Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design

Behavior Genetics

Volumn 35, Issue 6, 2005, Pages 707-721

  Keller, Matthew C ^a   Coventry, William L ^b   Heath, Andrew C ^c   Martin, Nicholas G ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Behavior genetics; Dominance; Epistasis; Non additive genetic variation; Personality

Indexed keywords

ADULT; AGED; ARTICLE; DIZYGOTIC TWINS; DOMINANCE BEHAVIOR; ENVIRONMENTAL FACTOR; EPISTASIS; EVOLUTION; EXTRAVERSION; FEMALE; GENETIC VARIABILITY; HARM REDUCTION; HERITABILITY; HUMAN; MALE; MONOZYGOTIC TWINS; PERSONALITY TEST; QUESTIONNAIRE; REWARD; SENSITIVITY ANALYSIS;

AUSTRALIA; FEMALE; HUMANS; LIFE STYLE; MALE; MODELS, GENETIC; PERSONALITY; PERSONALITY ASSESSMENT; QUESTIONNAIRES; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; SIBLINGS; VARIATION (GENETICS);

EID: 27844543227     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10519-005-6041-7     Document Type: Article

References (46)

1. D. I. Boomsma N. G. Martin 2002 Gene-environment interactions H. D. 'haenen J. A. Boer P. den Willner Biological psychiatry John Wiley and Sons New York 181 187
2. T. J. Bouchard D. T. Lykken M. [tmp] McGue N. Segal A. Tellegen 1990 Sources of human psychological differences: The Minnesota Study of Twins Reared Apart Science 250 223 228
3. G. Carey 1986 Sibling imitation and contrast effects Behav. Genet. 16 319 342
4. C. R. Cloninger 1994 The Temperament and Character Inventory (TCI): A Guide to its Development and Use Centre for Psychobiology of Personality St. Louis, MO
5. C. R. Cloninger T. R. Przybeck D. M. Svrakic 1991 The Tridimensional Personality Questionnaire: U.S. normative data Psychol. Rep. 69 1047 1057
6. Coventry, W.L. and Keller, M. C. (2005). Estimating the extent of parameter bias in the classical twin design: a comparison of parameter estimates from extended twin-family and classical twin designs. Twin Res. Human Genet., 8:214-223.
7. J. W. Curtisinger P. M. Service T. Prout 1994 Antagonistic pleiotropy, reversal of dominance, and genetic polymorphism Am. Nat. 144 210 228
8. C. V. Dolan D. I. Boomsma M. C. Neale 1999 A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL Behav. Genet. 29 163 170
9. L. J. Eaves 1976 A model fo sibling effects in man Heredity 36 205 214
10. L. J. Eaves H. J. Eysenck J. M. Martin 1989 Genes, culture, and personality: an empirical approach Academic Press Londong
11. L. J. Eaves 1988 Dominance alone is not enough Behav. Genet 8 201 213
12. L. J. Eaves A. C. Heath N. G. Martin H. H. Maes M. C. Neale K. S. Kendler 1999 Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives Twin Res. 2 62 80
13. L. J. Eaves A. C. Heath M. C. Neale J. K. Hewitt N. G. Martin 1998 Sex differences and non-additivity in the effects of genes on personality Twin Res. 1 131 137
14. L. J. Eaves K. Last J. M. Martin J. L. Jinks 1977 A progressive approach to non-additivity and genotype-environmental covariance in the analysis of human differences Br. J. Math. Stat. 30 1 42
15. H. J. Eysenck S. B. G. Eysenck P. Barrett 1985 A revised version of the Psychoticism scale Person. Ind. Diff. 76 21 29
16. D. S. Falconer T. F. C. Mackay 1996 Introduction to Quantitative Genetics 4 Addison Wesley Longman Harlow, Essex, UK
17. R. A. Fisher 1930 The Genetical Theory of Natural Selection Clarendon Press Oxford, UK
18. W. N. Frankel N. J. Schork 1996 Who's afraid of epistasis Nat. Genet. 14 371 373
19. N. A. Gillespie C. R. Cloninger A. C. Heath N. G. Martin 2003 The genetic and environmental relationship between Cloninger's dimensions of temperament and character Person. Ind. Differ. 35 1931 1946
20. A. C. Heath C. R. Cloninger N. G. Martin 1994a Testing a model for the genetic structure of personality: a comparison of the personality systems of Cloninger and Eysenk J. Person. Soc. Psychol. 66 762 775
21. A. C. Heath P. A. Madden C. R. Cloninger N. G. Martin 1994b Genetic and environmental structure of personality C. R. Cloninger Personality and psychopathology American Psychiatric Press Washington, DC
