial drug dependence in adolescence. Arch Gen Psychiatry 2005; 62: 1042-1051.
72. Nash MW, Huezo-Diaz P, Williamson RJ, Sterne A, Purcell S, Hoda F et al. Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. Hum Mol Genet 2004; 13: 2173-2182.
73. Neale BM, Sullivan PF, Kendler KS. A genome scan of neuroticism in nicotine dependent smokers. Am J Med Genet B Neuropsychiatr Genet 2005; 132: 65-69.
74. Cloninger CR, Van Eerdewegh P, Goate A, Edenberg HJ, Blangero J, Hesselbrock V et al. Anxiety proneness linked to epistatic loci in genome scan of human personality traits. Am J Med Genet 1998; 81: 313-317.
75. Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S et al. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet 2003; 72: 879-890.
76. Zohar AH, Dina C, Rosolio N, Osher Y, Gritsenko I, Bachner-Melman R et al. Tridimensional personality questionnaire trait of harm avoidance (anxiety proneness) is linked to a locus on chromosome 8p21. Am J Med Genet 2003; 117B: 66-69.
77. Dina C, Nemanov L, Gritsenko I, Rosolio N, Osher Y, Heresco-Levy U et al. Fine mapping of a region on chromosome 8p gives evidence for a QTL contributing to individual differences in an anxiety-related personality trait: TPQ harm avoidance. Am J Med Genet B Neuropsychiatr Genet 2005; 132: 104-108.
78. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS. Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet 1999; 65: 876-884.
79. Owen MJ, Craddock N, O'Donovan MC. Schizophrenia: genes at last? Trends Genet 2005; 21: 518-525.
80. Cloninger CR, Adolfsson R, Svrakic NM. Mapping genes for human personality [news]. Nat Genet 1996; 12: 3-4.
81. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645.
82. Benjamin J, Ebstein RP, Belmaker RH. Genes for human personality traits: 'endophenotypes' of psychiatric disorders? World J Biol Psychiatry 2001; 2: 54-57.
83. Smoller JW, Acierno Jr JS, Rosenbaum JF, Biederman J, Pollack MH, Meminger S et al. Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions. Am J Med Genet 2001; 105: 195-206.
84. Gelernter J, Bonvicini K, Page G, Woods SW, Goddard AW, Kruger S et al. Linkage genome scan for loci predisposing to panic disorder or agoraphobia. Am J Med Genet 2001; 105: 548-557.
85. Nurnberger Jr JI, Foroud T, Flury L, Su J, Meyer ET, Hu K et al. Evidence for a locus on chromosome 1 that influences vulnerability to alcoholism and affective disorder. Am J Psychiatry 2001; 158: 718-724.
86. Devlin B, Bacanu SA, Klump KL, Bulik CM, Fichter MM, Halmi KA et al. Linkage analysis of anorexia nervosa incorporating behavioral covariates. Hum Mol Genet 2002; 11: 689-696.
87. Crowe RR, Goedken R, Samuelson S, Wilson R, Nelson J, Noyes Jr R. Genomewide survey of panic disorder. Am J Med Genet 2001; 105: 105-109.
88. Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA et al. Results of a genome-wide genetic screen for panic disorder. Am J Med Genet 1998; 81: 139-147.
89. Fernandez-Teruel A, Escorihuela RM, Gray JA, Aguilar R, Gil L, Gimenez-Llort L et al. A quantitative trait locus influencing anxiety in the laboratory rat. Genome Res 2002; 12: 618-626.
90. Lowe N, Kirley A, Mullins C, Fitzgerald M, Gill M, Hawi Z. Multiple marker analysis at the promoter region of the DRD4 gene and ADHD: evidence of linkage and association with the SNP -616. Am J Med Genet B Neuropsychiatr Genet 2004; 131: 33-37.
