Molecular genetics of substance abuse vulnerability: Remarkable recent convergence of genome scan results

Annals of the New York Academy of Sciences

Volumn 1025, Issue , 2004, Pages 1-13

  Uhl, George R ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Addiction; Convergence; Genome scan; Loci; Substance abuse

Indexed keywords

ALCOHOL; NICOTINE;

ADDICTION; ALLELE; CHROMOSOME; CONFERENCE PAPER; DRUG DEPENDENCE; GENOMICS; HUMAN; MARKER GENE; MOLECULAR GENETICS; SUBSTANCE ABUSE;

EID: 10444266005     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1316.001     Document Type: Conference Paper

References (40)

1. EDENBERG, H.J. et al. 2004. Variations in GABRA2 are associated wtih alcohol dependence and with brain oscillations. Am. J. Hum. Genet. 74: 705.
2. CARMELLI, D., et al. 2002. Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins. Biol. Psychol. 61: 139-155.
3. CARTER, J.A., et al. 2001. Short-term stability of NEO-PI-R personality trait scores in opioid-dependent outpatients. Psychol. Addict. Behav. 15: 255-260.
4. COSTA, P.T., et al. 1998. Personality disorders and the five-factor model of personality. American Psychological Association. Washington, DC.
5. FEIN, G., et al. 2002. Cortical gray matter loss in treatment-naive alcohol dependent individuals. Alcohol Clin. Exp. Res. 26: 558-564.
6. FEIN, G., et al. 2002. Prefrontal cortical volume reduction associated with frontal cortex function deficit in 6-week abstinent crack-cocaine dependent men. Drug Alcohol Depend. 68: 87-93.
7. FOROUD, T., et al. 2000. Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin. Exp. Res. 24: 933-945.
8. GELERNTER, J. et al. 2004. Results of a genomewide linkage scans support for chromosomes 9 and 11 loci increasing risk for cigarette smoking. Am. J. Med. Genet. (Part B) 128: 94-101
9. GLAZIER, A.M., et al. 2002. Finding genes that underlie complex traits. Science 98:2345-2349.
10. JANG, K.L., et al. 1996. Heritability of the big five personality dimensions and their facets: a twin study. J. Pers. 64: 577-591.
11. KENDLER, K.S., et al. 1999. Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women. Br. J. Psychiatry 175: 351-356.
12. KENDLER, K.S., et al. 1998. Cocaine use, abuse and dependence in a population-based sample of female twins. Br. J. Psychiatry 173: 345-350.
13. KENDLER, K.S., et al. 1997. Temperance board registration for alcohol abuse in a national sample of Swedish male twins, born 1902 to 1949. Arch. Gen. Psychiatry 54: 178-184.
14. KENDLER, K.S., et al. 2000. Tobacco consumption in Swedish twins reared apart and reared together. Arch. Gen. Psychiatry 57: 886-892.
15. LONG, J.C., et al. 1998. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am. J. Med. Genet. 81: 216-221.
16. PERSICO, A.M., et al. 1996. D2 dopamine receptor gene TaqI A1 and B1 restriction fragment length polymorphisms: enhanced frequencies in psychostimulant - preferring polysubstance abusers. Biol. Psychiatry 40: 776-784.
17. PICKENS, R.W., et al. 1991. Heterogeneity in the inheritance of alcoholism. A study of male and female twins. Arch. Gen. Psychiatry 48: 19-28.
18. REGIER, D.A., et al. 1990. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA 264: 2511-2518.
19. REICH, D.E., et al. 2001. On the allelic spectrum of human disease. Trends Genet 17: 502-510.
20. REICH, T., et al. 1998. Genome-wide search for genes affecting the risk for alcohol dependence. Am. J. Med. Genet. 81: 207-215.
21. ROMERO, R., et al. 2002. The design, execution, and interpretation of genetic association studies to decipher complex diseases. Am. J. Obstet. Gynecol. 187: 1299-1312.
22. ROWLAND, A.S., et al. 2002. The epidemiology of attention-deficit/ hyperactivity disorder (ADHD): a public health view. Ment. Retard. Dev. Disabil. Res. Rev. 8: 162-170.
23. SIM, T., et al. 2002. Cognitive deficits among methamphetamine users with attention deficit hyperactivity disorder symptomatology. J. Addict. Dis. 21: 75-89.
24. SIMON, S.L., et al. 2002. Cognitive performance of current methamphetamine and cocaine abusers. J. Addict. Dis. 21: 61-74.
25. SMITH, S.S., et al. 1992. Genetic vulnerability to drug abuse. The D2 dopamine receptor Taq I fragment length polymorphism appears more frequently in polysubstance abusers. Arch. Psychiatry 49: 723-727.
26. STALLINGS, M.C., et al. 2003. A genome-wide search for QTLs influencing substance dependence vulnerabity in adolescence. Drug Alcohol Depend. 70: 295-307.
27. STRAUB, R.E., et al. 1999. Susceptibility genes for nicotine dependence: a genome scan and followup in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Mol. Psychiatry 4: 129-144.
28. SWAN, G.E., et al. 2002. Evidence for genetic mediation of executive control: a study of aging male twins. J. Gerontol. B Psychol. Sci. Soc. Sci. 57: 133-143.
29. TRUE, W.R., et al. 1999. Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. Am. J. Med. Genet. 88: 391-397.
30. TRUE, W.R., et al. 1999. Common genetic vulnerability for nicotine and alcohol dependence in men. Arch. Gen. Psychiatry 56: 655-661.
31. TSUANG, M.T., et al. 1996. Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs. Am. J. Med. Genet. 67: 473-477.
32. TSUANG, M.T., et al. 1999. Genetic and environmental influences on transitions in drug use. Behav. Genet. 29: 473-479.
33. TSUANG, M.T., et al. 1998. Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities. Arch. Gen. Psychiatry 55: 967-972.
34. UHL, G.R. 1999. Molecular genetics of substance abuse vulnerability: a current approach. Neuropsychopharmacology 20: 3-9.
35. UHL, G.R., et al. 1995. Genetic influences in drug abuse. In Psychopharmacology, 4th edit. F.E. Bloom & D.J. Kupfer, Eds.: 1793-1806. Raven Press. New York.
36. UHL, G.R., et al. 2002. Substance abuse vulnerability loci: converging genome scanning data. Trends Genet. 18: 420-425.
37. UHL, G.R., et al. 2001. Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms. Am. J. Hum. Genet. 69: 1290-1300.
38. VANDENBERGH, D.J., et al. 2000. Long forms of the dopamine receptor (DRD4) gene VNTR are more prevalent in substance abusers: no interaction with functional alleles of the catechol-O-methyltransferase (COMT) gene. Am. J. Med. Genet. 96: 678-683.
39. VANDENBERGH, D.J., et al. 1997. High-activity catechol-O- methyltransferase allele is more prevalent in polysubstance abusers. Am. J. Med. Genet. 74: 439-442.
40. YAMASHITA, I., et al. 1990. Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative Study. Jpn. J. Psychiatry Neurol. 44: 79-84.