22. N. Heiman M. C. Stallings S. E. Young J. K. Hewitt 2004 Investigating the genetic and environmental structure of Cloninger's personality dimensions in adolescence Twin Res. 7 462 470
23. R. M. C. Huntley 1966 Heritability of intelligence J. E. Meade A. S. Parkes Genetic and environmental factors in human ability Oliver and Boyd Edinburgh
24. Keller, M. C. and Coventry, W. L. (2005). Quantifying and addressing parameter indeterminacy in the classical twin design. Twin Res. Human Genet., 8:201-213.
25. K. S. Kendler 1983 Overview: a current perspective on twin studies of schizophrenia Am. J. Psychiatry 140 1413 1425
26. R. I. E. Lake L. J. Eaves H. H. Maes A. C. Heath N. G. Martin 2000 Further evidence against the environmental transmission of individual differences in neuroticism from a collaborative study of 45,850 twins and relatives on two continents Behav. Genet. 30 223 233
27. W. Li J. W. Reich 2000 A complete enumeration and classification of two-locus disease models Human Heredity 50 334 349
28. J. C. Loehlin L. Willerman J. Horn 1985 Personality resemblances in adoptive families when the children are late-adolescent or adult J. Person. Soc. Psychol. 48 376 392
29. D. T. Lykken M. [tmp] McGue A. Tellegen T. J. Bouchard 1992 Emergenesis: genetic traits that may not run in families Am. Psychol. 47 1565 1577
30. N. G. Martin L. J. Eaves M. J. Kearsey P. Davies 1978 The power of the classical twin study Heredity 28 79 95
31. K. Mather 1974 Non-allelic interaction in continuous variation of randomly breeding populations Heredity 32 414 419
32. S. E. Medland 2004 Alternate parameterization for scalar and non-scalar sex-limitation models in MX Twin Res. 7 299 305
33. J. Merilä B. C. Sheldon 1999 Genetic architecture of fitness and nonfitness traits: empirical patterns and development of ideas Heredity 83 103 109
34. R. T. Mulder P. R. Joyce 1997 Temperament and the structure of personality disorder symptoms Psychol. Med. 27 99 106
35. R. T. Mulder P. R. Joyce P. F. Sullivan C. M. Bulik F. A. Carter 1999 The relationship among three models of personality psychopathology: DSM-III-R personality disorder, TCI scores and DSQ defences Psychol. Med. 29 943 951
36. M. R. Munafo T. G. Clark L. R. Moore E. Payne R. Walton J. Flint 2003 Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis Mol. Psychiatry 8 471 484
37. M. C. Neale 1999 MX: Statistical Modelling 5 Department of Psychiatry Richmond, VA
38. S. Ooki K. Yamada A. Asaka K. Hayakawa 1990 Zygosity diagnosis of twins by questionnaire Acta Genet. Med. Gemel. (Roma) 39 109 115
39. D. Posthuma D. Boomsma 2000 A note on the statistical power in extended twin designs Behav. Genet. 30 147 158
40. S. Purcell P. C. Sham 2004 Epistasis in quantitative trait locus linkage analysis: interaction or main effect? Behav. Genet. 34 143 151
41. D. A. Roff T. A. Mousseau 1987 Quantitative genetics and fitness Heredity 58 103 118
42. M. C. Stallings J. K. Hewitt C. R. Cloninger A. C. Heath L. J. Eaves 1996 Genetic and environmental structure of the Tridimensional Personality Questionnaire: three or four temperamental dimensions? J. Person. Soc. Psychol. 70 127 140
43. A. Tellegen D. T. Lykken T. J. Bouchard K. J. Wilcox N. Segal S. Rich 1988 Personality similarity in twins reared apart and together J. Person. Soc. Psychol. 54 1031 1039
44. K. Wang J. Huang 2002 Score test for mapping quantitative-trait loci with sibships of arbitrary size when the dominance effect is not negligible Genet. Epidemiol. 23 398 412
45. D. Watson 2004 Stability versus change, dependability versus error: issues in the assessment of personality over time J. Res. Person. 38 319 350
46. G. Zhu D. M. Evans D. L. Duffy G. W. Montgomery S. E. Medland N. A. Gillespie 2004 A genome scan for eye color in 502 twin families: most variation is due to a QTL on Chromosome 15q Twin Res. 7 197 210