91. Bachner-Melman R, Gritsenko I, Nemanov L, Zohar AH, Dina C, Ebstein RP. Dopaminergic polymorphisms associated with self-report measures of human altruism: a fresh phenotype for the dopamine D4 receptor. Mol Psychiatry 2005; 10: 333-335.
92. Grady DL, Chi HC, Ding YC, Smith M, Wang E, Schuck S et al. High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. Mol Psychiatry 2003; 8: 536-545.
93. Petronis A, K OH, Barr CL, Kennedy JL, Van Tol HH. (G)n-mononucleotide polymorphism in the human D4 dopamine receptor (DRD4) gene. Hum Genet 1994; 93: 719.
94. Mill J, Fisher N, Curran S, Richards S, Taylor E, Asherson P. Polymorphisms in the dopamine D4 receptor gene and attention-deficit hyperactivity disorder. NeuroReport 2003; 14: 1463-1466.
95. Bakker SC, van der Meulen EM, Oteman N, Schelleman H, Pearson PL, Buitelaar JK et al. DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families. Am J Med Genet B Neuropsychiatr Genet 2005; 132: 50-52.
96. Catalano M, Nobile M, Novelli E, Nothen MM, Smeraldi E. Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biol Psychiatry 1993; 34: 459-464.
97. Hong CJ, Chiu HJ, Chang YS, Sim CB. Twelve-nucleotide repeat polymorphism of D4 dopamine receptor gene in Chinese familial schizophrenic patients [in process citation]. Biol Psychiatry 1998; 43: 432-435.
98. Zenner MT, Nobile M, Henningsen R, Smeraldi E, Civelli O, Hartman DS et al. Expression and characterization of a dopamine D4R variant associated with delusional disorder. FEBS Lett 1998; 422: 146-150.
99. Golimbet VE, Gritsenko IK, Alfimova MV, Ebstein RP. Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population. Genetika 2005; 41: 966-972.
100. Eichhammer P, Sand PG, Stoertebecker P, Langguth B, Zowe M, Hajak G. Variation at the DRD4 promoter modulates extraversion in Caucasians. Mol Psychiatry 2005; 10: 520-522.
101. Bookman EB, Taylor RE, Adams-Campbell L, Kittles RA. DRD4 promoter SNPs and gender effects on extraversion in African Americans. Mol Psychiatry 2002; 7: 786-789.
102. Ronai Z, Szekely A, Nemoda Z, Lakatos K, Gervai J, Staub M et al. Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene. Mol Psychiatry 2001; 6: 35-38.
103. Mitsuyasu H, Hirata N, Sakai Y, Shibata H, Takeda Y, Ninomiya H et al. Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits. J Hum Genet 2001; 46: 26-31.
104. Seaman MI, Fisher JB, Chang F, Kidd KK. Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4). Am J Med Genet 1999; 88; 705-709.
105. Xing QH, Wu SN, Lin ZG, Li HF, Yang JD, Feng GY et al. Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene in schizophrenia. Schizophr Res 2003; 65: 9-14.
106. McCracken JT, Smalley SL, McGough JJ, Crawford L, Del'Homme M, Cantor RM et al. Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD). Mol Psychiatry 2000; 5: 531-536.
107. Arcos-Burgos M, Castellanos FX, Konecki D, Lopera F, Pineda D, Palacio JD et al. Pedigree disequilibrium test (PDT) replicates association and linkage between DRD4 and ADHD in multi-generational and extended pedigrees from a genetic isolate. Mol Psychiatry 2004; 9: 252-259.
108. Rogers G, Joyce P, Mulder R, Sellman D, Miller A, Allington M et al. Association of a duplicated repeat polymorphism in the 5′-untranslated region of the DRD4 gene with novelty seeking. Am J Med Genet 2004; 126B: 95-98.
109. D'Souza UM, Russ C, Tahir E, Mill J, McGuffin P, Asherson PJ et al. Functional effects of a tandem duplication polymorphism in the 5′flanking region of the DRD4 gene. Biol Psychiatry 2004; 56: 691-697.
