The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism

Biological Psychiatry

Volumn 58, Issue 9, 2005, Pages 738-742

  Willis Owen, Saffron A G ^a   Fullerton, Jan ^a   Surtees, Paul G ^b   Wainwright, Nick W J ^b   Miller, Susette ^a   Flint, Jonathan ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Brain derived neurotrophic factor (BDNF); Depression; Neuroticism; val66met

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC CODE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; NEUROSIS; PERSONALITY; PERSONALITY TEST; POPULATION GENETICS; PRIORITY JOURNAL; QUESTIONNAIRE; SIMULATION; STATISTICAL SIGNIFICANCE; STRESS; UNITED KINGDOM;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; BAYES THEOREM; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; EMOTIONS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FAMILY; FEMALE; GENOTYPE; GREAT BRITAIN; HUMANS; MALE; MODELS, STATISTICAL; NEUROTIC DISORDERS; PERSONALITY; PERSONALITY TESTS; PSYCHIATRIC STATUS RATING SCALES; RETROSPECTIVE STUDIES; SOCIAL BEHAVIOR; SOCIAL ENVIRONMENT; VARIATION (GENETICS);

EID: 27544495491     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.05.014     Document Type: Article

References (45)

1. G.R. Abecasis, L.R. Cardon, W.O. Cookson A general test of association for quantitative traits in nuclear families Am J Hum Genet 66 2000 279 292
2. A. Aluja, O. Garcia, L.F. Garcia A comparative study of Zuckerman's three structural models for personality through the NEO-PI-R, ZKPQ-III-R, EPQ-RS and Goldberg's 50-bipolar adjectives Pers Individ Dif 33 2002 713 725
3. D.M. Bannerman, J.N. Rawlins, S.B. McHugh, R.M. Deacon, B.K. Yee, T. Bast Regional dissociations within the hippocampus-memory and anxiety Neurosci Biobehav Rev 28 2004 273 283
4. T. Brugha, P. Bebbington, C. Tennant, J. Hurry The List of Threatening Experiences A subset of 12 life event categories with considerable long-term contextual threat Psychol Med 15 1985 189 194
5. S. Campbell, M. Marriott, C. Nahmias, G.M. MacQueen Lower hippocampal volume in patients suffering from depression A meta-analysis Am J Psychiatry 161 2004 598 607
6. M. Cargill, D. Altshuler, J. Ireland, P. Sklar, K. Ardlie, N. Patil Characterization of single-nucleotide polymorphisms in coding regions of human genes Nat Genet 22 1999 231 238
7. P.T. Costa, R.R. McCrae The NEO Personality Manual 1985 Psychological Assessment Resources Odessa, FL
8. N. Day, S. Oakes, R. Luben, K.T. Khaw, S. Bingham, A. Welch European Prospective Investigation of Cancer EPIC-Norfolk Study design and characteristics of the cohort Br J Cancer 80 suppl 1 1999 95 103
9. R.S. Duman, D.S. Charney Cell atrophy and loss in major depression Biol Psychiatry 45 1999 1083 1084
10. M.F. Egan, M. Kojima, J.H. Callicott, T.E. Goldberg, B.S. Kolachana, A. Bertolino The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 2003 257 269
11. P.S. Eriksson, E. Perfilieva, T. Bjork-Eriksson, A.M. Alborn, C. Nordborg, D.A. Peterson Neurogenesis in the adult human hippocampus Nat Med 4 1998 1313 1317
12. H.J. Eysenck, S.B.G. Eysenck Manual of the Eysenck Personality Questionnaire 1975 Digits San Diego
13. S.B.G. Eysenck, H.J. Eysenck, P. Barrett A revised version of the psychoticism scale Pers Individ Dif 6 1985 21 29
14. D.S. Falconer, T.F.C. Mackay Introduction to Quantitative Genetics 4th ed 1996 Longman Harlow, UK 126
15. D. Falush, M. Stephens, J.K. Pritchard Inference of population structure using multilocus genotype data Linked loci and correlated allele frequencies Genetics 164 2003 1567 1587
16. A. Fanous, C.O. Gardner, C.A. Prescott, R. Cancro, K.S. Kendler Neuroticism, major depression and gender A population-based twin study Psychol Med 32 2002 719 728
17. J. Fullerton, M. Cubin, H. Tiwari, C. Wang, A. Bomhra, S. Davidson Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism Am J Hum Genet 72 2003 879 890
18. A.A. Garza, T.G. Ha, C. Garcia, M.J. Chen, A.A. Russo-Neustadt Exercise, antidepressant treatment, and BDNF mRNA expression in the aging brain Pharmacol Biochem Behav 77 2004 209 220
19. D. Hall, A. Dhilla, A. Charalambous, J.A. Gogos, M. Karayiorgou Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder Am J Hum Genet 73 2003 370 376
