Tridimensional personality questionnaire trait of harm avoidance (anxiety proneness) is linked to a locus on chromosome 8p21

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 117 B, Issue 1, 2003, Pages 66-69

  Zohar, Ada H ^a   Dina, Christian ^b   Rosolio, Naama ^c   Osher, Yamima ^c   Gritsenko, Inga ^e   Bachner Melman, Rachel ^e   Benjamin, Jonathan ^c   Belmaker, Robert H ^c   Ebstein, Richard P ^d  

^a RUPPIN ACADEMIC CENTER   (Israel)

^b INSTITUT DE BIOLOGIE DE LILLE   (France)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d HERZOG HOSPITAL   (Israel)

^e NONE

Author keywords

Anxiety related trait; Chromosome 8; Harm avoidance; Linkage; Personality; QTL; Quantitative trait locus; Schizophrenia; TPQ; Tridimensional personality questionnaire

Indexed keywords

ANXIETY; ARTICLE; CHROMOSOME 1Q; CHROMOSOME 22Q; CHROMOSOME 8P; GENE LOCUS; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MICROSATELLITE MARKER; PERSONALITY; PRIORITY JOURNAL; QUESTIONNAIRE; SCORING SYSTEM; SIBLING; TRIDIMENSIONAL PERSONALITY QUESTIONNAIRE TRAIT OF HARM AVOIDANCE;

GENETTA;

EID: 0041821968     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.10029     Document Type: Article

References (25)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. 2002. Merlin - Rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30(1):97-101.
2. Alcais A, Abel L. 1999. Maximum-likelihood-binomial method for genetic model-free linkage analysis of quantitative traits in sibships. Genet Epidemiol 17(2):102-117.
3. Alcais A, Philippi A, Abel L. 1999. Genetic model-free linkage analysis using the maximum-likelihood-binomial method for categorical traits. Genet Epidemiol 17(Suppl 1):S467-S472.
4. Belmaker RH, Biederman J. 1994. Genetic markers, temperament, and psychopathology [editorial]. Biol Psychiatry 36(2):71-72.
5. Brzustowicz LM, Hodgkinson KA, Chow EW, Honer WG, Bassett AS. 2000. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 288(5466):678-682.
6. Cloninger CR. 1987. A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 44(6):573-588.
7. Cloninger CR, Przybeck TR, Svrakic DM. 1991. The tridimensional personality questionnaire: U.S. normative data. Psychol Rep 69(3 Pt 1):1047-1057.
8. Cloninger CR, Adolfsson R, Svrakic NM. 1996. Mapping genes for human personality [news]. Nat Genet 12(1):3-4.
9. Cloninger CR, Van Eerdewegh P, Goate A, Edenberg HJ, Blangero J, Hesselbrock V, Reich T, Nurnberger J Jr, Schuckit M, Porjesz B, Crowe R, Rice JP, Foroud T, Przybeck TR, Almasy L, Bucholz K, Wu W, Shears S, Carr K, Crose C, Willig C, Zhao J, Tischfield JA, Li TK, Conneally PM, et al. 1998. Anxiety proneness linked to epistatic loci in genome scan of human personality traits. Am J Med Genet 81(4):313-317.
10. Ebstein RP, Benjamin J, Belmaker RH. 2000a. Genetics of personality dimensions. Curr Opin Psychiatry 13(6):617-622.
11. Ebstein RP, Benjamin J, Belmaker RH. 2000b. Personality and polymorphisms of genes involved in aminergic neurotransmission. Eur J Pharmacol 410(2-3):205-214.
12. Ebstein RP, Corbex M, Kremer I, Dobrusin M, Murad I, Rietschel M, Maier W. 2001. No evidence for linkage by transmission disequilibrium test analysis of microsatellite markers in chromosomal 1q21-22 region to schizophrenia in a Palestinian Arab population. Neuropsychiatr Genet 105(7):598.
13. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. 2001. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98(12):6917-6922.
14. Elston RC. 1998. Linkage and association [In Process Citation]. Genet Epidemiol 15(6):565-576.
15. Freedman R, Adler LE, Leonard S. 1999. Alternative phenotypes for the complex genetics of schizophrenia [In Process Citation]. Biol Psychiatry 45(5):551-558.
16. Gallina S, Lecoeur C, Delannoy V, Dina C. 2001. Intranet software environment for linkage analysis studies. Paper presented at the European Mathematical Genetics Meeting, Lille, France.
17. Gottesman II, Wolfgram DL. 1991. Schizophrenia genesis: The origins of madness. New York: Freeman.
18. Horvath S, Xu X, Laird N. 2001. The family based association test method: Strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301-306.
19. Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Luebbert H. 2001. A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc Natl Acad Sci USA 98(2):585-590.
20. Kluger AN, Siegfried Z, Ebstein RP. 2002. A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Mol Psychiatry 7:712-717.
21. Knoblauch H, Muller-Myhsok B, Busjahn A, Ben Avi L, Bahring S, Baron H, Heath SC, Uhlmann R, Faulhaber HD, Shpitzen S, Aydin A, Reshef A, Rosenthal M, Eliav O, Muhl A, Lowe A, Schurr D, Harats D, Jeschke E, Friedlander Y, Schuster H, Luft FC, Leitersdorf E. 2000. A cholesterollowering gene maps to chromosome 13q. Am J Hum Genet 66(1):157-166.
22. Loehlin JC. 1992. Genes and environment in personality development. Newbury Park: Sage Publications.
23. Mujaheed M, Corbex M, Lichtenberg P, Levinson DF, Deleuze JF, Mallet J, Ebstein RP. 2000. Evidence for linkage by transmission disequilibrium test analysis of a chromosome 22 microsatellite marker D22S278 and bipolar disorder in a palestinian arab population. Am J Med Genet 96(6):836-838.
24. Roberts SB, MacLean CJ, Neale MC, Eaves LJ, Kendler KS. 1999. Replication of linkage studies of complex traits: An examination of variation in location estimates. Am J Hum Genet 65(3):876-884.
25. Wildenauer DB, Schwab SG. 1999. Chromosomes 8 and 10 workshop. Am J Med Genet 88(3):239-243.