110. Asghari V, Schoots O, van Kats S, Ohara K, Jovanovic V, Guan HC et al. Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. Mol Pharmacol 1994; 46: 364-373.
111. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995; 65: 1157-1165.
112. Schoots O, Van Tol HH. The human dopamine D4 receptor repeat sequences modulate expression. Pharmacogenomics J 2003; 3: 343-348.
113. Van Craenenbroeck K, Clark SD, Cox MJ, Oak JN, Liu F, Van Tol HH. Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis. J Biol Chem 2005; 280: 19350-19357.
114. Gervai J, Nemoda Z, Lakatos K, Ronai Z, Toth I, Ney K et al. Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment. Am J Med Genet B Neuropsychiatr Genet 2005; 132: 126-130.
115. Lakatos K, Toth I, Nemoda Z, Ney K, Sasvari-Szekely M, Gervai J. Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganization in infants [in process citation]. Mol Psychiatry 2000; 5: 633-637.
116. Lakatos K, Nemoda Z, Toth I, Ronai Z, Ney K, Sasvari- Szekely M et al. Further evidence for the role of the dopamine D4 receptor (DRD4) gene in attachment disorganization: interaction of the exon III 48-bp repeat and the -521 C/T promoter polymorphisms. Mol Psychiatry 2002; 7: 27-31.
117. Lakatos K, Nemoda Z, Birkas E, Ronai Z, Kovacs E, Ney K et al. Association of D4 dopamine receptor gene and serotonin transporter promoter polymorphisms with infants' response to novelty. Mol Psychiatry 2003; 8: 90-97.
118. Bakermans-Kranenburg MJ, Van Ijzendoorn MH. No association of the dopamine D4 receptor (DRD4) and -521 C/T promoter polymorphisms with infant attachment disorganization. Attach Hum Dev 2004; 6: 211-218; discussion 219-22.
119. Downey KK, Stelson FW, Pomerleau OF, Giordani B. Adult attention deficit hyperactivity disorder: psychological test profiles in a clinical population. J Nerv Ment Dis 1997; 185: 32-38.
120. Downey KK, Pomerleau CS, Pomerleau OF. Personality differences related to smoking and adult attention deficit hyperactivity disorder. J Subst Abuse 1996; 8: 129-135.
121. Faraone SV, Doyle AE, Mick E, Biederman J. Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 2001; 158: 1052-1057.
122. Lynn DE, Lubke G, Yang M, McCracken JT, McGough JJ, Ishii J et al. Temperament and character profiles and the dopamine D4 receptor gene in ADHD. Am J Psychiatry 2005; 162: 906-913.
123. Buskila D, Cohen H, Neuman L, Ebstein RP. An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits. Mol Psychiatry 2004; 9: 730-731.
124. Laucht M, Becker K, El-Faddagh M, Hohm E, Schmidt MH. Association of the DRD4 exon III polymorphism with smoking in fifteen-year-olds: a mediating role for novelty seeking? J Am Acad Child Adolesc Psychiatry 2005; 44: 477-484.
125. Moffitt TE, Caspi A, Rutter M. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 2005; 62: 473-481.
126. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386-389.
127. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW et al. Role of genotype in the cycle of violence in maltreated children. Science 2002; 297: 851-854.
128. Barr CS, Newman TK, Becker ML, Parker CC, Champoux M, Lesch KP et al. The utility of the non-human primate; model for studying gene by environment interactions in behavioral research. Genes Brain Behav 2003; 2: 336-340.
129. Barr CS, Schwandt ML, Newman TK, Higley JD. The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variables. Ann N Y Acad Sci 2004; 1021: 221-233.
130. Barr CS, Newman TK, Lindell S, Shannon C, Champoux M, Lesch KP et al. Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates. Arch Gen Psychiatry 2004; 61: 1146-1152.
