Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene in schizophrenia

Schizophrenia Research

Volumn 65, Issue 1, 2003, Pages 9-14

  Xing, Qing He ^a,b   Wu, Sheng Nan ^a,b   Lin, Zhi Guang ^c   Li, Hua Fang ^c   Yang, Jian Dong ^a,b   Feng, Guo Yin ^c   Wang, Ming Tai ^d   Yang, Wei Wei ^a,b   He, Lin ^a,b  

^a Chinese Academy of Sciences   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c SHANGHAI MENTAL HEALTH CENTER   (China)

^d ZHENGZHOU UNIVERSITY   (China)

Author keywords

Chinese; Dopamine receptors; Polymorphism; Promoter; Schizophrenia

Indexed keywords

DOPAMINE 4 RECEPTOR; TRANSCRIPTION FACTOR;

ADULT; ALLELE; ARTICLE; BINDING SITE; CODON; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; GENE ACTIVITY; GENE DUPLICATION; GENE FREQUENCY; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; MUTATION; PRIORITY JOURNAL; PROMOTER REGION; SCHIZOPHRENIA; TRANSCRIPTION REGULATION;

EID: 0242660155     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(03)00064-1     Document Type: Article

References (24)

1. Ellison G. Stimulant-induced psychosis, the dopamine theory of schizophrenia, and the habenula. Brain Res. Brain Res. Rev. 19(2):1994;223-239.
2. Fan J.B., Tang J.X., Gu N.F., Feng G.Y., Zou F.G., Xing Y.L., Shi J.G., Zhao S.M., Zhu S.M., Ji L.P., Sun W.W., Zheng Y.L., Liu W.Q., Breen G., St. Clair D., He L. A family-based and case-control association study of the NOTCH4 gene and schizophrenia. Mol. Psychiatry. 7(1):2002;100-103.
3. Hong C.J., Chiu H.J., Chang Y.S., Sim C.B. Twelve-nucleotide repeat polymorphism of D4 dopamine receptor gene in Chinese familial schizophrenic patients. Biol. Psychiatry. 43(6):1998;432-435.
4. Jonsson E.G., Ivo R., Forslund K., Mattila-Evenden M., Rylander G., Cichon S., Propping P., Nothen M.M., Asberg M., Sedvall G.C. No association between a promoter dopamine D(4) receptor gene variant and schizophrenia. Am. J. Med. Genet. 105(6):2001;525-528.
5. Kamakura S., Iwaki A., Matsumoto M., Fukumaki Y. Cloning and characterization of the 5′-flanking region of the human dopamine D4 receptor gene. Biochem. Biophys. Res. Commun. 235(2):1997;321-326.
6. Kohn Y., Ebstein R.P., Heresco-Levy U., Shapira B., Nemanov L., Gritsenko I., Avnon M., Lerer B. Dopamine D4 receptor gene polymorphisms: relation to ethnicity, no association with schizophrenia and response to clozapine in Israeli subjects. Eur. Neuropsychopharmacol. 7(1):1997;39-43.
7. Lahti R.A., Roberts R.C., Cochrane E.V., Primus R.J., Gallager D.W., Conley R.R., Tamminga C.A. Direct determination of dopamine D4 receptors in normal and schizophrenic postmortem brain tissue: a [3H]NGD-94-1 study. Mol. Psychiatry. 3(6):1998;528-533.
8. Mitsuyasu H., Ozawa H., Takeda Y., Fukumaki Y. Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene. J. Hum. Genet. 44(6):1999;416-418.
9. Mitsuyasu H., Hirata N., Sakai Y., Shibata H., Takeda Y., Ninomiya H., Kawasaki H., Tashiro N., Fukumaki Y. Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits. J. Hum. Genet. 46(1):2001;26-31.
10. Murray A.M., Hyde T.M., Knable M.B., Herman M.M., Bigelow L.B., Carter J.M., Weinberger D.R., Kleinman J.E. Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia. J. Neurosci. 15(3 Pt 2):1995;2186-2191.
11. Okuyama Y., Ishiguro H., Toru M., Arinami T. A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia. Biochem. Biophys. Res. Commun. 258(2):1999;292-295.
12. O'Malley K.L., Harmon S., Tang L., Todd R.D. The rat dopamine D4 receptor: sequence, gene structure, and demonstration of expression in the cardiovascular system. New Biol. 4(2):1992;137-146.
13. Paterson A.D., Ying D.J., Petronis A., Schoots O., Lieberman J.A., Van Tol H.H., Kennedy J.L. A PstI restriction fragment length polymorphism in the 5' untranslated region of DRD4 is not associated with schizophrenia. Psychiatr. Genet. 6(4):1996;191-193.
14. Petronis A., Macciardi F., Athanassiades A., Paterson A.D., Verga M., Meltzer H.Y., Cola P., Buchanan J.A., Van Tol H.H., Kennedy J.L. Association study between the dopamine D4 receptor gene and schizophrenia. Am. J. Med. Genet. 60(5):1995;452-455.
15. Sanyal S., Van Tol H.H. Review the role of dopamine D4 receptors in schizophrenia and antipsychotic action. J. Psychiatr. Res. 31(2):1997;219-232.
16. Seaman M.I., Fisher J.B., Chang F.M., Kidd K.K. Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4). Am. J. Med. Genet. (Neuropsychiatr. Genet.). 88:1999;705-709.
17. Seeman P., Guan H.C., Van Tol H.H. Dopamine D4 receptors elevated in schizophrenia. Nature. 365(6445):1993;441-445.
18. Seeman P., Corbett R., Van Tol H.H. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology. 13:1995;177-213.
19. Stefanis N.C., Bresnick J.N., Kerwin R.W., Schofield W.N., McAllister G. Elevation of D4 dopamine receptor mRNA in postmortem schizophrenic brain. Mol. Brain Res. 53(1-2):1998;112-119.
20. Sumiyoshi T., Stockmeier C.A., Overholser J.C., Thompson P.A., Meltzer H.Y. Dopamine D4 receptors and effects of guanine nucleotides on [3H]raclopride binding in postmortem caudate nucleus of subjects with schizophrenia or major depression. Brain Res. 681(1-2):1995;109-116.
21. Tarazi F.I., Baldessarini R.J. Dopamine D4 receptors: significance for molecular psychiatry at the millennium. Mol. Psychiatry. 4(6):1999;529-538.
22. Van Tol H.H., Bunzow J.R., Guan H.C., Sunahara R.K., Seeman P., Niznik H.B., Civelli O. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature. 350(6319):1991;610-614.
23. Wong A.H., Buckle C.E., Van Tol H.H. Polymorphisms in dopamine receptors: what do they tell us? Eur. J. Pharmacol. 410(2-3):2000;183-203.
24. Zhao J.H., Curtis D., Sham P.C. Model-free analysis and permutation test for allelic associations. Hum. Hered. 50(2):2000;133-139.