BDNF variation and mood disorders: A novel functional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects

Neuropsychopharmacology

Volumn 30, Issue 7, 2005, Pages 1353-1361

  Jiang, Xueying ^a,b   Xu, Ke ^a   Hoberman, Joelle ^a   Tian, Feng ^a   Marko, Aimee J ^a   Waheed, Juwaria F ^a   Harris, Claudia R ^a   Marini, Ann M ^b   Enoch, Mary Anne ^a   Lipsky, Robert H ^a,c  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

^c Laboratory of Neurogenetics   (United States)

Author keywords

Anxiety; Brain derived neurotrophic factor; Depression; Gene; Polymorphism; Promoter

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; AFRICAN AMERICAN; ALLELE; AMERICAN INDIAN; AMINO ACID SEQUENCE; ANIMAL CELL; ANXIETY DISORDER; ARTICLE; AVOIDANCE BEHAVIOR; CAUCASIAN; CELL SURVIVAL; COMMUNITY CARE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DNA BINDING; DNA POLYMORPHISM; EMBRYO; FEMALE; GENE ACTIVITY; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HIPPOCAMPUS; HOMOZYGOSITY; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MOOD DISORDER; MORBIDITY; NERVE FUNCTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PSYCHIATRIC DIAGNOSIS; QUESTIONNAIRE; RAT; REPORTER GENE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPERAMENT; TRIDIMENSIONAL PERSONALITY QUESTIONNAIRE;

ADULT; AMINO ACID SUBSTITUTION; ANIMALS; ANXIETY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EMBRYO; FEMALE; GENE FREQUENCY; GENOTYPE; HIPPOCAMPUS; HUMANS; MALE; METHIONINE; MIDDLE AGED; MOOD DISORDERS; NEURONS; PERSONALITY INVENTORY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION; VALINE; VARIATION (GENETICS);

EID: 20544470482     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300703     Document Type: Article

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