131. Keltikangas-Jarvinen L, Raikkonen K, Ekelund J, Peltonen L. Nature and nurture in novelty seeking. Mol Psychiatry 2004; 9: 308-311.
132. Ekelund J, Lichtermann D, Jarvelin MR, Peltonen L. Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. Am J Psychiatry 1999; 156: 1453-1455.
133. Lahti J, Raikkonen K, Ekelund J, Peltonen L, Raitakari OT, Keltikangas-Jarvinen L. Novelty seeking: interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years. Psychiatr Genet 2005; 15: 133-139.
134. Fernandez-Teruel A, Driscoll P, Gil L, Aguilar R, Tobena A, Escorihuela RM. Enduring effects of environmental enrichment on novelty seeking, saccharin and ethanol intake in two rat lines (RHA/Verh and RLA/Verh) differing in incentive-seeking behavior. Pharmacol Biochem Behav 2002; 73: 225-231.
135. Uhl GR. Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results. Ann N Y Acad Sci 2004; 1025: 1-13.
136. Gelernter J, Liu X, Hesselbrock V, Page GP, Goddard A, Zhang H. Results of a genomewide linkage scan: support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am J Med Genet B Neuropsychiatr Genet 2004; 128: 94-101.
137. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E et al. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 1998; 81: 216-221.
138. Sher KJ, Bartholow BD, Wood MD. Personality and substance use disorders: a prospective study. J Consult Clin Psychol 2000; 68: 818-829.
139. Kotler M, Cohen H, Segman R, Gritsenko I, Nemanov L, Lerer B et al. Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. Mol Psychiatry 1997; 2: 251-254.
140. Dulawa SC, Grandy DK, Low MJ, Paulus MP, Geyer MA. Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci 1999; 19: 9550-9556.
141. Rubinstein M, Phillips TJ, Bunzow JR, Falzone TL, Dziewczapolski G, Zhang G et al. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 1997; 90: 991-1001.
142. Ito H, Nara H, Inoue-Murayama M, Shimada MK, Koshimura A, Ueda Y et al. Allele frequency distribution of the canine dopamine receptor D4 gene exon III and I in 23 breeds. J Vet Med Sci 2004; 66: 815-820.
143. Inoue-Murayama M, Matsuura N, Murayama Y, Tsubota T, Iwasaki T, Kitagawa H et al. Sequence comparison of the dopamine receptor D4 exon III repetitive region in several species of the order Carnivora. J Vet Med Sci 2002; 64: 747-749.
144. Niimi Y, Inoue-Murayama M, Kato K, Matsuura N, Murayama Y, Ito S et al. Breed differences in allele frequency of the dopamine receptor D4 gene in dogs. J Hered 2001; 92: 433-436.
145. Niimi Y, Inoue-Murayama M, Murayama Y, Ito S, Iwasaki T. Allelic variation of the D4 dopamine receptor polymorphic region in two dog breeds, Golden retriever and Shiba. J Vet Med Sci 1999; 61: 1281-1286.
146. Momozawa Y, Takeuchi Y, Kusunose R, Kikusui T, Mori Y. Association between equine temperament and polymorphisms in dopamine D4 receptor gene. Mamm Genome 2005; 16: 538-544.
147. Wang E, Ding YC, Flodman P, Kidd JR, Kidd KK, Grady DL et al. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 2004; 74: 931-944.
148. Ding YC, Chi HC, Grady DL, Morishima A, Kidd JR, Kidd KK et al. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA 2002; 99: 309-314.
149. Ding YC, Chi HC, Grady DL, Morishima A, Kidd JR, Kidd KK et al. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA 2002; 99: 309-314.
150. Bouchard TJ, Loehlin JC. Genes, evolution, and personality. Behav Genet 2001; 31: 243-273.
151. Flint J. Analysis of quantitative trait loci that influence animal behavior. J Neurobiol 2003; 54: 46-77.
152. Flint J, Mott R. Finding the molecular basis of quantitative traits: successes and pitfalls. Nat Rev Genet 2001; 2: 437-445.
153. Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 2005; 6: 271-286.
154. Carlborg O, Haley CS. Epistasis: too often neglected in complex trait studies? Nat Rev Genet 2004; 5: 618-625.
155. Keller MC, Coventry WL, Heath AC, Martin NG. Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design. Behav Genet 2005; 35: 707-721.
156. Ebstein RP, Segman R, Benjamin J, Osher Y, Nemanov L, Belmaker RH. 5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. Am J Med Genet (Neuropsychiatric Genet) 1997; 74: 65-72.
157. Kuhn KU, Meyer K, Nothen MM, Gansicke M, Papassotiropoulos A, Maier W. Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors: replication tests. Am J Med Genet 1999; 88: 168-172.
158. Benjamin J, Osher Y, Kotler M, Gritsenko I, Nemanov L, Belmaker RH et al. Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT). Mol Psychiatry 2000; 5: 96-100.
159. Strobel A, Lesch KP, Jatzke S, Paetzold F, Brocke B. Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants. Mol Psychiatry 2003; 8: 371-372.
160. De Luca A, Rizzardi M, Torrente I, Alessandroni R, Salvioli GP, Filograsso N et al. Dopamine D4 receptor (DRD4) polymorphism and adaptability trait during infancy: a longitudinal study in 1- to 5-month-old neonates. Neurogenetics 2001; 3: 79-82.
161. De Luca A, Rizzardi M, Buccino A, Alessandroni R, Salvioli GP, Filograsso N et al. Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants. Neurogenetics 2003; 4: 207-212.
162. Gervai J, Nemoda Z, Lakatos K, Ronai Z, Toth I, Ney K et al. Transmission disequilibrium tests confirm the link between DRD4 gene polymorphism and infant attachment. Am J Med Genet B Neuropsychiatr Genet 2004; 132B: 126-130.
163. Auerbach JG, Faroy M, Ebstein R, Kahana M, Levine J. The association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. J Child Psychol Psychiatry 2001; 42: 777-783.
164. Auerbach J, Geller V, Lezer S, Shinwell E, Belmaker RH, Levine J et al. Dopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants. Mol Psychiatry 1999; 4: 369-373.
165. Ebstein RP, Levine J, Geller V, Auerbach J, Gritsenko I, Belmaker RH. Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament. Mol Psychiatry 1998; 3: 238-246.
166. Sen S, Villafuerte S, Nesse R, Stoltenberg SF, Hopcian J, Gleiberman L et al. Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. Biol Psychiatry 2004; 55: 244-249.
167. Ott U, Reuter M, Hennig J, Vaitl D. Evidence for a common biological basis of the absorption trait, hallucinogen effects, and positive symptoms: epistasis between 5-HT2a and COMT polymorphisms. Am J Med Genet B Neuropsychiatr Genet 2005; 137: 29-32.
168. Tellegen A, Atkinson G. Openness to absorbing and self-altering experiences ('absorption'), a trait related to hypnotic susceptibility. J Abnorm Psychol 1974; 83: 268-277.
169. Lichtenberg P, Bachner-Melman R, Gritsenko I, Ebstein RP. Exploratory association study between catechol-O-methyltransferase (COMT) high/low enzyme activity polymorphism and hypnotizability [in process citation]. Am J Med Genet 2000; 96: 771-774.
170. Lichtenberg P, Bachner-Melman R, Ebstein RP, Crawford HJ. Hypnotic susceptibility: multidimensional relationships with Cloninger's Tridimensional Personality Questionnaire, COMT polymorphisms, absorption, and attentional characteristics. Int J Clin Exp Hypn 2004; 52: 47-72.
171. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003; 25: 115-121.
172. Koeleman BP, Dudbridge F, Cordell HJ, Todd JA. Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test. Ann Hum Genet 2000; 64(Part 3): 207-213.
