Results of a genomewide linkage scan: Support for chromosomes 9 and 11 loci increasing risk for cigarette smoking

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 128 B, Issue 1, 2004, Pages 94-101

  Gelernter, Joel ^a,b   Liu, Xuexuan ^c   Hesselbrock, Victor ^d   Page, Grier P ^e   Goddard, Andrew ^f   Zhang, Heping ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c YALE UNIVERSITY   (United States)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^f INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiety; Cigarette smoking; Genetic linkage; Nicotine dependence; Pedigrees; Substance dependence

Indexed keywords

ALCOHOLISM; ANXIETY; ARTICLE; CHROMOSOME 11; CHROMOSOME 14; CHROMOSOME 16; CHROMOSOME 9; CIGARETTE SMOKING; DRUG ABUSE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PANIC; PRIORITY JOURNAL; X CHROMOSOME;

EID: 3042806901     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30019     Document Type: Article

References (35)

1. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. 2002. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101.
2. Arinami T, Ishiguro H, Onaivi ES. 2000. Polymorphisms in genes involved in neurotransmission in relation to smoking. Eur J Pharmacol 410(2-3):215-226.
3. Bergen AW, Korczak JF, Weissbecker KA, Goldstein AM, et al. 1999. A genome-wide search for loci contributing to smoking and alcoholism. Genet Epidemiol 17(Suppl 1):S55-S60.
4. Bierut LJ, Rice JP, Goate A, Hinrichs AL, Saccone NL, Foroud T, Edenberg HJ, Cloninger CR, Begleiter H, Conneally MP, Crowe RR, Hesselbrock V, Li T-K, Nurnberger JI, Porjesz B, Schuckit MA, Reich TR. 2004. A genomic scan for habitual smoking in families of alcoholics: Common and specific genetic factors in substance dependence. Am J Med Genet 124A:19-27.
5. Boehnke M. 1986. Estimating the power of a proposed linkage study: A practical computer simulation approach. Am J Hum Genet 39:513-527.
6. Breslau N, Klein DF. 1999. Smoking and panic attacks: An epidemiologic investigation. Arch Gen Psychiatry 56(12):1141-1147.
7. Douglas JA, Boehnke M, Lange K. 2000. A multipoint method for detecting genotyping errors and mutations in sibling-pair linkage data. Am J Hum Genet 66(4):1287-1297.
8. Duggirala R, Almasy L, Blangero J. 1999. Smoking behavior is under the influence of a major quantitative trait locus on human chromosome 5q. Genet Epidemiol 17(Suppl 1): S139-S144.
9. Fagerstrom KO. 1978. Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addict Behav 3(3-4):235-241.
10. First MB, Spitzer RL, Gibbon M, Williams JBW, et al. 1997. Structured clinical interview for DSM-IV Axis I disorders, research version, non-patient edition (SCID-NP) version 2.0. New York: Biometrics Research, New York State Psychiatric Institute.
11. Foroud T, Edenberg HJ, Goate A, Rice J, Flury L, Koller DL, et al. 2000. Alcoholism susceptibility loci: Confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24(7):933-945.
12. Gelernter J, Kennedy J, van Tol HHM, Civelli O, Kidd KK. 1992. The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 13:208-210.
13. Gelernter J, Bonvicini K, Page G, Woods SW, Goddard AW, Kruger S, et al. 2001. Linkage genome scan for loci predisposing to panic disorder or agoraphobia. Am J Med Genet 105(6):548-557,
14. Gelernter J, Page G, Bonvicini K, Woods SW, Pauls DL, Kruger S. 2003. A chromosome 14 risk locus for simple phobia: Results from a genomewide linkage scan. Mol Psychiatry 8:71-82.
15. Gudbjartsson DF, Jonasson K, Frigge ML, Kong A. 2000. Allegro: A new computer program for multipoint linkage analysis. Nat Genet 25(1): 12-13.
16. Johnson JG, Cohen P, Pine DS, Klein DF, Kasen S, Brook JS. 2000. Association between cigarette smoking and anxiety disorders during adolescence and early adulthood. JAMA 284(18):2348-2351.
17. Kendler KS, Thornton LM, Pedersen NL. 2000. Tobacco consumption in Swedish twins reared apart and reared together. Arch Gen Psychiatry 57(9):886-892.
18. Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K. 2003. A high-resolution recombination map of the human genome. Nat Genet 31:241-247.
19. Lerman C, Caporaso NE, Bush A, Zheng YL, Audrain J, Main D, et al. 2001. Tryptophan hydroxylase gene variant and smoking behavior. Am J Med Genet 105(6):518-520.
20. Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, et al. 1998. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81(3):216-221.
21. McPeek MS, Sun L. 2000. Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet 66(3): 1076-1094.
22. O'Connell JR, Weeks DE. 1998, PedCheck: A program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63(1): 259-266.
23. Ott J. 1999. Analysis of human genetic linkage. 3rd edition. Baltimore, MD: The Johns Hopkins University Press.
24. Ploughman LM, Boehnke M. 1989. Estimating the power of a proposed linkage study for a complex genetic trait, Am J Hum Genet 44:543-551.
25. Reich T, Edenberg HJ, Goate A, Williams JT, Rice JP, Van Eerdewegh P, et al. 1998, Genome-wide search for genes affecting the risk for alcohol dependence, Am J Med Genet 81(3):207-215.
26. Shields PG, Lerman C, Audrain J, Bowman ED, Main D, Boyd NR, et al. 1998. Dopamine D4 receptors and the risk of cigarette smoking in African-Americans and Caucasians. Cancer Epidemiol Biomarkers Prev 7(6):453-458.
27. Spence MA, Greenberg DA, Hodge SE, Vieland VJ. 2003. The Emperor's New Methods. Am J Hum Genet 72:1084-1087.
28. Spitzer RL, Endicott J. 1975. Schedule for affective disorders and schizophrenia: Lifetime version.
29. Straub RE, Sullivan PF, Ma Y, Myakishev MV, Harris-Kerr C, Wormley B, et al. 1999. Susceptibility genes for nicotine dependence: A genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17, and 18 merit further study. Mol Psychiatry 4(2):129-144.
30. Sullivan PF, Jiang Y, Neale MC, Kendler KS, Straub RE. 2001. Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence. Am J Med Genet 105(5):479-484.
31. Sullivan PF, Neale BM, Neale MC, van den Oord E, Kendler KS. 2003. Multipoint and single point non-parametric linkage analysis with imperfect data. Am J Med Genet (Neuropsych Genet) [Online ISSN: 1096-8628; Print ISN: 0148-7299; full print reference information pending.]
32. Thorgeirsson TE, Oskarsson H, Desnica N, Kostic JP, Stefansson JG, Kolbeinsson H, Lindal E, Gagunashvili N, Frigge ML, Kong A, Stefansson K, Gulcher JR. 2003. Anxiety with panic disorder linked to chromosome 9q in Iceland. Am J Hum Genet 72:1221-1230.
33. True WR, Xian H, Scherrer JF, Madden PA, Bucholz KK, Heath AC, et al. 1999. Common genetic vulnerability for nicotine and alcohol dependence in men. Arch Gen Psychiatry 56(7):655-661.
34. Uhl GR, Liu QR, Walther D, Hess J, Naiman D. 2001. Polysubstance abuse-vulnerability genes: Genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am J Hum Genet 69(6): 1290-1300.
35. Uhl GR, Liu Q-R, Naiman D. 2002. Substance abuse vulnerability loci: Converging genome scanning data. Trends Genet 18:420-425.