Unbiased methods for population-based association studies

Genetic Epidemiology

Volumn 21, Issue 4, 2001, Pages 273-284

  Devlin, B ^a   Roeder, Kathryn ^b   Bacanu, Silviu Alin ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Case control study; Genomic control; Latent class model; Linkage disequilibrium; Population substructure; Structured association

Indexed keywords

DISEASE ASSOCIATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; METHODOLOGY; POPULATION RESEARCH; PROBABILITY; REVIEW; SAMPLING; STATISTICAL ANALYSIS;

ANALYSIS OF VARIANCE; BIAS (EPIDEMIOLOGY); CASE-CONTROL STUDIES; CONFOUNDING FACTORS (EPIDEMIOLOGY); DATA INTERPRETATION, STATISTICAL; EPIDEMIOLOGIC STUDIES; EPIDEMIOLOGY, MOLECULAR; GENE POOL; GENETIC HETEROGENEITY; GENETIC MARKERS; GENETICS, POPULATION; GENOMICS; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; POLYMORPHISM, GENETIC; QUANTITATIVE TRAIT, HERITABLE; REPRODUCIBILITY OF RESULTS;

EID: 0035191044     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.1034     Document Type: Review

References (29)

1. The power of genomic control
2. Association studies for quantitative traits in structured populations
3. Association mapping of disease loci, by use of a pooled DNA genomic screen
4. Controlling for the false discovery rate: A practical and powerful approach to multiple testing
5. High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
6. Heterozygote deficiency, population substructure and their implications in DNA fingerprinting
7. Genomic control for association studies
8. Genomic control for association studies: A semiparametric test to detect excess haplotype-sharing
9. Genomic control, a new approach to genetic-based association studies
10. The transmission/disequilibrium test: History, subdivision and admixture
11. Gm3-5,13,14 and type-2 diabetes-mellitusan association in American-Indians with genetic admixture
12. Distribution of gene frequencies as a test of the theory of selective neutrality of polymorphisms
13. Tests and estimates of allelic association in complex inheritance
14. Case-control studies of association in structured or admixed populations
15. Use of unlinked genetic markers to detect population stratification in association studies
16. Association mapping in structured populations
17. Inference of population structure using multilocus genotype data
18. Detecting association in a case-control study while correcting for population stratification
19. Searching for genetic determinants in the new millennium
20. The future of genetic studies of complex human diseases
21. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human disease. I. DNA pooling
22. Gene frequency distribution as a test of selective neutrality
23. Accounting for unmeasured population substructure in case-control studies of genetic association using a novel latent-class model
24. The future of genetic case-control studies
25. The future of genetic casecontrol studies
26. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
27. Outlier detection and false discovery rates for whole-genome DNA matching
28. Population stratification in epidemiologic studies of common genetic variants and cancer: Quantification of bias