173. Kim SJ, Young LJ, Gonen D, Veenstra-VanderWeele J, Courchesne R, Courchesne E et al. Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. Mol Psychiatry 2002; 7: 503-507.
174. Wassink TH, Piven J, Vieland VJ, Pietila J, Goedken RJ, Folstein SE et al. Examination of AVPR1a as an autism susceptibility gene. Mol Psychiatry 2004; 9: 968-972.
175. Yirmiya N, Rosenberg C, Levi S, Salomon S, Shulman C, Nemanov L et al. Association between the arginine vasopressin 1a receptor (AVPR1a) gene and autism in a family-based study: Mediation by socialization skills. Molecular Psychiatry 2006 in press.
176. Lim MM, Bielsky IF, Young LJ. Neuropeptides and the social brain: potential rodent models of autism. Int J Dev Neurosci 2005; 23: 235-243.
177. Young LJ. The neurobiology of social recognition, approach, and avoidance. Biol Psychiatry 2002; 51: 18-26.
178. Insel TR, O'Brien DJ, Leckman JF. Oxytocin, vasopressin, and autism: is there a connection? Biol Psychiatry 1999; 45: 145-157.
179. Bachner-Melman R, Zohar AH, Bacon-Shnoor N, Elizur Y, Nemanov L, Gritsenko I et al. Linkage between vasopressin receptor AVPR1A promoter region microsatellites and measures of social behavior in humans. J Indiv Differ 2005; 26: 2-10.
180. Arbelle S, Benjamin J, Golin M, Kremer I, Belmaker RH, Ebstein RP. Relation of shyness in grade school children to the genotype for the long form of the serotonin transporter promoter region polymorphism. Am J Psychiatry 2003; 160: 671-676.
181. Yu YW, Tsai SJ, Hong CJ, Chen TJ, Yang CW. Association analysis for MAOA gene polymorphism with long-latency auditory evoked potentials in healthy females. Neuropsychobiology 2004; 50: 288-291.
182. Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M et al. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry 2002; 59: 1085-1096.
183. Swerdlow NR, Wasserman LC, Talledo JA, Casas R, Bruins P, Stephany NL. Prestimulus modification of the startle reflex: relationship to personality and physiological markers of dopamine function. Biol Psychol 2003; 62: 17-26.
184. Hollander E, Pallanti S, Baldini Rossi N, Sood E, Baker BR, Buchsbaum MS. Imaging monetary reward in pathological gamblers. World J Biol Psychiatry 2005; 6: 113-120.
185. Swerdlow NR, Filion D, Geyer MA, Braff DL. 'Normal' personality correlates of sensorimotor, cognitive, and visuospatial gating. Biol Psychiatry 1995; 37: 286-299.
186. Swerdlow NR, Martinez ZA, Hanlon FM, Platten A, Farid M, Auerbach P et al. Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists. J Neurosci 2000; 20: 4325-4336.
187. Braff DL, Geyer MA, Swerdlow NR. Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl) 2001; 156: 234-258.
188. Gurrera RJ, Salisbury DF, O'Donnell BF, Nestor PG, McCarley RW. Auditory P3 indexes personality traits and cognitive function in healthy men and women. Psychiatry Res 2005; 133: 215-228.
189. Strobel A, Debener S, Anacker K, Muller J, Lesch KP, Brocke B. Dopamine D4 receptor exon III genotype influence on the auditory evoked novelty P3. NeuroReport 2004; 15: 2411-2415.
190. Staelens L, Oltenfreiter R, Blanckaert P, Kersemans V, Vandenbulcke K, Van De Wiele C et al. In vivo evaluation of [(123)I]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyrid in-5-one: a presumed dopamine D4 receptor ligand for SPECT studies. Nucl Med Biol 2005; 32: 293-299.
191. Passamonti L, Fera F, Magariello A, Cerasa A, Gioia MC, Muglia M et al. Monoamine oxidase-a genetic variations influence brain activity associated with inhibitory control: new insight into the neural correlates of impulsivity. Biol Psychiatry 2006; 59: 334-340.