20. M. Hofer, S.R. Pagliusi, A. Hohn, J. Leibrock, Y.A. Barde Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain EMBO J 9 1990 2459 2464
21. R. Ihaka, R. Gentleman R A language for data analysis and graphics J Comput Graph Stat 5 1996 299 314
22. O.P. John The "big five" factor taxonomy Dimensions of personality in the natural language and in questionnaires L.A. Pervin Handbook of Personality Theory and Research 1990 Guilford Press New York; London 66 100
23. K.S. Kendler, M.C. Neale, R.C. Kessler, A.C. Heath, L.J. Eaves A longitudinal twin study of personality and major depression in women Arch Gen Psychiatry 50 1993 853 862
24. H. Kunugi, Y. Iijima, M. Tatsumi, M. Yoshida, R. Hashimoto, T. Kato No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population A multicenter study Biol Psychiatry 56 2004 376 378
25. U.E. Lang, R. Hellweg, J. Gallinat BDNF serum concentrations in healthy volunteers are associated with depression-related personality traits Neuropsychopharmacology 29 2004 795 798
26. J.E. Malberg, A.J. Eisch, E.J. Nestler, R.S. Duman Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus J Neurosci 20 2000 9104 9110
27. L.A. Mamounas, C.A. Altar, M.E. Blue, D.R. Kaplan, L. Tessarollo, W.E. Lyons BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain J Neurosci 20 2000 771 782
28. N. Martin, G. Goodwin, C. Fairburn, R. Wilson, D. Allison, L.R. Cardon A population-based study of personality in 34,000 sib-pairs Twin Res 3 2000 310 315
29. M. Neves-Pereira, E. Mundo, P. Muglia, N. King, F. Macciardi, J.L. Kennedy The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder Evidence from a family-based association study Am J Hum Genet 71 2002 651 655
30. J.K. Pritchard, M. Stephens, P. Donnelly Inference of population structure using multilocus genotype data Genetics 155 2000 945 959
31. L.M. Rattiner, M. Davis, C.T. French, K.J. Ressler Brain-derived neurotrophic factor and tyrosine kinase receptor B involvement in amygdala-dependent fear conditioning J Neurosci 24 2004 4796 4806
32. J. Reich, R. Noyes Jr, R. Hirschfeld, W. Coryell, T. O'Gorman State and personality in depressed and panic patients Am J Psychiatry 144 1987 181 187
33. N.J. Risch Searching for genetic determinants in the new millennium Nature 405 2000 847 856
34. S. Sen, R.M. Nesse, S.F. Stoltenberg, S. Li, L. Gleiberman, A. Chakravarti A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression Neuropsychopharmacology 28 2003 397 401
35. Y. Shirayama, A.C. Chen, S. Nakagawa, D.S. Russell, R.S. Duman Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression J Neurosci 22 2002 3251 3261
36. P. Sklar, S.B. Gabriel, M.G. McInnis, P. Bennett, Y.M. Lim, G. Tsan Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor Mol Psychiatry 7 2002 579 593
37. M.A. Smith, S. Makino, S.Y. Kim, R. Kvetnansky Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary Endocrinology 136 1995 3743 3750
38. M.A. Smith, S. Makino, R. Kvetnansky, R.M. Post Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus J Neurosci 15 1995 1768 1777
39. C.A. Stockmeier, G.J. Mahajan, L.C. Konick, J.C. Overholser, G.J. Jurjus, H.Y. Meltzer Cellular changes in the postmortem hippocampus in major depression Biol Psychiatry 56 2004 640 650
40. Surtees PG, Wainwright N, Willis-Owen SAG, Luben R, Day NE, Flint J (in press): Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry
41. P.G. Surtees, N.W. Wainwright, C. Brayne Psychosocial aetiology of chronic disease A pragmatic approach to the assessment of lifetime affective morbidity in an EPIC component study J Epidemiol Community Health 54 2000 114 122
42. P.G. Surtees, N.W. Wainwright, K.T. Khaw, N.E. Day Functional health status, chronic medical conditions and disorders of mood Br J Psychiatry 183 2003 299 303
43. R.J. Tolwani, P.S. Buckmaster, S. Varma, J.M. Cosgaya, Y. Wu, C. Suri BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus Neuroscience 114 2002 795 805
44. Y. Watanabe, E. Gould, B.S. McEwen Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons Brain Res 588 1992 341 345
45. Willis-Owen SAG, Turri M, Surtees P, Wainwright NWJ, Brixey RD, Flint J (in press): The serotonin transporter length polymorphism, neuroticism and depression: A comprehensive assessment of association. Biol Psychiatry