Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens

Science

Volumn 309, Issue 5741, 2005, Pages 1720-1722

  Mekel Bobrov, Nitzan ^a   Gilbert, Sandra L ^a   Evans, Patrick D ^a   Vallender, Eric J ^a   Anderson, Jeffrey R ^a   Hudson, Richard R ^a   Tishkoff, Sarah A ^b   Lahn, Bruce T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b University of Maryland   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMEDICAL ENGINEERING; GENETIC ENGINEERING;

ADAPTIVE EVOLUTION; ASPM; POSITIVE SELECTION;

BRAIN;

EVOLUTION; GENETIC VARIATION;

ARTICLE; ASPM GENE; BRAIN SIZE; EVOLUTION; GENE; GENETIC SELECTION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; PRIORITY JOURNAL; REGULATOR GENE;

ADAPTATION, BIOLOGICAL; AFRICAN CONTINENTAL ANCESTRY GROUP; ANIMALS; ASIAN CONTINENTAL ANCESTRY GROUP; BRAIN; EUROPEAN CONTINENTAL ANCESTRY GROUP; EVOLUTION; GENE CONVERSION; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; NERVE TISSUE PROTEINS; ORGAN SIZE; PAN TROGLODYTES; PHYLOGENY; POLYMORPHISM, GENETIC; RECOMBINATION, GENETIC; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; TIME;

HOMO SAPIENS;

EID: 24644454655     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1116815     Document Type: Article

References (15)

1. J. Bond et al., Nat. Genet. 32, 316 (2002).
2. P. Ripoll, S. Pimpinelli, M. M. Valdivia, J. Avila, Cell 41, 907 (1985).
3. J. Zhang, Genetics 165, 2063 (2003).
4. P. D. Evans et al., Hum. Mol. Genet. 13, 489 (2004).
5. N. Kouprina et al., PLoS Biol. 2, E126 (2004).
6. S. L. Gilbert, W. B. Dobyns, B. T. Lahn, Nat. Rev. Genet. 6, 581 (2005).
7. Materials and methods are available as supporting material on Science Online.
8. M. Bamshad, S. P. Wooding, Nat. Rev. Genet. 4, 99 (2003).
9. N. A. Rosenberg et al., Science 298, 2381 (2002).
10. E. Zietkiewicz et al., J. Mol. Evol. 47, 146 (1998).
11. I. McDougall, F. H. Brown, J. G. Fleagle, Nature 433, 733 (2005).
12. S. Wright, Evolution and the Genetics of Populations (Univ. of Chicago Press, Chicago, 1978).
13. L. L. Cavalli-Sforza, P. Menozzi, A. Piazza, The History and Geography of Human Genes (Princeton Univ. Press, Princeton, 1994).
14. S. D. Houston, The First Writing: Script Invention as History and Process (Cambridge Univ. Press, New York, 2004).
15. We thank the Coriell Institute for Medical Research, the Centre d'Etude du Polymorphisme Humain, and A. Froment for human DNA samples; and H. M. Cann, A. Di Rienzo, S. Dorus, E. E. Eichler, M. Kreitman, N. M. Pearson, and J. K. Pritchard for technical support and helpful discussions. Supported in part by the Searle Scholarship and Burroughs Wellcome Career Award (to B.T.L) and by the David and Lucile Packard Career Award, Burroughs Wellcome Career Award, and NSF grant no. BCS-0196183 (to S.A.T).