192. Hess EJ, Rogan PK, Domoto M, Tinker DE, Ladda RL, Ramer JC. Absence of linkage of apparently single gene mediated ADHD with the human syntenic region of the mouse mutant Coloboma. Am J Med Genet 1995; 60: 573-579.
193. Heyser CJ, Wilson MC, Gold LH. Coloboma hyperactive mutant exhibits delayed neurobehavioral developmental milestones. Brain Res Dev Brain Res 1995; 89: 264-269.
194. Barr CL, Feng Y, Wigg K, Bloom S, Roberts W, Malone M et al. Identification of DNA variants in the SNAP-25 gene and linkage study of these polymorphisms and attention-deficit hyperactivity disorder. Mol Psychiatry 2000; 5: 405-409.
195. Mekel-Bobrov N, Gilbert SL, Evans PD, Vallender EJ, Anderson JR, Hudson RR et al. Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens. Science 2005; 309: 1720-1722.
196. Enard W, Przeworski M, Fisher SE, Lai CS, Wiebe V, Kitano T et al. Molecular evolution of FOXP2, a gene involved in speech and language. Nature 2002; 418: 869-872.
197. Webb DM, Zhang J. FoxP2 in song-learning birds and vocal-learning mammals. J Hered 2005; 96: 212-216.
198. Corballis MC. FOXP2 and the mirror system. Trends Cogn Sci 2004; 8: 95-96.
199. Cichon S, Nothen MM, Catalano M, Di Bella D, Maier W, Lichtermann D et al. Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene. Psychiatr Genet 1995; 5: 97-103.
200. Wacker J, Reuter M, Hennig J, Stemmler G. Sexually dimorphic link between dopamine D2 receptor gene and neuroticism-anxiety. NeuroReport 2005; 16: 611-614.
201. Ratsma JE, van der Stelt O, Schoffelmeer AN, Westerveld And A, Boudewijn Gunning W. P3 event-related potential, dopamine D2 receptor A1 allele, and sensation-seeking in adult children of alcoholics. Alcohol Clin Exp Res 2001; 25: 960-967.
202. Kaasinen V, Aalto S, Nagren K, Rinne JO. Insular dopamine D2 receptors and novelty seeking personality in Parkinson's disease. Mov Disord 2004; 19: 1348-1351.
203. Kaasinen V, Nurmi E, Bergman J, Eskola O, Solin O, Sonninen P et al. Personality traits and brain dopaminergic function in Parkinson's disease. Proc Natl Acad Sci USA 2001; 98: 13272-13277.
204. Lee IH, Cheng CC, Yang YK, Yeh TL, Chen PS, Chiu NT. Correlation between striatal dopamine D2 receptor density and neuroticism in community volunteers. Psychiatry Res 2005; 138: 259-264.
205. Noble EP, Ozkaragoz TZ, Ritchie TL, Zhang X, Belin TR, Sparkes RS. D2 and D4 dopamine receptor polymorphisms and personality. Am J Med Genet 1998; 81: 257-267.
206. Gorwood P, Limosin F, Batel P, Duaux E, Gouya L, Ades J. The genetics of addiction: alcohol-dependence and D3 dopamine receptor gene. Pathol Biol (Paris) 2001; 49: 710-717.
207. Limosin F, Romo L, Batel P, Ades J, Boni C, Gorwood P. Association between dopamine receptor D3 gene BalI polymorphism and cognitive impulsiveness in alcohol-dependent men. Eur Psychiatry 2005; 20: 304-306.
208. Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J et al. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry 2003; 8: 895, 933-936.
209. Ham BJ, Kim YH, Choi MJ, Cha JH, Choi YK, Lee MS. Serotonergic genes and personality traits in the Korean population. Neurosci Lett 2004; 354: 2-5.
