Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene

Journal of Neurochemistry

Volumn 72, Issue 4, 1999, Pages 1384-1388

  Battersby, Sharon ^a   Ogilvie, Alan D ^a   Blackwood, Douglas H R ^a   Shen, Sanbing ^a   Muqit, Miratul M K ^a   Muir, Walter J ^a   Teague, Peter ^b   Goodwin, Guy M ^c   Harmar, Anthony J ^a  

^a ROYAL EDINBURGH HOSPITAL   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

Affective disorder; Polyadenylation; Polymorphism; Serotonin transporter

Indexed keywords

COMPLEMENTARY DNA; SEROTONIN TRANSPORTER;

ADULT; AFFECTIVE NEUROSIS; ARTICLE; CONTROLLED STUDY; DEPRESSION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MANIC DEPRESSIVE PSYCHOSIS; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; STOP CODON;

3' UNTRANSLATED REGIONS; BASE SEQUENCE; BLOTTING, NORTHERN; BRAIN CHEMISTRY; CARRIER PROTEINS; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MOOD DISORDERS; NERVE TISSUE PROTEINS; POLY A; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; RNA, MESSENGER; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0032993895     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.721384.x     Document Type: Article

References (24)

1. Battersby S., Ogilvie A. D., Smith C. A., Blackwood D. H., Muir W. J., Quinn J. P., Fink G., Goodwin G. M., and Harmar A. J. (1996) Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatr. Genet. 6, 177-181.
2. Bradley C. C. and Blakely R. D. (1997) Alternative splicing of the human serotonin transporter gene. J. Neurochem. 69, 1356-1367.
3. Chang A. S., Chang S. M., Starnes D. M., Schroeter S., Bauman A. L., and Blakely R. D. (1996) Cloning and expression of the mouse serotonin transporter. Brain Res. Mol. Brain Res. 43, 185-192.
4. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
5. Collier D. A. (1998) The usual suspects: tyrosine hydroxylase and the serotonin transporter in affective disorders. Mol. Psychiatry 3, 103-105.
6. Collier D. A., Arranz M. J., Sham P., Battersby S., Vallada H., Gill P., Aitchison K. J., Sodhi M., Li T., Roberts G. W., Smith B., Morton J., Murray R. M., Smith D., and Kirov G. (1996a) The serotonin transporter gene is a potential susceptibility factor for bipolar affective disorder. Neuroreport 7, 1675-1679.
7. Collier D. A., Stoeber G., Li T., Hiels A., Catalano M., Di Bella D., Arranz M. J., Murray R. M., Smith D., and Kirov G. (1996b) A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol. Psychiatry 1, 453-460.
8. Endicott J. and Spitzer R. L. (1978) A diagnostic interview - the schedule for affective disorders and schizophrenia. Arch. Gen. Psychiatry 35, 837-844.
9. Esterling L. E., Yoshikawa T., Turner G., Badner J. A., Bengel D., Gershon E., Berrettini W. H., and Detera-Wadleigh S. D. (1998) Serotonin transporter (5-HTT) gene and bipolar affective disorder. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81, 37-40.
10. Furlong R. A., Ho L., Walsh C., Rubinsztein J. S., Jain S., Paykel E. S., Easton D. F., and Rubinsztein D. C. (1998) Analysis and metaanalysis of two serotonin transporter gene polymorphisms in bipolar and unipolar affective disorders. Am. J. Med. Genet. 81, 58-63.
11. Gregor P., Patel A., Shimada S., Lin C. L., Rochelle J. M., Kitayama S., Seldin M. F., and Uhl G. R. (1993) Murine serotonin transporter: sequence and localization to chromosome 11. Mamm. Genome 4, 283-284.
12. Harmar A. J., Ogilvie A. D., Battersby S., Smith C. A. D., Blackwood D. H. R., Muir W. J., Fink G., and Goodwin G. M. (1996) The serotonin transporter gene and affective disorder. Cold Spring Harbor Symp. Quant. Biol. 61, 791-795.
13. Heils A., Teufel A., Petri S., Seemann M., Bengel D., Balling U., Riederer P., and Lesch K. P. (1995) Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J. Neural Transm. 102, 247-254.
14. Heils A., Teufel A., Petri S., Stöber G., Riederer P., Bengel D., and Lesch K. P. (1996) Allelic variation of human serotonin transporter gene expression. J. Neurochem. 66, 2621-2624.
15. Hoehe M. R., Wendel B., Grunewald I., Chiaroni P., Levy N., Morris-Rosendahl D., Macher J.-P., Sander T., and Crocq M-A. (1998) Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am. J. Med. Genet. 81, 1-3.
16. Kawarai T., Kawakami H., Yamamura Y., and Nakamura S. (1997) Structure and organization of the gene encoding human dopamine transporter. Gene 195, 11-18.
17. Kunugi H., Hattori M., Kato T., Tatsumi M., Sakai T., Sasaki T., Hirose T., and Nanko S. (1997) Serotonin transporter gene polymorphisms: ethnic difference and possible association with bipolar affective disorder. Mol. Psychiatry 2, 457-462.
18. Lesch K. P., Balling U., Gross J., Strauss K., Wolozin B. L., Murphy D. L., and Riederer P. (1994) Organization of the human serotonin transporter gene. J. Neural Transm. 95, 157-162.
19. Owens M. J. and Nemeroff C. B. (1994) Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin. Chem. 40, 288-295.
20. Raymond M. and Rousset F. (1995) An exact test for population differentiation. Evolution 49, 1280-1283.
21. Rees M., Norton N., Jones I., McCandless F., Scourfield J., Holmans P., Moorhead S., Feldman E., Sadler S., Cole T., Redman K., Farmer A., McGuffin P., Owen M. J., and Craddock N. (1997) Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT). Mol. Psychiatry 2, 398-402.
22. Schneider S., Kueffer J.-M., Roessli D., and Excoffier L. (1997) Arlequin: a software for population genetic data analysis. Version 1.1. Genetics and Biometry Laboratory. Department of Anthropology. University of Geneva.
23. Smith C. A. D., Gough A. C., Leigh P. N., Summers B. A., Harding A. E., Maranganore D. M., Sturman S. G., Schapira A. H. V., Williams A. C., Spurr N. K., and Wolf C. R. (1992) Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease. Lancet 339, 1375-1377.
24. Wickens M. (1990) How the messenger got its tail: addition of poly (A) in the nucleus. Trends Biochem. Sci. 15, 277-281.