210. Tochigi M, Umekage T, Kato C, Marui T, Otowa T, Hibino H et al. Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association. Psychiatr Genet 2005; 15: 67-69.
211. Melke J, Westberg L, Nilsson S, Landen M, Soderstrom H, Baghaei F et al. A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women. Arch Gen Psychiatry 2003; 60: 1017-1023.
212. Jacob CP, Muller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A et al. Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology 2005; 30: 1711-1718.
213. Yu YW, Yang CW, Wu HC, Tsai SJ, Hong CJ, Chen MC et al. Association study of a functional MAOA-uVNTR gene polymorphism and personality traits in Chinese young females. Neuropsychobiology 2005; 52: 118-121.
214. Yu YW, Tsai SJ, Hong CJ, Chen MC, Yang CW, Chen TJ. Association study of a functional MAOA-uVNTR gene polymorphism and cognitive function in healthy females. Neuropsychobiology 2005; 52: 77-82.
215. Gerra G, Garofano L, Bosari S, Pellegrini C, Zaimovic A, Moi G et al. Analysis of monoamine oxidase A (MAO-A) promoter polymorphism in male heroin-dependent subjects: behavioural and personality correlates. J Neural Transm 2004; 111: 611-621.
216. Ham BJ, Choi MJ, Lee HJ, Kang RH, Lee MS. Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population. Psychiatr Genet 2005; 15: 145-147.
217. Yang L, Wang YF, Li J, Faraone SV. Association of norepinephrine transporter gene with methylphenidate response. J Am Acad Child Adolesc Psychiatry 2004; 43: 1154-1158.
218. Samochowiec J, Rybakowski F, Czerski P, Zakrzewska M, Stepien G, Pelka-Wysiecka J et al. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers. Neuropsychobiology 2001; 43: 248-253.
219. Tsai SJ, Wang YC, Hong CJ. Norepinephrine transporter and alpha(2c) adrenoceptor allelic variants and personality factors. Am J Med Genet 2002; 114: 649-651.
220. Stein MB, Schork NJ, Gelernter J. A polymorphism of the beta1-adrenergic receptor is associated with low extraversion. Biol Psychiatry 2004; 56: 217-224.
221. Oroszi G, Enoch MA, Chun J, Virkkunen M, Goldman D. Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations. Alcohol Clin Exp Res 2005; 29: 303-309.
222. Damberg M. Transcription factor AP-2 and monoaminergic functions in the central nervous system. J Neural Transm 2005; 112: 1281-1296.
223. Damberg M, Garpenstrand H, Hallman J, Oreland L. Genetic mechanisms of behavior - don't forget about the transcription factors. Mol Psychiatry 2001; 6: 503-510.
224. Lang UE, Hellweg R, Kalus P, Bajbouj M, Lenzen KP, Sander T et al. Association of a functional BDNF polymorphism and anxiety-related personality traits. Psychopharmacology (Berl) 2005; 180: 95-99.
225. Itoh K, Hashimoto K, Kumakiri C, Shimizu E, Iyo M. Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects. Am J Med Genet B Neuropsychiatr Genet 2004; 124: 61-63.
226. Tsai SJ, Liao DL, Yu YW, Chen TJ, Wu HC, Lin CH et al. A study of the association of (Val66Met) polymorphism in the brain-derived neurotrophic factor gene with alcohol dependence and extreme violence in Chinese males. Neurosci Lett 2005; 381: 340-343.
227. Sen S, Nesse RM, Stoltenberg SF, Li S, Gleiberman L, Chakravarti A et al. A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology 2003; 28: 397-401.
228. Jiang X, Xu K, Hoberman J, Tian F, Marko AJ, Waheed JF et al. BDNF variation and mood disorders: a novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 2005; 30: 1353-1361.
229. Tsai SJ, Hong CJ, Yu YW, Chen TJ. Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females. Neuropsychobiology 2004; 49: 13-16.